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Causal relationship between 14 site-specific cancers and venous thromboembolism

Cancer Innovation 2022年第4期1卷 316-327页

作者： Xiong Chen xiaosi hong Shulu Luo Jiahao Cai Guiwu Huang Runnan Shen Lin Lv Gaochen Bai Wen Fu Li Yan Guochang Liu Kai Huang Qinchang Chen Department of Paediatric Urology Guangzhou Women and Children's Medical CenterGuangzhou Medical UniversityGuangzhouChina Department of Paediatric Surgery Guangzhou Institute of PaediatricsGuangzhou Medical UniversityGuangzhouChina Department of Endocrinology Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhouChina Department of Prosthodontics Hospital of StomatologyGuanghua School of StomatologyGuangdong Provincial Key Laboratory of StomatologySun Yat-sen UniversityGuangzhouChina Department of Pediatric Neurology Guangzhou Women and Children's Medical CenterGuangzhou Medical UniversityGuangzhouChina Department of Orthopedics The First Affiliated Hospital of Sun Yat-Sen UniversityGuangzhouChina Medical School Sun Yat-sen UniversityGuangzhouChina Department of Cardiovascular Surgery Sun Yat-sen Memorial HospitalGuangzhouChina Department of Pediatric Cardiology Guangdong Provincial Key Laboratory of Structural Heart DiseaseGuangdong Provincial People's HospitalGuangdong Academy of Medical SciencesGuangdong Cardiovascular InstituteGuangzhouChina

Background:It has been observed that cancer and venous thromboembolism(VTE)are associated,but anticancer therapy may violate the causality.Therefore,this study aimed to elucidate the causal relationship of various cancers to VTE using Mendelian randomization(MR).Methods:Three MR methods were used to estimate causal effects:Inverse variance weighted(IVW),MR-Egger and weighted median.Sensitivity analyses included Cochran's Q-test,MR-Egger intercept test and MRPRESSO.Gene ontology enrichment analysis was performed to elucidate the underlying mechanisms of VTE development in cancer patients.Results:The primary IVW approach showed that non-Hodgkin's lymphoma(NHL)might increase the risk of VTE(odds ratio[OR]:1.20,95%confidence interval[95%CI]:1.00–1.44,p=0.045),while melanoma possibly reduced the risk of VTE(OR:0.89,95%CI:0.82–0.97,p=0.006),although there was no significance after adjustment for multiple testing.No association was observed between VTE risk and other site-specific cancers.Gene ontology enrichment analysis revealed that vitamin D played an important role in the development of VTE in cancer patients.Conclusions:Our findings suggested that genetically predicted NHL was associated with higher VTE risk,whereas melanoma had lower VTE risk compared with other site-specific cancers.Moreover,this study suggested that anticancer therapy and increased extensive examination might play a more important role in VTE development than the nature of cancer.

关键词： cancer venous thromboembolism Mendelian randomization causal effect

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Recent Advances in Covalent Organic Framework Electrode Materials for Alkali Metal-Ion Batteries

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CCS Chemistry 2023年第6期5卷 1259-1276页

作者： Jianlu Sun Yifan Xu Yanqi Lv Qichun Zhang xiaosi Zhou1 School of Chemistry and Materials Science Nanjing Normal UniversityNanjing 210023 Department of Materials Science and Engineering City University of Hong KongKowloonHong Kong SAR 999077 Center of Super-Diamond and Advanced Films(COSDAF) City University of Hong KongKowloonHong Kong SAR 999077

Owing to the shortcomings of traditional electrode materials in alkalimetal-ion batteries(AIBs),such as limited reversible specific capacity,low power density,and poor cycling performance,it is particularly important to develop new electrode materials.Covalent organic frameworks(COFs)are crystalline porous polymers that incorporate organic building blocks into their periodic structures through dynamic covalent bonds.COFs are superior to organic materials because of their high designability,regular channels,and stable topology.Since the first report of D_(TP)-A_(NDI)-COF as a cathode material for lithium-ion batteries in 2015,research on COF electrode materials has made continuous progress and breakthroughs.This review briefly introduces the characteristics and current challenges associated with COF electrode materials.Furthermore,we summarize the basic reaction types and active sites according to the categories of covalent bonds,including B–O,C=N,C–N,and C=C.Finally,we emphasize the perspectives on basic structure and morphology design,dimension and size design,and conductivity improvement of COFs based on the latest progress in AIBs.We believe that this review provides important guidelines for the development of high-efficiency COF electrode materials and devices for AIBs.

关键词： covalent organic frameworks alkali metal-ion batteries electrochemically active sites synthesis strategies high efficiency

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Tetra-EDOT substituted 3D electrochromic polymers with lower band gaps

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Science China Chemistry 2017年第1期60卷 90-98页

作者： Jingjing Shi Imran Murtaza Shan Shao xiaosi Zhu Yang Zhao Mengmeng Zhu Osamu Goto hong Meng School of Advanced Materials Peking University Shenzhen Graduate School Key Laboratory of Flexible Electronics & Institute of Advanced Materials Jiangsu National Synergetic Innovation Center for Advanced MaterialsNanjing Tech University Department of Physics International Islamic University

A couple of novel electrochromic materials poly(2,3,4,5-tetrakis(2,3-hydrothieno[3,4-b]dixin-5-yl)-1-methyl-1H-pyrrole)(P(t-EDOT-mPy))and poly(5,5',5",5'"-(thiophene-2,3,4,5-tetrayl)tetrakis(2,3-dihydrothieno[3,4-b][1,4]dioxine))(P(t-EDOTTh))are electrodeposited via multi-position polymerization of their tetra-EDOT substituted monomers t-EDOT-mPy and t-EDOT-Th,respectively.Compared with the linear 2D structured poly(thiophene)(E_g=2.2 eV)and poly(2,5-bis(2,3-dihydrothieno[3,4-b][1,4]dioxin-5-yl)thiophene)(E_g=1.7eV),P(t-EDOT-Th)(E_g=1.62eV)has the lowest band gap.Hence,we speculate that the band gaps of the two polymers,having 3D structures,are decreased in contrast to non-substituted polymers or bi-EDOT substituted polymers,thiophene and 1-methyl-1H-pyrrole.The results indicated that P(t-EDOT-Th)thin films are more stable and show higher transmittance amid two polymers,which may find their utilization in organic optoelectronics.

关键词：变色聚合物带隙 3d 电致变色材料 TETRA 二维结构三维结构光电子学

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Shenzhousia qilianshanensis gen. et sp. nov. (Protodonata, Meganeuridae), a giant dragonfly from the Upper Carboniferous of China

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Progress in Natural Science:Materials International 2006年第3期16卷 328-330页

作者： ZHANG Zhijun, hong Youchong, LU Liwu, FANG xiaosi and JIN Yuegao (Department of Palaeontology, the Geological Museum of China, Beijing 100034, China Beijing Museum of Natural History, Beijing 100050, China) Department of Palaeontology the Geological Museum of China Beijing 100034 China Beijing Museum of Natural History Beijing 100050 China

A new dragonfly of family Meganeuridae Shenzhousia qilianshanensis gen. et sp. nov., discovered from Ningxia Hui Autonomous Region in North China, is described in the present paper. It has an estimated wingspan of about 450-500mm and may be the largest fossil insect in Late Carboniferous Namurian Stage discovered by far. The new species is referred to Meganeuridae because of the presence of the characteristic oblique vein between anterior branch of radius (RA) and posterior branch of radius (RP) near the base of RP2. It differs from other genera within the family in the following characteristics: Precostal area short and not extending to the midwing; posterior branch of subcostal vein short, merging into costal vein near the level of originating point of IR2; RP forking earlier than anterior branch of media basally; RP1+2 and RP3+4 parallel and close to each other for a long distance, and then diverge gradually surpass midwing.

关键词： Namurian Meganeuridae Ningxia Hui Autonomous Region Upper Carboniferous Tupo Formation.

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Molecular engineering tuning optoelectronic properties of thieno[3,2-b]thiophenes-based electrochromic polymers

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Science China Chemistry 2017年第1期60卷 63-76页

作者： Mengmeng Zhu Weishuo Li Panpan Xu Jingjing Shi Shan Shao xiaosi Zhu Yitong Guo Yaowu He Zhao Hu hongtao Yu Yanan Zhu Igor F.Perepichka hong Meng School of Advanced Materials Peking University Shenzhen Graduate School School of Chemistry Bangor University

Thieno[3,2-b]thiophene(TT)monomers end-capped with 3,4-ethylenedioxythiophene(EDOT)moieties are electropolymerized to formπ-conjugated polymers with distinct electrochromic(EC)properties.Steric and electronic factors(electron donor and acceptor substituents)in the side groups of the TT core,as well as the structure of the polymer backbone strongly affect the electrochemical and optical properties of the polymers and their electrochromic characteristics.The studied polymers show low oxidation potentials,tunable from-0.78 to+0.30 V(vs.Fc/Fc^+)and the band gaps from 1.46 to 1.92 eV and demonstrate wide variety of color palettes in polymer films in different states,finely tunable by structural variations in the polymer backbone and the side chains.EC materials of different colors in their doped/dedoped states have been developed(violet,deep blue,light blue,green,brown,purple-red,pinkish-red,orange-red,light gray,cyan and colorless transparent).High optical contrast(up to 79%),short response time(0.57-0.80 s),good cycling stability(up to 91%at 2000 cycles)and high coloration efficiency(up to 234.6 cm2C^(-1))have been demonstrated and the influence of different factors on the above parameters of EC polymers have been discussed.

关键词：变色聚合物噻吩基光电性能分子工程调整电子供体乙撑二氧噻吩主链结构

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Room temperature ferromagnetism of Ni, (Ni, Li), (Ni, N)-doped ZnO thin films

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中国科学：技术科学 2010年第2期40卷 198-205页

作者： YE XiaoJuan SONG HaiAn Zhong Wei QI xiaosi XU MeiHua JIN ChangQing YANG ZaiXin AU ChakTong DU YouWei National Laboratory of Solid State Microstructures Nanjing University Nanjing 210093 China Chemistry Department Hong Kong Baptist University Hong Kong China

Ni-doped ZnO thin films (Ni concentration up to 10 mol%) were generated on Si (100) substrates by a sol-gel technique. The films showed wurtzite structure and no other phase was found. The chemical state of Ni was found to be bivalent by X-ray photoelectron spectroscopy. The results of magnetic measurements at room temperature indicated that the films were ferromagnetic, and magnetic moment decreased with rise of Ni concentration. The magnetization of Ni (10 mol%)-doped ZnO film annealed in nitrogen was lower than that annealed in argon, suggesting that the density of defects had an effect on ferromagnetism.

关键词：铁磁性镍锂温度化学工业化工材料

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将Cu_(2)S超细纳米粒子均匀植入碳纳米线以实现高效钾离子电池负极

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Science China Materials 2023年第7期66卷 2613-2620页

作者：朱川南赵旭雯徐一帆段丽平田瑞琪廖家英周小四 School of Chemistry and Materials Science Nanjing Normal UniversityNanjing 210023China Department of Materials Science and Engineering City University of Hong KongKowloon 999077Hong Kong SARChina

由于其高容量和丰富的资源,过渡金属硫化物(TMS)已被证明是钾离子电池具有吸引力的负极材料之一.然而,TMS通常受到导电性差和体积膨胀大的限制,可能导致结构不稳定和电池循环性能差.本工作通过将超小Cu_(2)S纳米粒子植入碳纳米线(Cu_(2)... 详细信息

由于其高容量和丰富的资源,过渡金属硫化物(TMS)已被证明是钾离子电池具有吸引力的负极材料之一.然而,TMS通常受到导电性差和体积膨胀大的限制,可能导致结构不稳定和电池循环性能差.本工作通过将超小Cu_(2)S纳米粒子植入碳纳米线(Cu_(2)S@C NWs),显著减轻了纳米粒子聚集和有害的结构退化.与传统的Cu_(2)S颗粒相比,每根纳米线的体积变化都得到了有效调节,这极大地改善了形态完整性,从而显著提高了循环寿命.正如预期的那样,Cu_(2)S@C NW负极可提供391.1 mA h g^(-1)的大可逆容量,在5 A g^(-1)时具有118.1 mA h g^(-1)的出色倍率性能,以及在2 A g^(-1)下经过500次循环后77.2%的高容量保持率.此外,当Cu_(2)S@C NW负极与KVP04F/CNTs正极组装形成钾离子全电池时,在50 mA g^(-1)下循环100次后显示出110.8 mA h g^(-1)的良好放电容量.这种纳米颗粒阻聚策略拓宽了纳米工程的视野,以释放嵌脱钾引起的应力,并促进钾离子电池高效负极的进一步发展.

关键词： potassium-ion battery anode Cu_(2)S carbon nanowires porous structure

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强迫性障碍患者厌恶加工的性别差异

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中华行为医学与脑科学杂志 2018年第6期27卷 544-550页

作者：王本红李晓驷钟慧谢雯穆菁菁靳红肖季平安徽医科大学医学心理学系合肥230032 安徽医科大学精神卫生临床学院、安徽省精神卫生中心合肥230032

目的探讨强迫性障碍患者厌恶加工的性别差异。方法采用帕多瓦量表（Paduain—ventory—Washington State University revision，PI-WSUR）、耶鲁布朗强迫量表（Yale—Browno bsessive-com-pulsive scale，Y-BOCS）和词汇判断任务对74例强迫性障碍患者（男39例，女35例）和65例健康对照者（男35例，女30例）评估其强迫症状及严重程度，并记录包括核心厌恶词、道德厌恶词和中性词的正确率、反应时以及厌恶评级，分析强迫性障碍患者组以及对照组厌恶加工的性别差异。结果强迫性障碍组男性与女性在核心厌恶词[（753．6±84．1）ms，（711．8±83．8）ms]、道德厌恶词[（813．5±89．0）ms，（749．4±81．4）ms]以及中性同[（775．3±91．8）ms，（725．9±104．2）ms]的反应时差异均具有统计学意义（P〈0．05或P〈0．01），正确率及厌恶评级上均差异无统计学意义。对照组仅在中性词反应时比较中男性比女性长[（712．7±95．7）ms，（658．8±64．0）ms]，差异具有统计学意义（P〈0．01）。Pearson相关分析显示男性与女性均具有核心厌恶词反应时与PI—WSUR总分的负相关（P〈0．05），OCD患者PI—WSUR、Y—BOCS与厌恶加工的相关变量存在性别差异。结论强迫性障碍患者厌恶加工存在性别差异，强迫性障碍患者女性的核心厌恶和道德厌恶均高于男性，女性强迫性障碍患者具有特殊的高道德厌恶感。

关键词：强迫性障碍核心厌恶道德厌恶性别差异

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华裔女作家汤亭亭《无名女子》中的创伤叙事

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安阳工学院学报 2020年第3期19卷 52-54页

作者：王晓驷广东南方职业学院经济贸易学院广东江门529020

在《无名女子》故事中,无名女子是中国19世纪20年代赴美劳工的留守妻子,因婚外生子,遭到全村人的攻击,被迫投井自杀,家人也从此不再提起她。作者利用东西方文化差别,站在西方文化的立场上对中国的创伤故事进行重构,对无名女子的沉默和... 详细信息

在《无名女子》故事中,无名女子是中国19世纪20年代赴美劳工的留守妻子,因婚外生子,遭到全村人的攻击,被迫投井自杀,家人也从此不再提起她。作者利用东西方文化差别,站在西方文化的立场上对中国的创伤故事进行重构,对无名女子的沉默和死亡采用隐喻叙事策略,将女性创伤经历从一种文化移植到另一种文化,从而达到给无名女子恢复名誉和治愈创伤的目的。

关键词：《无名女子》创伤叙事《女勇士》

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工艺冷凝液中压汽提装置的应用

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化工设备与管道 2000年第3期37卷 13-15页

作者：朱小四管泽沛闫宏河南中原大化集团公司濮阳457004 河南濮阳市甲醇厂濮阳457004

介绍大型氨厂中工艺冷凝液中压汽提装置的应用情况 ,对出现的问题进行了分析和探讨。

关键词：大型氨厂工艺冷凝液中压汽提装置合成氨生产

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