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一款400μm^(2)用于极短距离接收机具有中频补偿的56 Gb/s PAM4反相器型连续时间线性均衡器

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集成电路与嵌入式系统 2024年第3期24卷 27-34页

作者：王梦豪赵潇腾董志成张淼刘术彬朱樟明西安电子科技大学西安710071

高速极短距离有线数据接口是芯粒间互连的重要技术方案。传统的基于电流模逻辑的连续时间线性均衡器由于高电源电压和无源器件的使用已经无法满足芯粒间数据接口高密度、小型化、低功耗的需求。针对该问题,本文提出了一种带中频补偿的... 详细信息

高速极短距离有线数据接口是芯粒间互连的重要技术方案。传统的基于电流模逻辑的连续时间线性均衡器由于高电源电压和无源器件的使用已经无法满足芯粒间数据接口高密度、小型化、低功耗的需求。针对该问题,本文提出了一种带中频补偿的反相器型连续时间线性均衡器,可在极短距离应用中传输28 Gb/s非归零信号以及56 Gb/s四电平脉冲幅度调制信号。本设计采用28 nm CMOS工艺实现,核心面积仅为400μm^(2)。经过-9.4 dB@14 GHz的极短距离信道后,基于版图的仿真结果表明,所提出的连续时间线性均衡器使28 Gbaud的非归零信号与四电平脉冲幅度调制信号眼宽分别提升0.14 UI与0.41 UI,眼高提升328 mV与119 mV,56 Gb/s四电平脉冲幅度调制信号工况下功耗为6.12 mW。

关键词：连续时间线性均衡器反相器型有源电感负载中频补偿四电平脉冲幅度调制芯粒

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Divergent synthesis of four isomers of 6,7-dihydroxy-3,7-dimethyloct-2-enoic acid,esters and evaluation for the antifungal activity

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Chinese Chemical Letters 2018年第12期29卷 1872-1874页

作者： Weiwei Wang xiaoteng Zhang Yu zhao Xinlei Liu Zhenhua Zhang Ming'an Wang Department of Applied Chemistry China Agricultural University

The four isomers of 6,7-dihydroxy-3,7-dimethyloct-2-enoic acid 2 were synthesized via the selective direct Sharpless asymmetry dihydroxylation of geraniol as the key step in 35.0%-48.0% overall yields with91.9%-97.7% ee values for esters 4 and 31,3%-36.4% overall yields with 90.3-97.5% ee values for acids 2 using cis-and trans-geraniol as raw materials. Their structures were characterized by;H,;C NMR and HR-ESI-MS data. The in vivo bioassay results showed that the chiral acid（Z, S）-2 was a good lead compound with 80%-100% inhibitory rates against P. cubensis, E. graminis, P. sorghi and C. gloeosporioides at the concentration of 400 μg/mL.

关键词： 6,7-Dihydroxy-3,7-dimethyloct-2-enoic acid Sharpless asymmetry dihydroxylation Antifungal activity

一款0.16 mm^(2)基于180 nm CMOS采用全局去偏斜的半速率8×2.5 Gb/s时钟转发架构接收机

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集成电路与嵌入式系统 2024年第4期24卷 1-9页

作者：杨力宏李世新韩晨曦云越恒刘术彬赵潇腾朱樟明西安电子科技大学西安710071

在时钟转发架构的高速有线通信接收机中,需要去偏斜电路实现时钟与数据之间的最佳采样关系,并保证多路数据的同步。本文提出了一种全局去偏斜方案,仅采用一路数据与时钟进行对齐,并通过时钟延时匹配与分布技术实现多路数据同步,减小了... 详细信息

在时钟转发架构的高速有线通信接收机中,需要去偏斜电路实现时钟与数据之间的最佳采样关系,并保证多路数据的同步。本文提出了一种全局去偏斜方案,仅采用一路数据与时钟进行对齐,并通过时钟延时匹配与分布技术实现多路数据同步,减小了各通道独立去偏斜方案带来的功耗与面积开销。所提出的接收机由8路数据通道、1路半速率转发时钟通道与基于延迟锁定环路的全局去偏斜电路构成。基于180 nm CMOS工艺,在2.5 Gb/s数据率下,可去除输入时钟与数据任意偏斜,得到位于数据中心的采样相位,同时具有时钟占空比校准能力。在1.8 V电源电压下,所提出的接收机总功耗为187 mW,总面积为0.16 mm^(2),对比各通道独立去偏斜方案,功耗和面积开销分别节约了45.2%与62.8%。

关键词：时钟转发多路接收机全局去偏斜延迟锁定环路时钟分布数据同步半速率

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固氮酶固氮活性中心模型物的探索合成

兰州大学学报 1979年第4期 160-163页

作者：黄文魁赵孝腾谭镇林长增江飞龙崔育新卢嘉锡中国科学院福建物质结构研究所

关于固氮酶固氮活性中心的结构问题,我国化学家先后提出过具有独特见解的“福州模型”（M Fe8S7）和由“厦门模型”修订而成的“综合模型”（MoFe6S6L2）。“福州模型”和“综合模型”有某些共同的观点,即认为:固氮酶在固氮反应时必须... 详细信息

关于固氮酶固氮活性中心的结构问题,我国化学家先后提出过具有独特见解的“福州模型”（M Fe8S7）和由“厦门模型”修订而成的“综合模型”（MoFe6S6L2）。“福州模型”和“综合模型”有某些共同的观点,即认为:固氮酶在固氮反应时必须具有鸟窝开口式网兜状基本结构单元作为活性中心,而且具有M Fe6S6孪合重烷体的基本骨架。这种学术见解亟待化学合成予以验证。遗憾的是,这类钼铁混合簇孪合型重

关键词：固氮酶还原酶固氮活性模型物

Identification of the E2F1-RAD51AP1 axis as a key factor in MGMT-methylated GBM TMZ resistance

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Cancer Biology & Medicine 2023年第5期20卷 385-400页

作者： Junhu Zhou Fei Tong Jixing zhao xiaoteng Cui Yunfei Wang Guangxiu Wang Chunsheng Kang Xiaomin Liu Qixue Wang Tianjin Medical University General Hospital Tianjin 300052China Tianjin Neurological Institute Key Laboratory of NeurotraumaVariationand RegenerationMinistry of Education and Tianjin Municipal GovernmentTianjin 300052China Department of Oncology Gamma Knife CenterDepartment of Neurological SurgeryTianjin Huanhu HospitalNankai UniversityTianjin 300350China

Objective:Epidermal growth factor receptor variant III(EGFRvIII)is a constitutively-activated mutation of EGFR that contributes to the malignant progression of glioblastoma multiforme(GBM).Temozolomide(TMZ)is a standard chemotherapeutic for GBM,but TMZ treatment benefits are compromised by *** study aimed to elucidate the crucial mechanisms leading to EGFRvIII and TMZ ***:CRISPR-Cas13a single-cell RNA-seq was performed to thoroughly mine EGFRvIII function in *** blot,realtime PCR,flow cytometry,and immunofluorescence were used to determine the chemoresistance role of E2F1 and RAD51-associated protein 1(RAD51AP1).Results:Bioinformatic analysis identified E2F1 as the key transcription factor in EGFRvIII-positive living *** RNA-seq analysis revealed that E2F1 is a crucial transcription factor under TMZ *** blot suggested enhanced expression of E2F1 in EGFRvIII-positive and TMZ-treated glioma *** of E2F1 increased sensitivity to *** diagram profiling showed that RAD51AP1 is positively correlated with E2F1,mediates TMZ resistance,and has a potential E2F1 binding site on the *** of RAD51AP1 enhanced the sensitivity of TMZ;however,overexpression of RAD51AP1 was not sufficient to cause chemotherapy resistance in glioma ***,RAD51AP1 did not impact TMZ sensitivity in GBM cells with high O6-methylguanine-DNA methyltransferase(MGMT)*** level of RAD51AP1 expression correlated with the survival rate in MGMT-methylated,but not MGMT-unmethylated TMZ-treated GBM ***:Our results suggest that E2F1 is a key transcription factor in EGFRvIII-positive glioma cells and quickly responds to TMZ ***51AP1 was shown to be upregulated by E2F1 for DNA double strand break *** RAD51AP1 could facilitate achieving an ideal therapeutic effect in MGMT-methylated GBM cells.

关键词： TMZ EGFRvIII E2F1 RAD51AP1 MGMT

Blockage of EGFR/AKT and mevalonate pathways synergize the antitumor effect of temozolomide by reprogramming energy metabolism in glioblastoma

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Cancer Communications 2023年第12期43卷 1326-1353页

作者： xiaoteng Cui Jixing zhao Guanzhang Li Chao Yang Shixue Yang Qi Zhan Junhu Zhou Yunfei Wang Menglin Xiao Biao Hong Kaikai Yi Fei Tong Yanli Tan Hu Wang Qixue Wang Tao Jiang Chuan Fang Chunsheng Kang Laboratory of Neuro-oncology Tianjin Neurological Institute Tianjin Medical University General Hospital Tianjin P. R. China Key Laboratory of Post-Neuro Injury Neuro-repair and Regeneration in Central Nervous System Ministry of Education and Tianjin City Tianjin P. R. China Department of Neurosurgery Beijing Tiantan Hospital Capital Medical University Beijing P. R. China Chinese Glioma Genome Atlas Network (CGGA) and Asian Glioma Genome Atlas Network (AGGA) Beijing P. R. China Department of Neurosurgery The First Affiliated Hospital of Zhengzhou University Zhengzhou Henan P. R. China Tianjin Key Laboratory of Composite and Functional Materials School of Material Science and Engineering Tianjin University Tianjin P. R. China Department of Neurosurgery Affiliated Hospital of Hebei University Baoding Hebei P. R. China Hebei Key Laboratory of Precise Diagnosis and Treatment of Glioma Baoding Hebei P. R. China Department of Neuro-Oncology and Neurosurgery Tianjin Medical University Cancer Institute and Hospital Tianjin P. R. China Department of Pathology Affiliated Hospital of Hebei University Baoding Hebei P. R. China Department of Pathology Hebei University School of Basic Medical Sciences Baoding Hebei P. R. China Department of Neurosurgery Tianjin Huanhu Hospital Tianjin P. R. China Department of Molecular Neuropathology Beijing Neurosurgical Institute Capital Medical University Beijing P. R. China Research Unit of Accurate Diagnosis Treatment and Translational Medicine of Brain Tumors Chinese Academy of Medical Sciences Beijing P. R. China

Background Metabolism reprogramming plays a vital role in glioblastoma(GBM)progression and recurrence by producing enough energy for highly proliferating tumor *** addition,metabolic reprogramming is crucial for tumor growth and immune-escape *** growth factor receptor(EGFR)amplification and EGFR-vIII mutation are often detected in GBM cells,contributing to the malignant *** study aimed to investigate the functional role of the EGFR pathway on fatty acid metabolism remodeling and energy *** Clinical GBM specimens were selected for single-cell RNA sequencing and untargeted metabolomics analysis.A metabolism-associated RTK-fatty acid-gene signature was constructed and ***-2206 and MK-803 were utilized to block the RTK pathway and mevalonate pathway induced abnormal *** metabolism in GBM with activated EGFR pathway was *** antitumor effect of Osimertinib and Atorvastatin assisted by temozolomide(TMZ)was analyzed by an intracranial tumor model in *** GBM with high EGFR expression had characteristics of lipid remodeling and maintaining high cholesterol levels,supported by the single-cell RNA sequencing and metabolomics of clinical GBM *** of the EGFR/AKT and mevalonate pathways could remodel energy metabolism by repressing the tricarboxylic acid cycle and modulating ATP ***,the EGFR/AKT pathway upregulated the expressions of acyl-CoA synthetase short-chain family member 3(ACSS3),acyl-CoA synthetase long-chain family member 3(ACSL3),and long-chain fatty acid elongation-related gene ELOVL fatty acid elongase 2(ELOVL2)in an NF-κB-dependent ***,inhibition of the mevalonate pathway reduced the EGFR level on the cell membranes,thereby affecting the signal transduction of the EGFR/AKT ***,targeting the EGFR/AKT and mevalonate pathways enhanced the antitumor effect of TMZ in GBM cells and animal *** Our findings no

关键词： combinatorial therapeutic strategy EGFR energy metabolism glioblastoma

The role of SND1 ubiquitination in the chemosensitivity of hepatocellular carcinoma

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The role of SND1 ubiquitination in the chemosensitivity of h...

Lipid lowering effects and safety of evolocumab in Chinese patients at very high cardiovascular risk:a single-center study

第十一届全国免疫学学术大会

作者： Cui xiaoteng Qian Baoxin zhao Chunyan Fu Xue Gao Xingjie Yang Jie Tianjin medical university

Purpose: The reduced chemosensitivity of Hepatocellular carcinomas(HCC) often contributes to the poor clinical efficacy of chemotherapy for patients with HCC. Staphylococcal nuclease and tudor domain containing 1(SND1), a multifunctional protein, is involved in cell cycle, DNA damage repair and other cellular physiological processes. Here, we investigated the potential role of SND1 in chemosensitivity of ***: Several assays, such as Annexin V-FITC/PI, CRISPR/Cas9 n double-nick system, Mass spectrometry or western blotting, were ***: We found that SND1 protein was associated with the sensitivity of SMMC-7721 cells to chemotherapeutic agents 5-Fu. SMMC-7721 cells were more sensitive to 5-Fu after the knock-out of SND1 gene by CRISPR/Cas9 n double-nick system. In addition, 48 h after treated with 25 μg/m L Cycloheximide(an inhibitor of protein biosynthesis), SND1 protein was degraded. This process could be inhibited by MG-132(a proteasome inhibitor), and the ubiquitin signal of SND1 protein could be detected as well. Mass spectrometry data further showed that SND1 protein was associated with a series of chemosensitivity-associated proteins, such as Ubiquitin-Like With PHD And Ring Finger Domains 1(UHRF1), Poly(ADP-Ribose) Polymerase 1(PABP1) and X-Ray Repair Complementing Defective Repair In Chinese Hamster Cells 6(XRCC6).Conclusion: These results suggested that SND1 may affect the sensitivity of HCC cells to chemotherapeutic agents by means of ubiquitination modification.

关键词： SND1 hepatocellular carcinoma ubiquitination chemosensitivity

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Chinese Medical Journal 2023年第11期136卷 1358-1360页

作者： Meng Chai Haitao Zhang Lixia Yang Jing Liang Hongya Han Xiaoli Liu xiaoteng Ma Yan Liu Dongmei Shi Yingxin zhao Yuyang Liu Yujie Zhou Department of Cardiology Beijing Anzhen HospitalCapital Medical UniversityBeijing Institute of Heart Lung and Blood Vessel DiseaseBeijing Key Laboratory of Precision Medicine of Coronary Atherosclerotic DiseaseClinical Center for Coronary Heart DiseaseCapital Medical UniversityBeijing 100029China Department of Cardiology Air Force Medical CenterBeijing 100142China

Low-density lipoprotein cholesterol(LDL-C)is an independent risk factor for atherosclerotic cardiovascular disease(ASCVD).Even after lipid-lowering therapy(LLT)with statins or statin–ezetimibe,a large proportion of patients at very high risk still do not reach the LDL-C targets(<1.4 mmol/L and≥50%reduction).[1,2]Proprotein convertase subtilisin/kexin type 9 inhibitor(PCSK9i)is recommended for patients at high or very high cardiovascular risk inwhom LDL-C reduction is not adequate with statin therapy or in those with statin *** data are available regarding the use of PCSK9i in China.

关键词： patients Lipid cardiovascular

组蛋白乙酰化调控因子在动物早期胚胎发育过程中的作用研究进展

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浙江大学学报（农业与生命科学版） 2024年第5期50卷 715-723页

作者：李潇腾赵盼盼张坤浙江大学动物科学学院浙江省奶牛遗传改良与乳品质研究重点实验室浙江杭州310058

精卵结合后,动物胚胎在早期发育过程中会经历剧烈的表观遗传重编程,包括DNA甲基化、组蛋白修饰和染色质重塑等,以确保受精前后高度分化的配子形成全能性的细胞。重编程与早期胚胎发育过程的各个阶段紧密相关,有多种调控因子参与其中,如... 详细信息

精卵结合后,动物胚胎在早期发育过程中会经历剧烈的表观遗传重编程,包括DNA甲基化、组蛋白修饰和染色质重塑等,以确保受精前后高度分化的配子形成全能性的细胞。重编程与早期胚胎发育过程的各个阶段紧密相关,有多种调控因子参与其中,如乙酰转移酶、脱乙酰酶及组蛋白修饰阅读器等均参与组蛋白乙酰化的调控,并发挥重要功能。本文综述了组蛋白乙酰化调控因子在动物早期胚胎发育过程中的作用,探讨了早期胚胎发育过程中的表观遗传现象及机制,有助于更好地理解哺乳动物早期胚胎发育机制,减少胚胎发育缺陷,从而提升家畜繁殖力。

关键词：家畜繁殖早期胚胎着床前表观遗传组蛋白乙酰化