检索结果-南通市图书馆

在线全文

学校读者我要写书评

暂无评论

护理研究中理论的构建及验证

护理研究 2024年第12期38卷 2083-2087页

作者：王青朱明月丁晓彤李峥中国医学科学院北京协和医学院护理学院北京100144

护理理论构建和发展是拓展护理学科知识范畴、提升护理学科科学性的关键。以Walker和Avant的理论构建策略为切入点,围绕理论构建的全过程,对护理理论的相关概念、理论构建及理论验证的基本方法进行阐述,旨在为护理研究者构建并应用具有... 详细信息

护理理论构建和发展是拓展护理学科知识范畴、提升护理学科科学性的关键。以Walker和Avant的理论构建策略为切入点,围绕理论构建的全过程,对护理理论的相关概念、理论构建及理论验证的基本方法进行阐述,旨在为护理研究者构建并应用具有中国特色的护理理论提供参考,并促进护理知识体系的发展。

关键词：护理理论护理研究理论构建理论验证概念

2003年—2023年老年人主观认知下降的研究热点和护理启示

在线全文

学校读者我要写书评

暂无评论

International Journal of Nursing Sciences 2024年第2期11卷 222-232页

作者：丁晓彤史纪元王青陈红丽石秀秀李峥 School of Nursing Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijingChina School of Nursing Lanzhou UniversityLanzhouChina School of Nursing Hangzhou Normal UniversityHangzhouChina

目的老年人群中主观认知下降(Subjective Cognitive Decline,SCD)的研究显著增加。本研究采用文献计量学的方法分析近20年老年人SCD研究的热点和趋势,旨在为研究者开展该领域的研究提供参考。方法本研究选择Web of Science核心合集中200... 详细信息

目的老年人群中主观认知下降(Subjective Cognitive Decline,SCD)的研究显著增加。本研究采用文献计量学的方法分析近20年老年人SCD研究的热点和趋势,旨在为研究者开展该领域的研究提供参考。方法本研究选择Web of Science核心合集中2003年至2023年发表的关于老年人SCD的研究,初步检索获得1502篇,最终纳入1436篇。采用CiteSpace软件对国家、机构、作者、期刊、关键词和突现词等进行分析。结果老年人SCD研究整体呈现上升趋势。美国在该研究领域占据主导地位,其次为中国和法国;加州大学系统、法国国家健康与医学研究院及UDICE法国研究型大学联盟是发文量处于前3位的研究机构;Frank Jessen、韩瑛和Kathryn Ellis是发文量处于前3位的研究者;被引频次处于前3位的期刊为Neurology、Alzheimers&Dementia、Journal of Alzheimer’s Disease。关键词聚类分析显示关注热点涉及“抑郁”“功能连接”“认知储备”“认知功能”“身体活动”、“痴呆症预防”“行为障碍”“初级保健”和“早期诊断”等;关键词的突现词包括“身体活动”“临床前阿尔茨海默病”“框架”“未来痴呆症”和“老年抑郁症”。结论老年人SCD的研究逐年增长,成为研究者关注的热点,其研究范围和主题也逐渐扩大,重点关注早期筛查和预防、负性情绪及症状管理,可为后期护理研究者开展相关研究提供借鉴和参考。

关键词：主观认知下降老年人文献计量学可视化分析

实施性研究综合框架在护理领域应用的可视化分析

在线全文

学校读者我要写书评

暂无评论

中华现代护理杂志 2024年第4期30卷 505-510页

作者：刘纳孙爱民丁晓彤史纪元郑智中日友好医院护理部北京100029 中日友好医院国际部门诊北京100029 中国医学科学院北京协和医学院护理学院北京100144

目的分析实施性研究综合框架(CFIR)在护理领域应用的研究热点及研究趋势, 为我国护理领域开展实施性研究提供参考。方法检索Web of Science核心合集中有关CFIR在护理领域中应用的文献, 检索时限为建库至2023年8月8日;采用CiteSpace 6.2... 详细信息

目的分析实施性研究综合框架(CFIR)在护理领域应用的研究热点及研究趋势, 为我国护理领域开展实施性研究提供参考。方法检索Web of Science核心合集中有关CFIR在护理领域中应用的文献, 检索时限为建库至2023年8月8日;采用CiteSpace 6.2.R4软件进行分析。结果共纳入文献165篇。CFIR应用于护理领域的文献数量整体呈上升趋势;发文量前5位的国家分别是美国、加拿大、澳大利亚、英国和荷兰;发文量前5位的机构分别是美国退伍军人事务部、美国退伍军人健康管理局、北卡罗来纳大学、宾夕法尼亚大学和范伯格医学院;研究热点包括实施科学、实施研究、定性研究、可接受性、阻碍因素、系统评价、健康差距、症状管理、质量改进、初级保健护理等。结论国内护理领域CFIR相关研究处于起步阶段, 应借鉴国外研究的经验, 验证CFIR中文版的适用性及其各要素内涵, 推动高质量护理实施研究的开展。

关键词：护理实施科学实施性研究综合框架文献计量学可视化分析

Developing a fluorescence substrate for HRP-based diagnostic assays with superiorities over the commercial ADHP

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2024年第6期35卷 439-444页

作者： Zhichao Zhou Fuqian Chen xiaotong Xia Dong Ye Rong Zhou Lei Li Tao Deng Zhenhua ding Fang Liu Department of Radiation Medicine Guangdong Provincial Key Laboratory of Tropical Disease ResearchSchool of Public HealthSouthern Medical UniversityGuangzhou 510515China School of Pharmaceutical Sciences Guangzhou University of Chinese MedicineGuangzhou 510006China Artemisinin Research Center Guangzhou University of Chinese MedicineGuangzhou 510006China State Key Laboratory of Respiratory Disease the First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou Medical UniversityGuangzhou 510120China Guangzhou Laboratory Bio-IslandGuangzhou 510030China Nanshan Pharmaceutical Innovation Research Institute of Guangdong Province Foshan 528225China

The combination of horseradish peroxidase(HRP)and a fluorescence substrate has been attracting great interests in developing sensitive biochemical analysis and immunoassays.10-Acetyl-3,7-dihydroxyphenoxazine(ADHP or Amplex red)is the most sensitive fluorogenic substrate known for HRP in current market,however,it suffers from some drawbacks,such as non-specific reactivity to carboxylesterase and limited fluorescence *** the present study,a novel HRP substrate10-cyclopropylcarbonyl-dichloro-dihydroxyphenoxazine(AR-2),has been prepared,which exhibited improved sensitivity than ADHP in sensing ***,the fluorescence of AR-2/HRP demonstrated improved tolerance to physiological relevant p H fluctuation as compared to ADHP/*** detection of uric acid/urate oxidase reaction indicated excellent application prospect of AR-2/HRP for monitoring H_(2)O_(2)-generating biochemical *** interestingly,an enzyme-linked immunosorbent assay(ELISA)using AR-2 as the fluorescence reporter has been successfully used in detecting IgG against severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)from human serum ***,AR-2 exhibits improved performances over the commercial ADHP,which will be an ideal alternative to ADHP in HRP-based fluorescence biochemical analysis and immunoassays.

关键词： Fluorescence immunoassay HRP fluorescence substrate Hydroresorufin Amplex red/ADHP SARS-CoV-2

Significantly enhanced superconductivity in monolayer FeSe films on SrTiO3（001） via metallic δ-doping

在线全文

学校读者我要写书评

暂无评论

National Science Review 2024年第3期11卷 119-127页

作者： xiaotong Jiao Wenfeng Dong Mingxia Shi Heng Wang Cui ding Zhongxu Wei Guanming Gong Yanan Li Yuanzhao Li Binjie Zuo Jian Wang ding Zhang Minghu Pan Lili Wang Qi-Kun Xue State Key Laboratory of Low-Dimensional Quantum Physics Department of Physics Tsinghua University School of Physics&Information Technology Shaanxi Normal University Beijing Academy of Quantum Information Sciences Department of Physics Southern University of Science and Technology International Center for Quantum Materials School of Physics Peking University Department of Physics The Pennsylvania State University Collaborative Innovation Center of Quantum Matter Hefei National Laboratory

Superconductivity transition temperature（Tc） marks the inception of a macroscopic quantum phase-coherent paired state in fermionic systems. For 2D superconductivity, the paired electrons condense into a coherent superfluid state at Tc, which is usually lower than the pairing temperature, between which intrinsic physics including Berezinskii–Kosterlitz–Thouless transition and pseudogap state are hotly debated. In the case of monolayer FeSe superconducting films on SrTiO3（001）, although the pairing temperature（Tp） is revealed to be 65–83 K by using spectroscopy characterization, the measured zero-resistance temperature（Tc0） is limited to 20 K. Here, we report significantly enhanced superconductivity in monolayer FeSe films by δ-doping of Eu or Al on SrTiO3（001） surface, in which Tc0is enhanced by 12 K with a narrowed transition width ΔTc～8 K, compared with non-doped samples. Using scanning tunneling microscopy/spectroscopy measurements, we demonstrate lowered work function of the δ-doped SrTiO3（001） surface and enlarged superconducting gaps in the monolayer FeSe with improved morphology/electronic homogeneity. Our work provides a practical route to enhance 2D superconductivity by using interface engineering.

关键词： monolayer FeSe interface superconductivity δ-doping zero-resistance temperature superconductivity transition temperature

Skin 11β-hydroxysteroid dehydrogenase type 1 enzyme expression regulates burn wound healing and can be targeted to modify scar characteristics

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Burns & Trauma 2023年第1期11卷 32-45页

作者： Kevin H.-Y.Tsai Huaikai Shi Roxanne J.Parungao Sina Naficy xiaotong ding Xiaofeng ding Jonathan J.Hew Xiaosuo Wang Wojciech Chrzanowski Gareth G.Lavery Zhe Li Andrea C.Issler-Fisher Jun Chen Qian Tan Peter K.Maitz Mark S.Cooper Yiwei Wang Adrenal Steroid Group ANZAC Research InstituteConcord HospitalThe University of SydneySydneyNSW 2137Australia Burns and Reconstructive Surgery Research Group ANZAC Research InstituteConcord HospitalThe Uni-versity of SydneySydneyNSW 2137Australia School of Chemical and Biomolecular Engineering The University of SydneySydneyNSW 2006Australia Jiangsu Provincial Engineering Research Centre of TCM External Medication Development and Application Nanjing University of Chinese MedicineNanjingJiangsu210023China Department of Burns and Plastic Surgery Nanjing Drum Tower Hospital Clinical CollegeNanjing University of Chinese MedicineNanjingJiangsu210008China Heart Research Institute The University of SydneySydneyNSW 2006Australia Sydney Nano Institute Sydney Pharmacy SchoolFaculty of Medicine and HealthThe University of SydneySydneyNSW2006Australia Department of Biosciences Centre for Healthy Ageing and Understanding DiseaseNottingham Trent UniversityNG14BUUK Burns and Reconstructive Surgery Unit Concord Repatriation General HospitalSydneyNSW 2137Australia

Background:Excessive scarring and fibrosis are the most severe and common complications of burn *** exposure to high levels of glucocorticoids detrimentally impacts on skin,leading to skin thinning and impaired wound *** can generate active glucocorticoids locally through expression and activity of the 11β-hydroxysteroid dehydrogenase type 1 enzyme(11β-HSD1).We hypothesised that burn injury would induce 11β-HSD1 expression and local glucocorticoid metabolism,which would have important impacts on wound healing,fibrosis and *** additionally proposed that pharmacological manipulation of this system could improve aspects of post-burn ***:Skin 11β-HSD1 expression in burns patients and mice was *** impacts of 11β-HSD1 mediating glucocorticoid metabolism on burn wound healing,scar formation and scar elas-ticity and quality were additionally examined using a murine 11β-HSD1 genetic knockout ***-release scaffolds containing therapeutic agents,including active and inactive glucocorticoids,were developed and pre-clinically tested in mice with burn ***:We demonstrate that 11β-HSD1 expression levels increased substantially in both human and mouse skin after burn injury.11β-HSD1 knockout mice experienced faster wound healing than wild type mice but the healed wounds manifested significantly more collagen deposition,tensile strength and stiffness,features characteristic of excessive *** of slow-release prednisone,an inactive glucocorticoid,slowed the initial rate of wound closure but significantly reduced post-burn scarring via reductions in inflammation,myofibroblast generation,collagen production and scar ***:Skin 11β-HSD1 expression is a key regulator of wound healing and scarring after burn *** of an inactive glucocorticoid capable of activation by local 11β-HSD1 in skin slows the initial rate of wound closure but significantlyimproves scar characteristics po

关键词： Wound healing Burn injury Scarring Skin 11β-HSD1 11β-HSD1 knockout Glucocorticoid metabolism Polycaprolactone scaffold Drug delivery

Transcranial direct current stimulation for epilepsy:A Systematic Review and Meta-analysis

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Transcranial direct current stimulation for epilepsy:A Syste...

Microbiome and metabolome dysbiosis analysis in impaired glucose tolerance for the prediction of progression to diabetes mellitus

中华医学会疼痛学分会第十九届学术年会

作者： Mingyu Hu Houming Kan xiaotong ding Jinchao Huang Weiye Kang Weiye Xu Jiangsu Provincial Key Laboratory of Anesthesiology Xuzhou Medical University Peking Union Medical College

Objective This systematic review and meta-analysis aim to explore the efficacy and safety of treatment outcomes of transcranial direct current stimulation for epilepsy Methods We searched Cochrane Library,PubMed,Embas...

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Journal of Genetics and Genomics 2024年第1期51卷 75-86页

作者： Boxun Zhang Xuan Zhang Zhen Luo Jixiang Ren xiaotong Yu Haiyan Zhao Yitian Wang Wenhui Zhang Weiwei Tian Xiuxiu Wei Qiyou ding Haoyu Yang Zishan Jin Xiaolin Tong Jun Wang Linhua Zhao Institute of Metabolic Diseases Guang'anmen HospitalChina Academy of Chinese Medical SciencesBeijing 100053China Faculty of Biological Science and Technology Baotou Teacher's CollegeBaotouInner Mongolia 014030China CAS Key Laboratory of Pathogenic Microbiology and Immunology Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China Infinitus(China)Company Ltd GuangzhouGuangdong 510405China Affiliated Hospital of Changchun University of Chinese Medicine ChangchunJilin 130021China Department of Endocrinology Guang'anmen HospitalChina Academy of Chinese Medical SciencesBeijing 100053China Xinjiekou Community Health Service Center in Xicheng District Beijing 100035China Department of Spleen and Stomach Shenzhen Traditional Chinese Medicine HospitalShenzhenGuangdong 518033China University of Chinese Academy of Sciences Beijing 100049China Beijing University of Chinese Medicine Beijing 100105China Northeast Asia Institute of Traditional Chinese Medicine Changchun University of Chinese MedicineChangchunJilin 130117China

Gut microbiota and circulating metabolite dysbiosis predate important pathological changes in glucose metabolic disorders;however,comprehensive studies on impaired glucose tolerance(IGT),a diabetes mellitus(DM)precursor,are ***,we perform metagenomic sequencing and metabolomics on 47 pairs of individuals with IGT and newly diagnosed DM and 46 controls with normal glucose tolerance(NGT);patients with IGT are followed up after 4 years for progression to *** of baseline data reveals significant differences in gut microbiota and serum metabolites among the IGT,DM,and NGT *** addition,13 types of gut microbiota and 17 types of circulating metabolites showed significant differences at baseline before IGT progressed to DM,including higher levels of Eggerthella unclassified,Coprobacillus unclassified,Clostridium ramosum,L-valine,L-norleucine,and L-isoleucine,and lower levels of Eubacterium eligens,Bacteroides faecis,Lachnospiraceae bacterium 3_1_46FAA,Alistipes senegalensis,Megaspaera elsdenii,Clostridium perfringens,α-linolenic acid,10E,12Z-octadecadienoic acid,and dodecanoic acid.A random forest model based on differential intestinal microbiota and circulating metabolites can predict the progression from IGT to DM(AUC=0.87).These results suggest that microbiome and metabolome dysbiosis occur in individuals with IGT and have important predictive values and potential for intervention in preventing IGT from progressing to DM.

关键词： Impaired glucose tolerance Diabetes mellitus Gut microbiota Metabolomics

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

交直流混合微电网互联变流器改进控制策略

电力系统保护与控制 2020年第14期48卷 50-58页

作者：张国荣丁晓通彭勃解润生毕康军合肥工业大学电气与自动化工程学院安徽合肥230009

互联变流器是交直流混合微电网的重要组成部分,需要承担交流微电网与直流微电网间的功率分配任务,需要具有良好的动态性能。针对孤岛模式下传统下垂控制的互联变流器存在惯性小、系统瞬态性能差的问题,提出了基于自适应下垂控制的互联... 详细信息

互联变流器是交直流混合微电网的重要组成部分,需要承担交流微电网与直流微电网间的功率分配任务,需要具有良好的动态性能。针对孤岛模式下传统下垂控制的互联变流器存在惯性小、系统瞬态性能差的问题,提出了基于自适应下垂控制的互联变流器控制策略。在下垂系数中引入交流微电网频率的倍数与直流微电网电压差值的微分量,动态增加系统惯性,提高系统瞬态性能。在此基础上,为了避免互联变流器整流与逆变模式的频繁切换,提出滞回控制方法,提高了系统的稳定性。最后,Matlab/Simulink仿真结果表明,孤岛模式下自适应下垂控制方法能够有效增加系统的惯性,提高系统动态过程的稳定性。滞回控制方法可以有效减小死区加入导致的交直流两侧功率分配偏差。

关键词：混合微网孤岛模式互联变流器自适应下垂控制滞回控制