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Apigenin ameliorates imiquimod-induced psoriasis in C57BL/6J mice by inactivating STAT3 and NF-κB

Food Science and Human Wellness 2024年第1期13卷 211-224页

作者： Xianshe Meng Shihong Zheng Zequn Yin Xuerui Wang Daigang yang Tingfeng Zou Huaxin Li Yuanli Chen Chenzhong Liao Zhouling Xie Xiaodong Fan Jihong Han Yajun Duan xiaoxiao yang Key Laboratory of Metabolism and Regulation for Major Diseases of Anhui Higher Education Institutes College of Food and Biological EngineeringHefei University of TechnologyHefei 230601China Tianjin Key Laboratory of human Development and Reproductive Regulation Department of General GynecologyTianjin Central Hospital of Gynecology and ObstetricsTianjin 300100China Key Laboratory of Medicinal Chemical Biology Key Laboratory of Bioactive Materials of Ministry of EducationCollege of Life SciencesNankai UniversityTianjin 300071China

Psoriasis is a chronic autoimmune disease featured by patches on the skin.It is caused by malfunction of immune cells and keratinocytes with inflammation as one of its key features.Apigenin(API)is a natural flavonoid with anti-inflammatory and immunoregulatory properties.Therefore,we speculated that API can ameliorate psoriasis,and determined its effect on the development of psoriasis by using imiquimod(IMQ)-induced psoriasis mouse model.Our results showed that API attenuated IMQ-induced phenotypic changes,such as erythema,scaling and epidermal thickening,and improved splenic hyperplasia.Abnormal differentiation of immune cells was restored in API-treated mice.Mechanistically,we revealed that API is a key regulator of signal transducer activator of transcription 3(STAT3).API regulated immune responses by reducing interleukin-23(IL-23)/STAT3/IL-17A axis.Moreover,it suppressed IMQ-caused cell hyperproliferation by inactivating STAT3 through regulation of extracellular signal-regulated kinase 1/2 and nuclear factor-κB(NF-κB)pathway.Furthermore,API reduced expression of inflammatory cytokines through inactivation of NF-κB.Taken together,our study demonstrates that API can ameliorate psoriasis and may be considered as a strategy for psoriasis treatment.

关键词： Psoriasis Apigenin Imiquimod Inflammation Signal transducer activator of transcription 3 (STAT3) Nuclear factor-κB(NF-κB)

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Seismogenic Structure of the 1605 Qiongshan M7½ Earthquake and Its Holocene Activity History in Northern Hainan Island, China: Evidence from Cross-Section Drilling and Shallow Seismic Profile

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Journal of Earth Science 2024年第3期35卷 905-917页

作者： Chaoqun Wang Liyun Jia Daogong Hu Shibiao Bai Zhengwang Hu Dongxia Sun xiaoxiao yang Lei Zhang Xiumin Ma Institute of Geomechanics Chinese Academy of Geological SciencesBeijing 100081China Key Laboratory of Active Tectonics and Geological Safety Ministry of Natural ResourcesBeijing 100081China Key Laboratory of Geohazard Prevention of Hilly Mountains Ministry of Land and Resources(Fujian Key Laboratory of Geohazard Prevention)Fuzhou 350002China Observation and Research Station of Crustal Stress and Strain in Beijing Ministry of Natural ResourcesBeijing 100081China College of Marine Science and Engineering Nanjing Normal UniversityNanjing 210023China Hubei Subsurface Multi-Scale Imaging Key Laboratory School of Geophysics and GeomaticsChina University of GeosciencesWuhan 430074China

The 1605 M7½ Earthquake is the only earthquake in the history of China that has caused large-scale land subsidence into the sea,with the total area of land subsidence exceeding 100 km2.The disaster has led to the sinking of 72 villages.There is still no clear understanding of the source seismogenic fault of this earthquake.In this work,we conducted a detailed study of the middle segment of the Maniao-Puqian fault(MPF),which is the epicenter area,through geomorphological survey,data collection,shallow seismic exploration,cross-section drilling,and chronological dating.The results showed that the middle segment of the MPF zone is composed of three nearly parallel normal faults with a dextral strike-slip:“Macun-Luodou fault(F2-1),Haixiu-Dongyuan fault(F2-2),and ChangliuZhuxihe fault(F2-3)”.And F2-2 is composed of two secondary faults,namely F2-2′and F2-2″,with a flower-shaped structure buried under the ground.It is distributed nearly east-west,dipping to the north and has experienced at least five stages of activities since the Miocene.The vertical activity rates of F2-2′and F2-2″are~2.32 and~2.5 mm/a,since the Holocene,respectively.There were eight cycles of transgression and regression since the Miocene.The fault activity resulted in the thickening of the Holocene strata with a slight dip to the south,on the hanging wall,showing V-shaped characteristics.The MPF is likely the source seismogenic fault of the M7½ earthquake that hit Qiongshan in 1605.

关键词： seismogenic structure earthquakes Maniao-Puqian fault fault activity history geomorphology.

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L-Ergothioneine ameliorates MPTP-induced Parkinson's disease in C57BL/6J mice by activating DJ-1

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Food Science and Human Wellness 2024年

作者： Xianshe Meng# Huawen Meng# Shuzeng Hou Zequn Yin Xuerui Wang Ke Gong Feng Zhang Qingshan Li Shuang Zhang Yuanli Chen xiaoxiao yang Zhiwei Zhao Chenzhong Liao Yajun Duan Department of Cardiology the First Affiliated Hospital of USTC Division of Life Sciences and Medicine University of Science and Technology of China Key Laboratory of Metabolism and Regulation for Major Diseases of Anhui Higher Education Institutes Hefei University of Technology

Parkinson’s disease (PD) is one of the most common neurodegenerative diseases. The loss of dopaminergic (DAergic) neurons in the substantia nigra and the decrease of dopamine (DA) levels accelerate the process of PD. L-Ergothioneine (EGT) is a natural antioxidant derived from microorganisms， especially in edible mushrooms. EGT can penetrate blood-brain barrier and its levels are significantly decreased in the plasma of PD patients. Therefore， we speculated that EGT could ameliorate PD， and determined its effect on PD development by using 1-methyl-4-phenyl-1，2，3，6-tetrahydropyridine (MPTP)-induced PD mouse models and neurotoxin 1-methyl-4-phenylpyridinium (MPP+)-induced cell models. Our results show that EGT alleviated MPTP-induced behavioral dysfunction in mice. Mechanistically， we innovatively revealed that EGT is a key regulator of DJ-1. EGT restored DA levels by activating the DJ-1-Nuclear receptor-related factor 1(Nurr1) axis. Furthermore， it reduced reactive oxygen species (ROS) levels by regulating the DJ-1-Nuclear factor erythroid 2-related factor 2 (Nrf2) pathway， which inhibited oxidative stress-induced DAergic neuronal apoptosis. Combined treatment with DJ-1-siRNA transfection revealed that blocking DJ-1 reversed EGT upregulated Nurr1 and Nrf2 expression in the nucleus， which significantly decreased the benefits of EGT. Taken together， our study suggests that EGT can ameliorate PD and be considered as a strategy for PD treatment.

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HIF-1αpromotes virus replication and cytokine storm in H1N1 virus-induced severe pneumonia through cellular metabolic reprogramming

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Virologica Sinica 2024年第1期39卷 81-96页

作者： xiaoxiao Meng Yong Zhu Wenyu yang Jiaxiang Zhang Wei Jin Rui Tian Zhengfeng yang Ruilan Wang Department of Critical Care Medicine Shanghai General HospitalShanghai Jiaotong UniversitySchool of MedicineShanghai201620China Precision Research Center for Refractory Diseases Shanghai General HospitalShanghai Jiaotong UniversitySchool of MedicineShanghai201620China

The mortality of patients with severe pneumonia caused by H1N1 infection is closely related to viral replication and cytokine storm.However,the specific mechanisms triggering virus replication and cytokine storm are still not fully elucidated.Here,we identified hypoxia inducible factor-1α(HIF-1α)as one of the major host molecules that facilitates H1N1 virus replication followed by cytokine storm in alveolar epithelial cells.Specifically,HIF-1αprotein expression is upregulated after H1N1 infection.Deficiency of HIF-1αattenuates pulmonary injury,viral replication and cytokine storm in vivo.In addition,viral replication and cytokine storm were inhibited after HIF-1αknockdown in vitro.Mechanistically,the invasion of H1N1 virus into alveolar epithelial cells leads to a shift in glucose metabolism to glycolysis,with rapid production of ATP and lactate.Inhibition of glycolysis significantly suppresses viral replication and inflammatory responses.Further analysis revealed that H1N1-induced HIF-1αcan promote the expression of hexokinase 2(HK2),the key enzyme of glycolysis,and then not only provide energy for the rapid replication of H1N1 virus but also produce lactate,which reduces the accumulation of the MAVS/RIG-I complex and inhibits IFN-α/βproduction.In conclusion,this study demonstrated that the upregulation of HIF-1αby H1N1 infection augments viral replication and cytokine storm by cellular metabolic reprogramming toward glycolysis mainly through upregulation of HK2,providing a theoretical basis for finding potential targets for the treatment of severe pneumonia caused by H1N1 infection.

关键词： H1N1 Severe pneumonia Virus replication Hypoxia inducible factor-1α Glycolysis

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A Modified Tikhonov Regularization Method for a Cauchy Problem of the Biharmonic Equation

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Journal of Mathematical Research with Applications 2024年第3期44卷 359-386页

作者： Fan yang Jianming XU xiaoxiao LI School of Science Lanzhou University of Technology

In this paper, the Cauchy problem of biharmonic equation is considered. This problem is ill-posed, i.e., the solution(if exists) does not depend on the measurable data. Firstly, we give the conditional stability result under the a priori bound assumption for the exact solution.Secondly, a modified Tikhonov regularization method is used to solve this ill-posed problem.Under the a priori and the a posteriori regularization parameter choice rule, the error estimates between the regularization solutions and the exact solution are obtained. Finally, some numerical examples are presented to verify that our method is effective.

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Multiple thermal events recorded in the Acasta Gneiss Complex:Evidence from in-situ dating of zircon, titanite, and apatite

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Science China Earth Sciences 2024年第3期67卷 673-686页

作者： Qingfeng MEI Jinhui yang Jinfeng SUN Qiuli LI Shitou WU xiaoxiao LING Peng PENG Hao WANG State Key Laboratory of Lithospheric Evolution Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijing 100049China Key Laboratory of Computational Geodynamics University of Chinese Academy of SciencesBeijing 100049China

In-situ dating of the zircons, titanites, and apatites in the rock fragments of approximately 1 cm2in size from the Acasta Gneiss Complex was performed using secondary ion mass spectrometry or laser ablation inductively coupled plasma mass spectrometry to provide constraints on the thermal history of the Acasta Gneiss Complex. The zircons in these rock fragments typically exhibit multiple age populations, reflecting the presence of inherited zircons or the post-crystallization process of zircon overgrowth. Combined with previous studies, our zircon dating results reveal multiple magmatic events that occurred in the Acasta Gneiss Complex, specifically at >3.96, ~3.72, and ~3.57 Ga, respectively. A titanite Pb-Pb isochron age of2911±22 Ma(95% confidence level, MSWD=1.5) for sample AY199 is identified, consistent with the timing of the latest Archean magmatism in the Acasta Gneiss Complex. The titanite U-Pb ages for samples AC478 and AY066 are 1932±270 Ma(95% confidence level, MSWD=2.3) and 1813±45 Ma(95% confidence level, MSWD=2.3), respectively. The apatites in sample P090803-C exhibit a Pb-Pb isochron age of 1833±26 Ma(95% confidence level, MSWD=1.4). The apatite U-Pb ages for samples AC478, AY199, and AY066 are 1850±20 Ma(95% confidence level, MSWD=1.3), 1827±100 Ma(95% confidence level, MSWD=6.3), and 1807±58 Ma(95% confidence level, MSWD=3.9), respectively. Titanites in samples AC478 and AY066, as well as the apatites in all four investigated samples, show a uniform age(Pb-Pb or U-Pb age) of ~1.9–1.8 Ga,indicating U-Pb system reset in these minerals due to the Wopmay orogeny and documenting that the peak temperature condition associated with the Wopmay orogeny exceeded the apatite U-Pb closure temperature and approached or exceeded that of titanite.

关键词： Zircon Titanite Apatite Acasta Gneiss Complex Wopmay Orogen

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Weakly Polarized Organic Cation-Modified Hydrated Vanadium Oxides for High-Energy Efficiency Aqueous Zinc-Ion Batteries

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Nano-Micro Letters 2024年第7期16卷 169-186页

作者： xiaoxiao Jia Chaofeng Liu Zhi Wang Di Huang Guozhong Cao Department of Materials Science and Engineering University of WashingtonSeattleWA 98195USA School of Materials Science and Engineering Tongji UniversityShanghai 201804People’s Republic of China

Vanadium oxides,par-ticularly hydrated forms like V_(2)O_(5)·nH_(2)O(VOH),stand out as promising cathode candidates for aqueous zinc ion batteries due to their adjustable layered structure,unique electronic characteristics,and high theoretical capacities.However,challenges such as vanadium dissolution,sluggish Zn^(2+)diffusion kinetics,and low operating voltage still hinder their direct application.In this study,we present a novel vanadium oxide([C_(6)H_(6)N(CH_(3))_(3)]_(1.08)V_(8)O_(20)·0.06H_(2)O,TMPA-VOH),developed by pre-inserting trimethylphenylammonium(TMPA+)cations into VOH.The incorporation of weakly polarized organic cations capitalizes on both ionic pre-intercalation and molecular pre-intercalation effects,resulting in a phase and morphology transition,an expansion of the interlayer distance,extrusion of weakly bonded interlayer water,and a substantial increase in V^(4+)content.These modifications synergistically reduce the electrostatic interactions between Zn^(2+)and the V-O lattice,enhancing structural stability and reaction kinetics during cycling.As a result,TMPA-VOH achieves an elevated open circuit voltage and operation voltage,exhibits a large specific capacity(451 mAh g^(-1)at 0.1 A g^(-1))coupled with high energy efficiency(89%),the significantly-reduced battery polarization,and outstanding rate capability and cycling stability.The concept introduced in this study holds great promise for the development of high-performance oxide-based energy storage materials.

关键词： Zinc-ion battery Vanadium oxide V_(2)O_(5)·nH_(2)O Pre-intercalation Interlayer engineering

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Novel P-doping-tuned Pd nanoflowers/S,N-GQDs photo-electrocatalyst for high-efficient ethylene glycol oxidation

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Chinese Chemical Letters 2024年第6期35卷 541-545页

作者： xiaoxiao Huang Zhi-Long He yangpeng Chen Lei Li Zhenyu yang Chunyang Zhai Mingshan Zhu School of Materials Science and Chemical Engineering Ningbo UniversityNingbo 315211China College of Biological Chemical Sciences and EngineeringJiaxing UniversityJiaxing 314001China Guangdong Key Lab oratory of Environmental Pollution and Health School of EnvironmentJinan UniversityGuangzhou 510632China

Traditional photo-electcatalyst structures of small noble metal nanoparticles assembling into large-scale photoactive semiconductors still suffer from agglomeration of noble metal nanoparticles,insufficient charge transfer,undesirable photoresponse ability that restricted the photo-electrocatalytic performance.To this end,a novel design strategy is proposed in this work,namely integrating small-scale photoactive materials(doped graphene quantum dots,S,N-GQDs)with large-sized noble metal(Pd P)nanoflowers to form novel photo-electrocatalysts for high-efficient alcohol oxidation reaction.As expected,superior electrocatalytic performance of Pd P/S,N-GQDs for ethylene glycol oxidation is acquired,thanks to the nanoflower structure with larger specific surface area and abundant active sites.Furthermore,nonmetal P are demonstrated,especially optimizing the adsorption strength,enhancing the interfacial contact,reducing metal agglomeration,ensuring uniform and efficient doping of S,N-GQDs,and ultimately significantly boost the catalytic activity of photo-electrocatalysts.

关键词： Non-metallic P–doping Sulfur nitrogen co-doped graphene quantum dots Pd nanoflowers Photo-electrocatalytic Ethylene glycol oxidation

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Synergically regulated silver species and surface oxygen on manganese oxide for promoted activity of formaldehyde oxidation

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Journal of Environmental Sciences 2024年第4期138卷 709-718页

作者： Shuo Hu Jianghao Zhang Xueyan Chen xiaoxiao Qin Jinshui Yao Changbin Zhang School of Materials Science&Engineering Qilu University of Technology(Shandong Academy of Sciences)Jinan 250353China State Key Joint Laboratory of Environment Simulation and Pollution Control Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China University of Chinese Academy of Sciences Beijing 100049China

Formaldehyde(HCHO)is a common indoor pollutant that is detrimental to human health.Its efficient removal has become an urgent demand to reduce the public health risk.In this work,Ag-MnO_(x)-based catalysts were prepared and activated under different atmosphere(i.e.,air,hydrogen(H_(2))and carbon monoxide(CO))for efficient oxidation of HCHO.The catalyst activated with CO(Ag/Mn-CO)displayed the highest activity among the tested samples with 90% conversion at 100℃ under a gas space velocity of 75,000 mL/(g_(cat)·hr).Complementary characterizations demonstrate that CO reduction treatment resulted in synergically regulated content of surface oxygen on support to adsorb/activate HCHO and size of Ag particle to dissociate oxygen to oxidize the adsorbed HCHO.In contrast,other catalysts lack for either abundant surface oxygen species or metallic silver with the appropriate particle size,so that the integrate activity is limited by one specific reaction step.This study contributes to elucidating the mechanisms regulating the oxidation activity of Ag-based catalysts.

关键词： HCHO oxidation Ag-MnO_(x)-based catalyst Activation condition Synergic regulation Surface oxygen Oxidized Ag

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GreenPhos,a universal method for in-depth measurement of plant phosphoproteomes with high quantitative reproducibility

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Molecular Plant 2024年第1期17卷 199-213页

作者： xiaoxiao Duan Yuanya Zhang Xiahe Huang Xiao Ma Hui Gao Yan Wang Zhen Xiao Chengcheng Huang Zhongshu Wang Bolong Li Wenqiang yang Yingchun Wang State Key Laboratory of Molecular Developmental Biology Institute of Genetics and Developmental BiologyChinese Academy of SciencesBejing 100101China University of Chinese Academy of Sciences Bejing 100049China Key Laboratory of Photobiology Instute of BotanyChinese Academy of SciencesBejing 100093China

Protein phosphorylation regulates a variety of important cellular and physiological processes in plants.In-depth profiling of plant phosphoproteomes has been more technically challenging than that of animal phosphoproteomes.This is largely due to the need to improve protein extraction efficiency from plant cells,which have a dense cell wall,and to minimize sample loss resulting from the stringent sample clean-up steps required for the removal of a large amount of biomolecules interfering with phosphopeptide purification and mass spectrometry analysis.To this end,we developed a method with a streamlined workflow for highly efficient purification of phosphopeptides from tissues of various green organisms including Arabidopsis,rice,tomato,and Chlamydomonas reinhardtii,enabling in-depth identification with high quantitative reproducibility of about 11000 phosphosites,the greatest depth achieved so far with single liquid chromatography-mass spectrometry(LC-MS)runs operated in a data-dependent acquisition(DDA)mode.The mainstay features of the method are the minimal sample loss achieved through elimination of sample clean-up before protease digestion and of desalting before phosphopeptide enrichment and hence the dramatic increases of time-and cost-effectiveness.The method,named GreenPhos,combined with single-shot LC-MS,enabled in-depth quantitative identification of Arabidopsis phosphoproteins,including differentially phosphorylated spliceosomal proteins,at multiple time points during salt stress and a number of kinase substrate motifs.GreenPhos is expected to serve as a universal method for purification of plant phosphopeptides,which,if samples are further fractionated and analyzed by multiple LC-MS runs,could enable measurement of plant phosphoproteomes with an unprecedented depth using a given mass spectrometry technology.

关键词： plant phosphoproteomics phosphopeptides LC–MS Arabidopsis salt stress

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