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Managing Sino-U.S. Competitive Interdependence

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China International Studies 2013年第2期33卷 72-89,2页

作者： zhang xiaotong James Keith School of Politics and Public Administration Wuhan University McLarty Associates

Forty years ago, U.S. President Richard Nixon visited China and the two countries issued the Shanghai Communique. Nixon later recalled that ＂When our hands met, one era ended and another began.＂ Four decades later, ... 详细信息

关键词：中国外交政策对外关系国际问题边界问题岛屿问题

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外泌体的抗炎抗衰老作用

中国医药 2024年第8期19卷 1250-1253页

作者：王雨莹张晓彤李玙璠郝星闫继红首都医科大学基础医学院北京100069 首都医科大学附属北京潞河医院北京101199 首都医科大学附属北京安贞医院心外危重症中心北京100029 首都医科大学基础医学院组织胚胎学教研室北京100069

外泌体是一种纳米级别的囊泡,也是细胞间通讯的介质。外泌体由于特别的生物学效应以及组成而备受关注。许多研究表明外泌体具有调控机体免疫应答、细胞迁移、细胞分化、肿瘤侵袭等作用。本文着重综述其抗炎抗衰老机制,因为其复杂的机制... 详细信息

外泌体是一种纳米级别的囊泡,也是细胞间通讯的介质。外泌体由于特别的生物学效应以及组成而备受关注。许多研究表明外泌体具有调控机体免疫应答、细胞迁移、细胞分化、肿瘤侵袭等作用。本文着重综述其抗炎抗衰老机制,因为其复杂的机制不仅可以用于消除炎症,甚至还可以在一定程度上逆转组织器官的衰老,临床应用前景十分可观,可以应用于脑、皮肤、心脏等各个领域,有望解决许多疑难杂症。

关键词：外泌体抗炎免疫调节抗衰老临床应用

Evaluation of global ocean tide models based on tidal gravity observations in China

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Geodesy and Geodynamics 2021年第6期12卷 451-458页

作者： Hongbo Tan Olivier Francis Guiju Wu Guangliang Yang Jiapei Wang xiaotong zhang Jinshui Huang Chongyang Shen School of Earth and Space Sciences University of Science and Technology of ChinaHefei230026China Key Laboratory of Earthquake Geodesy Institute of SeismologyChina Earthquake AdministrationWuhan430071China Faculty of Science Technology and CommunicationUniversity of LuxembourgEsch-sur-AlzetteL-4365Luxembourg

Previous studies show that the calculated loading effects from global ocean tide models do not match actual measurements of gravity attraction and loading effects in Southeast *** this paper,taking advantage of a unique network of gravity tidal stations all over the Chinese mainland,we compare the observed and modeled tidal loading effects on the basis of the most recent global ocean tide *** results show that the average efficiencies of the ocean tidal loading correction for O_(1),K_(1),M_(2) are 77%,7 s3%and 59%,*** loading correction efficiencies using recent ocean tidal models are better than the 40 years old Schwiderskis model at coastal stations,but relative worse at stations far from ocean.

关键词： Gravity signals Ocean tidal loading Global ocean tide models gPhone gravimeter

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基于STM32的家用电器识别系统设计

山西电子技术 2024年第5期 4-7,116页

作者：孙芳杰霍青瑶丁纪峰张笑彤常新王宗恩泽大连民族大学信息与通信工程学院辽宁大连116600

随着能源危机不断加剧,电能节约和高效利用至关重要。基于此,提出一种家用电器识别系统及方法。系统以STM32F103为核心,应用传感技术和无线通信技术,通过非侵入式负荷监测方法,实现了电参数测量、用电器识别、电参数自学习和无线数据传... 详细信息

随着能源危机不断加剧,电能节约和高效利用至关重要。基于此,提出一种家用电器识别系统及方法。系统以STM32F103为核心,应用传感技术和无线通信技术,通过非侵入式负荷监测方法,实现了电参数测量、用电器识别、电参数自学习和无线数据传输等功能。采用欧氏距离的判别方法,识别电器种类,算法简单,算力要求低,识别准确率较高。通过移动互联网,实现远程云平台数据监测及数据可视化,系统使用灵活,效果良好。

关键词：用电器种类识别非侵入式负荷监测 STM32核心处理器欧氏距离

Halotolerant Bacillus *** RA coordinates myo-inositol metabolism to confer salt tolerance to tomato

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Journal of Integrative Plant Biology 2024年第9期66卷 1871-1885页

作者： Fenghui Wu Zengting Chen xiaotong Xu Xin Xue Yanling zhang Na Sui Shandong Provincial Key Laboratory of Plant Stress College of Life SciencesShandong Normal UniversityJinan 250014China Dongying Key Laboratory of Salt Tolerance Mechanism and Application of Halophytes Dongying InstituteShandong Normal UniversityNo.2 Kangyang RoadDongying 257000China

Soil salinity is a worldwide problem threatening crop *** plant growth-promoting rhizobacteria(PGPR)could survive in high salt environment and assist plant adaptation to ***,the genomic and metabolic features,as well as the regulatory mechanisms promoting salt tolerance in plants by these bacteria remain largely *** the current work,a novel halotolerant PGPR strain,namely,Bacillus *** RA can enhance tomato tolerance to salt *** genomic analysis of strain RA with its closely related species indicated a high level of evolutionary plasticity exhibited by strain-specific genes and evolutionary constraints driven by purifying selection,which facilitated its genomic adaptation to salt-affected *** transcriptome further showed that strain RA could tolerate salt stress by balancing energy metabolism via the reprogramming of biosynthetic *** exude a plethora of metabolites that can strongly influence plant *** accumulation of myo-inositol in leaves under salt stress was observed,leading to the promotion of plant growth triggered by Bacillus *** ***,myo-inositol serves as a selective force in the assembly of the phyllosphere microbiome and the recruitment of plant-beneficial *** promotes destabilizing properties in phyllosphere bacterial co-occurrence networks,but not in fungal ***,interdomain interactions between bacteria and fungi were strengthened by myo-inositol in response to salt *** work highlights the genetic adaptation of RA to salt-affected soils and its ability to impact phyllosphere microorganisms through the adjustment of myo-inositol metabolites,thereby imparting enduring resistance against salt stress in tomato.

关键词： myo‐inositol PGPR phyllosphere microorganisms salt stress tomato

An isoflavone derivative potently inhibits the angiogenesis and progression of triple-negative breast cancer by targeting the MTA2/SerRS/VEGFA pathway

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Cancer Biology & Medicine 2020年第3期17卷 693-706页

作者： xiaotong zhang Gengyi Zou Xiyang Li Lun Wang Tianyu Xie Jin Zhao Longlong Wang Shunchang Jiao Rong Xiang Haoyu Ye Yi Shi School of Medicine Nankai UniversityTianjin 300071China 2011 Project Collaborative Innovation Center for Biotherapy of Ministry of Education Tianjin 300071China Department of Oncology Chinese PLA General HospitalBeijing 100853China State Key Laboratory of Biotherapy and Cancer Center West China HospitalSichuan Universityand Collaborative Innovation Center for BiotherapyChengdu 610041China

Objective:Angiogenesis plays a vital role in tumor growth and ***,we aimed to find novel efficient antiangiogenic molecules targeting vascular endothelial growth factor A(VEGFA)at the transcriptional level to treat triple-negative breast cancer(TNBC).Methods:We used a cell-based seryl tRNA synthetase(SerRS)promoter-driven dual-luciferase reporter system to screen an in-house library of 384 naturally occurring small molecules and their derivatives to find candidate molecules that could upregulate the expression of SerRS,a potent transcriptional repressor of *** levels of SerRS and VEGFA were examined by quantitative RT-PCR(qRT-PCR),western blotting,and/or ELISAs in TNBC cells after candidate molecule ***,the Matrigel plug angiogenesis assay in mice,the TNBC allograft,and xenograft mouse models were used to evaluate thein vivoanti-angiogenic and anti-cancer ***,the potential direct targets of the candidates were identified by proteomics and biochemical ***:We found the most active compound was 3-(4-methoxyphenyl)quinolin-4(1H)-one(MEQ),an isoflavone *** TNBC cells,MEQ treatment resulted in increased SerRS mRNA(P<0.001)and protein levels and downregulated VEGFA *** the vascular development of zebrafish and Matrigel plug angiogenesis in mice were inhibited by *** also suppressed the angiogenesis in TNBC allografts and xenografts in mice,resulting in inhibited tumor growth and prolonged overall survival(P<0.05).Finally,we found that MEQ regulated SerRS transcription by interacting with MTA2(Metastasis Associated 1 Family Member 2).Conclusions:Our findings suggested that the MTA2/SerRS/VEGFA axis is a drug-treatable anti-angiogenic target,and MEQ is a promising anti-tumor molecule that merits further investigation for clinical applications.

关键词： Isoflavone MTA2 SerRS tumor angiogenesis VEGFA

某医疗机构对国家组织集中带量采购药品的精细化管理及其实践效果

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中国临床药学杂志 2024年第6期33卷 413-417页

作者：张文彭静朱艳虹徐青文张晓彤陈璐刘晓云栾家杰皖南医学院第一附属医院(弋矶山医院)临床药学科芜湖241001

目的通过对国家组织集中带量采购药品(简称:国家集采药品)实施精细化管理,为优化医疗机构国家集采药品的管理模式提供参考。方法围绕国家集采药品合理使用,该院采取了一系列举措,包括建立以患者为中心的用药保障措施、科学测算医疗机构... 详细信息

目的通过对国家组织集中带量采购药品(简称:国家集采药品)实施精细化管理,为优化医疗机构国家集采药品的管理模式提供参考。方法围绕国家集采药品合理使用,该院采取了一系列举措,包括建立以患者为中心的用药保障措施、科学测算医疗机构国家集采药品采购量、合同用量科学分配与完成进度实时监测、国家集采药品的临床合理使用管理及建立基于量化指标的使用国家集采药品的激励考核机制。通过计算2020-2022年该院国家集采中标药品的完成比例和使用比例,以及门诊和住院次均药品费用增幅,评价该院对国家集采药品实施精细化管理的效果。结果2020-2022年某院国家集采中标药品完成比例依次为97.67%、98.15%和98.25%,使用比例依次为46.61%、59.00%和92.13%。2020-2022年,门诊次均药品费用增幅依次为40.72%、-15.70%和2.78%,住院次均药品费用增幅依次为29.46%、-8.32%和-10.68%。结论对国家集采药品实施精细化管理,有助于提高国家集采中标药品完成比例和使用比例,降低药品费用,可有效促进医疗机构国家集采药品的临床合理使用。

关键词：国家组织集中带量采购药品医疗机构精细化管理成效分析

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失眠与焦虑共存的神经生物学机制研究进展

中国临床保健杂志 2024年第3期27卷 418-422页

作者：郑育新赵敏刘飞祥董紫琲张兢方李肇基张晓彤河南中医药大学研究生院郑州450040 河南中医药大学第一附属医院脑病科

失眠与焦虑之间存在着一种相对独立,却又相互作用的关系。焦虑会导致失眠反复发作,反之失眠也可加重焦虑状态,两者在临床常以共病形式存在。该文通过系统梳理文献,发现失眠共病焦虑的机制比较复杂,最主要涉及5-羟色胺系统、下丘脑-垂体... 详细信息

失眠与焦虑之间存在着一种相对独立,却又相互作用的关系。焦虑会导致失眠反复发作,反之失眠也可加重焦虑状态,两者在临床常以共病形式存在。该文通过系统梳理文献,发现失眠共病焦虑的机制比较复杂,最主要涉及5-羟色胺系统、下丘脑-垂体-肾上腺轴、食欲素及其受体通路、多巴胺通路、神经活性配体-受体相互作用通路等神经生物学通路。

关键词：睡眠异常焦虑神经生物学血清素综述

US-China Trade Relations： Managing Competitive Interdependence

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China International Business 2013年第4期 50-53页

作者： zhang xiaotong JAMES KEITH

INTRODUCTION The meeting between President Xi Jinping and US treasury secretary Jacob Lew on March 19 created two firsts： The first meeting for Mr. Xi in his new role as president was his first with a foreign cabinet minister; and it was Mr. Lew＇s first meeting with a foreign leader as treasury secretary. This, and Xi＇s telephone conversation with President Barack Obama, has fully demonstrated the importance attached by both sides to laying out a productive path forward for one of the world＇s most important bilateral relationships.

关键词：美国总统贸易关系竞争管理中国习近平部长副主席