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Advances and established therapies in linear scar prevention

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Chinese Journal of Plastic and Reconstructive Surgery 2023年第4期5卷 212-216页

作者： Jingjing Sun Yajing Qiu xiaoxi lin Department of Plastic and Reconstructive Surgery Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200011China

linear scars are scars formed after surgery or other trauma-healing procedures that typically exhibit a linear *** linear scars are characterized by narrowness,flatness,and a color closely resembling the adjacent *** to meet these criteria can have detrimental effects on the physical and psychological wellbeing of ***,early intervention for linear scars can effectively improve functionality and *** review aimed to consolidate the prevailing agreement on scar prevention therapies and provide clinical physicians with comprehensive and cutting-edge guidance.

关键词： linear scar Prevention Intralesional injection Laser therapy Radiation therapy

Advances in photodynamic therapy for port-wine stain and our experience

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Chinese Journal of Plastic and Reconstructive Surgery 2023年第2期5卷 96-99页

作者： Lixin Zhang Hanru Ying Gang Ma xiaoxi lin Department of Plastic and Reconstructive Surgery Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200011China

Port-wine stain(PWS)is a congenital capillary malformation that occurs in 0.3%–0.5%of *** pulsed dye laser is the current gold standard treatment for PWS;however,its efficacy is *** photodynamic therapy(PDT)is consid... 详细信息

关键词： Port-wine stain Photodynamic therapy Photosensitizer

The Practice of China’s Cosmetic Medicine Dated Back to 3800-4800 Years Ago

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Chinese Journal of Plastic and Reconstructive Surgery 2021年第2期3卷 109-112页

作者： Wei WANG xiaoxi lin Yuguang ZHANG Qingfeng LI Department of Plastic and Reconstructive Surgery Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200001China

Objective To investigate the developmental history of cosmetic surgery and cosmetic medicine in *** The history of cosmetic surgery and cosmetology in China was explored via a review of the literature reported across the globe and the archeological discoveries recorded in *** The ancient underground city of“Sanxingdui”,discovered in Guanghan,Sichuan,China,was built between 1800 and 2800 *** bronze figure sculptures with decorative perforations in the earlobe area were unearthed there,making it perhaps the earliest record of cosmetic surgery practice in the *** practice of decorative perforations in the earlobe predates the practice of nose jobs found in ancient *** Prescriptions for Fifty-two Diseases from the Western Han Dynasty,unearthed in Mawangdui,Changsha,Hunan Province,recorded the treatment of vitiligo in traditional Chinese medi*** might be one of the earliest records of aesthetic medicine in the *** China is one of the earliest birthplaces of cosmetic surgery and cosmetology in the *** practice of cosmetic medicine in China predates the practice of nasal reconstruction found in ancient India.

关键词： History Cosmetic surgery Cosmetic medicine Sanxingdui Prescriptions for Fifty-two Diseases

Angiogenesis and proliferation of endothelial cells in hypertrophic and nodular port-wine stain

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Chinese Journal of Plastic and Reconstructive Surgery 2021年第3期3卷 141-146页

作者： Wenxin Yu Jiafang Zhu Lizhen Wang Gang Ma xiaoxi lin Department of Laser and Aesthetic Medicine Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200011China Shanghai Key Laboratory of Stomatology Department of Oral PathologyShanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200011China Department of Oral Pathology Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShang

Background:Port-wine stain(PWS)has been classified not as the hyperplasia of cells,but rather,as an expansion of malformed ***,previous studies have reported upregulated expression of proangiogenic factors in *** studies have indicated that the pathology exhibits proliferation of numerous endothelial cells in hypertrophic/nodular *** study aimed to determine the expression of vascular epithelial growth factor(VEGF),matrix metalloproteinase-9(MMP-9),angiopoietin-2(ANG-2),and basic fibroblast growth factor(bFGF)in hypertrophic ***:Immunohistochemistry was used to analyze skin samples from 33 patients with hypertrophic *** levels of VEGF,MMP-9,ANG-2,and bFGF in hypertrophic PWS were determined by multiplying the intensity by the percentage of immunoreactive *** scores were classified as follows:negative(0),low(1),moderate(2,3,and 4),or high(6).Results:Based on pathological characteristics,hypertrophic PWS was divided into vascular malformation and pyogenic granuloma(PG)***,MMP-9,ANG-2,and bFGF were significantly activated in the blood vessels of PG-type PWS samples compared with their counterparts in blood vessels of vascular malformation-type PWS samples and ***-type hypertrophic PWS,which exhibited proliferation of endothelial cells,showed the strongest ***:The exuberant proliferation of endothelial cells in PG-type hypertrophic PWS may be associated with the regulation of proangiogenic factors during *** proangiogenic factors that function in the angiogenesis and proliferation of endothelial cells may play an important role in the pathogenesis and progression of ***,these factors may be dynamic and behave differently in various types of hypertrophic PWS.

关键词： Port-wine stain Capillary malformation Hypertrophy Nodule Angiogenesis Proliferation Pathology

Managing facial infiltrating lipomatosis associated with PIK3CA mutation:From surgery to targeted therapy

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Chinese Journal of Plastic and Reconstructive Surgery 2023年第1期5卷 25-29页

作者： Hongrui Chen Bin Sun Wei Gao Chen Hua xiaoxi lin Department of Plastic and Reconstructive Surgery Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200011China

Facial infiltrating lipomatosis(FIL)is a congenital asymmetrical deformity of the maxillofacial region that can significantly affect a patient’s facial appearance and *** the development of sequencing technologies,PIK3CA mutations are considered among the potential etiologies of *** management and treatment of FIL involves plastic surgery;more recently,an improved understanding of its pathogenesis has given rise to new treatment options,including targeted *** we report the clinical data of two patients diagnosed with FIL and present current curative concepts.

关键词： Facial infiltrating lipomatosis PIK3CA mutations Surgery Targeted therapy

Three-Dimensional Volumetric Analysis of Venous Malformations for Assessing the Effectiveness of Percutaneous Sclerotherapy

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Chinese Journal of Plastic and Reconstructive Surgery 2020年第4期2卷 241-247页

作者： Yungying WANG Hao GU Li HU Xi YANG Hui CHEN xiaoxi lin Department of Plastic and Reconstructive Surgery Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200011China

BACKGROUND Percutaneous sclerotherapy can be used to successfully treat venous malformations(VMs)of the head,neck,and ***,the standard curative effect of sclerotherapy has rarely been analyzed,and there is currently no accurate statistical method to measure the volume of VMs after ***,we propose a novel threedimensional(3D)reconstruction method to evaluate this *** To test the feasibility of 3D software(MIMICS 19.0)to evaluate the treatment effect of *** This retrospective study included patients with VMs on the head,neck,and limbs who were treated with ethanol sclerotherapy or foam sclerotherapy every 8 *** 19.0 was used to calculate the performance of the lesion after treatment and measure the VM volumes before and after the *** effect of the clinical treatment dose on the lesion was evaluated,and the treatment effect of each patient was *** relationship between the number of treatments and the reduced volume of VMs was *** Based on the MIMICS-calculated regions of interest(ROI),we found that 1 mL of ethanol reduced the lesion by 473 mm3 and that one dosage of foam(1 mL of polidocanol and 4 mL air content)reduced the lesion by 2138 mm3,demonstrating that the foam sclerosing agent exhibited greater efficacy in this *** The MIMICS 3D volume reconstruction method can effectively and safely evaluate the efficacy of sclerotherapy and provide a preoperative *** method is simple,accurate,and feasible.

关键词： Venous malformations Three-dimensional reconstruction Digital imaging technology Sclerotherapy

Absolute ethanol embolization for treatment of peripheral arteriovenous malformations

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Chinese Journal of Plastic and Reconstructive Surgery 2023年第3期5卷 136-140页

作者： Jingwei Zhou Chen Hua Xi Yang Yuxi Chen Yunbo Jin xiaoxi lin Department of Plastic and Reconstructive Surgery Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200011China

Arteriovenous malformations(AVMs)are aggressive congenital high-flow vascular anomalies,in which the feeding artery and draining vein are connected through fistulas without normal capillary *** severe cases,the condition may cause swelling,ulceration,bleeding,and even heart *** treatment options are available for AVMs,including laser,surgical resection,embolization,and targeted drug *** the development of endovascular treatment technology,absolute ethanol embolization of AVMs has become one of the first-line therapies owing to its sustained efficacy and low recurrence ***,administration of this therapy is challenging and may lead to serious complications if inappropriately *** this article,we reviewed and summarized previous clinical articles,literature reviews,and clinical trial data to comprehensively describe clinical manifestations of AVMs,the mechanism of ethanol embolotherapy,key points in treatment and management of complications,and issues that need to be *** expect to provide a reliable information reference source for clinical physicians and researchers.

关键词： Arteriovenous malformation Embolization Ethanol

Revival of the Cantonese Opera

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China Today 2021年第6期70卷 41-43页

作者： CHENG LONG lin xiaoxi People’s Daily

WALKING along the archaistic streets of Yongqingfang Square in Guangzhou,one will notice a museum built in the architectural style of a lingnan garden(a typical garden south of the Five Mountain Ridges in south China)... 详细信息

关键词： architectural Opera Canton

Bleomycin inhibits CLEC14A to attenuate the progression of extracranial arteriovenous malformations

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Chinese Journal of Plastic and Reconstructive Surgery 2021年第4期3卷 175-180页

作者： Congzhen Qiao Yajing Qiu Yun Zou Chen Hua Yuanbo Li Yunbo Jin xiaoxi lin Department of Plastic and Reconstructive Surgery Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200011China

Background:We previously reported that interstitial injection of bleomycin(BLM)reduces the size of early-stage extracranial arteriovenous malformation(AVM).Here,we sought to investigate the potential mechanism of BLM in treating extracranial ***:Samples of human extracranial AVM(n=3)with no pharmacological treatment were *** endothelial cells were isolated and cultured in primary cell *** transcriptome was examined using RNAsequencing,and differentially expressed C-type lectin domain family 14 member A(CLEC14A)was validated at the transcriptomic and protein *** staining of CLEC14A was performed in samples of human extracranial AVM,with and without BLM ***:Through second-generation sequencing,we found that the expression of 5689 genes were differentially increased or decreased following 24-h BLM *** found that CLEC14A may play an important role in the progression of AVM and can be inhibited by BLM ***:BLM inhibited CLEC14A expression to attenuate the progression of AVM.

关键词： Bleomycin Extracranial arteriovenous malformation CLEC14A RNA-Sequencing