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A Novel Prognostic Approach to Predict Recovery in Patients with Chronic Disorders of Consciousness

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Neuroscience Bulletin 2019年第5期35卷 953-954页

作者： Wangxiao Bao xiaoxia li Benyan Luo Department of Neurology First Affiliated Hospital Collaborative Innovation Center for Brain Science Zhejiang University School of Medicine

Severe brain injury can lead to acute or chronic disorders of consciousness (DOC), and the latter represents a more critical challenge in diagnosis and management. For most chronic unconsciousness survivors with preserved sleepwake cycles, including vegetative state (VS) and minimally conscious state (MCS), levels of consciousness are commonly monitored and determined based on behavioral evidence. VS, also termed unresponsive wakefulness syndrome (UWS), is characterized by complete absence of awareness and may be associated with poor recovery, while MCS exhibit discernible behavioral signs of environmental or self- awareness [1]. Since nearly 40% patients in MCS are initially misdiagnosed as VS/UWS due to the limitation of the existing diagnostic criterion, it is therefore necessary to define the accurate diagnostic and prognostic categorization for long-term outcome [2].

关键词： Chronic Disorders of Consciousness Prognostic

Effects of free ammonia on volatile fatty acid accumulation and process performance in the anaerobic digestion of two typical bio-wastes

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Journal of Environmental Sciences 2017年第5期29卷 49-57页

作者： Xuchuan Shi Jia lin Jiane Zuo Peng li xiaoxia li Xianglin Guo State Key Joint Laboratory of Environment Simulation and Pollution Control (SKLESPC) School of Environment Tsinghua University Beijing 100084 China Beijing Enterprises Water Group limited Beijing 100124 China

The effect of free ammonia on volatile fatty acid （VFA） accumulation and process instability was studied using a lab-scale anaerobic digester fed by two typical bio-wastes： fruit and vegetable waste （FVW） and food waste （FW） at 35℃ with an organic loading rate （OLR） of 3.0 kg VS/（m3-day）. The inhibitory effects of free ammonia on methanogenesis were observed due to the low C/N ratio of each substrate （15.6 and 17.2, respectively）. A high concentration of free ammonia inhibited methanogenesis resulting in the accumulation of VFAs and a low methane yield. In the inhibited state, acetate accumulated more quickly than propionate and was the main type of accumulated VFA. The co-accumulation of ammonia and VFAs led to an ＂inhibited steady state＂ and the ammonia was the main inhibitory substance that triggered the process perturbation. By statistical significance test and VFA fluctuation ratio analysis, the free ammonia inhibition threshold was identified as 45 mg/L. Moreover, propionate, iso-butyrate and valerate were determined to be the three most sensitive VFA parameters that were subject to ammonia inhibition.

关键词： Ammonia inhibition VFA accumulation Anaerobic digestion Process indicator Bio-wastes

Microstructure Evolution of Organic Matter and Clay Minerals in Shales with Increasing Thermal Maturity

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Acta Geologica Sinica(English Edition) 2020年第2期94卷 280-289页

作者： GU Yuantao li xiaoxia YANG Shuguang WAN Quan School of Resource and Environment Henan University of EngineeringZhengzhou 451191China State Key Laboratory of Ore Deposit Geochemistry Institute of GeochemistryChinese Academy of SciencesGuiyang550081China

As the two important components of shale, organic matter(OM) and clay minerals are usually thought to strongly influence the hydrocarbon generation, enrichment and exploitation. The evolution process of OM and clay minerals as well as their interrelationship over a wide range of thermal maturities are not completely clear. Taking Yanchang(T3y), Longmaxi(S1l) and Niutitang(?1n) shales as examples, we have studied the microstructure characteristics of OM and clay minerals in shales with different thermal maturities. The effects of clay minerals and OM on pores were reinforced through sedimentation experiments. Using a combination of field emission scanning electron microscopy(FESEM) and low-pressure N2 adsorption, we investigated the microstructure differences among the three shales. The results showed that both OM and clay minerals have strong effects on pores, and small mesopore(2–20 nm) is the dominant pore component for all three samples. However, the differences between the three samples are embodied in the distribution of pore size and the location. For the T3y shale, clay minerals are loosely arranged and develop large amounts of pores, and fine OM grains often fill in intergranular minerals or fractures. Widespread OM pores distribute irregularly in S1l shale, and most of the pores are elliptical and nondirectional. The ?1n shale is characterized by the preferred orientational OM-clay aggregates, and lots of pores in the composites are in the mesopore range, suggesting that over maturity lead to the collapse and compaction of pores under huge pressure of strata. The results of the current research imply that with increasing thermal maturity, OM pores are absent at low maturity(T3y), are maximized at high maturity(S1l) and are destroyed or compacted at over-mature stage(?1n). Meanwhile, clay minerals have gone through mineral transformation and orientational evolution. The interaction of the two processes makes a significant difference to the microstructure evo

关键词： organic matter clay minerals OM-clay composites microstructure evolution thermal maturity

Global dynamics of a heroin epidemic model with age structure and nonlinear incidence

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International Journal of Biomathematics 2016年第3期9卷 1-20页

作者： Junyuan Yang xiaoxia li Fengqin Zhang Department of Applied Mathematics Yuncheng University Yuncheng Shanxi 045000 P. R. China Shanxi University Shanxi 030051 P. R. China

A heroin model with nonlinear incidence rate and age structure is investigated. The basic reproduction number is determined whether or not a heroin epidemic breaks out. By employing the Lyapunov functionals, the drug-free equilibrium is globally asymptotically stable if R0 ≤1; while the drug spread equilibrium is also globally asymptotically stable if R0≤ 1. Our results imply that improving detected rates and drawing up the efficient prevention play more important role than increasing the treatment for drug users.

关键词： Nonlinear incidence equilibria global stability.

IL-17 signaling in host defense and inflammatory diseases

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Cellular & Molecular Immunology 2010年第5期7卷 328-333页

作者： Youcun Qian Zizhen Kang Caini liu xiaoxia li The Key Laboratory of Stem Cell Biology Institute of Health SciencesShanghai Institutes for Biological SciencesChinese Academy of Sciences/Shanghai Jiao Tong University School of MedicineShanghaiChina Department of Immunology Lerner Research InstituteCleveland ClinicClevelandOHUSA

Interleukin(IL)-17,the signature cytokine secreted by T helper(Th)17 cells,plays important roles in host defense against extracellular bacterial infection and fungal infection and contributes to the pathogenesis of various autoimmune inflammatory *** we review the recent advances in IL-17-mediated functions with emphasis on the studies of IL-17-mediated signal transduction,providing perspective on potential drug targets for the treatment of autoimmune inflammatory diseases.

关键词： inflammation interleukin-17 signaling

Occurrence modes of silver in the Ni-Mo-PGE polymetallic layer of the Lower Cambrian black shales in Zunyi, Guizhou Province, South China

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Chinese Journal Of Geochemistry 2014年第4期33卷 387-392页

作者： HAN Tao ZHU Xiaoqing liU Shirong li xiaoxia State Key Laboratory of Ore Deposit Geochemistry Institute of Geochemistry Chinese Academy of Sciences University of Chinese Academy of Sciences

The Ni-Mo-PGE polymetallic mineralization of the Lower Cambrian black shales locate in Zunyi, South China and contain abundant noble metals such as Ag, Au and PGE, and especially Ag with average concentration of 64×10-6. The occurrence modes of Ag have been investigated using methods of selective chemical dissolution and transmission electron microscopy. The results demonstrate that the occurrence modes of Ag are complex and diversiform. It might be associated with clay minerals, organic matter, sulfides and also occurred as native silver and sulfides with nanometer in size. Combined with results of previous studies, we suggest that the sulfides, clay minerals and organic matter which hosted in the Ni-Mo-PGE polymetallic ores of black shales can play the roles of important reduction and adsorption geochemical barriers for the enrichment and distribution of silver. This study further implies that the selective chemical dissolution and transmission electron microscopy may pave the way to study the occurrence modes of other noble metals in black shales.

关键词：多金属矿化黑色页岩下寒武统中国南方 PGE 白银镍钼遵义

Preparation and coagulation efficiency of polyaluminium ferric silicate chloride composite coagulant from wastewater of high-purity graphite production

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Journal of Environmental Sciences 2011年第7期23卷 1122-1128页

作者： xiaoxia Niu Xili li Jihong Zhao Yigang Ren Yanqin Yang Henan Provincial Key Laboratory of Surface and Interface Science School of Materials and Chemical Engineering Zhengzhou University of Light Industry Zhengzhou 450002 China

The aim of the present work was to produce a polyaluminium ferric silicate chloride （PAFSiC） coagulant from acidic and alkaline wastewater of purifying graphite by roasting, and subsequently to evaluate coagulation efficiency of the reagent by treating surface water from the Yellow River as well as municipal wastewater in comparison with the conventional coagulant polyaluminium chloride （PAC）. The PAFSiC coagulant was prepared by co-polymerization. The effects of （Al＋Fe）/Si molar ratio, OH/（Al＋Fe） molar ratio （i.e., γ value）, coagulant dosage and pH value of test suspension on the coagulation behavior of FAFSiC and the stability of the PAFSiC were also examined. Results showed that PAFSiC performed more efficiently than PAC in removing turbidity, chemical oxygen demand （COD）, and total phosphate （TP）. The PAFSiC with a γ value of 2.0 and （Al＋Fe）/Si ratio of 5 （PAFSiC 2.0/5） showed excellent coagulation effect for both turbidity and COD, while PAFSiC 1.0/5 was the best for TP. The optimum coagulation pH range of PAFSiC 2.0/5 was 5.0–9.0, slightly wider than that of PAC （6.0–8.0）. The process can be easily incorporated into high-purity graphite production plants, thereby reducing wastewater pollution and producing a valuable coagulant.

关键词： polyaluminium ferric silicate chloride industrial minerals recycling coagulant wastewater

Facet-dependent electro-optical properties of cholesteric liquid crystals doped with Cu2O nanocrystals

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Nano Research 2018年第9期11卷 4836-4845页

作者： Dongyu Zhao lihong Xu Yang Shang xiaoxia li lin Guo Key Laboratory of Bio-lnspired Smart Interfacial Science and Technology Ministry of Education School of Chemistry Beijing Advanced Innovation Center for Biomedical Engineering Beihang University Beijing 100191 China Key Laboratory of Micro-Nano Measurement-Manipulation and Physics Ministry of Education School of Physics and Nuclear Energy Engineering Beihang University Beijing 100191 China

Excellent electro-optical （E-O） performances are essential for high-quality reflective cholesteric liquid crystal （LC） displays, but are often limited by the high driving voltages required by these displays. Dispersing functional nanomaterials into the LCs has emerged as a promising approach to achieve outstanding E-O properties. In this work, we report the facet-controlled E-O properties of a chiral nematic LC （N＊LC） doped with cubic, octahedral, and rhornbic dodecahedral Cu20. The outstanding E-O properties of the doped systems are related to the interaction between the liquid crystals and Cu20 dopants with different exposed crystal planes. Doping with octahedral and rhombic dodecahedral Cu20 reduces the stability of the planar state, as a result of both the surface abundance of active Cu atoms that interact with the polarized LC molecules, and the large amounts of vertexes and edges on the crystal surfaces, which accelerate the transition from the planar to the focal conic state under an applied electric field. Rhombic Cu20 is the most effective dopant for improving the E-O properties of the present LCs, resulting in a 65.31% reduction of the threshold voltage. The facet and morphology effects highlighted in this work provide a new pathway to develop excellent energy-saving meso-materials with exposed high-reactivity facets, improving their potential applications in electro-optical technologies and information displays.

关键词： Cu2O nanocrystals liquid crystals electro-optical properties host-guest systems facet-dependence

Graphene-Gold Nanoparticle-modified Electrochemical Sensor for Detection of Kanamycin Based on Target-induced Aptamer Displacement

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Chemical Research in Chinese Universities 2018年第6期34卷 952-958页

作者： ZHENG Jingyi FENG Rongrong HE Caimei li xiaoxia School of Chemistry and Chemical Engineering Yah'an University Yah'an 716000 P. R. China

A highly sensitive and selective label-free electrochemical sensor was developed for the determination of kanamycin. To improve the sensitivity of the electrochemical sensor, graphene-gold nanoparticles were prepared by a one-step electrochemical coreduction process and were modified on the surface of a glassy carbon electrode. The double-stranded DNA（ds-DNA） duplex probe was immobilized onto the graphene-gold nanoparticle-modified elec-trode. The introduction of target kanamycin induced the displacement of aptamer from the ds-DNA duplex into the solution. Methylene blue（MB） as a redox indicator monitored the current change using differential pulse voltammetry Under optimal conditions, the designed electrochemical aptasensor exhibited a wide linear range from 0. i pmol/L to 10 pmol/L with a detection limit of 0.03 pmol/L for kanamycin. The experimental strategy enabled the direct analysis of milk samples, and the results showed high sensitivity and good selectivity.

关键词： kanamycin Electrochemical aptasensor Graphene Gold nanoparticle Methylene blue