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Bioeffects of different functionalized silica nano-particles on HaCaT cell line

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Chinese Science Bulletin 2006年第16期51卷 1939-1946页

作者： HE xiaoxiao LIU Fang WANG Kemin GE Jia qin Dilan GONG Ping TAN Weihong State Key Laboratory of Chemo/Biosensing and Chemometrics Engineering Center for Biomedicine Institute of Life Science and Biological Technology Engineering Research Center for Bio-Nanotechnology of Hunan Province Changsha 410082 China

The bioeffects of silica nanoparticles (SiNP), phosphorylate-terminated nanoparticles (PO4- NP) and amino-terminated nanoparticles (NH2NP) on HaCaT cell line have been studied in this paper. The effects of the three kinds of functionalized silica nanoparticles on adherence, proliferation and cycle of HaCaT cells have been investigated. And the cel- lular uptake of the three kinds of functionalized silica nanoparticles by HaCaT cells has also been exam- ined. Results indicated that the bioeffects of the three kinds of functionalized nanoparticles on HaCaT cells were concentration-dependent. And the three kinds of functionalized nanoparticles all exhibited well bio- compatibility if the concentration was below 0.2 μg/μL. While the cytotoxicities of the three kinds of function- alized nanoparticles on HaCaT cells would increase with the increasing of nanoparticles concentration, and the following order was observed: NH2NP > SiNP > PO4NP. In addition, the quantity and rapidity of cellular uptake of nanoparticles by HaCaT cells were diverse due to the different functional groups. Under the same conditions, NH2NP was most and fast internalized by HaCaT cells, followed by SiNP, and PO4NP was the least and slowest. These results provided theoretical foundation for the safe applica- tion and further modification of silica nanoparticles, which could broaden the application of silica nano- particles in biomedicine.

关键词： SiNP PO4NP 纳米粒子 HaCaT细胞系生物效应

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不同体积盆钵对生菜生长的影响

北京农学院学报 2021年第2期36卷 26-30页

作者：韩旭东韩莹琰郝敬虹秦晓晓刘超杰范双喜农业应用新技术北京市重点实验室植物生产国家级实验教学示范中心北京农学院北京102206

【目的】为了选择盆栽生菜适宜体积大小的盆钵。【方法】以椰糠为盆栽基质,研究不同体积盆钵(200 mL、380 mL、780 mL、1070 mL、1640 mL、2330 mL和4500 mL)对生菜的生长、地上部分干鲜质量、根干鲜质量、色素含量、光合参数和根系活... 详细信息

【目的】为了选择盆栽生菜适宜体积大小的盆钵。【方法】以椰糠为盆栽基质,研究不同体积盆钵(200 mL、380 mL、780 mL、1070 mL、1640 mL、2330 mL和4500 mL)对生菜的生长、地上部分干鲜质量、根干鲜质量、色素含量、光合参数和根系活力的影响。【结果】随着盆钵体积的增加,生菜的生长量、壮苗指数、色素含量、光合参数和根系活力均呈现先增高后降低的趋势,但生菜蒸腾速率升高不显著,而生菜根冠比呈显先降低后略有升高再降低后又升高的趋势;当盆钵体积为1070 mL时,除根冠比外的各项指标均高于其他处理,显著高于对照组(CK),而根冠比显著低于对照组(CK)。【结论】以上结果表明,盆钵体积为1070 mL时,较适宜生菜生长,可作为栽培生菜的盆钵参考体积。

关键词：盆钵体积椰糠生菜盆栽蔬菜

高温胁迫下外源亚精胺对生菜抗氧化酶系统的影响

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北京农学院学报 2020年第4期35卷 63-67页

作者：李书涵韩莹琰郝敬虹秦晓晓刘超杰范双喜北京农学院植物科学技术学院北京102206

【目的】为了将外源亚精胺应用到高温环境下生菜生产。【方法】以‘北散生3号’生菜为试验材料,研究外源亚精胺(Spd)对高温胁迫下生菜生长、叶绿素、丙二醛(MDA)含量及抗氧化酶活性的影响。【结果】高温胁迫下,生菜幼苗全株鲜质量、全... 详细信息

【目的】为了将外源亚精胺应用到高温环境下生菜生产。【方法】以‘北散生3号’生菜为试验材料,研究外源亚精胺(Spd)对高温胁迫下生菜生长、叶绿素、丙二醛(MDA)含量及抗氧化酶活性的影响。【结果】高温胁迫下,生菜幼苗全株鲜质量、全株干质量、地上部鲜质量显著减少,叶绿素a、b含量及总量显著增加;丙二醛(MDA)含量显著增加,超氧化物歧化酶(SOD)、过氧化氢酶(CAT)活性先升后降;过氧化物酶(POD)活性持续上升;抗坏血酸过氧化物酶(APX)活性显著下降。外源喷施Spd生菜全株鲜质量和地上部鲜质量显著增加,MDA含量显著减少,SOD、CAT、APX酶活性增加,POD活性降低。【结论】叶面喷施外源Spd能够通过提高生菜抗氧化酶系统活性,缓解高温胁迫对生菜伤害。

关键词：外源亚精胺生菜抗氧化酶系统高温胁迫

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中医药临床优势病种探讨——先兆流产

中国实验方剂学杂志 2024年第7期30卷 241-246页

作者：杨新春王树玉杜惠兰罗颂平金哲李蓉阮祥燕章勤冯晓玲陈世财贺丰杰魏绍斌鹿群王艳琴刘阳孟庆伟郝增平李颖莫美张霄潇赵瑞华中国中医科学院广安门医院北京100053 首都医科大学附属北京妇产医院北京100026 河北中医学院石家庄050091 广州中医药大学第一附属医院广州510405 北京中医药大学东方医院北京100078 北京大学第三医院北京100191 杭州市中医院杭州310007 黑龙江中医药大学附属第一医院哈尔滨150040 首都医科大学附属北京潞河医院北京101149 陕西中医药大学附属医院陕西咸阳712000 成都中医药大学附属医院成都610075 首都医科大学附属朝阳医院北京100020 清华大学玉泉医院北京100040 北京市垂杨柳医院北京100022 北京医院北京100730 首都医科大学附属友谊医院北京100050 河南省第二人民医院河南新郑451191 创新中药关键技术国家重点实验室天津300410 中华中医药学会北京100029

先兆流产是常见的妇产科疾病,也是中医药治疗的优势病种之一。中华中医药学会组织中医妇产科、西医妇产科及药学领域专家,深入探讨先兆流产的中医、中西医结合治疗优势及用药方案。与会专家讨论后认为,染色体、内分泌、免疫异常是先兆... 详细信息

先兆流产是常见的妇产科疾病,也是中医药治疗的优势病种之一。中华中医药学会组织中医妇产科、西医妇产科及药学领域专家,深入探讨先兆流产的中医、中西医结合治疗优势及用药方案。与会专家讨论后认为,染色体、内分泌、免疫异常是先兆流产发病的关键因素,冲任气血失调是核心病机;中医药治疗先兆流产在保胎、改善临床症状及中医证候、缓解焦虑状态、调节生殖内分泌及免疫异常、个体化、多样化治疗、增效减毒、未病先防等方面具有优势;中西医诊疗难点在于明确母体因素导致流产的预测指标和易栓症的治疗,在辨证的指导下,谨慎使用活血化瘀药;复发性流产是中西医结合治疗的切入点,未来亟需开展高质量循证医学研究,推进先兆流产的中医药现代化诊疗水平。

关键词：先兆流产优势病种中西医结合专家指导建议

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Synthesis and properties of binaphthyl chiral thermally activated delayed fluorescence molecules using thioxanthone as acceptor

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Chinese Chemical Letters 2023年第12期34卷 446-451页

作者： Xiangyu Dong Shaogang Shen Yuanyuan qin xiaoxiao Hu Honglei Gao Guanhao Liu Teng Ga Zhi Pang Pengfei Wang Ying Wang Key Laboratory of Photochemical Conversion and Optoelectronic Materials and CityU-CAS Joint Laboratory of Functional Materials and Devices Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China School of Chemistry and Chemical Engineering Suzhou UniversitySuzhou 234000China

The currently reported axial chiral molecules based on the 3,3'-substitution of the binaphthyl skeleton are limited by intrinsic fluorescence properties,resulting in generally low device efficiencies(EQE<5%)of related organic light emitting diodes(OLEDs).Herein,we designed and synthesized four pair of chiral binaphthyl enantiomers(R/S-1-R/S-4)adopting acceptor-donor-donor-acceptor(ADDA)structure by introducing different thioxanthone modification groups on the 3,3'-position of 2,2'-dimethoxy-1,1'-*** them,emitter R/S-2 and R/S-4 obtained by enhancing intramolecular charge transfer exhibited TADF characteristics due to relatively small Est of 0.12eV and 0.17eV,and relatively moderate SOC matrix elements of 0.28 cm^(-1)and 0.10 cm^(-1)between the 1CT and 3LE *** CD spectra of these enantiomers in diluted solutions showed perfect mirror images and reasonable gabs for small organic molecules(10^(-4)-10^(-3)).And the external quantum eficiencies(EQE)of 10.9%and 8.32%for device A and B based on emitter S-2 and S-4 were highest compared with currently reported axial chiral molecules based on the 3,3'-position substitution of binaphthyl skeleton,providing simple molecular design strategies to construct efficient CP-OLED device.

关键词： Thermally activated delayed fluorescence Organic light emitting diodes Binaphthyl skeleton Electronic circular dichroism Circularly polarized luminescence Thioxanthone

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硒浓度对高温胁迫下生菜抗氧化酶活性的影响

北京农学院学报 2021年第4期36卷 39-43页

作者：张岩松黄皓婷韩莹琰郝敬虹秦晓晓刘超杰范双喜北京农学院植物科学技术学院北京102206

【目的】硒能缓解高温胁迫对生菜的影响,为了探明喷施硒的适宜浓度。【方法】采用水培方式,分别设置0.5、1.0、1.5和2.0 mg/L的硒溶液,研究不同浓度硒对高温胁迫下生菜的生长、叶绿素和丙二醛(MDA)含量、过氧化物酶(POD)、超氧化物歧化... 详细信息

【目的】硒能缓解高温胁迫对生菜的影响,为了探明喷施硒的适宜浓度。【方法】采用水培方式,分别设置0.5、1.0、1.5和2.0 mg/L的硒溶液,研究不同浓度硒对高温胁迫下生菜的生长、叶绿素和丙二醛(MDA)含量、过氧化物酶(POD)、超氧化物歧化酶(SOD)及过氧化氢酶(CAT)活性的影响。【结果】生菜生长量、叶绿素含量及抗氧化酶活性均随喷施硒浓度的增加,呈先升高后降低的趋势。喷施1.0 mg/L硒时,生菜的根长、真叶数、地上及地下部干鲜质量最高;叶绿素a、叶绿素b、总叶绿素和类胡萝卜素含量显著提高,分别为对照的1.20、1.19、1.20、1.21倍;SOD、POD和CAT的活性显著增加,其中POD活性最高,为对照的1.54倍;丙二醛含量最低,为对照的65.9%。【结论】喷施1.0 mg/L硒溶液能显著缓解高温胁迫对水培生菜的伤害。

关键词：生菜高温胁迫硒抗氧化

Ionic Liquid-assisted Formation of Lanthanide Metal-organic Framework Nano/Microrods for Superefficient Removal of Congo Red

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Chemical Research in Chinese Universities 2015年第6期31卷 899-903页

作者： XIAO Yi CHEN Fang ZHU Xixi qin Hongling HUANG Hongmei ZHANG Youyu YIN Dulin HE xiaoxiao WANG Kemin Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research Ministry of EducationCollege of Chemistry and Chemical Engineering Hunan Normal University Changsha 410081 P. R. China State Key Laboratory of Chemo/Biosensing and Chemometrics College of Chemistry andChemical Engineering College of Biology Hunan University Changsha 410082 P. R. China

New lanthanide metal-organic framework（MOF） nano/microrods, [C4mim]Cl-Eu-MOF, [C8mim]Cl-Eu- MOF and [C12mim]Cl-Eu-MOF, were conveniently synthesized via an ionic liquid-assisted hydrothermal method and characterized by means of powder X-ray diffraction（XRD）, Fourier transform infrared spectroscopy（FTIR）, thermo- gravimetric analysis（TG） and transmission electron microscopy（TEM）. The obtained nano/microrods with low sur- face areas were efficient for the removal of Congo red（CR） from aqueous solutions. Under the optimum conditions, [C4mim]Cl-Eu-MOF with a specific surface area of 5.1 m^2/g exhibited an ultrahigh adsorption capacity of 2606 mg/g toward CR. Notably, the adsorption efficiency of [C4mim]Cl-Eu-MOF for CR via nano/microscale stacking can be directly demonstrated by TEM. In-depth understanding of CR removal by [C4mim]Cl-Eu-MOF nano/microrods was also supported by FTIR, Raman spectroscopy and zeta potential analyses.

关键词： Lanthanide metal-organic framework Nano/microrod Ionic liquid Congo red Adsorption

Concentrations and gas-particle partitioning of PCDD/Fs in the urban air of Dalian,China

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Chinese Science Bulletin 2012年第26期57卷 3442-3451页

作者： qin SongTao ZHU XiuHua WANG Wei CHEN JiPing NI YuWen LI xiaoxiao MU Jun Xu Qian SCHRAMM Karl-Werner School of Environmental and Chemical Engineering Dalian Jiaotong UniversityDalian 116028China Dalian hzstitute of Chemical Physics Chinese Academy of SciencesDalian 116023China Dalian Meteorological Observatory Dalian 116001China Helmholtz Center Munich-German Research Center for Environmental Health Molecular EXposomics(MEX)Ingolstgidter Landstr.185764 NeuherbergGermany

PCDD/Fs in the urban air of Dalian,China were monitored with high-volume active sampler from November 2009 to October *** concentration of Cl 4-8 DD/Fs ranged from 3065 to 49538 fg m-3,with an average of 10249 fg *** international toxic equivalents(I-TEQ) value of that was 61.8 1182 fg m-3,with an average of 235 fg m-3,which was comparable to those in the other urban locations around the *** was found that the Cl 4 8 DD/Fs appeared to be present mainly in the particle phase during winter,spring and autumn,while during summer which were dominantly in gas *** ratio of Cl 4-8 DD/Fs present in particle phase increased with the increasing level of *** concentrations of PCDFs and PCDDs decreased with the increase of chlorinated level,while the concentrations of 2,3,7,8-PCDDs congeners increased with the increase of chlorination *** homolog profiles of the concentrations of PCDFs presented were higher than those of the PCDDs,which indicated the PCDD/Fs pollution source of the air in Dalian was characteristic for thermal source *** correlation analysis of meteorological parameters with the concentrations of Cl 4-8 CDD/Fs was conducted using SPSS packages,and it was found that the ambient temperature and atmospheric pressure were important factors influence the concentration of PCDD/Fs in the *** respiratory risk and intake dioxins of the residents around the sampling sites were studied in the *** was found that Junge-Pankow model was much more accurate in predicting the gas-particle partitioning behavior of PCDD/Fs homologues during winter,while the Harner-Bidleman model shows better agreement with the measured data during winter and summer.

关键词： PCDD 城市空气气浓度大连中国多氯代二苯并呋喃分割粒子

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高速飞行器主动冷却试验技术研究

兵器装备工程学报 2023年第S1期44卷 24-28,66页

作者：秦强张肖肖成竹中国飞机强度研究所强度与结构完整性全国重点实验室西安710065

针对高超声速飞行器结构热强度验证中试验对象表面快速降温需求,采用隐式差分格式建立金属薄板结构在主动冷却下的热分析数值模型,计算结果表明强迫对流可以明显提升降温效果,但降温效果呈非线性下降;给出了基于压缩空气/氮气的强迫对... 详细信息

针对高超声速飞行器结构热强度验证中试验对象表面快速降温需求,采用隐式差分格式建立金属薄板结构在主动冷却下的热分析数值模型,计算结果表明强迫对流可以明显提升降温效果,但降温效果呈非线性下降;给出了基于压缩空气/氮气的强迫对流冷却、基于液氮的强迫对流冷却和基于“空气/氮气+水”混合物的喷雾冷却3种方案,搭建了快速降温试验系统,进行了基于室温压缩空气和液氮的强迫对流冷却能力试验,结果表明基于液氮的强迫对流冷却有较高的冷却效能。

关键词：高超声速飞行器热强度验证试验对象快速降温