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eALT-F:A New Non-Invasive Staging Method to Identify Medium to High-Risk Patients with HCC from Ultra-High HBV Viral Load Population—China,2010-2023

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China CDC weekly 2023年第49期5卷 1107-1114页

作者： Jiarui zheng xiaoxiao Wang Zilong Wang Linxiang Huang Yandi Xie Suzhen Jiang Bo Feng Peking University People’s Hospital Peking University Hepatology InstituteBeijingChina Peking University People’s Hospital Peking University Hepatology InstituteBeijing Key Laboratory of Hepatitis C and Immunotherapy for Liver DiseasesBeijing International Cooperation Base for Science and Technology on NAFLD DiagnosisBeijingChina

Background:The objective of this study was to examine the clinical characteristics of individuals with ultra-high hepatitis B virus(HBV)viral load and develop a novel staging method for chronic hepatitis B(CHB)that can more effectively identify patients with medium to high hepatocellular carcinoma(HCC)***:A total of 2,118 patients with HBV DNA>1×10^(7) IU/mL who visited Peking University People’s Hospital between January 2010 and March 2023 were enrolled *** data from the first visit were obtained and *** traditional phases and new‘eALT-F’stages were compared to evaluate the risk of ***:In the overall patients,more than onethird of the patients were under 30 years ***,a small proportion of older people(>60 years)also had ultra-high HBV viral load(4.3%).9.1%and 6.7%of individuals with ultra-high HBV viral load showed FIB-4>3.25 and aMAP≥50,*** the traditional stages of CHB,which are based on HBeAg and alanine aminotransferase(ALT)[the upper limit of normal(ULN)ALT level at 40 IU/L for both men and women],regardless of phase,a certain proportion of patients were at risk of developing HCC(4.1%,6.4%,25.0%,and 20.3%).However,in the new‘eALT-F’stages,which are based on HBeAg,ALT(the ULN of ALT level at 30 IU/L for men and 19 IU/L for women),and/or FIB-4 levels(>1.45),aMAP≥50 was only observed in chronic hepatitis patients with positive or negative HBeAg(6.4%and 22.1%,respectively).Conclusions:The‘eALT-F’staging method,based on HBeAg,ALT(males:the ULN of ALT was 30 IU/L,females:19 IU/L)and/or FIB-4 levels,was more effective in identifying medium to high-risk patients with HCC from patients with ultra-high HBV viral load than the traditional staging methods.

关键词： Patients Population Medium

Investigation on the crystal structure and mechanical properties of the ternary compound Mg_(11-x)Zn_(x)Sr combined with experimental measurements and first-principles calculations

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Journal of Magnesium and Alloys 2023年第3期11卷 1074-1082页

作者： Jian Wang Lingzhong Meng Zhang Zhang Baisheng Sa xiaoxiao Fu Liyuan Sheng Daokui Xu Yufeng zheng School of Mechanical Engineering Yangzhou UniversityYangzhou 225127China Key Laboratory of Eco-materials Advanced Technology College of Materials Science and EngineeringFuzhou UniversityFuzhou 350108China College of Materials Science and Engineering Chongqing UniversityChongqing 400044China Shenzhen Institute Peking UniversityShenzhen518057China PKU-HKUST ShenZhen-HongKong Institution Shenzhen 518057China Key Laboratory of Nuclear Materials and Safety Assessment Institute of Metal ResearchChinese Academy of SciencesShenyang110016China

A new ternary compound,Mg_(11-x)Zn_(x)Sr in the Mg-Zn-Sr system was observed and studied using Scanning Electron Microscopy(SEM),Energy-Dispersive Spectroscope(EDS),X-Ray Diffraction(XRD)and Transmission Electron Microscopy(TEM).The XRD patterns were refined by the Rietveld refinement method and the results revealed that the crystallized Mg_(11-x)Zn_(x)Sr phase belonged to tetragonal I41/amd space group and had the Cd_(11)Ba *** Mg atoms were successfully doped into Zn_(11)Sr crystal lattice by occupying Zn atomic ***,the Rietveld refinement and computational results demonstrated a gradual decrease in the a-axis and c-axis lattice parameters with decreasing concentration levels of Mg coordination substitution in the lattice of Mg_(11-x)Zn_(x)Sr *** elastic constants and modulus of the Mg_(11-x)Zn_(x)Sr compounds calculated by first-principles calculations(FPC)indicated they were increased with the increasing of Zn *** variation of hardness,D-band widths and the total density of states for Mg_(11-x)Zn_(x)Sr compounds with Zn content was discussed.

关键词： Mg-Zn-Sr system Crystal structure Hardness Elastic constants Modulus

成人特发性炎性肌病骨骼肌组织检查病理评分在评估疾病活动度中的价值

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中华风湿病学杂志 2019年第2期23卷 76-81页

作者：张立宁刘宏艳田小兰郑晓晓张亚妹李文丽刘青艳彭清林卢昕北京大学中日友好临床医学院风湿免疫科 100029 中日友好医院病理科北京100029 中日友好医院风湿免疫科北京100029

目的探讨特发性炎性肌病(IIM)患者肌活组织检查(肌活检)病理评分与疾病活动度的相关性。方法按照国际肌炎评估和临床研究组制定的特发性炎性肌病疾病活动度评价工具对中日友好医院风湿免疫科2008年12月至2017年6月住院的已行肌活检的423... 详细信息

目的探讨特发性炎性肌病(IIM)患者肌活组织检查(肌活检)病理评分与疾病活动度的相关性。方法按照国际肌炎评估和临床研究组制定的特发性炎性肌病疾病活动度评价工具对中日友好医院风湿免疫科2008年12月至2017年6月住院的已行肌活检的423例IIM患者的疾病活动度进行评分。所有IIM肌活检组织进行主要组织相容性复合体(MHC)-Ⅰ、CD3和CD20分子免疫组织化学染色,肌组织中按照肌细胞、炎症、血管和结缔组织4个部位分别评估,对IIM患者的肌活检进行病理评分。分析IIM患者肌活检病理评分与IIM疾病活动度的相关性。应用SPSS20.0软件进行统计学分析。非参数检验采用Mann-WittneyU检验、秩和检验和Fisher精确检验比较组间的差异。相关性分析使用Spearman等级相关分析。以P<0.05为差异有统计学意义。结果肌活检病理总评分与IIM疾病总体活动度呈弱相关(r=0.228,P<0.05),并且与肌肉活动度视觉模拟尺度评分(VAS)和肌酸肌酶(CK)升高相关(r=0.407和0.466,P值均<0.05)。127例未经治疗的IIM中DM占92例,PM占35例。在未经治疗的DM患者中,肌肉病理总评分、肌细胞病变和炎症浸润与患者肌肉活动度VAS相关(r=0.300,0.312和0.241,P值均<0.05);而在未经治疗的PM中,肌细胞病变评分与疾病总体活动度相关(r=0.478,P<0.05)。结论开展肌肉病理评分可用于指导PM疾病活动度和DM骨骼肌疾病活动度的判断。

关键词：肌炎肌骨骼病理评分疾病活动度

Amorphous core/shell Ti-doped SnO_(2) with synergistically improved N_(2) adsorption/activation and electrical conductivity for electrochemical N_(2) reduction

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Chinese Chemical Letters 2022年第10期33卷 4655-4658页

作者： Yu Yan Hongjiao Qu Xiaonan zheng Kexin Zhao xiaoxiao Li Yuan Yao Yang Liu School of Chemistry and Chemical Engineering Harbin Institute of TechnologyHarbin 150080China

Electrochemical nitrogen reduction reaction(NRR)has been considered as an appealing and sustainable method to produce ammonia from N_(2) under ambient conditions,attracting increasing *** by low solubility of N_(2) in water and high stability of Ntriple bondN triple bond,developing NRR electrocatalysts with both strong N_(2) adsorption/activation and high electrical conductivity remain ***,we demonstrate an efficient strategy to develop NRR electrocatalyst with synergistically enhanced N_(2) adsorption/activation and electrical conductivity by heteroatom *** computational and experimental study,the DFT-designed Ti-doped SnO_(2) exhibits significantly enhanced NRR performance with ammonia yield rate of 13.09µg h^(-1) mg^(-1) at −0.2 V ***,the Faradaic efficiency reaches up to 42.6%,outperforming most of Sn-based *** fundamental mechanism for improving NRR performance of SnO_(2) by Ti doping is also *** work highlights a powerful strategy for developing high-activity electrocatalysts for NRR and beyond.

关键词： Nitrogen reduction reaction Electrocatalysts Density functional theory Heteroatom doping Synergistical effect

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影响广州地区Rh阴性红细胞采供情况的原因

广州医药 2021年第2期52卷 54-57,62页

作者：郑晓晓罗伟峰黎世杰陈锦艳关飞舜梁华钦广州血液中心广州市医学重点实验室血液安全重点实验室广州510095 不详

目的通过回顾分析广州地区Rh阴性血的采供情况,了解Rh阴性红细胞的供应特点,更好地实施Rh阴性血液库存管理,保障输血安全。方法统计2011-2017年广州血液中心Rh阴性血液采集量与供应量,血型及医院供血量的分布情况。结果2011-2017年广州... 详细信息

目的通过回顾分析广州地区Rh阴性血的采供情况,了解Rh阴性红细胞的供应特点,更好地实施Rh阴性血液库存管理,保障输血安全。方法统计2011-2017年广州血液中心Rh阴性血液采集量与供应量,血型及医院供血量的分布情况。结果2011-2017年广州血液中心Rh阴性全血采集量为11283 U,占总采血量的0.39%(11283/2902485),供应总量为11693 U,占红细胞类成分血总供应量的0.43%(11693/2762229),其中悬浮红细胞供应比例逐年增加,冰冻解冻去甘油红细胞供应比例逐年下降,并从2014年起Rh阴性悬浮红细胞供应增长率明显高于血液采集增长率;4种血型供应量总体比较,差异有统计学意义(F=22.217,P<0.05),A、B型Rh阴性悬浮红细胞供应增长最快,增长率分别为137.3%和134.1%,医院分布以三级以上及综合医院为主。结论应根据广州地区Rh阴性红细胞采供特点,来持续改进Rh阴性血源招募和采供策略。通过建立一支Rh阴性定期献血者队伍,加强Rh阴性血液统筹管理和临床科室-输血科-采供血机构的沟通,促进Rh阴性血液的供需平衡,保障Rh阴性患者输血安全。

关键词： Rh阴性血液血型血液供应

Increasingγ-CD conversion rates by improving thermostability of Bacillus ***-44876γ-CGTase

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Food Bioscience 2023年第1期51卷 346-354页

作者： xiaoxiao Li Danni zheng Jing Wu zhengyu Jin Birte Svensson Yuxiang Bai State Key Laboratory of Food Science and Technology Jiangnan UniversityWuxiJiangsu214122China School of Food Science and Technology Jiangnan UniversityWuxiJiangsu214122China Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province Jiangnan UniversityWuxiJiangsu214122China Enzyme and Protein Chemistry Department of Biotechnology and BiomedicineTechnical University of DenmarkDK-2800 KgsLyngbyDenmark

Poor thermostability is a limiting factor for applications ofγ-CGTase that affects starch utilization and yield ofγ-*** thermostability of Bacillus ***-44876γ-CGTase(BFγ-CGTase)was improved by addition of Ca^(2+)and site-directed ***,10 mM Ca^(2+)increased the half-life(t1/2)at 55 and 60℃ from 3.0 to 0.3 h to 17.4 and 2.0 h,*** spectra indicated that Ca^(2+)stabilized the tertiary structure of the BFγ-CGTase and hence improved the *** to serine of a glycine residue in anα-helix related to thermostability also improved the stability especially at the higher ***,in 10 mM Ca^(2+)the G208S mutant further increased t1/2 to 20.0 h and 4.0 h at 55 and 60℃,*** G208S mutant in 10 mM Ca^(2+)producedγ-CD from tapioca starch with 40%increased yield of that from BFγ-*** work involving rational protein engineering provided a new tool for enzymaticγ-CD production.

关键词： Starch Protein engineering Three-dimensional structure

影响初次机采血小板献血者成为定期献血者的相关因素

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中国输血杂志 2022年第1期35卷 50-52页

作者：柯蓉蓉许颖莹郑晓晓谢桂芸陈锦艳黎世杰广州血液中心广州市血液安全重点实验室广东广州510095

目的分析影响广州地区2018年初次机采血小板捐献者成为定期献血者的相关因素,为机采血小板献血者的保留提供支持和参考。方法收集广州地区2018年初次献机采血小板的4361名献血者的年龄、性别、初次捐献治疗量、初次献机采血小板时间、... 详细信息

目的分析影响广州地区2018年初次机采血小板捐献者成为定期献血者的相关因素,为机采血小板献血者的保留提供支持和参考。方法收集广州地区2018年初次献机采血小板的4361名献血者的年龄、性别、初次捐献治疗量、初次献机采血小板时间、二次献机采血小板时间等资料,采用Logistic回归分析法分析影响初次机采血小板献血者成为定期献血者的相关因素。结果影响初次机采血小板献血者成为定期献血者的因素中,1个月内再次捐献机采血小板者成为定期献血者是未捐献者的5.569倍(OR 95%CI:4.748~6.533,P<0.05),45~60岁年龄组初次机采血小板献血者成为定期献血者是18~24岁年龄组的1.857倍(OR 95%CI:1.413~2.441,P<0.05);初次捐献2个单位治疗量的献血者成为定期献血者是初次捐献1个单位治疗量的献血者1.695倍(OR 95%CI:1.486~1.933,P<0.05)。结论初次机采血小板献血者是否成为定期献血者与其是否在1个月内再次捐献、年龄和初次捐献治疗量均有关,促进初次机采血小板献血者在1个月内再次捐献,其转化为定期献血者的可能性更大。

关键词：初次机采血小板捐献机采血小板再次献血 Logistic回归定期献血者

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皮寒感舒颗粒的制备工艺研究

华西药学杂志 2018年第3期33卷 245-250页

作者：王潇霖郑潇潇黄凤唐国琳王雯蒋桂华李培赵燕成都中医药大学药学院中药材标准化重点实验室中药资源系统研究与开发利用省部共建国家重点实验室培育基地四川成都611137 绵阳市中医院四川绵阳621000

目的优选皮寒感舒颗粒的制备工艺。方法采用正交设计法,以皮寒药水提液的干膏收率、高丽槐素及芒柄花素的含量为评价指标,优化皮寒感舒颗粒原料药的水提醇沉及浓缩工艺;采用单一变量法,以成型率、溶化性及吸收率为评价指标,优化皮寒感... 详细信息

目的优选皮寒感舒颗粒的制备工艺。方法采用正交设计法,以皮寒药水提液的干膏收率、高丽槐素及芒柄花素的含量为评价指标,优化皮寒感舒颗粒原料药的水提醇沉及浓缩工艺;采用单一变量法,以成型率、溶化性及吸收率为评价指标,优化皮寒感舒颗粒的制粒工艺。结果最佳水提工艺为A3B2C1D3,即样品药材粒度为粗粉、每次加水量为12倍、分别提取2次、每次0.5 h;最佳醇沉工艺为A2B2C3,即将药液浓缩至相对密度1.10、用60%乙醇沉淀18 h;最佳浓缩工艺为：在70℃减压条件下,将药液浓缩至相对密度1.201.25;最佳制粒工艺为：以葡萄糖为辅料、浸膏与辅料比例为1∶4、采用75%乙醇为润湿剂、于60℃干燥2 h。结论所用工艺条件稳定、可控、提取率高,可为皮寒感舒颗粒的深入研究提供参考。

关键词：皮寒感舒颗粒川滇米口袋高丽槐素芒柄花素浓缩工艺水提醇沉工艺制粒工艺高效液相色谱法

均一与梯度孔隙率Gyroid结构力学性能研究及多孔种植体增材制造

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中国口腔种植学杂志 2023年第3期28卷 204-209页

作者：宋颐函郑晓晓孙子惠张岩韩泽奎宿玉成王心彧佳木斯大学 154007 佳木斯大学口腔医学院佳木斯大学口腔医学工程实验中心黑龙江省口腔生物材料与临床应用重点实验室 154004 北京瑞城口腔医院北京口腔种植培训中心 100032 中国医学科学院北京协和医院口腔种植中心 100032

目的研究不同孔隙率及梯度孔隙率Gyroid结构力学性能,设计并制备新型多孔种植体。方法通过MSLattice和Magics软件建立均一孔隙率为60%、65%、70%、75%、80%和60%~80%梯度的Gyroid结构模型,分别通过有限元分析及力学压缩试验对比不同孔隙... 详细信息

目的研究不同孔隙率及梯度孔隙率Gyroid结构力学性能,设计并制备新型多孔种植体。方法通过MSLattice和Magics软件建立均一孔隙率为60%、65%、70%、75%、80%和60%~80%梯度的Gyroid结构模型,分别通过有限元分析及力学压缩试验对比不同孔隙率Gyroid结构力学性能,设计并通过激光选区熔融技术(selective laser melting,SLM)3D打印新型多孔种植体。结果随着孔隙率的上升,Gyroid结构的弹性模量和抗压强度下降。同一孔隙率下,SLA前后Gyroid结构的弹性模量差异不具有统计学显著性(P>0.05),梯度Gyroid结构的最大抗压应变均低于各均一孔隙率Gyroid结构。结论梯度Gyroid结构匹配了骨皮质及骨松质的弹性模量,且强度与人骨相近,具有优异的力学性能,有望应用在口腔种植体上。

关键词： Gyroid结构 3D打印多孔种植体激光选区熔融技术