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Design of a large-range rotary microgripper with freeform geometries using a genetic algorithm

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Microsystems & Nanoengineering 2022年第1期8卷 59-72页

作者： Chen Wang Yuan Wang Weidong Fang xiaoxiao song Aojie Quan Michiel Gidts Hemin Zhang Huafeng Liu Jian Bai Sina Sadeghpour Michael Kraft College of Optical Science and Engineering Zhejiang UniversityHangzhouChina Department of Electrical Engineering and Computer Science University of LiegeLiegeBelgium ESAT-MNS University of LeuvenLeuvenBelgium PGMF and School of Physics Huazhong University of Science and TechnologyWuhanChina

This paper describes a novel electrostatically actuated microgripper with freeform geometries designed by a genetic algorithm.This new semiautomated design methodology is capable of designing near-optimal MEMS devices that are robust to fabrication tolerances.The use of freeform geometries designed by a genetic algorithm significantly improves the performance of the microgripper.An experiment shows that the designed microgripper has a large displacement(91.5μm)with a low actuation voltage(47.5 V),which agrees well with the theory.The microgripper has a large actuation displacement and can handle micro-objects with a size from 10 to 100μm.A grasping experiment on human hair with a diameter of 77μm was performed to prove the functionality of the gripper.The result confirmed the superior performance of the new design methodology enabling freeform geometries.This design method can also be extended to the design of many other MEMS devices.

关键词： handle algorithm. algorithm

植物甾醇对O/W型纳米乳液物化稳定性及消化特性的影响

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中国食品学报 2024年第4期24卷 130-140页

作者：胡梦伟宋萧萧代志凯孙海辉殷军艺聂少平南昌大学、食品科学与资源挖掘全国重点实验室、中国-加拿大食品科学与技术联合实验室(南昌)、江西省生物活性多糖重点实验室南昌330047 宜春大海龟生命科学股份有限公司江西宜春336000

植物甾醇(PS)具有不溶于水,难溶于油的特性,构建水包油(O/W)型纳米乳液是目前提升其生物利用度、感官品质的常见方法,然而其乳化作用对O/W型纳米乳液的稳定机制尚未得到关注。本研究构建了荷载不同质量分数的植物甾醇(0.1%,0.5%,0.9%)... 详细信息

植物甾醇(PS)具有不溶于水,难溶于油的特性,构建水包油(O/W)型纳米乳液是目前提升其生物利用度、感官品质的常见方法,然而其乳化作用对O/W型纳米乳液的稳定机制尚未得到关注。本研究构建了荷载不同质量分数的植物甾醇(0.1%,0.5%,0.9%)的纳米乳液(PSN),系统探究了PS浓度对油-水界面张力,以及乳液的微观结构、粒径、ζ-电位、储藏稳定性、氧化稳定性以及消化特性的影响。结果表明:PS可降低油-水界面张力,并可在界面处形成部分结晶,影响PSN的物化稳定性;制得的PSN粒径为165.3~247.2 nm,ζ-电位范围为-24.3~-28.4 mV,随着PS浓度的增加逐渐增大;4℃储存28 d,0.1%PSN及0.5%PSN均可保持良好的稳定性,然而在60℃储存条件下,0.9%PSN表现出最优的动力学稳定性。此外,加速氧化试验及消化试验的结果均显示,较高浓度的PS可有效抑制乳液中的脂质氧化以及游离脂肪酸的释放(<31.41%)。本研究结果可为PS功能性食品或辅料的精准开发提供较好的理论参考。

关键词：植物甾醇纳米乳液稳定性界面张力体外消化

Design of freeform geometries in a MEMS accelerometer with a mechanical motion preamplifier based on a genetic algorithm

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Microsystems & Nanoengineering 2020年第1期6卷 122-135页

作者： Chen Wang xiaoxiao song Weidong Fang Fang Chen Ioannis Zeimpekis Yuan Wang Aojie Quan Jian Bai Huafeng Liu Gerold Schropfer Chris Welham Michael Kraft College of Optical Science and Engineering Zhejiang UniversityHangzhou 310027P.R.China Department of Electrical Engineering and Computer Science University of LiegeLiege B-4000Belgium ESAT-MICAS University of LeuvenLeuven 3001Belgium PGMF and School of Physics Huazhong University of Science and TechnologyWuhan 430074P.R.China Shanghai Institute of Microsystem and Information Technology Chinese Academy of SciencesShanghai 200050P.R.China ORC University of SouthamptonSouthampton SO171BJUK Coventor—A Lam Research Company Villebon sur Yvette 91140France

This paper describes a novel,semiautomated design methodology based on a genetic algorithm(GA)using freeform geometries for microelectromechanical systems(MEMS)devices.The proposed method can design MEMS devices comprising freeform geometries and optimize such MEMS devices to provide high sensitivity,large bandwidth,and large fabrication tolerances.The proposed method does not require much computation time or memory.The use of freeform geometries allows more degrees of freedom in the design process,improving the diversity and performance of MEMS devices.A MEMS accelerometer comprising a mechanical motion amplifier is presented to demonstrate the effectiveness of the design approach.Experimental results show an improvement in the product of sensitivity and bandwidth by 100%and a sensitivity improvement by 141%compared to the case of a device designed with conventional orthogonal shapes.Furthermore,excellent immunities to fabrication tolerance and parameter mismatch are achieved.

关键词： accelerometer algorithm motion

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综述杂豆酚类化合物多样性的影响因素

中国食品学报 2024年第1期24卷 390-406页

作者：李昱昊宋萧萧聂少平 Cui Steve W. 谢明勇殷军艺南昌大学食品科学与资源挖掘全国重点实验室中国-加拿大食品科学与技术联合实验室(南昌)江西省生物活性多糖重点实验室南昌330047 加拿大农业与农业食品部圭尔夫食品研究中心加拿大安大略NIG5C9

杂豆酚类化合物种类繁多,并影响杂豆的外观、感官特征及营养特性。杂豆酚类化合物多样性是杂豆营养特性研究的重点。本文总结杂豆酚类化合物多样性的影响因素,发现合理的提取与分析方法有利于酚类化合物提取的完整性以及表征的正确性。... 详细信息

杂豆酚类化合物种类繁多,并影响杂豆的外观、感官特征及营养特性。杂豆酚类化合物多样性是杂豆营养特性研究的重点。本文总结杂豆酚类化合物多样性的影响因素,发现合理的提取与分析方法有利于酚类化合物提取的完整性以及表征的正确性。在此基础上,指出种属与产地、生长与贮藏及加工过程影响杂豆酚类化合物的合成、溶出与释放,并促使酚类化合物多样性的形成。最后介绍杂豆酚类化合物多样性的代谢组学技术在杂豆多样性研究方面的贡献与优势,提出今后工作的重点与挑战,以期为杂豆酚类化合物的变化机制、加工利用及育种等提供参考。

关键词：杂豆酚类化合物多样性提取方法定性与定量影响因素

不同野生油菜农艺性状及其种子脂肪酸组成分析

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分子植物育种 2024年第1期22卷 188-198页

作者：王莉崔宏亮肖菁宋晓晓徐麟新疆农业科学院农作物品种资源研究所乌鲁木齐830091 新疆伊犁州农业科学研究所伊宁835000 新疆伊宁市园林管理中心伊宁835000

本研究通过鉴定来源不同的20份野生油菜资源的田间表现性状,利用GC-MS(气相色谱法-质谱法联用)技术检测野生油菜种子的脂肪酸组成与积累模式,阐明脂肪酸与种子、植株表观性状的相关性,为深入研究野生油菜资源表型与品质的关联性提供科... 详细信息

本研究通过鉴定来源不同的20份野生油菜资源的田间表现性状,利用GC-MS(气相色谱法-质谱法联用)技术检测野生油菜种子的脂肪酸组成与积累模式,阐明脂肪酸与种子、植株表观性状的相关性,为深入研究野生油菜资源表型与品质的关联性提供科学的理论基础。结果表明:20种野生油菜种子及植株性状共检测到48种变异类型,除8个基本植株性状表型一致外,其余性状均有明显差异;共检测出17种脂肪酸,其中8种饱和脂肪酸,9种不饱和脂肪酸,不同野生油菜资源中各种脂肪酸的积累情况有显著差异;脂肪酸含量与多个种子或植株性状存在一定的相关性,种子形状与多种脂肪酸有显著相关性,γ-亚麻酸与多个性状显著相关。根据脂肪酸积累模式可将这20个野生油菜资源分为3个种源聚类。其中野生油菜V205种子中7种脂肪酸相对含量显著高于其他品种。以上结论可为培育具有合理脂肪酸结构的油菜新品种提供科学依据。

关键词：野生油菜种质资源农艺性状脂肪酸相关性

基于人工势场法的水下机器人编队超声波测距设计

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机电工程技术 2024年第4期53卷 20-24,133页

作者：鲁佳慧宋逍潇王青春北京林业大学工学院北京100083

在水下机器人编队变换过程中,需要不断获得领航者与跟随者以及跟随者相互之间的距离信息。为了解决测距问题,基于STM32F103RET6单片机设计一个基于四通道超声波换能器的测距系统。该系统由单片机主控模块、电压转换模块、超声波产生与... 详细信息

在水下机器人编队变换过程中,需要不断获得领航者与跟随者以及跟随者相互之间的距离信息。为了解决测距问题,基于STM32F103RET6单片机设计一个基于四通道超声波换能器的测距系统。该系统由单片机主控模块、电压转换模块、超声波产生与发射模块、隔离模块、前级放大模块、带通滤波模块、后级放大与比较模块、温度采集模块以及多通道测量控制模块等部分构成。在ROV运动过程中,该系统可实现距离测量,并可以根据温度修正测距结果,提高精度,辅助人工势场法实现水下机器人的编队队形控制。在清水环境下,在不同深度对测距系统进行测试,最远测量距离为200 cm,误差最大为2.2 cm,测距结果可靠。在编队性能测试中,观测到队形变换顺利且可以基本保持,验证了该测距系统符合实际ROV编队应用要求。

关键词：多ROV编队超声波换能器测距人工势场法

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Familial Hypercholesterolemia with Two Mutations in LDLR Gene: A Case Report and Literature Review

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International Journal of Clinical Medicine 2017年第10期8卷 556-564页

作者： Hui Zhou xiaoxiao song Bo Sun Linjin Wu Thachapol Napawan Wei Gu Department of Endocrinology The Second Affiliated Hospital of Zhejiang University School of Medicine Hangzhou China Zhejiang University Hangzhou China

We report a case of Familial hypercholesterolemia (FH) with two mutations in low density lipoprotein receptor (LDLR) gene and speculate the correlation between the newly discovered mutation type of LDLR gene and FH. We collected and analyzed the clinical data of the proband in the case and her immediate family members, and detected the LDLR, Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK-9) and Apolipoprotein B (Apo B) gene in the peripheral blood of all the participants. We found that the curative effect of the patient is limited, but no obvious complication was detected. Genetic testing results pointed out that there were two mutations in the patient’s LDLR gene. One was p.W483* mutation in exon 10 (c. 1448 G > A), another was p.T534I mutation in exon 11 (c. 1601 C > T). The p. W483* mutation in exon 10 was detected in the father and sister, additionally p. T534I mutation in exon 11 was detected in the mother. Both the two LDLR gene mutations are inherited from her parents. We hypothesize that the patient in this case was a complex heterozygote. The newly discovered mutation gene (T534I) may be one of the important causes of dyslipidemia in patients, and its adverse effects are more serious than W483* which have been reported. Also, we predict that the T534I mutation will not cause serious early onset of cardiovascular complications.

关键词： Familial Hypercholesterolemia Inherited Disease Metabolism Low-Density Lipoprotein Receptor Gene Mutation

Virilizing Ovarian Leydig Cell Tumor with Multiple Non-Functional Endocrine Neoplasias: A Case Report

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International Journal of Clinical Medicine 2019年第4期10卷 306-315页

作者： Yining Xie Shan Zhong Qijing Zhou Zhiheng Huang xiaoxiao song Xiaohong Xu Department of Endocrine and Metabolic Diseases The Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou China Department of Radiology The Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou China Department of Surgical Oncology The Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou China Department of Otorhinolaryngology The Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou China

Ovarian Leydig cell tumor, a sub-type of ovarian steroid cell tumor, accounts for less than 0.1% of all ovarian tumors. It can affect women of any age group but is most common in postmenopausal women. We here report a case of virilizing ovarian Leydig cell tumor with multiple non-functional endocrine neoplasias (pituitary and adrenal adenomas) in a 48-year-old woman. She first presented with sub-abdominal pain and hirsutism since menopause three years ago. Subsequently, she had slight facial acne, voice deepening, breast atrophy, and a prominent Adam’s apple. Her hormone profile showed an elevated level of testosterone, high free androgen index, low levels of luteinizing hormone and follicle stimulating hormone, and normal levels of random cortisol, androstenedione, 17-hydroxyprogesterone and dehydroepiandrosterone sulfate. A pelvic enhanced magnetic resonance imaging (MRI) scan showed nodules in the right ovary, and a pituitary enhanced MRI revealed a microadenoma. An enhanced computerized tomography scan of the adrenal gland revealed left adrenal nodules, possibly adenomas. After a right cystectomy and right fallopian tube resection, her testosterone level declined to 0.38 nmol/L and the symptoms associated with hyperandrogenism improved. This is a rare case of virilizing ovarian Leydig cell tumor with multiple non-functional endocrine neoplasias. We believe our findings will be helpful in the clinical diagnosis and treatment of hyperandrogenism.

关键词： Leydig Cell Tumor Ovary Adrenal Adenomas Hyperandrogenism

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黄河三角洲湿地发展概述及治理修复建议

海洋开发与管理 2024年第2期41卷 110-114页

作者：尹聪兰丽茜宋晓晓陈默严晋山东省海洋生态环境与防灾减灾重点实验室青岛266061 自然资源部北海海洋技术中心青岛266102

黄河流域在我国经济社会发展和生态安全方面具有十分重要的地位,其下游的黄河三角洲分布有世界上暖温带保存最广阔、最完善、最年轻的滨海湿地生态系统,该区域特殊的地质地貌决定了其生态多样性,需要进行重点研究和保护。文章立足于我... 详细信息

黄河流域在我国经济社会发展和生态安全方面具有十分重要的地位,其下游的黄河三角洲分布有世界上暖温带保存最广阔、最完善、最年轻的滨海湿地生态系统,该区域特殊的地质地貌决定了其生态多样性,需要进行重点研究和保护。文章立足于我国现有湿地保护政策和湿地面积缩小的现状,提出黄河三角洲湿地保护可着重围绕其岸线变化、冲淤速率、地形地貌等开展研究,并采用减压分洪扩充法等治理修复方法扩大湿地面积,为推动黄河流域及黄河三角洲湿地的生态保护和高质量发展提供有效参考。

关键词：湿地黄河三角洲湿地退化湿地研究治理修复