检索结果-南通市图书馆

Dawn of CAR-T cell therapy in autoimmune diseases

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2024年第10期137卷 1140-1150页

作者： Yuxin Liu Minghao Dong Yunhui Chu Luoqi Zhou Yunfan You xiaowei pang Sheng Yang Luyang Zhang Lian Chen Lifang Zhu Jun Xiao Wei Wang Chuan Qin Daishi Tian Department of Neurology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430030China Hubei Key Laboratory of Neural Injury and Functional Reconstruction Huazhong University of Science and TechnologyWuhanHubei 430030China

Chimeric antigen receptor(CAR)-T cell therapy has achieved remarkable success in the treatment of hematological *** on the immunomodulatory capability of CAR-T cells,efforts have turned toward exploring their potential in treating autoimmune *** analysis of 210 records from 128 academic journals published by 372 institutions in 40 countries/regions indicates a growing number of publications on CAR-T therapy for autoimmune diseases,covering a range of subtypes such as systemic lupus erythematosus,multiple sclerosis,among ***-T therapy holds promise in mitigating several shortcomings,including the indiscriminate suppression of the immune system by traditional immunosuppressants,and non-sustaining therapeutic levels of monoclonal antibodies due to inherent pharmacokinetic *** persisting and proliferating in vivo,CAR-T cells can offer a tailored and precise *** paper reviewed preclinical experiments and clinical trials involving CAR-T and CAR-related therapies in various autoimmune diseases,incorporating innovations well-studied in the field of hematological tumors,aiming to explore a safe and effective therapeutic option for relapsed/refractory autoimmune diseases.

关键词： CAR-T cell therapy Autoimmune disease Immunotherapy Multiple sclerosis Neuromyelitis optica spectrum disorder Systemic lupus erythematosus

在线全文

学校读者我要写书评

暂无评论

面向6G多维扩展的新型多址接入技术综述

电子与信息学报 2024年第6期46卷 2323-2334页

作者：逄小玮蒋旭卢华兵赵楠大连理工大学信息与通信工程学院大连116024 哈尔滨工业大学(威海)信息科学与工程学院威海264209

随着移动通信技术的不断演进,第6代移动通信(6G)将实现从万物互联到万物智联的跨越,满足更高的数据需求和更广泛的应用场景。新型多址接入技术和多维扩展技术将在6G中协同发挥作用,为构建高效、智能、可靠的通信网络提供关键支持,满足... 详细信息

随着移动通信技术的不断演进,第6代移动通信(6G)将实现从万物互联到万物智联的跨越,满足更高的数据需求和更广泛的应用场景。新型多址接入技术和多维扩展技术将在6G中协同发挥作用,为构建高效、智能、可靠的通信网络提供关键支持,满足未来通信的多重需求。该文旨在探讨新型多址接入技术在6G多维扩展通信网络中的应用潜力。首先,该文对比了传统多址接入技术与6G潜在新型多址接入技术,并重点阐述了非正交多址接入技术在提升频谱效率和系统容量方面的优势。然后,详细介绍了卫星通信、无人机(UAV)通信和智能反射面(IRS)等多维扩展技术在6G场景下的优势。进一步,讨论了新型多址技术与卫星通信、UAV以及IRS相结合的优势及协同应用。最后,探讨了基于新型多址接入技术的多维扩展网络中的关键技术挑战,包括大规模多入多出技术、太赫兹技术、通感算一体化、用户信息安全、不完美信道状态信息(CSI)估计,同时对新型编码技术、人工智能和机器学习等研究方向进行了展望。

关键词： 6G移动通信多维扩展新型多址接入技术卫星通信无人机智能反射面

同方期刊数据库

Time and energy efficient data collection via UAV

在线全文

学校读者我要写书评

暂无评论

Science China(Information Sciences) 2022年第8期65卷 182-196页

作者： Tianhao WANG xiaowei pang Jie TANG Nan ZHAO Xiuyin ZHANG Xianbin WANG School of Information and Communication Engineering Dalian University of Technology Department of Electrical and Computer Engineering Western University School of Electronic and Information Engineering South China University of Technology

Using unmanned aerial vehicles(UAVs) for data collection has emerged as a promising technique to achieve both time-and energy-efficient data gathering while keeping data fresh. In this study, two schemes are proposed for flight cycle minimization and energy efficiency maximization to collect data from ground sensors. We first minimize the flight cycle by jointly optimizing the wake-up scheduling of sensors, the trajectory,and the time slot, which is a mixed-integer non-convex problem and difficult to solve directly. To this end,we propose an iterative algorithm based on block coordinate descent and successive convex approximation to decouple the original non-convex problem into two sub-problems and the constraints are turned to be convex approximately. Furthermore, the energy efficiency is maximized since the limited energy is a critical issue in UAV communication systems. We approximate the two subproblems as convex optimizations by introducing slack variables and applying SCA. The approximate energy efficiency is a fractional expression, and we use Dinkelbach’s method to solve it. Numerical results show that the flight cycle is minimized in the first scheme with the data requirement satisfied, while in the second scheme, the energy efficiency is maximized with the trade-off between the transmission data and the propulsion power consumption.

关键词： data collection energy efficiency maximization time minimization trajectory optimization unmanned aerial vehicle (UAV)

Energy-efficient design for mmW ave-enabled NOMA-UAV networks

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Science China(Information Sciences) 2021年第4期64卷 40-53页

作者： xiaowei pang Jie TANG Nan ZHAO Xiuyin ZHANG Yi QIAN School of Information and Communication Engineering Dalian University of Technology School of Electronic and Information Engineering South China University of Technology Department of Electrical and Computer Engineering University of Nebraska-Lincoln

Owing to the recent advances of non-orthogonal multiple access(NOMA) and millimeter-wave(mmWave), these two technologies are combined in unmanned aerial vehicle(UAV) networks in this ***, energy efficiency has become a significant metric for UAVs owning to their limited energy. Thus, we aim to maximize the energy efficiency for mmWave-enabled NOMA-UAV networks by optimizing the UAV placement, hybrid precoding and power allocation. However, the optimization problem is complicated and intractable, which is decomposed into several sub-problems. First, we solve the UAV placement problem by approximating it into a convex one. Then, the hybrid precoding with user clustering is performed to better reap the multi-antenna gain. Particularly, three schemes are proposed, where the cluster head selection algorithm is adopted while considering different equivalent channels of users. Finally, the power allocation is optimized to maximize the energy efficiency, which is converted to convex and solved via an iterative algorithm. Simulation results are provided to evaluate the performance of the proposed schemes.

关键词： energy efficiency hybrid precoding millimeter-wave non-orthogonal multiple access placement optimization power allocation unmanned aerial vehicle

Comparing the effects of dual-task training and single-task training on walking,balance and cognitive functions in individuals with Parkinson’s disease:A systematic review

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Chinese Medical Journal 2024年第13期137卷 1535-1543页

作者： Xiaoying Lin Yanming Zhang xiaowei Zhang Xi Chen Jianhua Liu Lei Yang Marco Yiu Chung pang Department of Rehabilitation Medicine the First Affiliated Hospital of Xi’an Jiaotong UniversityXi’anShaanxi 710061China Department of Rehabilitation Medicine The Second People’s Hospital of KunmingKunmingYunnan 650051China Department of Rehabilitation Medicine Xuanwu HospitalCapital Medical UniversityBeijing 100000China Department of Physical Therapy China Rehabilitation Research CenterBeijing 100000China Department of Rehabilitation Sciences The Hong Kong Polytechnic UniversityHong Kong 999077China

Background:This systematic review aimed to examine whether dual-task(DT)training was superior to single-task(ST)training in improving DT walking,balance and cognitive functions for individuals with Parkinson’s disease(PD).Methods:Literature search was performed in the following electronic databases:PubMed,the Cochrane Library,Web of Science,and Metstr covering inception to May 10,*** in order to facilitate comparison across trials,we calculated the effect size(Hedges’g)of gait,balance,cognitive,and other parameters under both ST and DT conditions,using the mean change score and standard deviation(SD)of change score of the experimental and control *** controlled trials that examined the effects of DT motor and cognitive training in individuals with Parkinson’s disease were included for this systematic ***:A total of 214 participants recruited from six articles(actually five trials)were involved in this *** terms of walking ability,only double support time and stride time variability showed significant between-group difference(Hedges’g=0.34,0.18,respectively).Compared to ST training group,DT training group had a more improvement effect in laboratory balance measurement(Hedges’g=0.18,1.25),but no significant improvement in clinical balance *** significant between-group differences were observed,thus its training effect on cognitive function was ***:The DT training failed to achieve promising results better than ST training in improving DT walking and balance functions for individuals with *** firm conclusion cannot be drawn at present,due to the limited number of eligible *** sample size and high-quality studies are needed to investigate the effectiveness of DT training in individuals with PD.

关键词： Parkinson’s disease Dual-task training Mobility Cognition Systematic review

Tungsten separation behavior on preparation of high-purity cerium by combined vacuum gravity sedimentation-directional solidification

在线全文

学校读者我要写书评

暂无评论

Journal of Rare Earths 2024年第6期42卷 1182-1186,I0007页

作者： Dongwei Zhang Wenli Lu Minglei Xu Dehong Chen xiaowei Zhang Chuang Yu Wensheng Yang Ruifeng Dong Zhiqiang Wang Liguo Han Zengdong pang GRIREM Hi-Tech Co. Ltd.Langfang065201China National Engineering Research Center for Rare Earth China GRINM Group Co.Ltd.Beijing100088China GRIREM Advanced Materials Co. Ltd.Beijing100088China

In light of the difficult removal of harmful impurity tungsten(W)in Ce metal,in this paper a combined vacuum gravity sedimentation-directional solidification method was innovatively designed and the W separation behavior was *** reducing the electron beam power instantly and gradually at reduction rates of 1,3 and 5 kW/min,it is found that W is enriched at the bottom of ingots as the melt *** enrichment effect is much better than that of single purification method and the enrichment degree increases as the beam reduction rate decreases,attributed to the k0(W)>1 andρ(W)>ρ(Ce).Overall,the minimum content of W impurity can decrease from 630 to 0.1 ppm at the top of the ingot,and the purity of Ce increases from 99.932 wt%to 99.995 wt%by this combined ***,this paper provides a new method for the removal of high density and low evaporation coefficient impurities in low vapor pressure rare earth metals.

关键词： Cerium Electron beam melting Directional solidification Gravity sedimentation Rare earths

Numerical simulations of Atlantic meridional overturning circulation(AMOC)from OMIP experiments and its sensitivity to surface forcing

在线全文

学校读者我要写书评

暂无评论

Journal of Oceanology and Limnology 2024年第2期42卷 454-467页

作者： xiaowei WANG Yongqiang YU State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics(LASG) Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China University of Chinese Academy of Sciences Beijing 100049China

Atlantic meridional overturning circulation(AMOC)plays an important role in transporting heat meridionally in the Earth’s climate system and is also a key metrical tool to verify oceanic general circulation *** OMIP(Ocean Model Intercomparison Project phase 1 and 2)simulations with LICOM3(version 3 of the LASG/IAP Climate System Ocean Model)developed at the State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics(LASG),Institute of Atmospheric Physics(IAP),are compared in this *** simulations well reproduce the fundamental characteristics of the AMOC,but the OMIP1 simulation shows a significantly stronger AMOC than the OMIP2 *** the LICOM3 configurations are identical between these two experiments,any differences between them must be attributed to the surface forcing *** analysis suggests that sea surface salinity(SSS)differences should be mainly responsible for the enhanced AMOC in the OMIP1 simulation,but sea surface temperature(SST)also play an unignorable role in modulating *** the North Atlantic,where deep convection occurs,the SSS in OMIP1 is more saline than that in *** find that in the major region of deep convection,the change of SSS has more significant effect on density than the change of *** a result,the SSS was more saline than that in OMIP2,leading to stronger deep convection and subsequently intensify the *** conduct a series of numerical experiments with LICOM3,and the results confirmed that the changes in SSS have more significant effect on the strength of AMOC than the changes in SST.

关键词： oceanic general circulation model(OGCM) Atlantic meridional overturning(AMOC) surface forcing deep convection

Review of Collocation Methods and Applications in Solving Science and Engineering Problems

在线全文

学校读者我要写书评

暂无评论

Computer Modeling in Engineering & Sciences 2024年第7期140卷 41-76页

作者： Weiwu Jiang xiaowei Gao School of Aeronautics and Astronautics Dalian University of TechnologyDalian116024China State Key Laboratory of Structural Analysis for Industrial Equipment Dalian University of TechnologyDalian116024China

The collocation method is a widely used numerical method for science and engineering problems governed by partial differential *** paper provides a comprehensive review of collocation methods and their applications,focused on elasticity,heat conduction,electromagnetic field analysis,and fluid *** merits of the collocation method can be attributed to the need for element mesh,simple implementation,high computational efficiency,and ease in handling irregular domain problems since the collocation method is a type of node-based numerical *** with the fundamental principles of the collocation method,the discretization process in the continuous domain is elucidated,and how the collocation method approximation solutions for solving differential equations are *** into the historical development of the collocation methods,their earliest applications and key milestones are traced,thereby demonstrating their evolution within the realm of numerical *** mathematical foundations of collocation methods,encompassing the selection of interpolation functions,definition of weighting functions,and derivation of integration rules,are examined in detail,emphasizing their significance in comprehending the method’s effectiveness and *** last,the practical application of the collocation methods in engineering contexts is emphasized,including heat conduction simulations,electromagnetic coupled field analysis,and fluid dynamics *** specific case studies can underscore collocation method’s broad applicability and effectiveness in addressing complex engineering *** conclusion,this paper puts forward the future development trend of the collocation method through rigorous analysis and discussion,thereby facilitating further advancements in research and practical applications within these fields.

关键词： Collocation method meshless method discrete schemes for functions numerical calculation

Study on damage mechanism and damage distribution of the rear plate under impact of debris cloud

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Defence Technology（防务技术） 2024年第5期35卷 151-167页

作者： Chenyang Wu xiaowei Chen Qiguang He State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyHaidian DistrictBeijing 100081China School of Mechatronical Engineering Beijing Institute of TechnologyHaidian DistrictBeijing 100081China Institute of Fluid Physics China Academy of Engineering PhysicsMianyang 621900SichuanChina

The debris cloud generated by the hypervelocity impact(HVI)of orbiting space debris directly threatens the spacecraft.A full understanding of the damage mechanism of rear plate is useful for the optimal design of protective *** this study,the hypervelocity yaw impact of a cylindrical aluminum projectile on a double-layer aluminum plate is simulated by the FE-SPH adaptive method,and the damage process of the rear plate under the impact of the debris cloud is analyzed based on the debris cloud *** damage process can be divided into the main impact stage of the debris cloud and the structural response of the rear *** main impact stage lasts a short time and is the basis of the rear plate *** the stage of structure response,the continuous deformation and inertial motion of the rear plate dominate the perforation of the rear *** further analyze the damage mechanism and damage distribution characteristics of the rear plate in ***,the connection between velocity space and position space of the debris cloud is established,which promotes the general analysis of the damage law of debris *** on the relationship,the features of typical damage areas are identified by the localized fine *** the cumulative effect and structural response cause the perforation of rear plate;in the non-perforated area,cratering by the impact of hazardous fragments is the main damage mode of the rear plate.

关键词： Damage of rear plate Debris cloud Secondary impact Hypervelocity yaw impact FE-SPH adaptive method