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The characteristics of the structure, strain and kinematic vorticity of the Wulian detachment fault zone, Shandong Peninsula, China

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Science China Earth Sciences 2019年第9期62卷 1399-1415页

作者： Jinlong NI Junlai LIU Yujie SUN xiaoxiao shi Shen LI Shandong Provincial Key Laboratory of Depositional Mineralization and Sedimentary Minerals College of Earth Sciences and Engineering Shandong University of Science and Technology Qingdao 266590 China State Key Laboratory of Geological Processes and Mineral Resources China University of Geosciences Beijing 100083 China Laboratory for Marine Mineral Resources Qingdao National Laboratory for Marine Science and Technology Qingdao 266071 China Cores and Samples Center of Land & Resources China Geological Survey Langfang 065200 China

As one of the vital tectonic units of the Wulian Metamorphic Core Complex(MCC), the Wulian detachment fault zone(WDFZ), which developed in the Jiaodong peninsula, separates the lower plate of the ultrahigh pressure(UHP) metamorphic rocks in the Sulu orogenic belt from the upper plate of the early Cretaceous Zhucheng basin and the basin basement. The fault zone generally strikes NNE with a dip in the west along the southern portion of the MCC and strikes NE with a dip in the WNWalong the northern portion. The fault zone displays a wavy-tile-shaped extension on the plane, principally composed of the fault breccias and mylonite and transits downward to the mylonitic gneiss. As a whole, the detachment fault zone shows a top-towest or a WNW extension. By calculating the harmonic mean, we obtain a Flynn index K of 0.98–2.0, and the mean value is approximately 1.35 in the fault zone. According to the polar Mohr construction, the extensional crenulation cleavage, the RS/θ,and the quartz C-axial fabric methods, we acquire mean kinematic vorticity values of 0.64–0.97, 0.76–0.93, 0.6–0.92, and 0.63–0.98 with mean values of 0.83, 0.80, 0.78 and 0.86, respectively, for mylonite and promylonite. The strain measurement results and the kinematic vorticity values indicate that the WDFZ is a normal ductile shear zone developed in the extensional *** kinematic track shows that the kinematic vorticity value decreases gradually from the NW to the SE as a whole. A simple shear dominates in the middle and upper parts of the shear zone, which is reflected by a higher vorticity value(>0.75, up to 0.98),a low thinning rate and a lower K value. In contrast, toward the footwall, the pure shear is increased significantly, showing a lower vorticity value(<0.70, low to 0.64), a relatively high thinning rate and a higher K value. Combined with the geotectonic background, the development and evolution of the WDFZ should respond to lithospheric thinning and the destruction of the North China

关键词： Wulian Strain intensity Kinematic vorticity Mylonite Detachment fault zone

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Recent Advances in Interventional Fluorescence Imaging: Toward the Precise Visualization of Transarterial Mini-Invasive Delivery Systems

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Accounts of Materials Research 2023年第3期4卷 251-263页

作者： xiaoxiao shi Dazhuang Xu Hongwei Cheng Chengchao Chu Gang Liu State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics&Center for Molecular Imaging and Translational Medicine School of Public HealthXiamen UniversityXiamen 361102China

CONSPECTUS:Interventional fluorescence imaging has gradually developed into a promising imaging strategy for the diagnosis of diseases in *** strategy could benefit interventional targeted treatment because of the clear display of microstructures at the margins and *** are some stranded crucial issues in clinical application:(i)fast clearance of fluorescence probes;(ii)light instability and photobleaching;and(iii)residual and microsatellite *** development of superstable homoge-neous intermixed formulation technology(shiFT)can solve the aforementioned clinical problems for precision *** fluorescence imaging based on shiFT-prepared product has some advantages such as(i)strong stability,(ii)greatly extending imageable time window,and(iii)precisely visualizing microsatellite *** this Account,we overview our current progress in interventional fluorescence imaging based on shiFT method for surgical resection following long-lasting embolization *** greatly realize interventional fluorescence imaging,we summarize clinical and preclinical application of interventional fluorescence imaging in a transarterial delivery ***,compared with conventional fluorescence imaging,interventional fluorescence imaging possesses non-negligible strengths on improved intensity in target location and step-down systemic ***,a challenging issue is that immobile fluorescence performance is difficult to maintain after long-time embolization,resulting in a failed *** this basis,associated with our previous research,shiFT was proposed and ***,we detailedly introduce and account the development and preponderance of shiFT on interventional fluorescence ***,after lengthy embolization,its lightful fluorescence was still observable in tumor targets of a clinical *** regulate the fluorescence rendering of microsatellite lesion,shiFT combining with pure nanoprobes(nan

关键词： formulation rendering maintain

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Gas-propelled nanomotors alleviate colitis through the regulation of intestinal immunoenvironment-hematopexis-microbiota circuits

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Acta Pharmaceutica Sinica B 2024年第6期14卷 2732-2747页

作者： Bo Xiao Yuqi Liang Ga Liu Lingshuang Wang Zhan Zhang Libin Qiu Haiting Xu Sean Carr xiaoxiao shi Rui LReis Subhas CKundu Zhenghua Zhu Department of Gastroenterology the First Affiliated Hospital of Nanchang UniversityNanchang 330006China College of Sericulture Textileand Biomass SciencesSouthwest UniversityChongqing 400715China Department of Neurology School of MedicineEmory UniversityAtlantaGA 30322USA Atlanta Veterans Affairs Medical Center DecaturGA 30033USA Department of Surgery School of MedicineEmory UniversityAtlantaGA 30322USA Bs Research Group I3Bs—Research Institute on BiomaterialsBiodegradables and BiomimeticsUniversity of MinhoHeadquarters of the European Institute of Excellence on Tissue Engineering and Regenerative MedicineAveParkBarcoGuimaraes 4805-017Portugal

The progression of ulcerative colitis(UC)is associated with immunologic derangement,intestinal hemorrhage,and microbiota *** traditional medications mainly focus on mitigating inflammation,it remains challenging to address multiple ***,a versatile gas-propelled nanomotor was constructed by mild fusion of post-ultrasonic CaO_(2) nanospheres with Cu_(2)O *** resulting CaO_(2)–Cu_(2)O possessed a desirable diameter(291.3 nm)and a uniform size *** could be efficiently internalized by colonic epithelial cells and macrophages,scavenge intracellular reactive oxygen/nitrogen species,and alleviate immune reactions by pro-polarizing macrophages to the anti-inflammatory M2 *** nanomotor was found to penetrate through the mucus barrier and accumulate in the colitis mucosa due to the driving force of the generated oxygen *** administration of CaO_(2)–Cu_(2)O could stanch the bleeding,repair the disrupted colonic epithelial layer,and reduce the inflammatory responses through its interaction with the genes relevant to blood coagulation,anti-oxidation,wound healing,and ***,it restored intestinal microbiota balance by elevating the proportions of beneficial bacteria(e.g.,Odoribacter and Bifidobacterium)and decreasing the abundances of harmful bacteria(e.g.,Prevotellaceae and Helicobacter).Our gas-driven CaO_(2)–Cu_(2)O offers a promising therapeutic platform for robust treatment of UC via the rectal route.

关键词： Nanomotor Anti-inflammation Blood coagulation Immune regulation Hematopexis Microbiota rebalance Ulcerative colitis Rectal administration

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Bioresponsive immune-booster-based prodrug nanogel for cancer immunotherapy

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Acta Pharmaceutica Sinica B 2022年第1期12卷 451-466页

作者： Xianbin Ma Shaochen Yang Tian Zhang Shuo Wang Qichao Yang Yao Xiao xiaoxiao shi Peng Xue Yuejun Kang Gang Liu Zhi-Jun Sun Zhigang Xu Key Laboratory of Luminescence Analysis and Molecular Sensing(Southwest University) Ministry of EducationSchool of Materials and Energy&Chongqing Engineering Research Center for Micro-Nano Biomedical Materials and DevicesSouthwest UniversityChongqing 400715China The State Key Laboratory Breeding Base of Basic Science of Stomatology(Hubei-MOST)&Key Laboratory of Oral Biomedicine Ministry of EducationSchool and Hospital of StomatologyWuhan UniversityWuhan 430079China State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics&Center for Molecular Imaging and Translational Medicine School of Public HealthXiamen UniversityXiamen 361102China

The combination of chemotherapy and immunotherapy motivates a potent immune system by triggering immunogenic cell death(ICD), showing great potential in inhibiting tumor growth and improving the immunosuppressive tumor microenvironment(ITM). However, the therapeutic effectiveness has been restricted by inferior drug bioavailability. Herein, we reported a universal bioresponsive doxorubicin(DOX)-based nanogel to achieve tumor-specific co-delivery of drugs. DOX-based mannose nanogels(DM NGs) was designed and choosed as an example to elucidate the mechanism of combined chemo-immunotherapy. As expected, the DM NGs exhibited prominent micellar stability, selective drug release and prolonged survival time, benefited from the enhanced tumor permeability and prolonged blood circulation. We discovered that the DOX delivered by DM NGs could induce powerful antitumor immune response facilitated by promoting ICD. Meanwhile, the released mannose from DM NGs was proved as a powerful and synergetic treatment for breast cancer in vitro and in vivo, via damaging the glucose metabolism in glycolysis and the tricarboxylic acid cycle. Overall, the regulation of tumor microenvironment with DOX-based nanogel is expected to be an effectual candidate strategy to overcome the current limitations of ICD-based immunotherapy, offering a paradigm for the exploitation of immunomodulatory nanomedicines.

关键词： Bioresponsive Prodrug Nanogel Doxorubicin Mannose Immunogenic cell death Chemotherapy Immunotherapy

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Protective and Adverse Roles of DDX3X in Different Cell Types in Nonalcoholic Steatohepatitis Progression

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Research 2024年第3期6卷 561-574页

作者： Suzhen Yang Lin Zhou Tianming Zhao Hanlong Zhu Tingting Luo Kang Jiang xiaoxiao shi Chunyan Chen Han Zhang Si Zhao Xiaoping Zou Yuzheng Zhuge Fangyu Wang Lei Wang Mingzuo Jiang Bing Xu Department of Gastroenterology the Affiliated Drum Tower Hospital of Nanjing University Medical SchoolJiangsuNanjing210002China. Department of Gastroenterology and Hepatology the Affiliated Jinling Hospital of Nanjing University Medical SchoolJiangsuNanjing210002China School of Medicine Northwest UniversityShaanxiXi’an710069China. Department of Gastroenterology Nanjing Drum Tower HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeJiangsuNanjing210008China.

Persistent hepatic cellular metabolic stress and liver inflammatory stimuli are key signatures of nonalcoholic steatohepatitis(NASH).DDX3X is a vital molecule involved in cell fate decisions in both pro-survival stress granule(SG)and pro-death NOD-like receptor family pyrin domain containing 3(NLRP3)inflammasome assembly in response to stress ***,the role of DDX3X in NASH remains *** characterized the cell type-specific roles of DDX3X in *** liver tissues from NASH patients and normal control subjects were collected to assess DDX3X expression and *** steatohepatitis models were constructed by feeding macrophage-specific DDX3X knockout(DDX3^(XΔMφ)),hepatocyte-specific DDX3X knockout(DDX3X^(Δhep)),and wild-type control(DDX3X^(fl/fl))mice a high-fat and high-cholesterol(HFHC)diet,a methionine-and choline-deficient(MCD)diet,and a high-fat/high-iron/high-fructose/high-cholesterol,low-methionine,and choline-deficient(HFHIHFHC-MCD)*** study demonstrated that DDX3X was predominantly expressed in macrophages and hepatocytes in control liver tissues,and its expression was down-regulated in patients or mice with *** to DDX3X^(fl/fl) littermates,DDX3^(XΔMφ)mice showed improved liver histology in nutritional steatohepatitis *** of macrophage DDX3X inhibited NLRP3 inflammasome-mediated pyroptosis,causing anti-inflammatory M2 polarization and alleviating hepatocyte steatohepatitic ***3X^(Δhep) mice developed marked steatohepatitis in multiple nutritional steatohepatitis models compared to DDX3X^(fl/fl) ***3X-deleted hepatocytes showed impaired SG assembly,leading to increased sensitivity and intolerance to metabolic stimulation and resultant *** conclusion,DDX3X plays opposite roles in different cell types during the progression of NASH.A better understanding of the cell-specific differences in the crosstalk between SG formation and NLRP3 activation is crucial for developing pr

关键词： NLRP3 impaired inhibited

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Mulberry Biomass-Derived Nanomedicines Mitigate Colitis through Improved Inflamed Mucosa Accumulation and Intestinal Microenvironment Modulation

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Research 2024年第1期2023卷 791-807页

作者： Wenjing Yang Ya Ma Haiting Xu Zhenhua Zhu Jiaxue Wu Cheng Xu Wei Sun Erhu Zhao Min Wang Rui L.Reis Subhas C.Kundu xiaoxiao shi Bo Xiao State Key Laboratory of Silkworm Genome Biology College of SericultureTextileand Biomass SciencesSouthwest UniversityChongqing 400715China Chongqing Key Laboratory of Soft-Matter Material Chemistry and Function Manufacturing Faculty of Materials and EnergySouthwest UniversityChongqing 400715China Department of Gastroenterology The First Affiliated Hospital of Nanchang UniversityNanchang 330006China Bs Research Group I3Bs—Research Institute on BiomaterialsBiodegradables and BiomimeticsUniversity of MinhoHeadquarters of the European Institute of Excellence on Tissue Engineering and Regenerative MedicineAveParkBarco 4805-017GuimaraesPortugal ICVS/3B’s-PT Government Associate Laboratory BragaGuimarãesPortugal

The therapeutic outcomes of conventional oral medications against ulcerative colitis(UC)are restricted by inefficient drug delivery to the colitis mucosa and weak capacity to modulate the inflammatory ***,a fluorinated pluronic(FP127)was synthesized and employed to functionalize the surface of mulberry leaf-derived nanoparticles(MLNs)loading with resveratrol nanocrystals(RNs).The obtained FP127@RN-MLNs possessed exosome-like morphologies,desirable particle sizes(around 171.4 nm),and negatively charged surfaces(−14.8 mV).The introduction of FP127 to RN-MLNs greatly improved their stability in the colon and promoted their mucus infiltration and mucosal penetration capacities due to the unique fluorine effect.

关键词： fluorine sizes Biomass

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自适应神经网络在发动机故障诊断中的应用

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计算机工程 2005年第B07期31卷 82-84页

作者：杨慧施潇潇中国民航学院计算机学院天津300300

为适应民航系统发展的要求,确保飞机的飞行安全、提高飞机发动机的可靠性和利用率、改变对发动机故障的诊断和探测能力的局限性以及降低传统的定期维护成本,提出了应用自适应神经网络技术对飞机发动机进行诊断。该文根据在飞行中检测或... 详细信息

为适应民航系统发展的要求,确保飞机的飞行安全、提高飞机发动机的可靠性和利用率、改变对发动机故障的诊断和探测能力的局限性以及降低传统的定期维护成本,提出了应用自适应神经网络技术对飞机发动机进行诊断。该文根据在飞行中检测或地面维修时采集到的数据,并将这些数据分为故障现象和故障集分别进行编码,而后利用神经网络的自学习、联想、推测、记忆、容错、自适应和多模式处理等功能对飞机发动机的故障进行诊断。应用结果表明,诊断的精度基本符合实际应用的需要。

关键词：自适应神经网络故障诊断飞机发动机

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组织惯性对企业渐进性创新能力影响研究

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科学学与科学技术管理 2017年第11期38卷 101-115页

作者：施萧萧张庆普哈尔滨工业大学管理学院哈尔滨150001

在产业技术发展的不同阶段,企业在创新网络中的惯性行为究竟如何影响其创新能力的发展,尤其是如何作用于渐进性创新能力已经成为学术界和产业界关注的热点。基于开放式创新视角,以智能手机产业为研究对象,通过对该产业2000—2014年间主... 详细信息

在产业技术发展的不同阶段,企业在创新网络中的惯性行为究竟如何影响其创新能力的发展,尤其是如何作用于渐进性创新能力已经成为学术界和产业界关注的热点。基于开放式创新视角,以智能手机产业为研究对象,通过对该产业2000—2014年间主要企业间的专利引用数据进行专利网络分析和层次回归分析,探讨不同技术发展阶段企业惯性行为对其渐进性创新能力的影响。结果表明:(1)企业渐进性创新能力主要受其在创新网络中开放度水平的直接影响,组织惯性通过调节二者关系间接影响渐进性创新能力;(2)在产业技术发展的萌芽期,仅结构惯性正向调节企业创新开放度对其渐进性创新能力的影响;(3)在产业技术发展的涌现期,组织惯性的调节作用消失;(4)在产业技术发展的稳定期,结构惯性正向调节企业开放度对渐进性创新能力的影响,认知惯性负向调节开放度对渐进性创新能力的影响。

关键词：组织惯性渐进性创新能力创新开放度技术发展阶段

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网络嵌入对企业突破性创新能力影响研究——以网络分裂断层为调节变量

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科学学与科学技术管理 2021年第1期42卷 90-109页

作者：施萧萧张庆普北京航空航天大学经济管理学院哈尔滨工业大学管理学院

分裂断层是产业技术创新网络演化中普遍存在的现象,其对企业突破性创新能力的影响已经成为学术界和产业界的关注的热点。为此,将分裂断层引入创新网络嵌入与突破性创新能力的研究框架中,探讨网络分裂断层的直接作用机制及调节作用机制... 详细信息

分裂断层是产业技术创新网络演化中普遍存在的现象,其对企业突破性创新能力的影响已经成为学术界和产业界的关注的热点。为此,将分裂断层引入创新网络嵌入与突破性创新能力的研究框架中,探讨网络分裂断层的直接作用机制及调节作用机制。结果表明:(1)企业网络结构嵌入和关系嵌入均与其突破性创新能力呈倒U型关系。(2)网络关系分裂断层会直接促进企业突破性创新能力的提升;网络地位分裂断层不会直接影响突破性创新能力。(3)网络关系分裂断层正向调节企业网络嵌入对其突破性创新能力的影响;网络地位分裂断层仅正向调节企业结构嵌入对其突破性创新能力的影响。

关键词：分裂断层网络嵌入突破性创新能力创新网络

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基于共词分析的国外颠覆性创新研究现状及发展趋势

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情报学报 2017年第7期36卷 748-759页

作者：施萧萧张庆普哈尔滨工业大学管理学院哈尔滨150001

运用共词分析方法,以Scopus数据库于1998-2015年收录的490篇颠覆性创新研究文献为分析对象,绘制了该领域知识图谱和知识网络,分析了颠覆性创新领域的研究热点、研究主题及其演化趋势。研究表明:国外颠覆性创新研究分为三个阶段,研究主... 详细信息

运用共词分析方法,以Scopus数据库于1998-2015年收录的490篇颠覆性创新研究文献为分析对象,绘制了该领域知识图谱和知识网络,分析了颠覆性创新领域的研究热点、研究主题及其演化趋势。研究表明:国外颠覆性创新研究分为三个阶段,研究主题从颠覆性技术和概念内涵到内部驱动因素、有效实施路径和类型细分,最后聚焦到外部驱动因素、市场驱动因素和技术驱动因素。研究热点从颠覆性技术、创新到技术创新、技术管理,最后聚焦到市场驱动、竞争策略。在未来的研究中,该领域可着力于颠覆性创新中的技术预测方法的创新与变革、中国情境理论的构建与实施、颠覆性创新程度的测量与应用和"互联网+"跨界颠覆性实践的挖掘和探索等角度展开研究。

关键词：颠覆性创新共词分析知识图谱文献计量

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