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Klotho蛋白与充血性心力衰竭的关联及炎症的介导作用

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郑州大学学报（医学版） 2024年第5期59卷 639-645页

作者：曹青青宋宇郇昌盛贾泽鑫高倩王重建毛振兴侯建刘晓田霍文倩郑州大学公共卫生学院环境卫生学教研室郑州450001 郑州大学公共卫生学院流行病学教研室郑州450001 郑州大学公共卫生学院计算机与卫生统计学教研室郑州450001

目的:探讨Klotho蛋白与充血性心力衰竭(CHF)的关联及炎症的介导作用。方法:选取美国国家健康与营养调查2007-2016年的10762例研究对象(男5240例,女5522例),根据Klotho蛋白的四分位数将研究对象分为4组(Q1、Q2、Q3、Q4组),采用Logistic... 详细信息

目的:探讨Klotho蛋白与充血性心力衰竭(CHF)的关联及炎症的介导作用。方法:选取美国国家健康与营养调查2007-2016年的10762例研究对象(男5240例,女5522例),根据Klotho蛋白的四分位数将研究对象分为4组(Q1、Q2、Q3、Q4组),采用Logistic回归模型分析Klotho蛋白及炎症生物标志物与CHF的关系,采用广义线性模型分析Klotho蛋白与炎症生物标志物的关联,中介分析用于评估炎症生物标志物在Klotho蛋白与CHF关联中的中介效应。结果:Klotho蛋白可降低CHF风险(OR=0.695,95%CI为0.513~0.942),且在男性中更显著(OR=0.604,95%CI为0.406~0.898)。炎症生物标志物在Klotho蛋白与CHF的关联中具有中介效应,其中中性粒细胞计数与淋巴细胞计数比值的中介作用最大,在总人群和男性中分别为11.93%和9.92%,中介效应β(95%CI)分别为-0.047(-0.078~-0.026)和-0.050(-0.093~-0.021)。结论:高水平的Klotho蛋白、低水平的炎症生物标志物可降低CHF风险。炎症生物标志物部分介导了Klotho蛋白对CHF的保护作用。

关键词： Klotho蛋白充血性心力衰竭炎症生物标志物中介作用

Tailoring the electronic structure of PdAg_(x) alloy nanowires for high oxygen reduction reaction

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Chinese Journal of Structural Chemistry 2023年第6期42卷 8-14页

作者： Fan Yang Ruiqin Ren Xiaojia Zhang Muhammad Waqas Xinglan Peng Limin Wang xiaotian liu Du-Hong Chen Youjun Fan Wei Chen Guangxi Key Laboratory of Low Carbon Energy Materials School of Chemistry and Pharmaceutical SciencesGuangxi Normal UniversityGuilin541004China

Lowering the cost while maintaining the highly catalytic performance is greatly beneficial for the development of commercial fuel cells and metal-air *** with platinum,palladium holds a stronger oxygen affinity and high abundance on earth,endowing it a promising alternative to platinum in anion-exchange membrane fuel ***,the sluggish oxygen reduction reaction of palladium still remains a great issue and requires the design of stable and efficient palladium-based ***,we report the solvothermal/hydrothermal reduction method to prepare a series of PdAg_(x)*** prepared PdAg_(x)NWs exhibit hollow structure,which greatly improves the utilization of Pd atoms,offering an outstanding ORR ***,PdAg_(2)NWs exhibit an onset potential of 0.92 V and mass activity of 350.7 mA mgPd^(-1)at 0.7 V *** for ORR in 0.1 M KOH *** work provides a novel approach for the construction of hollow NWs and their subsequent applications in other electrocatalytic reactions.

关键词： Hollow nanowire Palladium catalyst Tailoring the electronic structure Oxygen reduction reaction Composition-performance relationship

Unpredictable Sharing Economy: Barbaric Growth, Deceptive Representation and Divergent Regulation

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Contemporary Social Sciences 2017年第6期2卷 82-93页

作者： Xie Xinshui liu xiaotian Wu Lingwei Capital Normal University

In the context of globalization and informatization, some traditionally lowtech and labor-intensive sectors have developed mobile Internet-based platforms and formed a new business format: the sharing economy. In the beginning, such a new business format lowered the threshold of participation, cut dealing costs, and enjoyed the relative advantage of being free from regulatory institutions. Therefore, it easily attracted investments and witnessed rapid development. Early-stage of the sharing economy features were "being shared, collaborative and on-demand." For a variety of reasons, the development of the sharing economy has already been accepted and recognized by current society. It is expected to become a new growth point and has the chance to replace the established business format of our industrial society and subsequently trigger many more "pain points." Regarding the regulation and governance of the sharing economy, there are divergences in its legality, platform nature, industrial impact and employment relationships. Identifying and resolving such regulatory divergences to the maximum degree is a prerequisite for the governance of the sharing economy and also a key to its smooth development.

关键词： sharing behavior sharing economy regulation governance

ON MAJOR FACTORS OF SUCCESSFUL LANGUAGE LEARNING

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Chinese Journal of Applied Linguistics 2001年第1期24卷 9-11,45页

作者： liu xiaotian Capital Normal University

As is well known, some people are more successful thanothers in learning. This different levels of achievement may beattributed to variables associated with the learner. In recentyears there has been extensive research into aspects of differencesin learning a second language. This paper briefly reviews anddiscusses the major parameters of the differences among individu-als which research studies indicate may influence the success ofsecond language learning, citing six areas of interest: age, intel-ligence, cognitive styles, personality, motivation and attitude.

关键词： ON MAJOR FACTORS OF SUCCESSFUL LANGUAGE LEARNING oral than more

Sustainable thermal energy harvest for generating electricity

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The Innovation 2024年第2期5卷 24-26页

作者： Shuai Zhang Zekun liu xiaotian Zhang Zhenhua Wu Zhiyu Hu Department of Micro/Nano Electronics School of Electronic Information and Electrical EngineeringShanghai Jiao Tong UniversityShanghai 200240China Zhangjiang Institute for Advanced Study Shanghai Jiao Tong UniversityShanghai 200240China School of Mechanical Engineering Shanghai Jiao Tong UniversityShanghai 200240China

Electricity is the lifeblood of modern ***,the predominant source of electricity generation still relies on non-renewable fossil fuels,whose combustion releases greenhouse gases contributing to global *** increasing demand for energy and escalating environmental concerns necessitate proactive measures to develop innovative green energy technologies capable of both cooling the Earth and generating ***,we look forward to an interdisciplinary power system integrating solar absorbers,radiative coolers,and thermoelectric *** system can simultaneously harvest thermal energy from the sun and from cold space,thereby transforming the challenges posed by global warming into opportunities for the production of clean *** underscore recent advancements in this field and address key challenges while also exploring forward-looking opportunities in the foreseeable *** proposed integrated energy technology achieves uninterrupted power supply through the unrestricted capture of thermal energy,offering a robust alternative pathway for next-generation sustainable energy technologies.

关键词： Sustainable generating electricity

装配式工业设备支架复合隔震结构振动台试验研究

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建筑结构学报 2023年第10期44卷 15-25页

作者：王伟刘笑天同济大学土木工程防灾减灾全国重点实验室上海200092 上海韧性城市与智能防灾工程技术研究中心上海200092

为解决在役工业设备支架中存在的现场湿作业环境污染、专用设备加速度超限以及无真实地震响应试验模拟现状等问题,对分别采用对角布置天然橡胶-铅锌橡胶支座(linear natural rubber-lead rubber,LNR-LR)型和水平布置天然橡胶支座-黏滞... 详细信息

为解决在役工业设备支架中存在的现场湿作业环境污染、专用设备加速度超限以及无真实地震响应试验模拟现状等问题,对分别采用对角布置天然橡胶-铅锌橡胶支座(linear natural rubber-lead rubber,LNR-LR)型和水平布置天然橡胶支座-黏滞阻尼器(linear natural rubber-viscous damper,LNR-VD)型复合隔震结构及采用固定组件连接的非隔震结构开展足尺振动台试验研究,通过对比远近场和人工地震波激励下复合隔震结构和非隔震结构的设备加速度峰值响应和隔震层位移响应,分析附加不同阻尼装置的整体复合隔震结构体系动力特性与振动控制效果。结果表明:与非隔震结构相比,分别采用LNR-LR型和LNR-VD型的两种复合隔震结构均可有效延长结构基本周期,在保持主体结构处于“大震弹性”状态下,设备支架最不利挂机点处水平加速度峰值严格不超过设备限值,罕遇地震作用下隔震层最大水平位移响应满足隔震位移要求(依据GB/T 51408—2021《建筑隔震设计标准》,限值为110 mm),且基本无残余位移;与LNR-LR型复合隔震结构相比,LNR-VD型复合隔震结构具有更为优异的振动控制效果,能够进一步降低上部结构水平加速度响应及隔震层水平位移响应,平均减震系数可达80.82%。

关键词：装配式工业设备支架复合隔震结构振动台试验地震响应振动控制

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基于两堵两注通管直连技术的瓦斯抽采研究

煤炭技术 2024年第8期43卷 214-218页

作者：许胜军王楹刘笑天张志康张东鑫李海超李阳河南理工大学矿业研究院河南焦作454000 义煤集团孟津煤矿有限责任公司河南三门峡472000 河南理工大学继续教育学院河南焦作454000 河南理工大学瓦斯地质与瓦斯治理国家重点实验室培育基地河南焦作454000

为解决“两堵一注”封孔工艺及传统连管方式在孟津煤矿实施存在的弊端,提出了“两堵两注”通管直连技术,提高了瓦斯抽采浓度,延长了瓦斯抽采时间。为此,采用巷道松动圈理论分析了该矿合适的封孔长度;采用离散元数值模拟方法建立巷道模型... 详细信息

为解决“两堵一注”封孔工艺及传统连管方式在孟津煤矿实施存在的弊端,提出了“两堵两注”通管直连技术,提高了瓦斯抽采浓度,延长了瓦斯抽采时间。为此,采用巷道松动圈理论分析了该矿合适的封孔长度;采用离散元数值模拟方法建立巷道模型,分析了巷道周围应力分布,确定了钻孔的最佳封孔深度;开展了“两堵两注”封孔地面实验和通管直连技术现场实验。结果表明:孟津煤矿二1煤层工作面顺层瓦斯抽采钻孔封孔长度至少为6.75 m;该矿12070工作面穿层钻孔最佳封孔深度为15~30 m;“两堵两注”技术能有效对抽采钻孔进行封堵;通管直连技术在现场应用中大幅度提高了瓦斯抽采浓度,延长了瓦斯抽采时间。

关键词：松软煤层瓦斯抽采两堵两注通管直连技术

Palladium nanoparticles/wool keratin-assisted carbon composite-modified flexible and disposable electrochemical solid-state pH sensor

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Chinese Physics B 2022年第2期31卷 634-640页

作者： Wenli Zhang xiaotian liu Youhui Lin Liyun Ma Linqing Kong Guangzong Min Ronghui Wu Sharwari K.Mengane Likun Yang Aniruddha B.Patil Xiang Yang liu Department of Plysics College of Materialsand Shenzhen Research Institute of Xiamen UniversityXiamcn University.Xiamen 361005China Department of Botany M.H.Shinde Mahavidyalaya.TisangiKolhapur 416226India Department ot Chemitry M.D.CollegeParelMumbai-400012India

Several p H-dependent processes and reactions take place in the human body;hence,the p H of body fluids is the best indicator of disturbed health ***,accurate and real-time diagnosis of the p H of body fluids is complicated because of limited commercially available p H ***,we aimed to prepare a flexible,transparent,disposable,userfriendly,and economic strip-based solid-state p H sensor using palladium nanoparticles(Pd NPs)/N-doped carbon(NC)composite *** Pd NPs/NC composite material was synthesized using wool keratin(WK)as a *** insitu prepared Pd NPs played a key role in the controlled switching of protein structure to the N-doped carbon skeleton withπ–πarrangement at the mesoscale level,which mimics the A–B type polymeric structure,and hence,is highly susceptible to H+*** optimized carbonization condition in the presence of Pd NPs showed that the material obtained using a modified Ag/Ag Cl reference electrode had the highest p H sensitivity with excellent stability and *** optimized p H sensor showed high specificity and selectivity with a sensitivity of 55 m V/p H unit and a relative standard deviation of 0.79%.This study is the first to synthesize Pd NPs using WK as a stabilizing and reducing *** applicability of the sensor was investigated for biological samples,namely,saliva and gastric *** proposed protocol and material have implications in solid-state chemistry,where biological material will be the best choice for the synthesis of materials with anticipated performance.

关键词： palladium nanoparticle electrochemical sensor solid-state pH sensor flexible strip sensor

Shifting the Paradigm:A Fresh Look at Physical Activity Frequency and Its Impact on Mental Health,Life Satisfaction,and Self-Rated Health in Adolescents

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International Journal of Mental Health Promotion 2024年第2期26卷 83-92页

作者： Wenjie Li Yucheng Gao Guoqing liu Rongkai Hao Meijie Zhang xiaotian Li Country School of Recreation and Community Sport Capital University of Physical Education and SportsBeijing100191China Institute of Physical Education and Training Capital University of Physical Education and SportsBeijing100191China

As adolescent mental health problems are becoming a more serious issue globally,this paper explores the relationship of physical activity in adolescents and its frequency on mental health as well as examines the mediating effects of life satisfaction and self-rated health in order to provide a reference for the promotion of mental health in adolescents.A sample of 3578 Chinese high school students completed questionnaires assessing their mental health,physical activity frequency,life satisfaction,and self-rated *** mean SCL-90 value for adolescents was found to be 1.629%,and 24.73%of adolescents had varying degrees of mental health *** physical activity frequency is positively associated with improved mental health(p<0.001).Additionally,life satisfaction and self-rated health were found to play significant mediating roles in the relationship between physical activity frequency and mental ***,low-frequency physical activity had the most pronounced mediating effect on mental health through life satisfaction,while high-frequency physical activity exerted the most significant mediating effect on mental health through self-rated *** findings underscore the importance of promoting physical activity among adolescents and highlight the distinct pathways through which physical activity frequency can influence mental health *** research is needed to explore these relationships in diverse populations and settings,as well as to develop targeted intervention.

关键词： Adolescents physical activity mental health life satisfaction self-rated health