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基于区块链的中医消化领域临床科研一体化数据共享平台的研究与设计

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中华中医药学刊 2024年第6期42卷 29-33,I0007页

作者：张泽丹王斌陈婷李青山吴琛胡旭磊杨星辰温宵宵唐旭东中国中医科学院中医药数据中心北京100700 中国中医科学院西苑医院北京100091 博雅正链(北京)科技有限公司北京100032 中国中医科学院北京100700

利用区块链和联邦学习等技术,构建基于区块链的中医消化领域临床科研一体化数据共享平台,包括中医消化领域优势病种数据管理系统、中医消化领域优势病种可信联合循证分析联盟链和中医消化领域优势病种可信联合循证分析平台。该方案支持... 详细信息

利用区块链和联邦学习等技术,构建基于区块链的中医消化领域临床科研一体化数据共享平台,包括中医消化领域优势病种数据管理系统、中医消化领域优势病种可信联合循证分析联盟链和中医消化领域优势病种可信联合循证分析平台。该方案支持多途径数据采集,包括医院信息管理系统(Hospital Information System, HIS)/医学实验室信息管理系统(Laboratory Information Management System, LIS)/电子病历(Electronic Medical Record, EMR)等业务系统中临床数据定时抽取和手动导入,科研数据经病例报告表(Case Report Form, CRF)手动录入和自动映射等方式;并支持原始数据本地存储,仅将数据索引和数据Hash特征进行共识上链存证;基于RegLang智能合约监管,实现监管规则的数字化、自动化和智能化,保证智能合约的安全性,实现数据安全共享的函数级控制;借助分布式算法实现各节点本地单独计算、汇总结果链上流转等功能,做到“算法多跑路,数据不跑路”,充分保障数据安全与隐私。整个平台架构在数据安全存储和可信计算之上实现了多中心医学研究全场景的解决方案,拥有面向多样化医疗科研场景所需的上层应用能力,如多中心临床研究开展、跨区域专病数据库建设等。临床科研一体化数据共享平台的建立,对促进中医药临床与科研数据多方平等共享、合作共赢提供了有力支撑,为中医药行业快速发展奠定了坚实基础。

关键词：中医药数据共享数据存储区块链

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Cobalt phosphide-based composites as anodes for lithium-ion batteries:From mechanism,preparation to performance

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Particuology 2024年第5期88卷 11-31页

作者： Bo Lan Yishan Wang Jialei Lu Dongdong Liu Chuncheng Wei Xueqian Zhang xiaoxiao Huang Guangwu wen School of Materials Science and Engineering Shandong University of TechnologyZibo255000China School of Materials Science and Engineering Harbin Institute of TechnologyHarbin150001China School of Materials Science and Engineering Harbin Institute of TechnologyWeihai264209China

With the further requirements of electronic products and powered vehicles,the development of a new generation with low-voltage and high-capacity anode materials is crucial for lithium-ion batteries(LIBs).Transition metal phosphides,especially cobalt phosphide(CoP)composites,have become a research hotspot for LIBs anode materials in recent years due to their high theoretical specific capacity,low polarization,and suitable voltage *** review first systematically discusses the lithium storage mechanism and preparation methods of CoP in current ***,the applications of CoP anode materials in LIBs are categorically reviewed,including the composites of CoP with various types of carbon materials and ***,the challenges and future development directions of CoP anode materials are summarized to provide guidance for further improving the lithium storage performance of CoP and its practical applications.

关键词： CoP Composites Preparation Anodes Lithium-ion batteries

MoS2-based anode materials for lithium-ion batteries:Developments and perspectives

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Particuology 2024年第4期87卷 240-270页

作者： Lianyu Zhao Yishan Wang Chuncheng Wei xiaoxiao Huang Xueqian Zhang Guangwu wena School of Materials Science and Engineering Shandong University of TechnologyZibo255000China Schoolof Materials Science and Engineering Harbin Institute of TechnologyHarbin10001China

In recent years,significant progress has been achieved in the creation of innovative functional materials for energy storage and *** to their distinct physicochemical characteristics,ultrathin nanosheets composed of common layered transition metal sulfide materials(MoS2)have demonstrated promise as high-capacity anode materials for lithium-ion batteries(LIBs).Nevertheless,their practical application is severely limited by the tendency of monolayer nanosheets to restack due to strong van der Waals forces,dramatic volume changes during successive cycles,and low intrinsic *** research advances have shown that composite structures and nanowire morphologies with specific morphologies effectively overcome these *** paper reviews the recent research progress on molybdenum disulfide-based composites as anode materials for LIBs and discusses in detail the struc-tural characteristics of pure molybdenum disulfide and other composite forms of molybdenum *** addition,the phase engineering,defect engineering,and lithium storage mechanisms of molybdenum disulfide and the synthesis of molybdenum disulfide-based nanocomposites by different preparation methods are focused ***,we review the design(structure),recent developments,and challenges of novel anode materials and consider their electrochemical performance in Li-ion batteries.

关键词： Lithium-ion battery MoS_(2)-Based anode composites Synthesis methods Defect engineering Lithium storage mechanism

Analysis of the acoustoelectric response of SAW gas sensors using a COM model

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Microsystems & Nanoengineering 2024年第3期10卷 87-96页

作者： Yang Yuan Tao Yang Xi Chen Linglang Yu xiaoxiao Hou Guangzu Zhang wen Dong Zixiao Lu Honglang Li Leonhard Reindl Wei Luo School of Integrated Circuits Huazhong University of Science and Technology430074 WuhanPeople’s Republic of China CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology100190 BeijingPeople’s Republic of China Department of Microsystems Engineering Laboratory for Electrical Instrumentation and Embedded SystemsUniversity of Freiburg79110 FreiburgGermany Research Institute of Huazhong University of Science and Technology in Shenzhen 518057 ShenzhenPeople’s Republic of China

Surface acoustic wave(SAW)gas sensors based on the acoustoelectric effect exhibit wide application prospects for in situ gas ***,establishing accurate models for calculating the scattering parameters of SAW gas sensors remains a ***,we present a coupling of modes(COM)model that includes the acoustoelectric effect and specifically explains the nonmonotonic variation in the center frequency with respect to the sensing film’s sheet *** sensing parameters of the gas sensors,including the center frequency,insertion loss,and phase,were experimentally compared for accuracy and ***,the frequency of the phase extremum(FPE)shift was determined to vary monotonically,and the range of selectable test points was wide,making the FPE an appropriate response parameter for leveraging in SAW gas *** simulation results of the COM model were highly consistent with the experimental *** study is proposed to provide theoretical guidance for the future development of gas SAW sensors.

关键词： COM SAW establishing

Exogenous Hematin Alleviates Mercury-induced Oxidative Damage in the Roots of Medicago sativa

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Journal of Integrative Plant Biology 2007年第12期49卷 1703-1713页

作者： Yi Han Wei Xuan Tian Yu wen-Bing Fang Tian-Ling Lou Yin Gao Xiao-Yue Chen xiaoxiao wen-Biao Shen College of Life Sciences Laboratory of Nanjing Agricultural University and Carl Zeiss Far East Nanjing Agricultural University Nanjing 210095 China

In the present study, we evaluated the protective effect of exogenous heme oxygenase-1 （HO-1 EC 1.***.99.3） inducer hematin against mercury-induced oxidative damage in the roots of Alfalfa （Medicago sativa L.）. Plants exposed to mercury （HgCl2） exhibited a significant increase of lipid peroxidation, as well as inhibition of root elongation. However, hematin （50 μM） supplementation to HgCl2 （100 μmol/L） treated plants effectively reduced the lipid peroxidation and partially increased the root elongation. These responses were mimicked by the application of aqueous solution of carbon monoxide （CO） with 50% saturation. Also, treatment with hematin could result in the potent induction of HO-1 transcript in the root tissues, as detected 12h following treatment. Moreover, the activation of anti-oxidant enzyme, including glutathione reductase, monodehydroascorbate reductase and superoxide dismutase activities, and the decrease of lipoxygenase activity, were induced by hematin at 12h or 24h, which was further confirmed by histochemical staining for the detection of lipid peroxidation and loss of membrane integrity. Whereas, ascorbate peroxidase and guaiacol peroxidase isozyme activities or their transcripts were reduced, respectively, indicating that hydrogen peroxide might act as a signal to mediate Hg- tolerance at the beginning of treatment. The ameliorating effects of hematin were specific, since the CO scavenger hemoglobin differentially reversed the above actions. Taken together, our results suggested that hematin exhibits a vital role in protecting the plant against Hg-induced oxidative damage.

关键词： carbon monoxide hematin Medicago sativa mercury toxicity oxidative stress.

In vitro and in vivo investigation of bacterial cellulose dressing containing uniform silver sulfadiazine nanoparticles for burn wound healing

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Progress in Natural Science:Materials International 2015年第3期25卷 197-203页

作者： xiaoxiao wen Yudong Zheng Jian Wu Lina Yue Cai Wang Jiabin Luan Zhigu Wu Kaisheng Wang School of Materials Science and Engineering University of Science and Technology Beijing Suzhou Institute of Nano-Tech and Nano-biobics Chinese Academy of Sciences Hospital Affiliated to Chinese PLA General Hospital

Silver sulfadiazine(SSD) particles in homogeneous dispersion state were prepared by an ultrasonic method and then nano- and microparticles were separated using centrifugation. SSD particles with narrow size distribution were impregnated with bacterial cellulose(BC) to produce BC–SSD composite membrane used as burn wound dressing. A scanning electron microscope(SEM) was used to examine the surface morphology of BC–SSD membranes. The incorporation of SSD in BC–SSD was confirmed by X-ray diffraction(XRD). Antimicrobial tests in vitro indicated that BC–SSD showed excellent antibacterial activity against Staphylococcus aureus, Pseudomonas aeruginosa and Escherichia coli. The effects of BC–SSD on burn wound healing were assessed by rat models. The comparative study confirmed that the wound treated with BC–SSD showed high healing rate. The bacteria count in BC–SSD group was far less than control group. Histological analysis showed that epithelialization progressed better in wound treated with BC–SSD. These values demonstrated that the BC–SSD composite membrane could be a promising wound dressing for burn.

关键词： Bacterial cellulose Silver sulfadiazine Antibacterial activity Burn wound healing

基于单细胞测序探索SENP2在肾细胞癌不同亚型中的作用

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基因组学与应用生物学 2022年第11期41卷 2218-2232页

作者：王嘉璞温笑笑孟子楹梁紫微太原理工大学生物医学工程学院太原030002

本研究基于单细胞测序数据探讨SENP2在肾细胞癌(renal cell carcinoma,RCC)3种不同亚型中的表达差异和作用机制。通过R语言进行UMAP降维可视化和差异表达基因(differentially expressed genes,DEGs)的筛选;对DEGs进行功能注释和富集分... 详细信息

本研究基于单细胞测序数据探讨SENP2在肾细胞癌(renal cell carcinoma,RCC)3种不同亚型中的表达差异和作用机制。通过R语言进行UMAP降维可视化和差异表达基因(differentially expressed genes,DEGs)的筛选;对DEGs进行功能注释和富集分析并构建蛋白相互作用(protein-protein interaction,PPI)网络,通过Cytoscape软件筛选关键基因;通过分析SENP2的表达差异与3种RCC亚型患者生存预后和临床分期的关系,揭示其在不同亚型中的作用;通过分析SENP2及其互作基因的相关性,探索SENP2引起3种不同RCC亚型患者生存预后和临床分期差异性的调控机制;最后,对肾透明细胞癌(kidney renal clear cell carcinoma,KIRC)中的SENP2进行免疫组化实验。本研究结果表明,RCC 3种亚型中的基因表达具有差异性;RCC 3种亚型中差异表达基因显著富集于细胞增殖、蛋白质代谢、细胞衰老以及TP53调节等生物学过程中;筛选关键基因,锁定SENP2;生存分析和临床分期分析结果表明,在KIRC中,随着临床分期的增加,SENP2表达量逐渐减少,患者的生存预后变差,在肾嫌色细胞癌(kidney chromophobe,KICH)中,SENP2表达与患者的生存预后呈正相关,但与临床分期没有相关性,在肾乳头状细胞癌(kidney renal papillary cellcarcinoma,KIRP)中SENP2表达与患者的生存预后呈负相关,SENP2表达越高,患者的预后越差,但与临床分期没有相关性;SENP2及其互作基因相关性研究表明,在KIRC和KICH中,SENP2通过SUMO化修饰正相关调控抑癌基因TP53,而在KIRP中,SENP2通过SUMO化修饰负相关调控TP53家族成员TP73,进而导致SENP2调控RCC 3种亚型的差异性;免疫组化结果显示,SENP2在KIRC呈现低表达且与年龄、性别和肿瘤大小无关。综上所述,SENP2通过不同调控机制参与了RCC 3种亚型的发生和发展,有望成为判断RCC的肿瘤标志物,为相关机制的研究提供了新思路。

关键词：肾细胞癌单细胞测序 SENP2 SUMO化修饰

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清代名医徐灵胎元气论学说理论研究

山西中医药大学学报 2023年第6期24卷 608-612页

作者：田雨杨杰温宵宵中国中医科学院中医药数据中心/中国中医科学院中医药信息研究所北京100700

以文献研究方法入手,通过阅读整理清代著名医家徐灵胎的著作及相关文献,从揣摩经典、继承前人观点、综合时域地域影响、承袭儒道思想等方面对徐灵胎继承前人并创新的元气学说的源流及学术特点开展系统研究。从元气的概念及特点、作用等... 详细信息

以文献研究方法入手,通过阅读整理清代著名医家徐灵胎的著作及相关文献,从揣摩经典、继承前人观点、综合时域地域影响、承袭儒道思想等方面对徐灵胎继承前人并创新的元气学说的源流及学术特点开展系统研究。从元气的概念及特点、作用等方面系统阐发了徐灵胎元气学说理论,强调了诊治过程中,元气论学说实际运作的指导原则。指出辨别元气的存亡及保全元气的方法,提出根据元气的盛衰判断预后的治疗方法。徐灵胎元气学说在中医精气理论中极具自身特色,在临床辨证施治时风格鲜明,对中医理论的发展产生了较大的影响,在中医的诊法、治则、方药等多方面迄今仍有重要的指导意义。

关键词：徐灵胎元气论学术思想中医理论研究

一种非戊二醛化学体系处理的生物瓣膜材料的生物相容性研究

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中国胸心血管外科临床杂志 2022年第12期29卷 1653-1659页

作者：温晓晓张坤潘孔荣汪文涛潘文志沛嘉医疗科技(苏州)有限公司江苏苏州215000 复旦大学附属中山医院心内科中国医学科学院心血管技术与器械创新单元上海200032

目的研究一种基于非戊二醛化学体系处理的生物瓣膜材料的生物相容性,为其临床应用提供安全性数据。方法所有实验均参照GB/T16886系列标准:采用噻唑蓝法进行体外细胞毒性实验;取15只豚鼠,分为实验组(n=10)和对照组(n=5),进行皮肤致敏实验... 详细信息

目的研究一种基于非戊二醛化学体系处理的生物瓣膜材料的生物相容性,为其临床应用提供安全性数据。方法所有实验均参照GB/T16886系列标准:采用噻唑蓝法进行体外细胞毒性实验;取15只豚鼠,分为实验组(n=10)和对照组(n=5),进行皮肤致敏实验;取3只新西兰大白兔,每只动物左右两侧背部各取5个点作为实验部位和对照部位,进行皮内反应实验;取20只ICR小鼠,随机分为4组:实验组(极性介质)、对照组(极性介质)、实验组(非极性介质)、对照组(非极性介质),每组5只,开展急性全身毒性实验;取40只SD大鼠,分为实验组(n=20)和对照组(n=20),开展亚慢性全身毒性实验。结果非戊二醛化学体系处理的生物瓣膜材料100%样品浸提液的细胞活力为75.2%,皮肤致敏阳性率为0.0%,皮内反应最终计分为0分,急性全身毒性实验中实验组与对照组动物体重差异无统计学意义(P>0.05),亚慢性全身毒性实验中实验组与对照组体重、主要器官重量、血常规和血生化数据差异均无统计学意义(P>0.05)。结论非戊二醛化学体系处理的生物瓣膜材料具有良好的生物相容性,符合国家相关标准,有可能应用于临床瓣膜置换中。

关键词：生物瓣膜牛心包碳二亚胺生物相容性毒性反应