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Down-Regulation of TLR9 Expression Affects the Maturation and Function of Murine Bone Marrow-Derived Dendritic Cells Induced by CpG

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Cellular & Molecular Immunology 2009年第3期6卷 199-205页

作者： ling Ma Guangfeng Zhao Chunyan Hua xiaoxi li Xiaoyin Zhao lingyun Sun Yayi Hou Immunology and Reproductive Biology Lab Medical School ＆ State Key Laboratory of Pharmaceutical Biotechnology Nanjing University Nanjing 210093 China The affiliated Drum Tower Hospital of Nanjing University Medical School Nanjing 210008 China

Toll-like receptor 9 （TLR9） is expressed intracellularly by dendritic cells （DCs） and specifically recognizes unmethylated CpG motif. Recognition of TLR9 to CpG DNA can induce DC maturation followed by the subsequent immune responses. Here, RNA interference （RNAi） was used to identify the effect of CpG DNA signaling on DC function. The results showed that transfection of DCs with siRNA specific for TLR9 gene significantly down-regulated TLR9 expression. Immature DCs transfected with TLR9 siRNA did not differentiate into mature DCs with exposure to CpG. TLR9 siRNA-treated DCs expressed low levels of MHC II and CD40 without reducing endocytosis. Furthermore, TLR9 siRNA-transfected DCs exhibited a decreased allostimulatory capacity in a lymphocyte proliferation assay and attenuated Thl responses by decreasing IL-12p70 production. Our findings indicate that siRNA in silencing TLR9 gene in DCs may offer a potential tool to study the TLR9-CpG pathway.

关键词： DC RNA interference TLR9 CpG

丙戊酸镁缓释片治疗躁狂发作的药品临床综合评价

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中国医院用药评价与分析 2024年第8期24卷 973-977页

作者：李晓曦邢晓璇冯英楠庄伟王之舟王可张蔷张兰董宪喆首都医科大学宣武医院药学部国家老年疾病临床医学研究中心北京100053 首都医科大学药学院北京100069

目的:对丙戊酸镁缓释片治疗躁狂发作的临床综合价值进行评价,为临床合理用药和相关用药决策提供证据支持。方法:系统检索PubMed、the Cochrane library、中国知网、万方数据库等中英文数据库(检索时限均为建库至2023年7月11日),筛选丙... 详细信息

目的:对丙戊酸镁缓释片治疗躁狂发作的临床综合价值进行评价,为临床合理用药和相关用药决策提供证据支持。方法:系统检索PubMed、the Cochrane library、中国知网、万方数据库等中英文数据库(检索时限均为建库至2023年7月11日),筛选丙戊酸镁缓释片治疗躁狂发作的随机对照试验(研究组为丙戊酸镁缓释片或在其基础上联合常规抗躁狂药物治疗,对照组为常规抗躁狂药物治疗)。采用文献研究的方法,基于当前可获得的证据,围绕丙戊酸镁缓释片治疗躁狂发作的有效性、安全性、经济性、创新性、适宜性和可及性6个维度,开展临床综合评价。结果:共纳入20篇随机对照试验研究进行Meta分析。有效性方面,丙戊酸镁缓释片改善躁狂症状的总有效率与喹硫平、碳酸锂等一线药物相似(OR=1.19,95%CI=0.94~1.49,P=0.14);安全性方面,使用丙戊酸镁缓释片的患者出现头晕头痛、乏力等不良反应的发生率(OR=0.57,95%CI=0.37~0.89,P=0.01)及严重程度(MD=-1.23,95%CI=-1.70~-0.75,P<0.000 01)均低于对照药物;经济学方面,最小成本分析结果显示,丙戊酸镁缓释片治疗躁狂发作的经济性优于喹硫平;创新性方面,丙戊酸镁缓释片由我国湖南省湘中制药有限公司生产,其可通过多途径提高脑内抑制性递质的含量,是目前全球唯一的丙戊酸镁制剂,该药制备工艺及外观均获得专利保护;适宜性方面,丙戊酸镁具有良好的技术特点适宜性,使用方便且便于存储;可及性方面,丙戊酸镁缓释片已被纳入国家医保目录,覆盖范围广,且可负担性较高。结论:丙戊酸镁缓释片作为我国自主生产研发的药物,在有效性、安全性和经济性方面具有显著优势,药品作用机制具有创新性,适宜性、可获得性及可负担性均较好。

关键词：丙戊酸镁缓释片躁狂发作药品临床综合评价

A monolithically sculpted van der Waals nano-opto-electro-mechanical coupler

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light(Science & Applications) 2022年第3期11卷 76-85页

作者： Tongyao Zhang Hanwen Wang Xiuxin Xia Ning Yan Xuanzhe Sha Jinqiang Huang Kenji Watanabe Takashi Taniguchi Mengjian Zhu Lei Wang Jiantou Gao Xilong liang Chengbing Qin liantuan Xiao Dongming Sun Jing Zhang Zheng Han xiaoxi li State Key Laboratory of Quantum Optics and Quantum Optics Devices Institute of Opto-ElectronicsShanxi UniversityTaiyuan 030006China Collaborative Innovation Center of Extreme Optics Shanxi UniversityTaiyuan 030006China Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China School of Material Science and Engineering University of Science and Technology of ChinaAnhui 230026China Research Center for Functional Materials National Institute for Materials Science1-1 NamikiTsukuba 305-0044Japan International Center for Materials Nanoarchitectonics National Institute for Materials Science1-1 NamikiTsukuba 305-0044Japan College of Advanced Interdisciplinary Studies National University of Defense TechnologyChangsha 410073China The Key Laboratory of Science and Technology on Silicon Devices Institute of MicroelectronicsChinese Academy of SciencesBeijing 100029China The University of Chinese Academy of Sciences Beijing 100029China State Key Laboratory of Quantum Optics and Quantum Optics Devices Institute of Laser SpectroscopyShanxi UniversityTaiyuan 030006China

The nano-opto-electro-mechanical systems(NOEMS)are a class of hybrid solid devices that hold promises in both classical and quantum manipulations of the interplay between one or more degrees of freedom in optical,electrical and mechanical *** date,studies of NOEMS using van der Waals(vdW)heterostructures are very limited,although vdW materials are known for emerging phenomena such as spin,valley,and topological ***,we devise a universal method to easily and robustly fabricate vdW heterostructures into an architecture that hosts opto-electro-mechanical couplings in one single *** demonstrated several functionalities,including nano-mechanical resonator,vacuum channel diodes,and ultrafast thermo-radiator,using monolithically sculpted graphene NOEMS as a *** readout of electric and magnetic field tuning of mechanical resonance in a CrOCl/graphene vdW NOEMS is further *** results suggest that the introduction of the vdW heterostructure into the NOEMS family will be of particular potential for the development of novel lab-on-a-chip systems.

关键词： monolithic tuning resonator

不同气氛固溶氮化处理对不锈钢组织性能的影响

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热加工工艺 2012年第18期41卷 203-204页

作者：李晓希武汉理工大学能源与动力工程学院湖北武汉430063

研究了3Cr13不锈钢在不同气氛下的固溶氮化。结果表明:1100℃、0.15MPa的N2、NH3气氛下,均可实现固溶氮化,并获得厚氮铁素体层。以NH3为渗剂固溶渗氮,得到的扩散层的晶粒比N2为渗剂的更加细小,试样表面硬度高达45HRC;高硬度的获得主要... 详细信息

研究了3Cr13不锈钢在不同气氛下的固溶氮化。结果表明:1100℃、0.15MPa的N2、NH3气氛下,均可实现固溶氮化,并获得厚氮铁素体层。以NH3为渗剂固溶渗氮,得到的扩散层的晶粒比N2为渗剂的更加细小,试样表面硬度高达45HRC;高硬度的获得主要是靠渗氮层中形成与母相共格的合金元素氮化物的沉淀硬化。

关键词： 3Cr13不锈钢固溶氮化表面硬度

Overexpression of estrogen receptor beta alleviates the toxic effects of beta-amyloid protein on PC12 cells via non-hormonal ligands

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Neural Regeneration Research 2012年第14期7卷 1095-1100页

作者： Hui Wang lihui Si xiaoxi li Weiguo Deng Haimiao Yang Yuyan Yang Yan Fu Department of Gynaecology and Obstetrics First Hospital of Jilin University Changchun 130021 Jilin Province China Department of Gynaecology and Obstetrics Second Hospital of Jilin University Changchun 130044 Jilin Province China Department of Gynaecology Affiliated Hospital of Changchun University of Traditional Chinese Medicine Changchun 130021 Jilin Province China Department of Children＇s Heatlh School of Public Health Jilin Univeristy Changchun 130021 China Department of Scientific Research Affiliated Hospital of Changchun University of Traditional Chinese Medicine Changchun 130021 China Department of Gynaecology and Obstetrics Minzu Hospital of Yitong County Yitong 130700 Jilin Province China

After binding to the estrogen receptor, estrogen can alleviate the toxic effects of beta-amyloid protein, and thereby exert a therapeutic effect on Alzheimer＇s disease patients. Estrogen can increase the incidence of breast carcinoma and endometrial cancer in post-menopausal women, so it is not suitable for clinical treatment of Alzheimer＇s disease. There is recent evidence that the estrogen receptor can exert its neuroprotective effects without estrogen dependence. Real-time quantitative PCR and flow cytometry results showed that, compared with non-transfected PC12 cells, adenovirus-mediated estrogen receptor β gene-transfected PC12 cells exhibited lower expression of tumor necrosis factor a and interleukin 1β under stimulation with beta-amyloid protein and stronger protection from apoptosis. The Akt-specific inhibitor Abi-2 decreased the anti-inflammatory and anti-apoptotic effects of estrogen receptor β gene-transfection. These findings suggest that overexpression of estrogen receptor β can alleviate the toxic effect of beta-amyloid protein on PC12 cells, without estrogen dependence. The Akt pathway is one of the potential means for the anti-inflammatory and anti-apoptotic effects of the estrogen receptor.

关键词： estrogen estrogen receptor β Alzheimer's disease beta-amyloid protein adenovirus neural regeneration

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制备工艺对超高强度钢组织及断口形貌的影响

热加工工艺 2012年第15期41卷 19-21页

作者：李晓希武汉理工大学能源与动力工程学院湖北武汉430063

热轧态Q235钢经历加热奥氏体化、淬火马氏体相变、大塑性变形轧制、轧后退火等工艺处理,材料组织由最初的铁素体+珠光体转变为细化的板条马氏体,断口形貌也随之发生了显著变化。初始热轧态试样断口呈典型的韧窝状形貌,然而轧后马氏体试... 详细信息

热轧态Q235钢经历加热奥氏体化、淬火马氏体相变、大塑性变形轧制、轧后退火等工艺处理,材料组织由最初的铁素体+珠光体转变为细化的板条马氏体,断口形貌也随之发生了显著变化。初始热轧态试样断口呈典型的韧窝状形貌,然而轧后马氏体试样的断口形貌主要为分层状特征。虽然轧后退火试样断口形貌与冷轧态的样品相似,但断口中出现数量众多的小韧窝。在该制备工艺下,材料不仅获得了16%的伸长率,表现出良好的塑性,而且抗拉强度高达1300 MPa。

关键词：制备工艺超高强度钢组织断口形貌

Variations in the Prevalence of Anemia of Varying Severity Among Urban Non-Pregnant Women—China,2021

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China CDC weekly 2024年第10期6卷 175-180页

作者： xiaoxi liu Bo Wang Sailimai Man Heling Bao Yuanyuan Huang Canqing Yu Jun Lyu linhong Wang liming li Hui liu Institute of Medical Information Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijingChina Peking University Health Science Center Meinian Public Health Institute BeijingChina Meinian Institute of Health BeijingChina Peking University Center for Public Health and Epidemic Preparedness&Response BeijingChina Department of Epidemiology and Biostatistics School of Public HealthPeking UniversityBeijingChina Key Laboratory of Epidemiology of Major Diseases(Peking University) Ministry of EducationBeijingChina National Center for Chronic and Non-communicable Disease Control and Prevention Chinese Center for Disease Control and PreventionBeijingChina

Summary What is already known about this topic?Anemia is a significant public health issue affecting women *** studies in China predominantly concentrated on anemia in pregnant or reproductiveage women,leaving a gap i... 详细信息

关键词： Anemia anemia China.

China, A Developing Market Economy Country

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China & World Economy 2003年第4期11卷 3-11页

作者： li xiaoxi, Director, Institute of Economic and Resource Management, Beijing Normal University.

China’s accession to the WTO in the year 2001 isan event of great significance in the history of *** World Trade Organization,with theoverwhelming majority of its members being marketeconomy countries,follows the rul... 详细信息

关键词： for of that China A Developing Market Economy Country into were is been

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美国货币政策、企业出口与杠杆增长差异

金融经济学研究 2021年第3期36卷 62-75页

作者：李晓曦南开大学经济学院天津300071 海南大学经济学院海南海口570228

以2003—2016年上市企业出口和财务数据为样本,研究发现美国货币宽松政策不仅对中国企业杠杆增长存在显著推动作用,而且对出口企业杠杆增长产生更大影响。原因在于,出口企业涉足国内外多个市场,拥有更稳定的现金流以及更广阔的融资市场... 详细信息

以2003—2016年上市企业出口和财务数据为样本,研究发现美国货币宽松政策不仅对中国企业杠杆增长存在显著推动作用,而且对出口企业杠杆增长产生更大影响。原因在于,出口企业涉足国内外多个市场,拥有更稳定的现金流以及更广阔的融资市场来源,从而实现更大的杠杆增长。这一效应在出口收入更高、更加依赖长期债务融资、信贷收紧以及金融市场化程度更高的地区更显著。面对美国2020年"量化宽松",一方面银行部门需警惕国内企业,尤其出口企业出现新一轮杠杆增长和债务风险增加;另一方面政府可以通过引导出口企业贸易结构转变增加出口企业对美国货币政策冲击的抵抗能力。

关键词：美国货币政策企业出口杠杆增长