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Hypofibrinogenemia Caused by Hemocoagulase Injection:A Retrospective Study on Clinical Laboratory Findings

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Chinese Medical Sciences Journal 2020年第2期35卷 151-156页

作者： Jingwen Hu xiaosong qin Department of Laboratory Medicine Shengjing Hospital of China Medical UniversityShenyang 110004China

Objective Hemocoagulase injection based on the venom of Agkistrodon halys Pallas is widely used in the treatment of hemorrhagic *** study aimed to characterize the clinical laboratory findings of hemocoagulase-induced hypofibrinogenemia as the associated adverse reaction of hemocoagulase *** Wie retrospectively enrolled 27 in-patients who were treated with hemocoagulase injection for hemoptysis and developed hypofibrinogenemia during the period of January 1,2015 to March 31,*** data were collected and investigated,including clinical manifestations,hemostatic and fibrinolytic parameters,dosage of hemocoagulase,the medication time,and the cryoprecipitate blood product *** in fibrinogen,D-dimer,and fibrin/fibrinogen degradation products(FDP)before,during,and after the application of hemocoagulase injection were analyzed *** Plasma fibrinogen level during medication of hemocoagulase injection decreased significantly compared to that before the treatment(F=1.80,P<0.001),with the average decrease of 2.28 g/L(0.63-3.9 g/L).After withdrawal,fibrinogen level increased significantly compared to that during the medication(F=l.20,P<0.001),but was still lower than that before the medication(F=0.59,P=0.03).The D-dimer level and the FDP level after withdrawal decreased significantly compared to the levels during the medication(F=0.83,P=0.002;Wilcoxon-test,Z=-4.54,P<0.001).Spearman's correlation analyses did not find either fibrinogen change during-before the administration or FDP change after-during the administration was associated with the dosage of hemo coagulase(r=-0.17,P=0.40;r=-0.28,P=0.15;respectively)and the time of recovery from hypofibrinogenemia(r=-0.45,P=0.05;r=0.13,P=0.61;respectively).Conclusion Monitoring both clotting and fibrinolysis parameters is essential in the management of hemoptysis patients treated with hemocoagulase *** should be aware of hypofibrinogenemia and consider

关键词： hypofibrinogenemia hemocoagulase fibrinogen fibrinolysis

A low-cost and high-efficiency 10-in-1 test for the PCR-based screening of SARS-CoV-2 infection in low-risk areas

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Chinese Medical Journal 2022年第4期135卷 496-498页

作者： xiaosong qin Peng Gao Zhijie Zhang Zhijian Bo Shijun Li Mei Yang Jianhua Liu Lina Wu Ting Li Zuowei Zhao Yan Li Haodong Bian Yong Liu Department of Laboratory Medicine Shengjing Hospital of China Medical UniversityShenyangLiaoning 110004China Department of Laboratory Medicine Dalian Sixth People’s HospitalDalianLiaoning 1160311China Microbiological Laboratory Dalian Municipal Center for Disease Control and PreventionDalianLiaoning 116019China Department of Laboratory Medicine First Affiliated Hospital of Dalian Medical UniversityDalianLiaoning 116011China Committee of the Party Group Health Commission of DalianDalianLiaoning 116006China Clinical Laboratory and Medical Quality Control Center Health Service Center of Liaoning ProvinceShenyangLiaoning 110005China

To the Editor:As of August 9,2020,the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has infected 19,432,244 people and caused 721,594 deaths *** timely identify the infected persons,nucleic acid detection screenings have been carried out for high-infection risk groups in areas known to have coronavirus disease 19(COVID-19)cases,such as Wuhan,Beijing,and *** rapid identification of infected patients and the implementation of quarantine measures play an important role in preventing the transmission of ***,there are some issues associated with large-scale screening for this *** consumption of equipment and reagents for specimen collection and detection is high,resulting in elevated screening ***,with the increase in the number of samples collected,the testing capabilities of medical institutions have reached a saturation point,hindering the speed and scope of large-scale *** this reason,the mixed detection after RNA extraction(detection in a mixture of nucleic acids extracted from several patients)or before RNA extraction(detection in a mixture of pharyngeal swab transfer buffer obtained from different patients before nucleic acid extraction)has been proposed in many regions.[1]However,both the pooling of swab transfer buffer before nucleic acid extraction and pooling of RNA after nucleic acid extraction inevitably cause dilution of samples and decrease of detection ***,there is still a lack of research on how to effectively improve the screening efficiency and control the decrease of sensitivity caused by dilution in an appropriate *** this study,we designed a novel 10-in-1 test(ten pharyngeal swab samples from ten individuals were placed in one custom-made virus collection tube[CMT]for nucleic acid extraction and testing)by optimizing the current mixed acquisition technique,and after a promising pilot test.

关键词： screening cost globally

Correlation of gut microorganisms and non-volatile flavor substances provides new insights for breeding Scylla paramamosain

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JOURNAL OF OCEANOLOGY AND LIMNOLOGY 2024年第4期42卷 1-12页

作者： Gao, Gao Li, Xing qin, Kangxiang Hu, Yun Jiang, xiaosong Che, Chenxi Li, Yuntao Mu, Changkao Wang, Chunlin Wang, Huan Ningbo Univ Sch Marine Sci Ningbo 315211 Peoples R China Ningbo Univ Key Lab Appl Marine Biotechnol Minist Educ Ningbo 315211 Peoples R China

The farming of Scylla paramamosain with specific flavors has a higher commercial value, and the flavors are related to the integrated farming environment and non-volatile flavor substances, while the survival environment is one of the important ways to source gut microorganisms in the organism. In this study, the levels of dominant taxa in the gut flora of S. paramamosain from Mong Cai, Vietnam (VN), Taishan City, Guangdong Province (TS) of China, and Ninghai County, Ningbo City (NB) Zhejiang Province of China converged with those of S. paramamosain from Sanmen County, Ningbo City (CK1, CK2, and CK3) at 28 d of domestication. The top 15 genera with the highest abundance of VN, TS, and NB gut flora were the same as CK1, CK2, and CK3, but with different percentages, and gradually converged to CK1, CK2, and CK3, respectively, at 28 d of domestication. Correlation between intestinal flora and non-volatile flavor substances in the hepatopancreas at the percentage level of relative abundance of bacterial genera found that above 28 d of domestication, Muribaculaceae, Psychrilyobacter, Clostridia_vadinBB60_group, Halarcobacter Carboxylicivirga, Sediminispirochaeta may be the most important genera affecting flavor amino acids of VN. Sediminispirochaeta, Carboxylicivirga, Halarcobacter, Photobacterium, ZOR0006, Psychrilyobacter, and Pseudomonas may be the most important genera affecting flavor amino acids of NB. Sediminispirochaeta, Carboxylicivirga, Halarcobacter, Photobacterium, ZOR0006, Vibrio, and Sphingomonas may be the most important genera affecting flavor amino acids of TS. These results show that the intestinal flora structure of crabs from different areas were domesticated in the same area for at least 28 d before they converged to that of the domesticated crab, and the most important genera affecting the flavor amino acids of TS, VN, and NB were also identified. The results of this study provide a reference and basis for the technique of directional cultivation of

关键词： survival environment Scylla paramamosain intestinal flora structure non-volatile flavor substances directional breeding MUD CRAB SCYLLA MICROBIOTA SEQUENCES

以孤立性天门冬氨酸转氨酶升高为表现的儿童巨天门冬氨酸转氨酶血症1例

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中华检验医学杂志 2022年第12期45卷 1279-1281页

作者：张晋吴丽娜刘文翰秦晓松中国医科大学附属盛京医院检验科辽宁省医学检验临床医学研究中心沈阳110004

当临床中遇到无法解释的天门冬氨酸转氨酶(AST)活性升高时,需要考虑到巨天门冬氨酸转氨酶血症的可能。本病例为1例3岁女童发现血清AST活性孤立性升高,围绕引起AST升高的常见病因进行检查,未发现明显异常。应用聚乙二醇沉淀法检测,其沉... 详细信息

当临床中遇到无法解释的天门冬氨酸转氨酶(AST)活性升高时,需要考虑到巨天门冬氨酸转氨酶血症的可能。本病例为1例3岁女童发现血清AST活性孤立性升高,围绕引起AST升高的常见病因进行检查,未发现明显异常。应用聚乙二醇沉淀法检测,其沉淀活性为98.7%,诊断为巨天门冬氨酸转氨酶血症。

关键词：天门冬氨酸转氨酶巨天门冬氨酸转氨酶聚乙二醇聚乙二醇沉淀法

Heterogeneous Mixed Species Immunization Reduces Protective Effect on Re-challenge of Plasmodium yoelii 17XL in BALB/c Mice

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Heterogeneous Mixed Species Immunization Reduces Protective ...

外周血NLR、MLR、SⅡ在甲状腺髓样癌中的应用价值

第八届全国免疫学学术大会

作者： xiaosong qin Jun Liu Yonghui Feng Yaming Cao Department of Immunology Basic Medicine College of China Medical University Department of Laboratory Medicine Shengjing Hospital of China Medical University

To determine the interactions between infections of different species Plasmodium,we established murine malaria models with P.c AS,***,***(P.v)single immunization,or P.c AS+***+P.v mixed immunization and then observed the effects of different immunization styles on P.y17XL *** proliferation of parasites,Th cellular expansion,the changes in the proportions of CD4+CD25+Foxp3+T cells(regulatory T cells,Tregs)and the production of cytokines associated and humoral immune response were dynamically and systematically *** P.c and P.v single immunized mice survived for 7 days and

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现代肿瘤医学 2022年第10期30卷 1753-1757页

作者：林琳李娜吴丽娜秦晓松中国医科大学附属盛京医院检验科辽宁沈阳110000

目的:探讨外周血中性粒细胞与淋巴细胞比值(NLR)、单核细胞与淋巴细胞比值(MLR)、系统免疫炎症指数(SⅡ)在甲状腺髓样癌(MTC)中的应用价值。方法:以我院2012年2月至2020年7月收治的MTC患者50例(MTC组)、甲状腺乳头状癌患者50例(PTC组)... 详细信息

目的:探讨外周血中性粒细胞与淋巴细胞比值(NLR)、单核细胞与淋巴细胞比值(MLR)、系统免疫炎症指数(SⅡ)在甲状腺髓样癌(MTC)中的应用价值。方法:以我院2012年2月至2020年7月收治的MTC患者50例(MTC组)、甲状腺乳头状癌患者50例(PTC组)、健康体检者50例(健康对照组)为研究对象,比较三组患者外周血NLR、MLR、SⅡ水平的差异,并采用受试者工作特征曲线(ROC)分析上述三个指标及其联合检测在MTC中的诊断效能,进一步根据上述三个指标在诊断MTC中的最佳诊断界值分析其与MTC临床病理特征的相关性。结果:比较各组间外周血NLR、MLR、SⅡ水平示:MTC组NLR显著高于PTC组,差异有统计学意义(P<0.05);MTC组MLR、SⅡ水平显著高于PTC组与HC组,差异有统计学意义(P<0.05)。通过ROC曲线分析发现,NLR、MLR、SⅡ单独诊断MTC患者的ROC曲线下面积分别为0.620、0.681、0.634,NLR、MLR、SⅡ三者联合检测ROC曲线下面积为0.726。MLR单独检测及联合检测对MTC的诊断效能高于NLR、SⅡ单独检测(P<0.05)。MTC患者MLR与淋巴结转移及TNM分期有关,比较差异有统计学意义(P<0.05)。结论:NLR、MLR、SⅡ对MTC具有诊断价值,MLR单独检测及联合检测对MTC的诊断效能高于NLR、SⅡ单独检测。MLR与MTC患者淋巴结转移及TNM分期有关。

关键词：甲状腺髓样癌中性粒细胞-淋巴细胞比值单核细胞-淋巴细胞比值系统免疫炎症指数

基于机器学习算法评估七种肿瘤相关自身抗体在非小细胞肺癌中的应用价值

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中华预防医学杂志 2023年第11期57卷 1827-1838页

作者：郝莹吴丽娜吕薏潼刘毓哲秦晓松郑锐中国医科大学附属盛京医院检验科沈阳110000 辽宁省医学检验临床医学研究中心沈阳110000 香港城市大学生物科学专业中国香港999077 中国医科大学附属盛京医院呼吸与危重症医学科沈阳110000

目的以机器学习算法建立并验证的诊断模型为依据,探讨7种肿瘤相关自身抗体(TAABs),即抗p53、PGP9.5、SOX2、GAGE7、GBU4-5、MAGEA1和CAGE抗体,在非小细胞肺癌(NSCLC)诊断及其与良性肺结节鉴别诊断中的应用价值。方法本研究为临床病例回... 详细信息

目的以机器学习算法建立并验证的诊断模型为依据,探讨7种肿瘤相关自身抗体(TAABs),即抗p53、PGP9.5、SOX2、GAGE7、GBU4-5、MAGEA1和CAGE抗体,在非小细胞肺癌(NSCLC)诊断及其与良性肺结节鉴别诊断中的应用价值。方法本研究为临床病例回顾性研究。模型建立队列来自2018年11月至2021年6月于中国医科大学附属盛京医院胸外科进行肺癌根治术的227例初治NSCLC患者为NSCLC组,同时选择良性肺结节120例、肺炎122例及健康者120名作为对照组;外部验证队列来自2022年5月至12月,中国医科大学附属盛京医院胸外科行肺癌根治术的100例初治NSCLC患者为NSCLC组,同时选择良性肺结节36例、肺炎32例及健康者44名作为对照组。将NSCLC分成早期(0~ⅠB期)与中晚期(ⅡA~ⅢB期)亚组。采用酶联免疫法检测7种TAABs,电化学发光法检测癌胚抗原(CEA)和细胞角蛋白19片段(CYFRA21-1)在各组之间的血清浓度。采用4种机器学习算法,包括极限梯度提升(XGBoost)、Lasso逻辑回归(LR)、朴素贝叶斯(NB)、以及支持向量机(SVM)分别建立多指标联合检测模型,并选择XGBoost作为最佳算法建立了针对临床应用的患者在线风险评估工具。结果除抗p53抗体外,其余6种TAABs及CEA、CYFRA21-1在NSCLC中血清浓度显著升高(P<0.05);中晚期NSCLC患者血清抗SOX2[1.50(0.60,10.85)U/ml vs.0.8(0.20,2.10)U/ml,Z=2.630,P<0.05]和MAGEA1抗体[0.20(0.10,0.43)U/ml vs.0.10(0.10,0.20)U/ml,Z=2.289,P<0.05]及CEA[3.13(2.12,5.64)ng/ml vs.2.11(1.25,3.09)ng/ml,Z=3.970,P<0.05]和CYFRA21-1[4.31(2.37,7.14)ng/ml vs.2.53(1.92,3.48)ng/ml,Z=3.959,P<0.05]浓度显著高于早期。采用机器学习算法XGBoost建立多指标联合检测模型(剔除p53后),6-TAABs联合CYFRA21-1均为诊断NSCLC及NSCLC早期的最佳组合模型,诊断最佳界值分别为0.410、0.701、0.744,AUC分别为0.828、0.757、0.741(NSCLC vs.对照组,NSCLC vs.良性肺结节组,早期NSCLC vs.良性肺结节组)。模型的外部验证队列的AUC分别为0.760、0.710、0.660(NSCLC vs.对照组,NSCLC vs.良性肺结节组,早期NSCLC vs.良性肺结节组)。结论在NSCLC诊断中,6-TAABs诊断效能优于传统肿瘤标志物CEA和CYFRA21-1;6-TAABs+CYFRA21-1检测模型为诊断NSCLC最优的模型,其可有效地辅助临床用于NSCLC及NSCLC早期与良性肺结节的鉴别诊断,在肺癌预防和早期筛查中发挥重要作用。

关键词：非小细胞肺癌自身抗体机器学习诊断价值

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基于分数阶模型的锂离子电池荷电状态估计

机械工程学报 2024年第8期60卷 224-232,244页

作者：石琴蒋正信刘翼闻魏宇江胡晓松贺林合肥工业大学汽车与交通工程学院合肥230009 自动驾驶汽车安全安徽省重点实验室合肥230009 安徽省智慧交通车路协同工程研究中心合肥230009 重庆大学机械与运载工程学院重庆400044

荷电状态精确估计是锂离子动力电池安全应用的关键技术之一,现有的估计方法并不完全适配锂离子电池系统,在准确性、稳定性和实用性方面均有较大的提升空间。为了准确描述锂离子电池系统动态特性并且提升估计精度与稳定性,提出一种基于... 详细信息

荷电状态精确估计是锂离子动力电池安全应用的关键技术之一,现有的估计方法并不完全适配锂离子电池系统,在准确性、稳定性和实用性方面均有较大的提升空间。为了准确描述锂离子电池系统动态特性并且提升估计精度与稳定性,提出一种基于分数阶电池模型的自适应扩展卡尔曼粒子滤波方法。在采用免疫遗传算法对锂离子电池分数阶模型进行参数辨识的过程中,应用“记忆库”减小算法计算量,引入“亲和度”缓解算法陷入局部最优解的问题。采用基于模型开发的手段,将提出的控制算法下载到电池管理系统控制器中,经过ECE和UDDS工况测试对比验证:二阶分数阶电路模型的端电压误差最大不超过13.96 mV,平均误差为2.4~4.2 mV,表明分数阶模型对电流的变化更为敏感且更能表现电池的电压变化性能,可以有效保证电池荷电状态的计算精度。提出方法较EKF的荷电状态估计精度提升50%以上,并且收敛时间大大缩短,表明在粒子滤波中引入自适应卡尔曼滤波进行校正,可以滤除噪声、增强估计算法准确性和鲁棒性。

关键词：电池荷电状态分数阶电池模型自适应卡尔曼粒子滤波免疫遗传算法

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自流充填系统的管道压力与流量特征研究

矿冶工程 2024年第3期44卷 6-10页

作者：李小松赵承佑秦帅肖柏林中色非洲矿业有限公司基特韦赞比亚22592 北京科技大学土木与资源工程学院北京100083

以某高浓度自流充填矿山为例,采用理论分析、室内试验及实测验证相结合的方式,研究了自流充填系统管网参数与阻力特征。结果表明,自流充填系统工序多,正常充填的流量波动范围可达100~240 m^(3)/h,压力1.2~2.2 MPa。管道具体点位的流量... 详细信息

以某高浓度自流充填矿山为例,采用理论分析、室内试验及实测验证相结合的方式,研究了自流充填系统管网参数与阻力特征。结果表明,自流充填系统工序多,正常充填的流量波动范围可达100~240 m^(3)/h,压力1.2~2.2 MPa。管道具体点位的流量呈似正态分布,均值为190 m^(3)/h;压力具有2个区间特征峰,分别为1.86 MPa和3.04 MPa,单一点位的管道参数不能用于分析与判断堵管、泄漏等工况。管道区间压力差和流量差具有显著的正态分布特征,统计数学期望值分别为4.62 m^(3)/h和0.64 MPa,可用瞬时流量差和压力差判断管道堵泄状态。用Swamee-Aggarwal公式预测层流-紊流过渡区的管流阻力为2.08 MPa/km,与实测值2.15 MPa/km相吻合。

关键词：深井充填自流充填管道压力管流阻力浆体流量管道输送