检索结果-南通市图书馆

Deep Neural Network with Strip Pooling for Image Classification of Yarn-Dyed Plaid Fabrics

Computer Modeling in Engineering & Sciences 2022年第3期130卷 1533-1546页

作者： xiaoting zhang Weidong Gao Ruru Pan School of Artificial Intelligence and Computer Science Jiangnan UniversityWuxi214122China College of Textile and Science Engineering Jiangnan UniversityWuxi214122China

Historically,yarn-dyed plaid fabrics(YDPFs)have enjoyed enduring popularity with many rich plaid patterns,but production data are still classified and searched only according to production parameters.The process does not satisfy the visual needs of sample order production,fabric design,and stock management.This study produced an image dataset for YDPFs,collected from 10,661 fabric samples.The authors believe that the dataset will have significant utility in further research into YDPFs.Convolutional neural networks,such as VGG,ResNet,and DenseNet,with different hyperparameter groups,seemed themost promising tools for the study.This paper reports on the authors’exhaustive evaluation of the YDPF dataset.With an overall accuracy of 88.78%,CNNs proved to be effective in YDPF image classification.This was true even for the low accuracy of Windowpane fabrics,which often mistakenly includes the Prince ofWales pattern.Image classification of traditional patterns is also improved by utilizing the strip pooling model to extract local detail features and horizontal and vertical directions.The strip pooling model characterizes the horizontal and vertical crisscross patterns of YDPFs with considerable success.The proposed method using the strip pooling model(SPM)improves the classification performance on the YDPF dataset by 2.64%for ResNet18,by 3.66%for VGG16,and by 3.54%for DenseNet121.The results reveal that the SPM significantly improves YDPF classification accuracy and reduces the error rate of Windowpane patterns as well.

关键词： Yarn-dyed plaid fabric image classification image dataset deep neural network strip pooling model

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

ARIG inhibition improves the prognosis of liver cancer through autophagy regulation and tumor immunity enhancement

引用

Genes & Diseases 2023年第5期10卷 1731-1734页

作者： Jiaqi Chen xiaoting zhang Weijian Hu Yang Bai Yi Zhou Stomatology Hospital School of StomatologyZhejiang University School of MedicineClinical Research Center for Oral Diseases of Zhejiang ProvinceKey Laboratory of Oral Biomedical Research of Zhejiang ProvinceCancer Center of Zhejiang UniversityHangzhouZhejiang 310006China Department of Surgery The Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang 310009China Department of Hepatobiliary and Pancreatic Surgery Affiliated Jinhua HospitalZhejiang University School of MedicineJinhuaZhejiang 321000China

Currently, the primary treatment for hepatocellular carcinoma (HCC) is a comprehensive treatment based on surgery.1 In the case of advanced HCC that may not be removed surgically, additional issues, such as drug resistance and drug inefficacy with long-term use of chemotherapeutic drugs, highlight the pressing need for new treatment strategies.2 Autophagy plays an essential role in cellular physiology, which was reported to modulate components of the immune system.3 Autophagy-related immune genes (ARIGs) are linked to both autophagy and immunity. Here we identified histone deacetylase 1 (HDAC1), an ARIG strongly expressed in HCC, as a therapeutic target.4 Then valproic acid (VPA), a specific inhibitor of HDAC1,5 was used to treat liver cancer in vitro and in vivo. The results demonstrated that VPA could significantly induce autophagy and apoptosis of Hepa1-6 cells and inhibit tumor growth in vivo. This effect could be related to the regulation of autophagy and tumor immune microenvironment by VPA.

关键词： drugs liver treatment

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Transcriptional coactivator MED1 in the interface of anti-estrogen and anti-HER2 therapeutic resistance

引用

Cancer Drug Resistance 2022年第2期5卷 498-510页

作者： Gregory Bick Jasmine zhang Elyse E.Lower xiaoting zhang Department of Cancer Biology Vontz Center for Molecular StudiesUniversity of Cincinnati College of MedicineCincinnatiOH 45267USA Department of Internal Medicine University of Cincinnati College of MedicineCincinnatiOH 45267USA. University of Cincinnati Cancer Center University of Cincinnati College of MedicineCincinnatiOH 45267USA.

Breast cancer is one of the most common cancer and leading causes of death in women in the United States and Worldwide.About 90%of breast cancers belong to ER+or HER2+subtypes and are driven by key breast cancer genes Estrogen Receptor and HER2,respectively.Despite the advances in anti-estrogen(endocrine)and anti-HER2 therapies for the treatment of these breast cancer subtypes,unwanted side effects,frequent recurrence and resistance to these treatments remain major clinical challenges.Recent studies have identified ER coactivator MED1 as a key mediator of ER functions and anti-estrogen treatment resistance.Interestingly,MED1 is also coamplified with HER2 and activated by the HER2 signaling cascade,and plays critical roles in HER2-mediated tumorigenesis and response to anti-HER2 treatment as well.Thus,MED1 represents a novel crosstalk point of the HER2 and ER pathways and a highly promising new therapeutic target for ER+and HER2+breast cancer treatment.In this review,we will discuss the recent progress on the role of this key ER/HER2 downstream effector MED1 in breast cancer therapy resistance and our development of an innovative RNA nanotechnology-based approach to target MED1 for potential future breast cancer therapy to overcome treatment resistance.

关键词： MED1 transcription cofactor estrogen receptor HER2 therapy resistance RNA nanotechnology

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Structural characteristic and formation mechanism of hemihydrate calcium sulfate whiskers prepared using FGD gypsum

引用

Particuology 2022年第3期20卷 98-103页

作者： xiaoting zhang Lingwei Ran Xiao Wang Biao Jin Jianwu zhang Shanying Li Liushuan Yang Department of Civil&Material Engineering Henan University of Urban ConstructionPingdingshan 467036HenanChina不详

Hemihydrate calcium sulfate whiskers(HH-CSWs)were hydrothermally synthesized in a sulfuric acid solution at 120℃ for different holding times(20,40,and 60 min).The phase structures and morphologies were characterized by XRD and SEM,respectively.The XRD pattern of the sample under 60 min was refined via the Rietveld fitting method.The structure models of the HH-CSW sample under a 60-min holding time was established based on Rietveld fitting results.No difference in the positions of diffraction peaks was determined.The as-prepared holding time increased the intensity and aspect ratio of the diffraction peaks of both samples.In the prepared HH-CSW structure,Ca-O polyhedron is a 12-sided polyhedron similar to that in the gypsum structure;the Ca atom is located in two positions in the one-unit cell;the H_(2)O channel along the c-axis similar is O-shaped and bigger than that in hexagonal and monoclinic CaSO_(4)·0.5H_(2)O structures.Therefore,although the prepared HH-CSW crystals’structure are similar to that of the reported hexagonal and monoclinic CaSO_(4)·0.5H_(2)O structures,they are not the same.The formation mechanism of HH-CSW from flue gas desulfurization(FGD)gypsum is discussed based on the analysis of gypsum structure.

关键词： FGD gypsum HH-CSW Rietveld method Crystal structure

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Microbial electrosynthesis of acetate from CO_(2)under hypersaline conditions

引用

Environmental Science and Ecotechnology 2023年第1期13卷 86-95页

作者： xiaoting zhang Tyler Arbour Daijun zhang Shiqiang Wei Korneel Rabaey College of Resources and Environment Southwest UniversityChongqing400715China Center for Microbial Ecology and Technology(CMET) Ghent UniversityCoupure Links 6539000GhentBelgium State Key Laboratory of Coal Mine Disaster Dynamics and Control Chongqing UniversityChongqing400044China Center for Advanced Process Technology for Urban Resource Recovery(CAPTURE) Frieda Saeysstraat 19052GhentBelgium

Microbial electrosynthesis(MES)enables the bioproduction of multicarbon compounds from CO_(2)using electricity as the driver.Although high salinity can improve the energetic performance of bioelectrochemical systems,acetogenic processes under elevated salinity are poorly known.Here MES under 35e60 g L^(-1)salinity was evaluated.Acetate production in two-chamber MES systems at 35 g L^(-1)salinity(seawater composition)gradually decreased within 60 days,both under-1.2 V cathode potential(vs.Ag/AgCl)and^(-1).56 A m^(-2)reductive current.Carbonate precipitation on cathodes(mostly CaCO3)likely declined the production through inhibiting CO_(2)supply,the direct electrode contact for acetogens and H2 production.Upon decreasing Ca2t and Mg2t levels in three-chamber reactors,acetate was stably produced over 137 days along with a low cathode apparent resistance at 1.9±0.6 mU m^(2)and an average production rate at 3.80±0.21 g m^(-2)d^(-1).Increasing the salinity step-wise from 35 to 60 g L^(-1)gave the most efficient acetate production at 40 g L^(-1)salinity with average rates of acetate production and CO_(2)consumption at 4.56±3.09 and 7.02±4.75 g m^(-2)d^(-1),respectively.The instantaneous coulombic efficiency for VFA averaged 55.1±31.4%.Acetate production dropped at higher salinity likely due to the inhibited CO_(2)dissolution and acetogenic metabolism.Acetobacterium up to 78%was enriched on cathodes as the main acetogen at 35 g L^(-1).Under high-salinity selection,96.5%Acetobacterium dominated on the cathode along with 34.0%Sphaerochaeta in catholyte.This research provides a first proof of concept that MES starting from CO_(2)reduction can be achieved at elevated salinity.

关键词： Carbon capture and utilization High salinity Carbonate precipitates Acetogenesis Marine bacteria

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

SnoRNP is essential for thermospermine-mediated development in Arabidopsis thaliana

引用

Science China(Life Sciences) 2023年第1期66卷 2-11页

作者： Xilong Li Zongyun Yan Meiling zhang Jiayin Wang Peiyong Xin Shujing Cheng Liquan Kou xiaoting zhang Songlin Wu Jinfang Chu Chengqi Yi Keqiong Ye Bing Wang Jiayang Li State Key Laboratory of Plant Genomics and National Center for Plant Gene Research(Beijing) Institute of Genetics and Developmental BiologyInnovation Academy for Seed DesignChinese Academy of SciencesBeijing 100101China State Key Laboratory of Protein and Plant Gene Research School of Life SciencesPeking UniversityBeijing 100871China Key Laboratory of RNA Biology CAS Center for Excellence in BiomacromoleculesInstitute of BiophysicsChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100039China Hainan Yazhou Bay Seed Laboratory Sanya 572025China

Polyamines have been discovered for hundreds of years and once considered as a class of phytohormones.Polyamines play critical roles in a range of developmental processes.However,the molecular mechanisms of polyamine signaling pathways remain poorly understood.Here,we measured the contents of main types of polyamines,and found that endogenous level of thermospermine(T-Spm)in Arabidopsis thaliana is comparable to those of classic phytohormones and is significantly lower than those of putrescine(Put),spermidine(Spd),and spermine(Spm).We further found a nodule-like structure around the junction area connecting the shoot and root of the T-Spm biosynthetic mutant acl5 and obtained more than 50 suppressors of acl5 nodule structure(san)through suppressor screening.An in-depth study of two san suppressors revealed that NAP57 and NOP56,core components of box H/ACA and C/D snoRNPs,were essential for T-Spm-mediated nodule-like structure formation and plant height.Furthermore,analyses of rRNA modifications showed that the overall levels of pseudouridylation and 2′-O-methylation were compromised in san1 and san2 respectively.Taken together,these results establish a strong genetic relationship between rRNA modification and T-Spm-mediated growth and development,which was previously undiscovered in all organisms.

关键词： polyamines thermospermine snoRNP pseudouridylation 2’-O-methylation Arabidopsis thaliana

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

红树植物功能性状对盐和铜胁迫的响应

引用

生态学报 2024年第3期44卷 1284-1297页

作者：张晓婷王俊杰广西山口红树林生态国家级自然保护区管理中心北海536000 深圳大学生命与海洋科学学院深圳518060

目前,室内通过人工控制方式开展红树林对环境胁迫的响应研究,忽视了不同红树植物物种的生长习性,且以单一胁迫为主。通过野外生长与人工控制相结合方式,研究5个时期(2018.6—2020.8)盐和铜胁迫对3种红树植物(秋茄、拉关木和木榄)11种功... 详细信息

目前,室内通过人工控制方式开展红树林对环境胁迫的响应研究,忽视了不同红树植物物种的生长习性,且以单一胁迫为主。通过野外生长与人工控制相结合方式,研究5个时期(2018.6—2020.8)盐和铜胁迫对3种红树植物(秋茄、拉关木和木榄)11种功能性状的影响,使用单因素和双因素方差分析研究不同时期不同树种下盐和铜胁迫对叶片功能性状的影响,回答红树植物功能性状对盐和铜单一及复合胁迫响应的科学问题。结果表明,不同时期下,三种红树植物功能性状具有明显差异。随着时间增长,三种植物的碳含量和冠层高度均呈升高趋势,其他功能性状因物种不同而表现出不同趋势;与乡土红树植物(秋茄和木榄)相比,外来入侵物种(拉关木)具有更快的生长速度。不同时期下,拉关木比秋茄和木榄具有更好耐盐性,三个物种的植物生长发育对铜胁迫的响应均不敏感。大部分时期下,单一盐胁迫对拉关木的植物功能性状无显著影响(P<0.05),对秋茄和木榄的碳含量、冠层高度和比叶面积有显著影响(P<0.05);单一铜胁迫对三个物种的绝大多数功能性状无显著影响。另外,盐-铜复合胁迫对秋茄叶片碳、磷、氮磷比及冠层高度有显著影响(P<0.05),对拉关木叶片碳、铜含量、冠层高度、比叶面积有显著影响(P<0.05),仅对木榄SPAD值有显著影响(P<0.05)。在红树林保护修复工作中,研究成果可为红树林退化原因和机理阐释、红树林生长监测评估、生境治理以及树种选择提供一定的理论依据。

关键词：红树林盐铜胁迫植物功能性状

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

内皮细胞机械敏感离子通道蛋白Piezo1在疾病中作用的研究进展

引用

中华危重病急救医学 2024年第5期36卷 557-560页

作者：张笑婷刘金海邓小明薄禄龙海军军医大学第一附属医院麻醉学部上海200433

内皮细胞具有重要的生理功能和与多种疾病发生发展相关的调节作用。机械敏感离子通道蛋白Piezo1广泛分布于机体多种组织中,参与多种疾病的发生发展。Piezo1在内皮细胞中高表达,对内皮细胞功能发挥重要的调控作用。本文对Piezo1的结构与... 详细信息

内皮细胞具有重要的生理功能和与多种疾病发生发展相关的调节作用。机械敏感离子通道蛋白Piezo1广泛分布于机体多种组织中,参与多种疾病的发生发展。Piezo1在内皮细胞中高表达,对内皮细胞功能发挥重要的调控作用。本文对Piezo1的结构与功能、内皮细胞的生理功能及病理损伤机制、内皮细胞Piezo1在多种疾病中作用的研究进展进行综述,以期深入了解内皮细胞Piezo1的功能和调控机制,为相关疾病的治疗提供新的靶点和策略。

关键词：内皮细胞 Piezo1 心血管系统呼吸系统

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

乳腺癌组织特异性治疗靶标MED（英文）

引用

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2019年第5期20卷 381-390页

作者： Marissa LEONARD xiaoting zhang Department of Cancer Biology University of Cincinnati College of Medicine

在这篇综述中,我们讨论了雌激素受体共激活子转录中介体亚基1(MED1)作为独特的组织特异性辅因子在乳腺癌干细胞形成、转移和治疗抗性中的关键作用。此外,我们详细介绍了目前使用最先进的RNA纳米技术靶标MED1的成果,并提出了未来的展望。

关键词：转录中介体亚基1(MED1) 中介体雌激素受体乳腺癌内分泌治疗抗性 RNA纳米技术

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A readily monitored and controllable hydrothermal system for the facile,cost-effective transformation of FGD gypsum to calcium sulfate hemihydrate whiskers

引用

Particuology 2021年第1期19卷 173-180页

作者： Bolun Cao Xiao Wang xiaoting zhang Biao Jin Zhuoyue Xu Xueping Liu Wei zhang Liushuan Yang College of Materials Science and Engineering Zhengzhou UniversityZhengzhou 410001China School of Materials and Chemical Engineering Henan University of Urban ConstructionPingdingshan 467036China Zhengzhou Key Laboratory of Water Resource and Environment Zhengzhou450001China

The controllable transformation of flue gas desulfurization(FGD)gypsum to calcium sulfate hemihydrate(HH)whiskers under facile,readily monitored,and cost-effective hydrothermal conditions could play a vital role in the preparation of high quality HH whiskers and improve our understanding of the transformation process.This work assessed the conversion of FGD gypsum to HH whiskers in 5×10^(-4)mol/L H_(2)SO_(4)and 1.5 wt%CuCl_(2)at 120℃while determining the effects of temperature as well as H_(2)SO_(4)and CuCl_(2)concentrations on transformation kinetics.The preparation of HH whiskers was found to involve a solution-mediated transformation from the dihydrate(DH)to theα-HH.This transition was determined to proceed via a dissolution crystallization mechanism,the rate of which was controlled by nucleation and growth of the HH whiskers.An autocatalytic kinetic model was established based on variations in the HH whiskers mole fraction over time,and this model accurately fit the experimental data with R2=0.990.Increasing the temperature or H_(2)SO_(4)concentration accelerated the transformation by modifying the super-saturation and water activity in the reaction solution,while increasing the CuCl_(2)concentration had the opposite effect.The hydrothermal conditions had an important effect on the transformation from FGD gypsum to HH whiskers.

关键词： FGD gypsum Whisker Hydrothermal condition Transformation process Kinetic

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：