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Pumping-induced Well Hydraulics and Groundwater Budget in a leaky Aquifer System with Vertical Heterogeneity in Aquitard Hydraulic Properties

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Acta Geologica Sinica(English Edition) 2024年第2期98卷 477-490页

作者： ZHuANG Chao lÜChenyang YAN long lI Yabing ZHOu Zhifang WANG Jinguo DOu Zhi Walter A.IllMAN School of Earth Sciences and Engineering Hohai UniversityNanjing 211100China School of Geography Earth and Environmental SciencesUniversity of BirminghamBirmingham B152TTU.K. Department of Modern Mechanics University of Science and Technology of ChinaHefei 230027China Department of Earth and Environmental Sciences University of WaterlooOntario N2L 3G1Canada

In groundwater hydrology,aquitard heterogeneity is often less considered compared to aquifers,despite its significant impact on groundwater hydraulics and groundwater resources evaluation.A semi-analytical solution is derived for pumping-induced well hydraulics and groundwater budget with consideration of vertical heterogeneity in aquitard hydraulic conductivity(K)and specific storage(S_(s)).The proposed new solution is innovative in its partitioning of the aquitard into multiple homogeneous sub-layers to enable consideration of various forms of vertically heterogeneous K or S_(s).Two scenarios of analytical investigations are explored:one is the presence of aquitard interlayers with distinct K or S_(s) values,a common field-scale occurrence;another is an exponentially depth-decaying aquitard S_(s),a regional-scale phenomenon supported by statistical *** investigations reveal that a low-K interlayer can significantly increase aquifer drawdown and enhance aquifer/aquitard depletion;a high-S_(s) interlayer can noticeably reduce aquifer drawdown and increase aquitard *** of low-K or high-S_(s) interlayers also significantly impact well hydraulics and groundwater *** the context of an exponentially depth-decaying aquitard S_(s),a larger decay exponent can enhance aquifer *** using current models with a vertically homogeneous aquitard,half the sum of the geometric and harmonic means of exponentially depth-decaying aquitard S_(s) should be used to cal.ulate aquitard depletion and unconfined aquifer leakage.

关键词： hydrogeology aquitard vertical heterogeneity semi-analytical solution well hydraulics groundwater budget

牙周炎症环境中内皮细胞焦亡现象的体内外研究初探

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中华口腔医学杂志 2024年第5期59卷 486-495页

作者：李蕊王晓雨叶庆元王垭铮张曦戈葛晓彤王勤涛第四军医大学口腔医院牙周病科、口颌系统重建与再生全国重点实验室、国家口腔疾病临床医学研究中心、陕西省口腔疾病国际联合研究中心西安710032 第四军医大学口腔医院数字化口腔医学中心口颌系统重建与再生全国重点实验室国家口腔疾病临床医学研究中心陕西省口腔医学重点实验室西安710032

目的通过体内外模型观察牙周炎局部组织内皮细胞在炎症环境下是否发生焦亡,为探究牙周炎发病机制提供实验依据。方法根据牙周病2018年新分类标准收集无全身疾病、牙周健康者及Ⅲ~Ⅳ期C级牙周炎患者的牙龈组织,免疫组化染色检测牙龈组织... 详细信息

目的通过体内外模型观察牙周炎局部组织内皮细胞在炎症环境下是否发生焦亡,为探究牙周炎发病机制提供实验依据。方法根据牙周病2018年新分类标准收集无全身疾病、牙周健康者及Ⅲ~Ⅳ期C级牙周炎患者的牙龈组织,免疫组化染色检测牙龈组织中焦亡标志性蛋白消皮素D(GSDMD)的表达水平及分布情况;每组通过结扎3只小鼠上颌第二磨牙2周建立牙周炎模型(结扎组),使用显微CT(micro-CT)检测小鼠牙槽骨吸收情况(以不做结扎处理的小鼠作为对照组);使用免疫荧光染色对健康及炎症小鼠牙龈组织中血管内皮细胞血小板内皮细胞黏附分子(CD31)与GSDMD共定位进行定量分析;体外培养人脐静脉内皮细胞(HuVECs),分别以质量浓度为0.5、1.0、2.5、5.0、10.0 mg/l牙龈卟啉单胞菌(Pg)脂多糖(lPS)联合腺苷三磷酸(ATP)处理HuVECs,同期设置0 mg/l Pg-lPS组为对照组。使用扫描电镜观察HuVECs形态,蛋白质印迹法检测GSDMD的N端结构域(GSDMD-N)蛋白表达,细胞免疫荧光染色检测GSDMD蛋白表达及分布,细胞计数试剂盒(CCK-8)检测HuVECs的增殖能力,碘化丙啶(PI)染色检测HuVECs细胞膜的完整性。结果免疫组化结果显示,牙周炎患者牙龈组织中GSDMD主要分布于血管周围,且表达水平较健康组织显著升高;micro-CT结果显示,结扎组小鼠上颌第二磨牙周围牙槽骨吸收较对照组小鼠显著增多(t=8.88,PlPS联合ATP模拟的炎症环境中,HuVECs细胞膜上出现不同大小的孔洞,呈现典型的细胞焦亡形态,其中2.5 mg/l Pg-lPS+ATP组细胞膜上孔洞最多且扩张融合,细胞有裂解死亡的趋势。蛋白质印迹法结果显示,2.5和5.0 mg/l Pg-lPS+ATP组焦亡标志性蛋白GSDMD-N表达显著高于对照组(F=3.86,Pl Pg-lPS+ATP组较对照组GSDMD平均荧光强度升高最显著(F=35.25,Pl Pg-lPS+ATP组细胞增殖相对值(分别为0.52±0.07、0.57±0.10、0.58±0.04、0.55±0.04和0.61±0.03)均显著低于对照组(1.00±0.02)(F=39.95,Pl Pg-lPS+ATP组最高[(56.07±3.22)%](F=88.24,P<0.001)。结论牙周炎症环境中内皮细胞发生明显的焦亡现象,提示内皮细胞焦亡可能是造成牙周炎发生的重要致病因素。

关键词：牙周炎内皮细胞细胞焦亡脂多糖腺苷三磷酸

Whole-genome RNAi screen identifies methylation-related genes influencing lipid metabolism in Caenorhabditis elegans

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Journal of Genetics and Genomics 2018年第5期45卷 259-272页

作者： xiaotong Zhu Yangli l.u Hong Zhang Pingsheng l.u National laboratory of Biomacromolecules CAS Center for Excellence in BiomacromoleculesInstitute of BiophysicsChinese Academy of SciencesBeijing 100101China university of Chinese Academy of Sciences Beijing 100049China

lipid droplets （lDs） are highly conserved multifunctional cel.ular organelles and aberrant lipid storage in lDs can lead to many metabolic diseases. However, the molecular mechanisms governing lipid dynamic changes remain elusive, and the high-throughput screen of genes influencing lD morphology was limited by lacking specific lD marker proteins in the powerful genetic tool Caenorhabditis elegons. In this study, we established a new method to conduct whole-genome RNAi screen using lD resident protein DHS-3 as a lD marker, and identified 78 genes involved in significant lD morphologic changes. Among them, mrhf-1, as well as a series of methylation-related genes, was found dramatically influencing lipid metabolism. SREBP-1 and SCD1 homologs in C. elegans were involved in the lipid metabolic change of rnthf-1（RNAi） worms, and the regulation of ATGl-1 also contributed to it by decreasing triacylglycerol （TAG） hydrolysis. Overall, this study not only identified important genes involved in lD dynamics, but also provided a new tool for lD study using C. elegans, with implications for the study of lipid metabolic diseases.

关键词： lipid droplet C.elegans RNAi screen lipid metabolism One-carbon metabolism

Wear of semi-solid rheocast SiC_p/Al metal matrix composites

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中国有色金属学会会刊：英文版 2010年第S3期20卷 852-856页

作者： u.A.CuRlE l.IVANCHEV Materials Science and Manufacturing Council for Scientific and Industrial Research(South Africa)

Rheocasting of plates in Al alloy 359 reinforced with SiC at 11%,27% and 50%(volume fractions) exhibits the capability of the council for scientific and industrial research-rheocasting system(CSIR-RCS) in rheo-processing and high pressure die casting of SiC metal matrix *** metal matrix consisting of nearly spherical proeutectic α(Al) globules was *** of fibrous eutectic silicon took place upon heat treatment of the as-cast metal matrix composites(MMCs).Hardness increases as the volume fractions of SiC *** rates of the MMCs in the F and T6 heat treatment conditions were assessed with a metallographic preparation *** is found that the 11% SiC MMC wear rate is higher on SiC abrasives compared with the 50% SiC MMC wear rate due to wear of the aluminum *** trend is reversed on diamond abrasives due to pull-out of the irregular shaped composite *** 50% SiC MMC suffers from composite particle fracture porosity after high pressure die casting(HPDC).

关键词： CSIR-RCS HPDC SiC F condition T6 condition wear rate hardness porosity

On the detection of closed orbits in time-dependent systems by using double-pulse lasers

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Communications in Theoretical Physics 2020年第9期72卷 111-117页

作者： S u Khan M l Du Institute of Theoretical Physics Chinese Academy of Sciences.Beijing 100190China university of Chinese Academy of Sciences Beijing100049China

In the photodetachment of atoms or negative ions by a double-pulse laser, the first pulse of the double-pulse laser generates waves and the delayed second pulse may detect them. The phenomenon of the excitation and detection of waves by a double-pulse laser can be used to identify the closed orbits in the system. We demonstrate this phenomenon with a negative hydrogen ion(H^-) by analyzing the total population excited by a double-pulse laser in a timedependent field for different physical parameters. By analyzing the total excited population using a double-pulse laser, we can uncover all the closed orbits existing in the system. We demonstrate that this can be realized by scanning the first pulse position and the time delay between the two pulses.

关键词： double-pulse laser detection of closed orbits photodetachment spectra time-dependent systems

Sr Isotopes and REEs Geochemistry of Anhydrites from l Vent Black Smoker Chimney, East Pacific Rise 9oN–10oN

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Journal of Earth Science 2015年第6期26卷 920-928页

作者： Huiqiang Yao Huaiyang Zhou xiaotong Peng Gaowen He Guangzhou Marine Geological Survey National Key laboratory of Marine Geology Tongji University Guangzhou Institute of Geochemistry Chinese Academy of Sciences

High resolution sampling, for Sr isotope and REE analyses, was carried out along a transaction of l vent chimney collected from East Pacific Rise 9oN–10oN. Sr isotopes show these anhydrites are precipitated from a mixture between hydrothermal fluid and seawater. The cal.ulated relative proportion of seawater and hydrothermal fluid shows that the mixing is heterogeneous on the transection of the l vent chimney. Anhydrites from the chimney show uniform chondrite-normalized REE pattern with enrichment of lREE and positive Eu anomaly. While normalized to the REE of end-member hydrothermal fluid, anhydrites also show uniform REE pattern but with negative Eu anomaly and enrichment of HREE. Combining previous studies on REEs of hydrothermal fluids from different hydrothermal systems and the hydrothermal fluid data from this region, we suggested that REE-anion complexing, rather than crystallography controlling, is the main factor that controls the REE partition behavior in the anhydrite during its precipitation from the mixture of hydrothermal fluid and seawater.

关键词： East Pacific Rise 9°N-10°N black smoker chimney anhydrite Sr isotope REE.

Effect of densification distribution on the Young's modulus of porous coatings after nano-indentation

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Acta Metal.urgica Sinica(English letters) 2012年第5期25卷 383-390页

作者： Xiaojuan l.u Ping XIAO Haiyan lI School of Environment Science and Engineering North China Electric Power University Yonghua North Street Baoding 071000 China School of Materials The University of Manchester Manchester M1 7HS UK School of Mechanical Aerospace and Civil Engineering The University of Manchester P.O. Box 88Sackville Street Manchester M60 1QD UK

Nano-indentation of a porous ceramic coating leads to crushing and densification of the coating under the indenter. In this work, finite element simulations of indentation on the porous coating have been carried out to study the effect of the size and dis- tribution of densification on Youngts modulus measured by nano-indentation. Two totally different distribution patterns have been simulated in this work. In the case of gradient densification, the Youngts modulus increased by 8.6% when the densifi- cation has occurred in the maximum influenced area. While the Young^s modulus increased by 2% with a uniformed densification. Examinations of the cross-section of the coatings have suggested that the densification after the indentation is close to the second model. The measured Young＇s modulus could have differed by 2%. The effect of densification on the Young＇s modulus measured by using nano-indentation is strongly dependent on the densification patterns of the porous coating.

关键词： Film Mechanical property Finite element simulation Porosity Electron Microscopy

Surface Water Quality Profiling using Physicochemical Parameters in Open Defecation Free and Non-Open Defecation Free local Government Areas in Benue State, Nigeria

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Open Journal of Modern Hydrology 2024年第3期14卷 174-191页

作者： Moses T. Asoo Celestine u. Aguoru Innocent O. Ogbonna Hyacinth O.A. Oluma Benue State Ministry of Health Makurdi Nigeria Department of Plant Science and Biotechnology College of Biological Sciences Joseph Sarwuan Tarka University Makurdi Nigeria Department of Microbiology College of Biological Sciences Joseph Sarwuan Tarka University Makurdi Nigeria

Physicochemical parameters of surface water sources in the study of local government areas (lGAs) were assessed using standard procedures. The mean physicochemical parameters for pH (5.49), NO2 (0.23 mg/l), SO4 (0.77 mg/l), Na (28.72 mg/l), Ca (28.94 mg/l), Mg (17.50 mg/l), Cl (11.65 mg/l), TSS (6.27 mg/l), TDS (104.23 mg/l), BOD (2.83 mg/l) and F (0.87 mg/l) were below WHO standards irrespective of their defecation status. The values for electrical conductivity (EC) (2770.50 µs/cm, turbidity (481.24 NTu), dissolved oxygen (DO) (5.32 mg/l), chemical oxygen demand (COD) (445.50 mg/l), K (125.06 mg/l), PO4 (0.78 mg/l) and Fe (0.57 mg/l) were above the WHO limits for safe water. Higher EC and COD values obtained in the study is evidence of pol.ution of the water sources by organic matter.

关键词： Open Defecation Surface Water Water Quality Standard Physicochemical Parameters

A simple denoising approach to exploit multi-fidelity data for machine learning materials properties

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npj Computational Materials 2022年第1期8卷 2226-2238页

作者： xiaotong l.u Pierre-Paul De Breuck linghui Wang Gian-Marco Rignanese Beijing Advanced Innovation Center for Materials Genome Engineering Beijing Information Science and Technology UniversityNo.35 Beisihuan Middle RoadBeijing100101BeijingP.R.China School of Computer Beijing Information Science and Technology UniversityNo.35 Beisihuan Middle RoadBeijing100101BeijingP.R.China Institute of Condensed Matter and Nanosciences UCLouvainChemin desÉtoiles 8Louvain-la-Neuve1348Belgium School of Materials Science and Engineering Northwestern Polytechnical UniversityNo.127 Youyi West RoadXi’an710072ShaanxiP.R.China

Machine-learning models have recently encountered enormous success for predicting the properties of *** are often trained based on data that present various levels of accuracy,with typically much less high-than low-fidelity *** order to extract as much information as possible from all available data,we here introduce an approach which aims to improve the quality of the data through *** investigate the possibilities that it offers in the case of the prediction of the band gap using both limited experimental data and density-functional theory relying on different exchange-correlation *** analyzing the raw data thoroughly,we explore different ways to combine the data into training sequences and analyze the effect of the chosen *** also study the effect of applying the denoising procedure several times until ***,we compare our approach with various existing methods to exploit multi-fidelity data and show that it provides an interesting improvement.

关键词： approach learning exploit