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Coated sodium butyrate ameliorates high‑energy and low‑protein diet induced hepatic dysfunction via modulating mitochondrial dynamics, autophagy and apoptosis in laying hens

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Journal of Animal Science and Biotechnology 2024年第3期15卷 1190-1206页

作者： Sasa Miao Tianming Mu Ru Li Yan Li Wenyan Zhao Jiankui Li Xinyang Dong xiaoting zou Key Laboratory of Animal Feed and Nutrition of Zhejiang Province Key Laboratory of Animal Nutrition and Feed Science(Eastern of China)Ministry of Agriculture and Rural AffairsThe Key Laboratory of Molecular Animal NutritionMinistry of EducationCollege of Animal SciencesZhejiang UniversityHangzhou 310058China.

Background Fatty liver hemorrhagic syndrome(FLHS),a fatty liver disease in laying hens,poses a grave threat to the layer industry,stemming from its ability to trigger an alarming plummet in egg production and usher in acute mortality among laying *** evidence suggests that the onset and progression of fatty liver was closely related to mitochondria *** butyrate was demonstrated to modulate hepatic lipid metabolism,alle-viate oxidative stress and improve mitochondrial dysfunction in vitro and mice ***,there is limited existing research on coated sodium butyrate(CSB)to prevent FLHS in laying hens,and whether and how CSB exerts the anti-FLHS effect still needs to be *** this experiment,the FLHS model was induced by administering a high-energy low-protein(HELP)diet in laying *** objective was to investigate the effects of CSB on alleviating FLHS with a focus on the role of CSB in modulating mitochondrial *** A total of 288 healthy 28-week-old Huafeng laying hens were arbitrarily allocated into 4 groups with 6 replicates each,namely,the CON group(normal diet),HELP group(HELP diet),CH500 group(500 mg/kg CSB added to HELP diet)and CH750 group(750 mg/kg CSB added to HELP diet).The duration of the trial encompassed a period of 10 *** The result revealed that CSB ameliorated the HELP-induced FLHS by improving hepatic steatosis and patho-logical damage,reducing the gene levels of fatty acid synthesis,and promoting the mRNA levels of key enzymes of fatty acid *** reduced oxidative stress induced by the HELP diet,upregulated the activity of GSH-Px and SOD,and decreased the content of MDA and *** also mitigated the HELP diet-induced inflammatory response by blocking TNF-α,IL-1β,and F4/*** addition,dietary CSB supplementation attenuated HELP-induced activation of the mitochondrial unfolded protein response(UPRmt),mitochondrial damage,and decline of ATPase *** diet decreased th

关键词： Autophagy Coated sodium butyrate Laying hens Lipid metabolism Mitochondria

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饲粮添加不同比例小麦对凤达1号产蛋高峰期蛋鸡生产性能、蛋品质、血清生化指标、小肠形态以及盲肠菌群的影响

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动物营养学报 2024年第4期36卷 2356-2369页

作者：牟天铭李燕苗洒洒简华锋董信阳邹晓庭浙江大学动物科学学院饲料科学研究所生物饲料安全与污染防控国家工程实验室浙江大学动物分子营养学教育部重点实验室农业农村部(华东)动物营养与饲料重点实验室浙江省饲料与动物营养重点实验室杭州310058

本试验旨在研究饲粮中添加不同比例小麦对凤达1号产蛋高峰期蛋鸡生产性能、蛋品质、血清生化指标、小肠形态结构以及盲肠菌群的影响。试验选取生长良好、体况相似的300日龄凤达1号蛋鸡768只,随机分为4个组,每组6个重复,每个重复32只鸡... 详细信息

本试验旨在研究饲粮中添加不同比例小麦对凤达1号产蛋高峰期蛋鸡生产性能、蛋品质、血清生化指标、小肠形态结构以及盲肠菌群的影响。试验选取生长良好、体况相似的300日龄凤达1号蛋鸡768只,随机分为4个组,每组6个重复,每个重复32只鸡。对照组饲喂玉米-豆粕型基础饲粮,试验组以对照组饲粮营养水平为基础,分别在饲粮中添加20%、40%和60%小麦,并根据小麦用量添加适宜比例的复合型小麦酶,同时相应调整饲粮配方以保证各组饲粮能量和蛋白质水平基本一致。预试期7 d,正试期49 d。结果表明:1)与对照组相比,添加20%、40%和60%小麦对产蛋高峰期蛋鸡各主要生产性能指标均无显著影响(P>0.05)。2)与对照组相比,添加不同比例小麦显著降低蛋黄颜色(P0.05)。5)与对照组相比,40%小麦组盲肠菌群α多样性和β多样性均无显著差异(P>0.05);在门水平上,添加40%小麦显著提高盲肠脱硫杆菌门和WPS-2相对丰度(P<0.05)。综上所述,饲粮添加不同比例小麦可以提高凤达1号产蛋高峰期蛋鸡的蛋壳强度和蛋壳厚度,降低蛋鸡血清脂质含量,改善蛋鸡营养代谢;在本试验条件下,凤达1号产蛋高峰期蛋鸡饲粮中添加40%小麦较为适宜。

关键词：小麦产蛋高峰期蛋鸡生产性能蛋品质血清生化指标小肠形态结构盲肠菌群

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Set-Membership Filtering Approach to Dynamic Event-Triggered Fault Estimation for a Class of Nonlinear Time-Varying Complex Networks

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IEEE/CAA Journal of Automatica Sinica 2024年第3期11卷 638-648页

作者： xiaoting Du Lei zou Maiying Zhong the College of Electrical Engineering and Automation Shandong University of Science and TechnologyQingdao 266590China IEEE the College of Information Science and Technology Donghua UniversityShanghai 201620 the Engineering Research Center of Digitalized Textile and Fashion Technology Ministry of EducationShanghai 201620China

The present study addresses the problem of fault estimation for a specific class of nonlinear time-varying complex networks,utilizing an unknown-input-observer approach within the framework of dynamic event-triggered mechanism(DETM).In order to optimize communication resource utilization,the DETM is employed to determine whether the current measurement data should be transmitted to the estimator or *** guarantee a satisfactory estimation performance for the fault signal,an unknown-input-observer-based estimator is constructed to decouple the estimation error dynamics from the influence of fault *** aim of this paper is to find the suitable estimator parameters under the effects of DETM such that both the state estimates and fault estimates are confined within two sets of closed ellipsoid *** techniques of recursive matrix inequality are applied to derive sufficient conditions for the existence of the desired estimator,ensuring that the specified performance requirements are met under certain ***,the estimator gains are derived by minimizing the ellipsoid domain in the sense of trace and a recursive estimator parameter design algorithm is then ***,a numerical example is conducted to demonstrate the effectiveness of the designed estimator.

关键词： Dynamic event-triggered mechanism(DETM) fault estimation nonlinear time-varying complex networks set-member-ship filtering unknown input observer

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凝结芽孢杆菌对畜禽肠道健康调控作用的研究进展

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中国畜牧杂志 2024年第2期60卷 130-135页

作者：李茹李燕邹晓庭浙江大学动物科学学院浙江省饲料与动物营养重点实验室浙江杭州310058

凝结芽孢杆菌是一种新型的饲用益生菌,不仅具有乳酸菌和双歧杆菌的益生作用,还具有芽孢杆菌的耐高温、耐胃酸和耐胆盐等抗逆性,以及易培养、易储存的生物学特性。诸多研究表明,凝结芽孢杆菌具有平衡肠道菌群结构、改善肠道形态、促进消... 详细信息

凝结芽孢杆菌是一种新型的饲用益生菌,不仅具有乳酸菌和双歧杆菌的益生作用,还具有芽孢杆菌的耐高温、耐胃酸和耐胆盐等抗逆性,以及易培养、易储存的生物学特性。诸多研究表明,凝结芽孢杆菌具有平衡肠道菌群结构、改善肠道形态、促进消化吸收、增强肠道免疫等多种作用。本文主要综述了凝结芽孢杆菌对畜禽肠道健康的调控作用,旨在为凝结芽孢杆菌在畜禽绿色养殖和生产的进一步应用提供理论参考。

关键词：凝结芽孢杆菌生物学特性肠道菌群肠道形态肠道免疫消化吸收

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Accelerated regeneration of the skeletal muscle in RNF13-knockout mice is mediated by macrophage-secreted IL-4/IL-6

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Protein & Cell 2014年第3期5卷 235-247页

作者： Jiao Meng xiaoting zou Rimao Wu Ran Zhong Dahai Zhu Yong Zhang The National Laboratory of Medical Molecular Biology Institute of Basic Medical Sciences Chinese Academy of MedicalSciences and School of Basic Medicine Peking Union Medical College Beijing 100005 China

RING finger protein 13 （RNF13） is a newly identified E3 ligase reported to be functionally significant in the reg- ulation of cancer development, muscle cell growth, and neuronal development. In this study, the function of RNF13 in cardiotoxin-induced skeletal muscle regener- ation was investigated using RNF13-knockout mice. RNF13-/- mice exhibited enhanced muscle regeneration --characterized by accelerated satellite cell proliferation --compared with wild-type mice. The expression of RNF13 was remarkably induced in macrophages rather than in the satellite cells of wild-type mice at the very early stage of muscle damage. This result indicated that inflammatory cells are important in RNF13-mediated satellite cell functions. The cytokine levels in skeletal muscles were further analyzed and showed that RNF13＂i＂ mice produced greater amounts of various cytokines than wild-type mice. Among these, IL-4 and IL-6 levels significantly increased in RNF13-/＂ mice. The accelerated muscle regeneration phenotype was abrogated by inhibiting IL-4/IL-6 action in RNF13＂/- mice with blocking antibodies. These results indicate that RNF13 deficiency promotes skeletal muscle regeneration via the effects on satellite cell niche mediated by IL-4 and IL-6.

关键词： RNF13 muscle regeneration satellite celniche. IL-4/IL-6

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Early inoculation with caecal fermentation broth alters small intestine morphology,gene expression of tight junction proteins in the ileum,and the caecal metabolomic profiling of broilers

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Journal of Animal Science and Biotechnology 2020年第2期11卷 440-452页

作者： Yujie Gong Wenrui Xia Xueting Wen Wentao Lyu Yingping Xiao Hua Yang xiaoting zou Key Laboratory for Molecular Animal Nutrition of Ministry of Education Feed Sciences InstituteCollege of Animal SciencesZhejiang University(Zijingang Campus)Hangzhou 310058China State Key Laboratory for Quality and Safety of Agro-products Institute of Quality and Standards for Agro-productsZhejiang Academy of Agricultural SciencesHangzhou 310021China

Background:The establishment of stable microbiota in early life is beneficial to the *** in the intestinal environment during early life play a crucial role in modulating the gut ***,early intervention to change the intestinal environment can be regarded as a new regulation strategy for the growth and health of ***,the effects of intestinal environmental changes on host physiology and metabolism are rarely *** study was conducted to investigate the effects of early inoculation with caecal fermentation broth on small intestine morphology,gene expression of tight junction proteins in the ileum,and cecum microbial metabolism of ***:Our data showed that early inoculation with caecal fermentation broth could improve intestine *** small intestine villus height was significantly increased(P<0.05)in the intervened broilers compared to the control group,especially on day 28.A similar result was observed in the ratio of villus height to crypt depth(P<0.05).Meanwhile,we found early inoculation significantly increased(P<0.05)the expression levels of zonula occludens-1(ZO1)on days 14 and 28,claudin-1(CLDN1)on day 28,whereas the gene expression of claudin-2(CLDN2)was significantly decreased(P<0.05)on days 14 and *** chromatography time-of-flight/mass spectrometry(GC-TOF/MS)technology was further implemented to systematically evaluate the microbial metabolite *** component analysis(PCA)and orthogonal partial least squares discriminant analysis(OPLS-DA)displayed a distinct trend towards separation between the fermentation broth group(F group)and the control group(C group).The differentially expressed metabolites were identified,and they were mainly functionally enriched in beta-alanine metabolism and biosynthesis of unsaturated fatty *** addition,1,3-diaminopropane was selected as a key biomarker that responded to early inoculation with caecal fermentation ***:These re

关键词： Broilers Early inoculation Gene expression Intestine morphology Metabolomics profiling

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探寻自然真理:施特劳斯自由教育的根本主张

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教育研究与实验 2023年第6期 11-20页

作者：邹小婷扈中平韩山师范学院教育科学学院潮州521041 华南师范大学现代教育研究与开发中心广州510631

施特劳斯关于自由教育的思想主要包括三方面:自由教育危机、克服自由教育危机的出路以及复归自由教育的本质。这三方面内容体现了他的自由教育思想的根本主张:探寻自然真理。施特劳斯的努力本质上是复兴苏格拉底式的哲学,他始终用追问... 详细信息

施特劳斯关于自由教育的思想主要包括三方面:自由教育危机、克服自由教育危机的出路以及复归自由教育的本质。这三方面内容体现了他的自由教育思想的根本主张:探寻自然真理。施特劳斯的努力本质上是复兴苏格拉底式的哲学,他始终用追问“什么是自然正当”的方式使正当保持着被质疑的状态。自由教育是对自然真理的探寻。施特劳斯竭力向我们宣称:人类必须要在无知中努力向上,不断向自然真理攀升,否则人类就必然往下堕落。自由教育的提出旨在为人类抵御这一巨大的危险。

关键词：施特劳斯自由教育自然真理古典自然

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Effects of metabolizable energy and crude protein levels on laying performance,egg quality and serum biochemical indices of Fengda-1 layers

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Animal Nutrition 2016年第2期2卷 93-98页

作者： Yang Ding Xingchen Bu Nannan Zhang Lanlan Li xiaoting zou Key Laboratory of Animal Nutrition and Feed Science Ministry of Agriculture Zhejiang Provincial Laboratory of Feed and Animal Nutrition Feed Science Institute Zhejiang University

This study was conducted to investigate the effects of dietary ME and CP levels on laying performance, egg quality and serum biochemical indices of Fengda-1 layers. In a 2 × 3 factorial arrangement, 2,400 Fengda-1 layers(32 wk of age) were randomly assigned to 6 experimental diets with 2,650 and 2,750 kcal of ME/kg of diet, each containing 14.50%, 15.00% and 15.50% CP, respectively. Each dietary treatment was replicated 5 times, and feed and water were provided ad libitum. The trial lasted for 10 wk, including a2-week acclimation period and an 8-week experimental period. Our results showed that ADFI decreased as the ME level of diet increased from 2,650 to 2,750 kcal/kg(P 0.05). Based on the data under the experimental conditions, the optimal dietary ME and CP levels of Fengda-1 layers are 2,650 kcal/kg and 15.00%(33 to 41 wk of age).

关键词： Energy Protein Laying performance Egg quality Fengda-1 layers

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微量矿物元素硒对畜禽生产性能和产品品质影响的研究进展

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动物营养学报 2023年第7期35卷 4191-4199页

作者：李燕牟天铭苗洒洒邹晓庭浙江大学动物科学学院饲料科学研究所生物饲料安全与污染防控国家工程实验室浙江大学动物分子营养学教育部重点实验室农业农村部(华东)动物营养与饲料重点实验室浙江省饲料与动物营养重点实验室杭州310058

硒是维持动物机体健康所必需的微量矿物元素,在机体抗氧化、免疫应答、生长发育和繁殖等生理过程中发挥着重要作用。硒在动物机体内主要以硒蛋白形式存在,是多种抗氧化蛋白酶的重要组成成分。在畜禽生产中,饲粮中添加硒补充剂对于提升... 详细信息

硒是维持动物机体健康所必需的微量矿物元素,在机体抗氧化、免疫应答、生长发育和繁殖等生理过程中发挥着重要作用。硒在动物机体内主要以硒蛋白形式存在,是多种抗氧化蛋白酶的重要组成成分。在畜禽生产中,饲粮中添加硒补充剂对于提升畜禽机体健康和生产富硒肉、蛋及奶产品具有重要意义。本文综述了近年来不同硒源对畜禽生产性能、机体健康以及产品品质和硒沉积效果影响的研究进展,以期为硒对畜禽产品品质的进一步研究提供理论参考。

关键词：硒抗氧化畜禽产品肉蛋奶

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皮亚杰发生认识论之哲学意蕴

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学术交流 2009年第5期 1-5页

作者：邹小婷韩山师范学院广东潮州521041

康德在认识论上高扬主体性,提出用先验的、不变的感性、知性范畴建构知识,完成了所谓的"哥白尼式的革命"。皮亚杰一方面同意康德先验范畴在认识过程中的逻辑先在性;另一方面不同意康德把范畴看成固定不变的思想。皮亚杰认为范畴起源于动... 详细信息

康德在认识论上高扬主体性,提出用先验的、不变的感性、知性范畴建构知识,完成了所谓的"哥白尼式的革命"。皮亚杰一方面同意康德先验范畴在认识过程中的逻辑先在性;另一方面不同意康德把范畴看成固定不变的思想。皮亚杰认为范畴起源于动作,因而不是不变的,而是不断发展的。我们认为汲取皮亚杰的以动作或活动为基础的主客相互作用认识发展图式,对于丰富发展马克思主义认识来源于实践哲学思想有重要的理论价值。

关键词：皮亚杰康德发生认识论

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