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两种Shirodkar宫颈环扎术式对单胎宫颈机能不全孕妇妊娠结局的影响

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同济大学学报（医学版） 2024年第4期45卷 496-502页

作者：刘云雷胜瑶倪晓田徐文怡汝萍刘铭同济大学附属东方医院产科上海200120

目的探讨Shirodkar埋线环扎术式与Shirodkar非埋线环扎术式对单胎宫颈机能不全孕妇妊娠结局的影响。方法选取2021年2月—2023年12月因病史指征或超声指征在同济大学附属东方医院产科行经阴道宫颈环扎术(Shirodkar术式)的373例宫颈机能... 详细信息

目的探讨Shirodkar埋线环扎术式与Shirodkar非埋线环扎术式对单胎宫颈机能不全孕妇妊娠结局的影响。方法选取2021年2月—2023年12月因病史指征或超声指征在同济大学附属东方医院产科行经阴道宫颈环扎术(Shirodkar术式)的373例宫颈机能不全单胎妊娠孕妇为研究对象。完整收集孕妇的一般临床资料和母婴结局,根据术中是否将缝线线尾包埋于阴道黏膜下,分为Shirodkar埋线环扎术式组(埋线环扎组,n=115)组和Shirodkar非埋线环扎术式组(非埋线环扎组,n=258)。使用独立样本t检验、秩和检验、χ^(2)检验或Fisher精确概率检验比较两组孕妇的一般临床资料、孕妇妊娠结局及新生儿结局,并采用多因素Logistic回归模型分析评估早产和妊娠36周前拆线发生的危险因素。结果与非埋线环扎组相比,埋线环扎组早产率降低(13.0%vs 22.5%,P=0.048),妊娠36周前拆线率降低(19.1%vs 33.3%,P=0.005),拆线孕周较晚[37(36.0,37.0)周vs 36(35.0,37.0)周,PniCU率、新生儿并发症等方面的差异均无统计学意义(均P>0.05)。多因素Logistic回归分析显示,是否埋线与早产发生风险降低无显著相关,与妊娠36周前拆线发生风险降低相关(OR=0.516,95%CI:0.2930.909,P=0.022);环扎前宫颈长度与早产发生风险降低相关(OR=0.954,95%CI:0.9150.996,P=0.031),与妊娠36周前拆线发生率增加相关(OR=1.062,95%CI:1.0021.104,P=0.002)。结论Shirodkar埋线环扎术式可以延长拆线孕周、降低妊娠36周前拆线率,但该术式在改善妊娠结局方面尚未见明显优势。

关键词：宫颈机能不全宫颈环扎术 Shirodkar术式妊娠结局

sRAGE alleviates SARS-CoV-2-induced pneumonia in hamster

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Signal Transduction and Targeted Therapy 2022年第3期7卷 610-612页

作者： Xiuqin Zhang Dan Li Rui Sun Xinli Hu Zhiqi Song xiaotian ni Hua Zhu Tiannan Guo Chuan Qin Rui-Ping Xiao Institute of Molecular Medicine College of Future TechnologyPeking UniversityBeijingChino Key Laboratory of Human Disease Comparative Medicine of National Health Commission of the People’s Republic of China Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious DiseasesInstitute of Laboratory Animal ScienceChinese Academy of Medical Sciences and Comparative Medicine CenterPeking Union Medical CollegeBeijingChina Westlake Laboratory of Life Sciences and Biomedicine Key Laboratory of Structural Biology of Zhejiang ProvinceSchool of Life SciencesWestlake UniversityHangzhouChina

Dear Editor Since last year,the most demanding task of the global pharmaceutical community has been focused on the development of strategies to treat coronavirus disease 2019(COVID-19).To date,several vaccines have been developed and already demonstrated their efficacy in reducing the incidence of COVID-19.1 However,the development of drugs treating COVID-19 is lagging far behind,and all the current treatment regimens have their limitations.

关键词： drugs regimen pneumonia

Could urinary ACE2 protein level help identify individuals susceptible to SARS-CoV-2 infection and complication?

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Science China(Life Sciences) 2020年第11期63卷 1766-1767页

作者： xiaotian ni Changqing Sun Yaping Tian Yanjie Huang Tongqing Gong Lan Song Xing Yang Kai Li Nairen Zheng Jianping Wang Hongxing Wu Ruoxian Zhang Yi Wang Guangshun Wang &Jun Qin State Key Laboratory of Proteomics Beijing Proteome Research CenterNational Center for Protein Sciences(Beijing)Beijing Institute of LifeomicsBeijing 102206China Joint Center for Translational Medicine Tianjin Medical University Baodi Clinical CollegeTianjin 301800China Pineal Health Beijing 102206China Department of Translational Medicine Chinese PLA General HospitalBeijing 100039China Department of Pediatrics Henan University of Chinese MedicineZhengzhou 450046China

Globally, SARS-CoV-2 has infected 3,113,447 people and killed 216,930 as of April 29, 2020. Identifying populations vulnerable to infection and their disease progression is critical to mitigating the negative impacts on healthcare systems. Recent studies have shown that angiotensin converting enzyme 2 (ACE2) is the receptor for SARS-CoV-2 to enter human cells (Zhou et al., 2020), raising the possibility that a higher ACE2 expression level could facilitate SARS-CoV-2infection.

关键词： ACE2 urinary infection

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梳棉机喂入棉层握持与检测技术探析

棉纺织技术 2005年第6期33卷 17-20页

作者：倪远倪笑天上海太平洋克罗斯罗尔机械有限公司东华大学

通过对梳棉机喂入棉层握持与检测技术现状的分析,指出了现有技术中对喂入棉层握持与检测存在的不足。创新设计的细分段给棉技术和结构方案应用气动加压以及液流传导原理,可以更合理地握持给棉棉层、更精确地检测给棉棉层动态线密度,从... 详细信息

通过对梳棉机喂入棉层握持与检测技术现状的分析,指出了现有技术中对喂入棉层握持与检测存在的不足。创新设计的细分段给棉技术和结构方案应用气动加压以及液流传导原理,可以更合理地握持给棉棉层、更精确地检测给棉棉层动态线密度,从而改善分梳效果,提高匀整精度。

关键词：梳棉机加压握持棉层检测横向不匀细分段给棉检测精度

A urinary proteomic landscape of COVID-19 progression identifies signaling pathways and therapeutic options

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Science China(Life Sciences) 2022年第9期65卷 1866-1880页

作者： Yuntao Liu Lan Song Nairen Zheng Jinwen Shi Hongxing Wu Xing Yang nianci Xue Xing Chen Yimin Li Changqing Sun Cha Chen Lijuan Tang xiaotian ni Yi Wang Yaling Shi Jianwen Guo Guangshun Wang Zhongde Zhang Jun Qin The Second Affiliated Hospital of Guangzhou University of Chinese Medicine Guangzhou 510120China State Key Laboratory of Proteomics Beijing Proteome Research CenterNational Center for Protein Sciences(Beijing)Beijing Institute of LifeomicsBeijing 102206China Beijing Pineal Health Management Co.Ltd Beijing 102206China Guangzhou Eighth People’s Hospital Guangzhou Medical UniversityGuangzhou 510060China The First Affiliated Hospital of Guangzhou Medical University Guangzhou 510120China Guangzhou Institute of Respiratory Disease Guangzhou 510120China Guangdong Provincial Key Laboratory of Research on Emergency in TCM Guangzhou 510120China Joint Center for Translational Medicine Tianjin Medical University Baodi Clinical CollegeTianjin 301800China

Signaling pathway alterations in COVID-19 of living humans as well as therapeutic targets of the host proteins are not *** analyzed 317 urine proteomes,including 86 COVID-19,55 pneumonia and 176 healthy controls,and identified specific RNA virus detector protein DDX58/RIG-I only in COVID-19 *** of the COVID-19 urinary proteomes with controls revealed major pathway alterations in immunity,metabolism and protein *** that may stratify severe symptoms from moderate ones suggested that macrophage induced inflammation and thrombolysis may play a critical role in worsening the *** activation of the TCA cycle is evident and a macrophage enriched enzyme CLYBL is up regulated in COVID-19 *** CLYBL converts the immune modulatory TCA cycle metabolite itaconate through the citramalyl-CoA intermediate to acetyl-CoA,an increase in CLYBL may lead to the depletion of itaconate,limiting its anti-inflammatory *** observations suggest that supplementation of itaconate and inhibition of CLYBL are possible therapeutic options for treating COVID-19,opening an avenue of modulating host defense as a means of combating SARS-CoV-2 viruses.

关键词： COVID-19 urine proteome CLYBL itaconate

洋留守儿童营养与食品安全知识、态度、行为现状调查——以江门市为例

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现代食品 2016年第15期8卷 121-122页

作者：倪晓添江门职业技术学院

江门有着"中国第一侨乡"的美誉,海外侨民人数越来越多,国内的留守儿童问题也日益突显,本文通过调查江门市洋留守儿童营养与食品安全知识、态度和行为现状,旨在为在五邑地区开展营养与食品安全健康教育活动提供依据。

关键词：洋留守儿童食品安全态度

Proteomics provides individualized options of precision medicine for patients with gastric cancer

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Science China(Life Sciences) 2021年第8期64卷 1199-1211页

作者： Wenwen Huang Dongdong Zhan Yazhuo Li Nairen Zheng Xin Wei Bin Bai Kecheng Zhang Mingwei Liu Xuefei Zhao xiaotian ni Xia Xia Jinwen Shi Cheng Zhang Zhihao Lu Jiafu Ji Juan Wang Shiqi Wang Gang Ji Jipeng Li Yongzhan nie Wenquan Liang Xiaosong Wu Jianxin Cui Yongsheng Meng Feilin Cao Tieliu Shi Weimin Zhu Yi Wang Lin Chen Qingchuan Zhao Hongwei Wang Lin Shen Jun Qin Department of Gastrointestinal Oncology Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing)Peking University Cancer Hospital and InstituteBeijing 100142China State Key Laboratory of Proteomics Beijing Proteome Research CenterNational Center for Protein Sciences(Beijing)Beijing Institute of LifeomicsBeijing 102206China Department of Pathology The Fourth Medical Center of PLA General HospitalBeijing 100048China State Key Laboratory of Cancer Biology National Clinical Research Center for Digestive Diseases and Department of Digestive SurgeryXijing Hospital of Digestive DiseasesFourth Military Medical UniversityXi’an 710032China Department of General Surgery&Institute of General Surgery Chinese PLA General Hospital First Medical CenterBeijing 100853China Department of Gastrointestinal Surgery Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing)Peking University Cancer Hospital and InstituteBeijing 100142China Department of tumor biobank Shanxi Cancer HospitalTaiyuan 030013China Center for Bioinformatics and Computational Biology Shanghai Key Laboratory of Regulatory BiologyInstitute ofBiomedical Sciences and School of Life SciencesEast China Normal UniversityShanghai 200241China State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development School of Life SciencesInstitute of Biomedical SciencesFudan UniversityShanghai 200433China Life Sciences Institute Zhejiang UniversityHangzhou 310058China

While precision medicine driven by genome sequencing has revolutionized cancer care,such as lung cancer,its impact on gastric cancer(GC)has been *** patients are routinely treated with chemotherapy,but only a fraction of them receive the clinical *** is an urgent need to develop biomarkers or algorithms to select chemo-sensitive patients or apply targeted ***,we carried out retrospective analyses of 1,020 formalin-fixed,paraffin-embedded GC surgical resection samples from 5 hospitals and developed a mass spectrometry-based workflow for proteomic subtyping of *** identified two proteomic subtypes:the chemo-sensitive group(CSG)and the chemo-insensitive group(CIG)in the discovery *** 5-year overall survival of CSG was significantly improved in patients who had received adjuvant chemotherapy after surgery compared with those who received surgery only(64.2%vs.49.6%;Cox P-value=0.002),whereas no such improvement was observed in CIG(50.0%vs.58.6%;Cox P-value=0.495).We validated these results in an independent validation ***,differential proteome analysis uncovered 9 FDA-approved drugs that may be applicable for targeted therapy of GC.A prospective study is warranted to test these findings for future GC patient care.

关键词： patients chemotherapy cancer