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What are the changes in the hotspots and frontiers of microRNAs in hepatocellular carcinoma over the past decade?

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World Journal of Clinical Oncology 2024年第1期15卷 145-158页

作者： Lu Zhang zu-Yuan Chen Xiao-Xian Wei Jian-Di Li Gang Chen Department of Pathology The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina

BACKGROUND Emerging research suggests that microRNAs(miRNAs)play an important role in the development of hepatocellular carcinoma(HCC).A comprehensive analysis of recent research concerning miRNAs in HCC development could provide researchers with a valuable reference for further studies.AIM To make a comprehensive analysis of recent studies concerning miRNAs in HCC.METHODS All relevant publications were retrieved from the Web of Science Core Collection database.Bibliometrix software,VOSviewer software and CiteSpace software were used to visually analyze the distribution by time,countries,institutions,journals,and authors,as well as the keywords,burst keywords and thematic map.RESULTS A total of 9426 publications on this topic were found worldwide.According to the keywords analysis,we found that the studies of miRNAs focused on their expression level,effects,and mechanisms on the biological behaviour of HCC.Keywords bursting analysis showed that in the early years(2013–2017),“micro-RNA expression”,“gene expression”,“expression profile”,“functional polymorphism”,“circulating microRNA”,“susceptibility”and“mir 21”started to attract attention.In the latest phase(2018–2022),the hot topics turned to“sorafenib resistance”,“tumor microenvironment”and so on.CONCLUSION This study provides a comprehensive overview of the role of miRNAs in HCC development based on bibliometric analysis.The hotspots in this field focus on miRNAs expression level,effects,and mechanisms on the biological behavior of HCC.The frontiers turned to sorafenib resistance,tumor microenvironment and so on.

关键词： miRNA Hepatocellular carcinoma Bibliometric VOSviewer CiteSpace

Compositional dependence of hydrogenation performance of Ti-Zr-Hf-Mo-Nb high-entropy alloys for hydrogen/tritium storage

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Journal of Materials Science & Technology 2020年第20期52卷 116-125页

作者： Huahai Shen Jutao Hu Pengcheng Li Gang Huang Jianwei Zhang Jinchao Zhang Yiwu Mao Haiyan Xiao Xiaosong Zhou xiaotao zu Xinggui Long Shuming Peng Institute of Nuclear Physics and Chemistry China Academy of Engineering PhysicsMianyang 621900China School of Physics University of Electronic Science and Technology of ChinaChengdu 610054China

A series of Ti-Zr-Hf-Mo-Nb high-entropy alloys with different Mo concentrations were developed as candidate materials for hydrogen/tritium storage in solid phase.The crystal structures and hydrogenation properties of the Ti-Zr-Hf-Mo-Nb alloys were investigated by X-ray diffraction and differential scanning calorimetry techniques.All the alloys have a body-centred cubic single phase structure.The results demonstrate that the cell volume of the Ti-Zr-Hf-Mo-Nb hydride decreases with increasing Mo concentration,which reduces their thermal stability.The theoretical calculation proposes that the lower binding energy of the Ti-Zr-Hf-Mo-Nb hydride decreases the thermal stability of Ti-Zr-Hf-Mo-Nb alloys with higher Mo content.The great hydrogenation performance for all the Ti-Zr-Hf-Mo-Nb alloys is owing to their reversible single-phase transformation during the hydrogen absorption-desorption cycle,which would be bene ficial to improving the hydrogen recycling rate and preventing the disproportionation.The compositional dependence of the hydrogenation performance of the Ti-Zr-Hf-Mo-Nb alloys was established and will be useful in designing novel hydrogen/tritium storage materials to satisfy the requirements of diffe rent application fields in hydrogen,solar thermal and nuclear energy.

关键词： High-entropy alloy Hydrogen/tritium storage Crystal structure Phase transformation Binding energy

Scalar Particles’ Tunneling and Effect of Quantum Gravity

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Journal of Applied Mathematics and Physics 2015年第2期3卷 134-139页

作者： Guoping Li xiaotao zu School of Physical Electronics University of Electronic Science and Technology of China Chengdu China

According to the generalized uncertainty principle (GUP), the Klein-Gordon equation is corrected by the quantum gravity exactly. Hence, the corrected Klein-Gordon equation will be more precise on the expression of the tunneling behavior. Then, the corrected Hawking temperature of the Gibbons-Maeda-Dilaton black hole is obtained near the horizon by quantum gravity. Analyzing the results carefully, it is obvious for us that the tunneling result is not only related to the mass of black hole, but also related to the mass and energy of outgoing fermions. Finally, we also infer that the tunneling radiation would be stopped at some particular temperature.

关键词： The Quantum Gravity The Gibbons-Maeda-Dilaton Black Hole The Corrected Klein-Gordon Equation The Generalized Uncertainty Principle

Modified Tunneling Radiation of Fermions from a Spherically Symmetric Spacetime with Dark Matter

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Journal of Applied Mathematics and Physics 2015年第8期3卷 931-936页

作者： Zhongwen Feng xiaotao zu School of Physical Electronics University of Electronic Science and Technology of China Chengdu China

In the paper, we use the generalized Dirac equation to study the Hawking temperature and entropy of a spherically symmetric spacetime with the dark matter. The results show that the dark matter can influence the thermodynamic properties of the black hole. Meanwhile, we find the GUP corrected temperature and entropy are not only determined by the nature of black but also related to the properties of tunneling particles. Besides, the GUP can slow down the increase of Hawking temperature and causes the remnants.

关键词： Generalized Uncertainty Principle Spherically Symmetric Spacetime Dark Matter

Excess non-COVID-19-related mortality among inflammatory bowel disease decedents during the COVID-19 pandemic

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World Journal of Gastroenterology 2024年第20期30卷 2677-2688页

作者： Sarah Rotondo-Trivette Xin-Yuan He Jamil S Samaan Fan Lv Emily Truong Michaela Juels Anthony Nguyen Xu Gao Jian zu Yee Hui Yeo Fan-Pu Ji Gil Y Melmed Department of Medicine Cedars-Sinai Medical CenterLos AngelesCA 90048United States Department of Infectious Disease The Second Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710004Shaanxi ProvinceChina Karsh Division of Gastroenterology and Hepatology Department of Medicine Cedars-Sinai Medical CenterLos AngelesCA 90048United States School of Mathematics and Statistics Xi’an Jiaotong UniversityXi’an 710049Shaanxi ProvinceChina David Geffen School of Medicine University of CaliforniaLos AngelesLos AngelesCA 90095United States Division of Gastroenterology The Second Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710004Shaanxi ProvinceChina National and Local Joint Engineering Research Center of Biodiagnosis and Biotherapy The Second Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710004Shaanxi ProvinceChina Key Laboratory of Surgical Critical Care and Life Support(Xi’an Jiaotong University) Ministry of EducationXi’an 710004Shaanxi ProvinceChina

BACKGROUND The coronavirus disease 2019(COVID-19)pandemic disrupted healthcare in the United States.AIM To investigate COVID-19-related and non-COVID-19-related death and characteristics associated with excess death among inflammatory bowel disease(IBD)decedents.METHODS We performed a register-based study using data from the National Vital Statistics System,which reports death data from over 99%of the United States population,from January 1,2006 through December 31,2021.IBD-related deaths among adults 25 years and older were stratified by age,sex,race/ethnicity,place of death,and primary cause of death.Predicted and actual age-standardized mortality rates(ASMRs)per 100000 persons were compared.RESULTS 49782 IBD-related deaths occurred during the study period.Non-COVID-19-related deaths increased by 13.14%in 2020 and 18.12%in 2021[2020 ASMR:1.55 actual vs 1.37 predicted,95%confidence interval(CI):1.26-1.49;2021 ASMR:1.63 actual vs 1.38 predicted,95%CI:1.26-1.49].In 2020,non-COVID-19-related mortality increased by 17.65%in ulcerative colitis(UC)patients between the ages of 25 and 65 and 36.36%in non-Hispanic black(NHB)Crohn’s disease(CD)patients.During the pandemic,deaths at home or on arrival and at medical facilities as well as deaths due to neoplasms also increased.CONCLUSION IBD patients suffered excess non-COVID-19-related death during the pandemic.Excess death was associated with younger age among UC patients,and with NHB race among CD patients.Increased death at home or on arrival and due to neoplasms suggests that delayed presentation and difficulty accessing healthcare may have led to increased IBD mortality.

关键词： Inflammatory bowel disease Ulcerative colitis Crohn’s disease COVID-19 Excess death Race Sex Disparities

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张奠宙数学教育思想概述

数学教育学报 2024年第3期33卷 89-95页

作者：刘祖希华东师范大学出版社

张奠宙是中国著名数学教育家，他的数学教育思想值得研究与传承．张奠宙数学教育思想包括以下7个方面：数学的学术形态与教育形态思想；数学文化就是要“文而化之”的思想；数学美与数学欣赏的思想；重视数学应用的思想；数学史融入数... 详细信息

张奠宙是中国著名数学教育家，他的数学教育思想值得研究与传承．张奠宙数学教育思想包括以下7个方面：数学的学术形态与教育形态思想；数学文化就是要“文而化之”的思想；数学美与数学欣赏的思想；重视数学应用的思想；数学史融入数学教育的思想；数学“双基”“四基”教学模型的思想；数学教育的“中国道路”思想．7个方面构成知行合一、教学相长、辩证统一的有机整体．

关键词：张奠宙数学的教育形态数学文化数学美数学应用数学史双基中国道路

中国式现代化与人类文明新形态的实践合理性和道义价值论

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西北师大学报（社会科学版） 2024年第2期61卷 5-13页

作者：袁祖社陕西师范大学哲学社会科学高等研究院/哲学学院陕西西安710119

中国式现代化既是一种合规律性与合目的性有机统一的客观的、自然的、辩证历史过程,又是基于实践合理性与价值合理性的中国式现代性逻辑的自我生成、确立与证成的过程。作为对中国式现代化合法性、正当性理据的探寻、辩护与有效诠释,中... 详细信息

中国式现代化既是一种合规律性与合目的性有机统一的客观的、自然的、辩证历史过程,又是基于实践合理性与价值合理性的中国式现代性逻辑的自我生成、确立与证成的过程。作为对中国式现代化合法性、正当性理据的探寻、辩护与有效诠释,中国的现代性或现代性的中国逻辑,从立场、宗旨、逻辑和根本价值目标等方面根本有别于西方现代化。其话语表达一旦生成,就会自然地嵌入某种自主性的历史进步历程,起到其内在的规约性、引领性。中国的现代性或现代性的中国逻辑之理论纲领的确立,是典范性模式、道路意义上社会现代化成功实践的中国智慧的集中体现,其核心要素和基本构成体现为以下三个方面:一是社会现代化何以可能的价值理念纠偏与价值基础重置;二是通向人类现代化正道和文明新道的合理性价值实践和价值目标的变革;三是“现代化多元主体并生共在”视域内人类新型现代化模式及其多元差异主体并生共在场域价值塑造。这三个方面核心要素的有机整合与良性互动,勾勒出了“中国式现代性”或“现代性中国逻辑”的基本结构和内在实质。

关键词：中国式现代化人类文明新形态生存论智慧中国现代性实践合理性

困境破境化境——音乐表演专业硕士学位论文写作路径探究

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中国音乐 2024年第3期 28-37页

作者：李祖胜中南林业科技大学

文章围绕音乐表演专业硕士学位论文写作的现状,就写作路径分困境、破境、化境三个层次进行递进式分析,结合“新文科”建设和跨学科研究理念,基于音乐表演专业硕士的独特性身份和知识结构所造成的写作困境,构建跨学科和多元化的应用性写... 详细信息

文章围绕音乐表演专业硕士学位论文写作的现状,就写作路径分困境、破境、化境三个层次进行递进式分析,结合“新文科”建设和跨学科研究理念,基于音乐表演专业硕士的独特性身份和知识结构所造成的写作困境,构建跨学科和多元化的应用性写作途径,并就如何可持续性地保障音乐表演专业硕士学位论文写作质量提出了人才培养的优化策略。

关键词：音乐表演专业硕士学位论文写作路径新文科

创新水平视角下数字经济对环境污染的影响——以长江经济带40个沿线城市为例

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长江流域资源与环境 2024年第1期33卷 126-138页

作者：陈祖海符斌中南民族大学经济学院湖北武汉430074 中国武陵山乡村发展研究院湖北武汉430074

数字经济发展迅速,探究数字经济对环境污染的影响和作用机制,对于推动长江经济带高质量发展具有重要意义。基于2011~2019年长江经济带沿线40个地级及以上城市的面板数据,探讨创新水平在数字经济与环境污染之间的作用机制,利用门槛效应... 详细信息

数字经济发展迅速,探究数字经济对环境污染的影响和作用机制,对于推动长江经济带高质量发展具有重要意义。基于2011~2019年长江经济带沿线40个地级及以上城市的面板数据,探讨创新水平在数字经济与环境污染之间的作用机制,利用门槛效应模型分析其非线性关系及作用区间,进一步借助空间杜宾模型考察数字经济产生的空间溢出效应。结果表明:(1)数字经济对于本地的环境污染具有显著的抑制作用,且经过多种稳健性检验,结论依然成立。(2)创新水平是数字经济影响环境污染的重要路径,且当创新水平超过门槛值6.41后,数字经济对于环境污染的影响系数将从-0.024变为-0.042,存在边际递增的治污效果。(3)在抑制本地环境污染的同时数字经济的空间溢出效应会加剧周边地区的污染排放;产量规模的扩张可能成为污染加剧的原因,数字经济对环境污染的抑制效果被生产规模扩大带来的污染增长所覆盖;为此,需要加强地区间协同治理,避免生产规模的不合理稀释数字经济的治污效果。

关键词：数字经济创新水平环境污染门槛效应空间溢出长江经济带