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Regularized automatic frequency response function acquisition of a milling robot operating in a high-dimensional workspace

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Science China Technological Sciences 2024年第6期67卷 1783-1797页

作者： LUO WenLong TANG xiaowei MA Tao GUO QiuShuang XU YanYan YUAN Xing ZHANG Lei mao XinYong School of Mechanical Science and Engineering Huazhong University of Science and Technology State Key Laboratory of Smart Manufacturing for Special Vehicles and Transmission System Wuhan Heavy Duty Machine Tool Group Corporation

Because robotic milling has become an important means for machining significant large parts, obtaining the structural frequency response function(FRF) of a milling robot is an important basis for machining process optimization. However, because of its articulated serial structure, a milling robot has an enormous number of operating postures, and its dynamics are affected by the motion state. To accurately obtain the FRF in the operating state of a milling robot, this paper proposes a method based on the structural modification concept. Unlike the traditional excitation method, the proposed method uses robot joint motion excitation instead of hammering excitation to realize automation. To address the problem of the lack of information brought by motion excitation, which leads to inaccurate FRF amplitudes, this paper derives the milling robot regularization theory based on the sensitivity of structural modification, establishes the modal regularization factor, and calibrates the FRF amplitude. Compared to the commonly used manual hammering experiments, the proposed method has high accuracy and reliability when the milling robot is in different postures. Because the measurement can be performed directly and automatically in the operation state, and the problem of inaccurate amplitudes is solved, the proposed method provides a basis for optimizing the machining posture of a milling robot and improving machining efficiency.

关键词： milling robot structural dynamics frequency response function automatic identification modal regularization factor high-dimensional workspace

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Sensitivity and resistance risk analysis of Didymella bryoniae populations to fluopyram

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Journal of Integrative Agriculture 2024年第7期23卷 2306-2317页

作者： Zhiwen Wu xiaowei Cai Xuewei mao Mingguo Zhou Yiping Hou College of Plant Protection Nanjing Agricultural UniversityNanjing 210095China

Fluopyram is an succinate dehydrogenase inhibitors(SDHI)fungicide that has been registered in China to control gummy stem blight(GSB)in watermelons for many years.However,whether the field pathogens of GSB are still sensitive to fluopyram or not is unknown.Therefore,we collected 69 Didymella bryoniae isolates from the fields that usually use fluopyram to control GSB to determine the sensitivity change.The EC50(50%inhibition effect)values of fluopyram against D.bryoniae ranged from 0.0691 to 0.3503μg mL–1 and the variation factor was 5.07.The mean EC50 value was(0.1579±0.0669)μg mL–1 and the curve of sensitivity was unimodal.No resistant strains were found in the isolates,which means that the pathogens were still sensitive to fluopyram.The minimal inhibition concentration(MIC)of fluopyram against D.bryoniae was 3μg mL–1.Four low-resistant mutants and two mediumresistant mutants were obtained using fungicide taming and the resistance of mutants could be inherited stably.The growth rate of mutants decreased significantly compared with that of wild-type strains while the biomass of most mutants was similar to that of wild-type strains.The sensitivity of most resistant mutants to various stresses was increased compared with that of wild-type strains.The virulence of mutants receded except for low-resistant mutant XN51FR-1,which had the same lesion area as XN51 on the watermelon leaves.The results indicated that the fitness of resistant mutants was decreased compared with that of wild-type strains.The cross-resistance assay indicated that fluopyram-resistant mutants were positive cross-resistant to all six SDHI fungicides in this test but were still sensitive to fluazinam and tebuconazole.So the resistance risk of D.bryoniae to fluopyram was moderate.In addition,we found that the SdhB gene of low-resistant mutant XN30FR-1 had three new point mutations at positions K258N,A259P,and H277N.Medium-resistant mutant XN52FR-1 showed a mutation at position H277N and other mutants did not have any point mutation.

关键词： fluopyram D.bryoniae sensitivity risk assessment

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Bioinspired surface functionalization of biodegradable mesoporous silica nanoparticles for enhanced lubrication and drug release

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Friction 2023年第7期11卷 1194-1211页

作者： xiaowei mao Kexin CHEN Yanlong ZHAO Chunrong Xiong Jing LUO Yuguang WANG Bo WANG Hongyu ZHANG School of Chemical Engineering and Technology Hainan UniversityHaikou 570228China State Key Laboratory of Tribology Department of Mechanical EngineeringTsinghua UniversityBeijing 100084China Peking University School of Nursing&National Engineering Laboratory for Digital and Material Technology of Stomatology Beijing 100191China Beijing Research Institute of Automation for Machinery Industry Co. Ltd.Beijing 100120China Center of Digital Dentistry Peking University School and Hospital of Stomatology&NHC Research Center of Engineering and Technology for Computerized DentistryBeijing 100081China College of Chemical and Biological Engineering Shandong University of Science and TechnologyQingdao 266590China

Osteoarthritis is associated with the significantly increased friction of the joint,which results in progressive and irreversible damage to the articular cartilage.A synergistic therapy integrating lubrication enhancement and drug delivery is recently proposed for the treatment of early-stage osteoarthritis.In the present study,bioinspired by the self-adhesion performance of mussels and super-lubrication property of articular cartilages,a biomimetic self-adhesive dopamine methacrylamide-poly(2-methacryloyloxyethyl phosphorylcholine)(DMA-MPC)copolymer was designed and synthesized via free radical polymerization.The copolymer was successfully modified onto the surface of biodegradable mesoporous silica nanoparticles(bMSNs)by the dip-coating method to prepare the dual-functional nanoparticles(bMSNs@DMA-MPC),which were evaluated using a series of surface characterizations including the transmission electron microscope(TEM),Fourier transform infrared(FTIR)spectrum,thermogravimetric analysis(TGA),X-ray photoelectron spectroscopy(XPS),etc.The tribological test and in vitro drug release test demonstrated that the developed nanoparticles were endowed with improved lubrication performance and achieved the sustained release of an anti-inflammatory drug,i.e.,diclofenac sodium(DS).In addition,the in vitro biodegradation test showed that the nanoparticles were almost completely biodegraded within 10 d.Furthermore,the dual-functional nanoparticles were biocompatible and effectively reduced the expression levels of two inflammation factors such as interleukin-1β(IL-1β)and interleukin-6(IL-6).In summary,the surface functionalized nanoparticles with improved lubrication and local drug release can be applied as a potential intra-articularly injected biolubricant for synergistic treatment of early-stage osteoarthritis.

关键词： surface functionalization phosphorylcholine coating mesoporous silica nanoparticles hydration lubrication osteoarthritis

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中国式学校体育现代化:国情、路径、课题与发展

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武汉体育学院学报 2024年第3期58卷 1-9,33页

作者：毛振明彭小伟胡庆山郑州大学体育学院(主校区) 河南郑州450001 武汉体育学院体育教育学院湖北武汉430079 华中师范大学体育学院湖北武汉430079

党的二十大提出了“中国式现代化”的新论述,它是指导各条战线对自身发展理念、道路、经验、成果进行总结和展望未来发展的最精辟、最高屋建瓴的思想与方法论。新中国成立以来,中国学校体育取得巨大成就,它的发展也是中国式的学校体育... 详细信息

党的二十大提出了“中国式现代化”的新论述,它是指导各条战线对自身发展理念、道路、经验、成果进行总结和展望未来发展的最精辟、最高屋建瓴的思想与方法论。新中国成立以来,中国学校体育取得巨大成就,它的发展也是中国式的学校体育现代化,其发展路径与方法必然具有“中国式现代化”、中国教育现代化和“体育强国”的基本特征。从“中国式现代化”、中国教育现代化和“体育强国”的视角审视中国式的学校体育现代化,归纳出以下八个基本特征:党的领导性、困难艰巨性、素质教育性、公平全体性、民族文化性、改革创新性、终身基础性和竞体提高性。对中国式学校体育现代化的国情背景、独特路径、面临课题和未来发展进行充分研讨,旨在丰富中国式学校体育现代化的内涵,促进其更鲜明的特色发展。

关键词：中国式现代化中国式学校体育现代化立德树人素质教育增强体质终身体育中华民族传统体育体教融合竞技体育

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用于刑侦检测的日盲紫外折衍混合变焦光学系统设计

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光学学报 2024年第4期44卷 273-282页

作者：宋逸辰唐玉凤赖涛袁沛琦丁骁炜毛珊赵建林西北工业大学物理科学与技术学院光场调控与信息感知工业和信息化部重点实验室陕西省光信息技术重点实验室陕西西安710129

基于ARTCAM-407UV-WOM型紫外探测器,结合光学系统成像性能要求和光学元件成像特性,提出一种基于Qcon非球面和衍射表面的日盲紫外折衍混合变焦光学系统设计方法。所设计的系统仅由5块透镜组成,采用氟化钙和熔融石英两种材料,工作波段为0.... 详细信息

基于ARTCAM-407UV-WOM型紫外探测器,结合光学系统成像性能要求和光学元件成像特性,提出一种基于Qcon非球面和衍射表面的日盲紫外折衍混合变焦光学系统设计方法。所设计的系统仅由5块透镜组成,采用氟化钙和熔融石英两种材料,工作波段为0.24~0.27μm,连续变焦范围为40~100 mm。分析结果显示,该系统在整个变焦范围内,奈奎斯特空间频率在11 lp/mm处的调制传递函数值均高于0.7,全视场畸变小于0.06%,表明该设计方法能够满足日盲紫外连续变焦系统结构简单、体积小、像质优良、像面稳定等设计和刑侦检测使用要求,对此类光学系统的设计具有一定借鉴意义。

关键词：光学设计混合光学系统 Q型非球面日盲紫外光变焦光学系统

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非制冷长波红外连续变焦光学系统的一种无热化设计

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光学学报 2024年第7期44卷 150-158页

作者：唐玉凤毛珊宋逸辰赖涛袁沛琦丁骁炜赵建林西北工业大学物理科学与技术学院光场调控与信息感知工业和信息化部重点实验室陕西省光信息技术重点实验室陕西西安710129

为了满足长波红外(LWIR)热像仪在宽温度范围下连续变焦的需求,基于LWIR 320 pixel×320 pixel型红外探测器,设计了一款非制冷长波红外连续变焦光学系统。该系统可在宽温度范围下实现无热化,采用常见的硫系玻璃,工作波段为8~12μm,总长为... 详细信息

为了满足长波红外(LWIR)热像仪在宽温度范围下连续变焦的需求,基于LWIR 320 pixel×320 pixel型红外探测器,设计了一款非制冷长波红外连续变焦光学系统。该系统可在宽温度范围下实现无热化,采用常见的硫系玻璃,工作波段为8~12μm,总长为200 mm,仅由7片透镜组成。通过引入偶次非球面,可以使系统色差和轴外像差得到良好的校正,同时选用后固定组的最后一片透镜充当温度补偿组来调节焦距实现无热化。分析结果表明,该系统结构紧凑,可以在-40~60℃温度范围内和60~180 mm焦距范围内连续平滑变焦,并且全程成像质量良好(调制传递函数在20 lp/mm处均大于0.3),变焦和公差也具有良好的可实现性。

关键词：光学设计红外变焦系统长波红外像质评价

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新疆南天山乌宗布拉克铅锌矿床地质特征及矿床成因探讨

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地质找矿论丛 2024年第1期39卷 1-8页

作者：毛红伟梁孝伟万生楠祁斌年中国冶金地质总局新疆地质勘查院乌鲁木齐830063 中国冶金地质总局矿产资源研究院北京101300

新疆南天山乌宗布拉克铅锌矿床地处艾尔宾山(残余海盆)成矿带的东段,经过多年来地质探矿,矿床规模在不断扩大,铅锌矿体产于中泥盆统萨阿尔明组大理岩与绢云千枚岩的岩性界面附近,其含矿性与地层层位、特定的岩性关系密切,成矿作用与石... 详细信息

新疆南天山乌宗布拉克铅锌矿床地处艾尔宾山(残余海盆)成矿带的东段,经过多年来地质探矿,矿床规模在不断扩大,铅锌矿体产于中泥盆统萨阿尔明组大理岩与绢云千枚岩的岩性界面附近,其含矿性与地层层位、特定的岩性关系密切,成矿作用与石炭二叠纪岩浆岩关系密切,该铅锌矿体显示出明显的热液交代充填成矿作用的特征。本文从矿区地质特征入手,结合前人资料,对乌宗布拉克铅锌矿床成矿条件、矿石特征等进行研究,认为乌宗布拉克铅锌矿床为产于泥盆系碳酸盐岩地层中的中低温热液铅锌矿床,属于沉积热液改造型复成因矿床。

关键词：乌宗布拉克铅锌矿地质特征矿床成因找矿标志南天山新疆维吾尔自治区

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基于蒽[2,3⁃b]苯并呋喃为核心的高效长寿命蓝光材料

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发光学报 2024年第1期45卷 86-93页

作者：王小伟孙军袁江波张宏科毛涛王晨何海晓田密刘凯鹏杨丹丹李江楠西安瑞联新材料股份有限公司陕西西安710077

设计合成了一种以蒽[2,3-b]苯并呋喃为核心的新型化合物,通过给体咔唑基团修饰得到化合物2-(蒽[2,3-b]苯并呋喃-3-基)-9-苯基-9H-咔唑(ABPCz)。经过掺杂器件研究,ABPCz可以实现蓝光发射,最大电流效率为8.79 cd/A,最大外量子效率为7.8%,C... 详细信息

设计合成了一种以蒽[2,3-b]苯并呋喃为核心的新型化合物,通过给体咔唑基团修饰得到化合物2-(蒽[2,3-b]苯并呋喃-3-基)-9-苯基-9H-咔唑(ABPCz)。经过掺杂器件研究,ABPCz可以实现蓝光发射,最大电流效率为8.79 cd/A,最大外量子效率为7.8%,CIE(0.17,0.23),峰值光谱448 nm,在476 nm处有较强的肩峰,在1000 cd/m2初始亮度下测试器件LT90(亮度衰减到初始亮度的90%)寿命达到153 h。结果表明,蒽[2,3-b]苯并呋喃经过咔唑基修饰可以得到高效、长寿命的蓝光器件,这为设计开发高性能蓝光材料提供了一个新途径。

关键词：有机电致发光蒽[2,3-b]苯并呋喃蓝光荧光材料

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Integrated Organ-on-a-chip with Human-induced Pluripotent Stem Cells Directional Differentiation for 3D Skin Model Generation

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Journal of Wuhan University of Technology(Materials Science) 2022年第6期37卷 1271-1278页

作者：罗章 GONG Chaihong mao xiaowei WANG Zhe LIU Zhifan BEN Yali 张玮莹 School of Life Sciences Key Laboratory of Optoelectronic Chemical Materials and Devices of Ministry of EducationJianghan UniversityWuhan 430056China School of medicine Jianghan UniversityWuhan 430056China School of Environment and Health Jianghan UniversityWuhan 430056China

Keratinocytes and fibroblasts,derived from hiPSCs,were used to construct the human epidermal model by a culture patch made by monolayer poly-(lactic-co-glycolic acid)(PLGA)nanofibers and a human skin-on-a-chip device.Unlike the conventional culture dish method,two different epidermal cells are successfully adhered to the front and back sides of the patch,which produces a three-dimensional nanofibrous scaffold similar to a natural extracellular matrix before the patch was cultured in the skin-on-a-chip device to mimic the physiological conditions of human skin.As expected,the differentiated hiPSCs show the expression of keratinocyte-and fibroblast-specific proteins on the patch,and the layering is found between these two kinds of cells,indicating that this approach creates a powerful in vitro system for modeling skin development and diseases.

关键词： organ-on-a-chip human-induced pluripotent stem cells 3D skin model direction differentiation

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Last glacial terrestrial vegetation record of leaf wax n-alkanols in the northern South China Sea:Contrast to scenarios from longchain n-alkanes

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Acta Oceanologica Sinica 2022年第8期41卷 22-30页

作者： Shengyi mao Guodong Jia xiaowei Zhu Nengyou Wu Daidai Wu Hongxiang Guan Lihua Liu CAS Key Laboratory of Gas Hydrate Guangzhou Institute of Energy ConversionChinese Academy of SciencesGuangzhou 510640China Southern Marine Science and Engineering Guangdong Laboratory(Guangzhou) Guangzhou 511458China State Key Laboratory of Marine Geology Tongji UniversityShanghai 200092China Key Laboratory of Ocean and Marginal Sea Geology South China Sea Institute of OceanologyChinese Academy of SciencesGuangzhou 510301China Key Laboratory of Gas Hydrate of Ministry of Natural Resources Qingdao Institute of Marine GeologyQingdao 266237China Laboratory for Marine Mineral Resources Pilot National Laboratory for Marine Science and Technology(Qingdao)Qingdao 266237China

Long-chain n-alkanols and n-alkanes in core sediments from the northern South China Sea(SCS)were measured to make a comparison during terrestrial vegetation reconstruction from~42 ka to~7 ka.The results showed that terrestrial vegetation record from long-chain n-alkanes matched well with previous studies in nearby cores,showing that more C_(4)plants developed during the Last Glacial Maximum(LGM)and C_(3)plants dominated in the interglacial period.However,these scenarios were not revealed by terrestrial vegetation reconstruction using long-chain n-alkanols,which showed C_(3)plant expansion during the LGM.The discrepancy during the interglacial period could be attributed to the aerobic degradation of functionalized long-chain n-alkanols in the oxygen-rich bottom water,resulting in poor preservation of terrestrial vegetation signals.On the other hand,the different advantages of functionalized n-alkanols and non-functional n-alkanes to record local and distal vegetation signals,respectively,may offer a potential explanation for the contradiction during the LGM when the SCS was characterized by low-oxygen deep water.Nevertheless,large variations on n-alkyl lipid compositions in C_(3)/C_(4)plants could play a part in modulating sedimentary long-chain n-alkanols and n-alkanes toward different vegetation signals,thereby suggesting that caution must be taken in respect to the terrestrial vegetation reconstruction using long-chain n-alkanes and long-chain n-alkanols.

关键词： South China Sea long-chain n-alkanols long-chain n-alkanes Last Glacial Maximum terrestrial vegetation record

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