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L-GrAFT_(7) has High Accuracy in Predicting Early Allograft Failure after Liver Transplantation: A Multicenter Cohort Study in China

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Journal of Clinical and Translational hepatology 2024年第1期12卷 62-69页

作者： Songming Li Qijie Luo Shirui Chen Zehua Jia Tielong Wang Xinyu Yu Wenjing Wang YuyiZhang Jiaxing Zhu Feiwen Deng Qiang Sun Zhiyong Guo xiaoshun he Organ Transplant Center The First Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdongChina Guangdong Provincial Key Laboratory of Organ Donation and Transplant Immunology GuangzhouGuangdongChina Guangdong Provincial International Cooperation Base of Science and Technology GuangzhouGuangdongChina NHC Key Laboratory of Assisted Circulation(Sun Yat-sen University) GuangzhouGuangdongChina General Surgery Dept.1 Zhongshan People’s HospitalZhongshan Hospital of Sun Yat-Sen UniversityZhongshanGuangdongChina Department of hepatobiliary Surgery The First People’s Hospital of FoshanFoshanGuangdongChina

Background and Aims:Increasing utilization of extended criteria donor leads to an increasing rate of early allograft failure after liver ***,consensus of definition of early allograft failure is ***:A retrospective,multicenter study was performed to validate the Liver Graft Assessment Following Transplantation(L-GrAFT)risk model in a Chinese cohort of 942 adult patients undergoing primary liver transplantation at three Chinese centers.L-GrAFT(L-GrAFT7 and L-GrAFT10)was compared with existing models:the Early Allograft Failure Simplified Estimation(EASE)score,the model of early allograft function(MEAF),and the Early Allograft Dysfunction(EAD)*** and multivariate logistic regression were used to find risk factors of L-GrAFT high-risk ***:L-GrAFT7 had an area under the curve of 0.85 in predicting 90-day graft survival,significantly superior to MEAF[area under the curve(AUC=0.78,p=0.044)]and EAD(AUC=0.78,p=0.006),while there was no statistical significance between the predicting abilities of L-GrAFT7 and EASE(AUC=0.84,p>0.05).Furthermore,L-GrAFT7 maintains good predicting ability in the subgroup of high-donor risk index(DRI)cases(AUC=0.83 ***,p=0.007 ***,p=0.014)and recipients of donors after cardiac death(AUC=0.92 ***,phe DRI score were selected as independent risk factors of a L-GrAFT7 high-risk ***:The accuracy of L-GrAFT7 in predicting early allograft failure was validated in a Chinese multicenter cohort,indicating that it has the potential to become an accurate endpoint of clinical practice and transitional study of machine perfusion.

关键词： Early allograft failure Graft survival Liver transplantation Risk prediction model Multicenter study

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The future of organ-oriented research and treatment

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hepatobiliary Surgery and Nutrition 2019年第5期8卷 502-505页

作者： Qiang Zhao Yu Nie Zhiyong Guo xiaoshun he Organ Transplant Center The First Afifliated HospitalSun Yat-sen UniversityGuangzhou 510080China

Organ-oriented research platform is based on machineperfusion(MP)technology providing continuous oxygenand nutrient supply for harvested *** permitsin vivo and in vitro investigation and represents one of thelatest innovations in the quest for a model to explore eitherphysiological or pathological processes of the whole ***,the ex vivo animal perfusion model has provento be an effective and reproducible translational researchplatform(1).

关键词： treatment vivo organs

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无缺血器官技术移植研究进展

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科技导报 2024年第8期42卷 76-82页

作者：李冶夫张明熙吴少海陈宏珲黄金波鲁昌涛姚尧赵强何晓顺奇点医疗科技(广州)有限公司广州511338 中山大学附属第一医院广州510062 广东省医疗器械质量监督检验所广州510663

近年来,加入移植等待名单的患者数量逐年升高,但由于供体缺乏,因此扩展标准供体(ECD)器官的利用率逐年增高。从改善病人预后、改变肝内代谢,同时避免缺血-再灌注损伤(IRI),实现肝脏活性评估并提高移植物利用率3个方面,总结了无缺血器官... 详细信息

近年来,加入移植等待名单的患者数量逐年升高,但由于供体缺乏,因此扩展标准供体(ECD)器官的利用率逐年增高。从改善病人预后、改变肝内代谢,同时避免缺血-再灌注损伤(IRI),实现肝脏活性评估并提高移植物利用率3个方面,总结了无缺血器官移植(IFOT)技术进展,展望了无缺血器官移植的发展前景。无缺血器官移植技术在未来可能会改变器官移植的方式,技术创新和可移动机器灌注设备开发使用将助推该技术的进一步发展。

关键词：无缺血器官移植常温机械灌注缺血-再灌注损伤早期同种异体移植物功能障碍

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累及髂窝的巨大多囊肝多囊肾患者的肝肾联合移植1例

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中华器官移植杂志 2024年第10期45卷 728-728,F0003页

作者：刘龙山张纹彬鞠卫强陈茂根韦勇成何映蓁李军王长希何晓顺中山大学附属第一医院器官移植中心广州510080

本文报道1例累及髂窝的巨大多囊肝多囊肾患者的肝肾联合移植。术前CT影像提示多囊肾体积大占据部分髂窝空间,拟行原肾脏下极去顶减压术以摆放移植肾。经"全肝切除+原位肝移植"后,发现右侧多囊肾可自行上移,释放了髂窝空间顺利放置移植肾... 详细信息

本文报道1例累及髂窝的巨大多囊肝多囊肾患者的肝肾联合移植。术前CT影像提示多囊肾体积大占据部分髂窝空间,拟行原肾脏下极去顶减压术以摆放移植肾。经"全肝切除+原位肝移植"后,发现右侧多囊肾可自行上移,释放了髂窝空间顺利放置移植肾,术后多囊肾明显缩小。该病例为此类疾病的肝肾联合移植手术方案提供了一定参考。

关键词：多囊肝多囊肾肝肾联合移植肝移植肾移植

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The development and function of follicular helper T cells in immune responses

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Cellular & Molecular Immunology 2012年第5期9卷 375-379页

作者： Maogen Chen Zhiyong Guo Weiqiang Ju Bernhard Ryffel xiaoshun he Song Guo Zheng Organ Transplant Center 1st Affiliated Hospital of Sun Yat-Sen UniversityGuangzhouChina Division of Rheumatology and Immunology Department of MedicineUniversity of2Division of Rheumatology and ImmunologyDepartment of MedicineUniversity of Southern CaliforniaKeck School of MedicineLos AngelesCAUSA UMR6218 Molecular ImmunologyUniversity of Orleans and CNRS3b rue de la FerollerieOrleansFrance

Follicular helper T cells （Tfh） have been referred as a lineage that provides a help for B cells to proliferate and undergo antibody affinity maturation in the germinal center. Evidence has supported that Tfh subset development, like other lineages, is dependent on microenvironment where a particular transcriptional program is initiated. It has been shown that Bcl-6 and IL-21 act as master regulators for the development and function of Tfh cells. Tfh dysregulation is involved in the development of autoimmune pathologies, such as systemic lupus erythematosus, rheumatoid arthritis and other autoimmune diseases. The present review highlights the recent advances in the field of Tfh cells and focus on their development and function.

关键词： autoimmune diseases follicular helper T cells systemic lupus erythematousus

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Blocking P2X7R signaling pathway abate chronic allograft rejection by inhibiting M2 macrophage subset polarization and infiltration

Blocking P2X7R signaling pathway abate chronic allograft rej...

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第十一届全国免疫学学术大会

作者： Wu chenglin Wang Changxi he xiaoshun Li Xianchang Organ Transplant Center 1st Affiliated Hospital of Sun Yat-Sen University Center for Immunobiology and Transplantation Research Houston Methodist Hospital and Houston Methodist Research Institute

The long-term outcome of allografts remains poor in the clinic,and most transplants are lost due to chronic rejection,and the exact mechanism underlying the slow and progressive vasculature damage in allografts remains poorly *** used a mouse heart transplant model to examine cell types that infiltrate chronically rejected allografts and

关键词： chronic rejection heart transplantation CTLA-4Ig P2X7R bone marrow derived macrophage

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常温区域机械灌注研究进展

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实用器官移植电子杂志 2024年第3期12卷 281-284页

作者：李冶夫张明熙黄敏菊吴少海刘国光黄金波张嘉懿赵强何晓顺中山大学附属第一医院广东广州510062 广东省医疗器械质量监督检验所广东广州510663

肝移植是解决各种肝脏终末期疾病最有效的方法,随着越来越多终末期肝脏疾病的患者加入移植名单等待肝脏移植,导致现如今肝脏资源短缺[1]。因此,扩展标准供体(expanded criteria donors,ECD)肝脏越来越受到移植界的重视,而心脏死亡后器... 详细信息

肝移植是解决各种肝脏终末期疾病最有效的方法,随着越来越多终末期肝脏疾病的患者加入移植名单等待肝脏移植,导致现如今肝脏资源短缺[1]。因此,扩展标准供体(expanded criteria donors,ECD)肝脏越来越受到移植界的重视,而心脏死亡后器官捐献(donation after cardiac death,DCD)肝脏是扩展标准供体肝脏中的重要组成部分,随着近些年移植理念的更新和移植技术的发展,DCD肝脏越来越受到移植界的关注[2],但DCD肝脏由于心脏骤停,循环中止,不可避免的会遭受一段时间的热缺血损伤。

关键词：肝脏移植心脏骤停肝脏疾病资源短缺 death 机械灌注肝移植 DCD

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Parameter optimization and experiment of the negative pressure precision seed-metering device for wheat

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International Journal of Agricultural and Biological Engineering 2024年第1期17卷 154-162页

作者： Yubo Feng xiaoshun Zhao Jincai Li Huali Yu Hongpeng Zhao Baozhong Yin State Key Laboratory of North China Crop Improvement and Regulation Hebei Agricultural UniversityBaoding 071001HebeiChina College of Mechanical and Electrical Engineering Hebei Agricultural UniversityBaoding 071001HebeiChina College of Plant Protection Hebei Agricultural UniversityBaoding 071001HebeiChina

In order to ensure the most reasonable distribution of wheat seeds in the field to improve seeding quality and uniformity,a set of negative pressure precision seed-metering device was designed,which shares a hollow *** seed-metering device can sow two rows of *** the STAR-CCM+,the analysis of nephogram,vectogram and streamline graph showed that more ideal structural parameters of the seed-metering device are 0.5 mm width of the slit sucking seed(WSS),150-200 mm diameter of the seed-metering disc(DSD),2.0 mm axial depth of air chamber in the seed-metering disc(ADS),and arc-shaped cross-section shape of the ring groove sucking seed(CSGS).Single-factor test on the JPS-12 test-bed analyzed the influence of the CSGS,WSS,DSD,and ADS on the qualified index(Iq),multiple index(Imul),miss index(Imiss)and coefficient of variation of qualified seed spacing(CV).Through the orthogonal on the JPS-12 test-bed,it is found that the influence of vacuum negative pressure and seed-metering device shaft speed is significant on the Iq,Imiss and *** on these,the structural parameters of the seed-metering device were *** DSD is 180 mm,the WSS is 0.7 mm,the ADS is 2.5 mm,and the CSGS is *** optimization seed-metering device was tested on the JPS-12 *** Iq is 86.66%,the Imiss is 5.09%,the Imul is 8.25%,and the CV is 24.50%.These testing results fully coincide with the standard JB/T 10293-2013 Specifications of single seed drill(precision drill).The seed-metering device meets fully the requirements for wheat precision seeding.

关键词： wheat seed-metering device negative pressure precision parameter optimization STAR-CCM+ orthogonal test variance analysis

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Electronic control seed-metering system for precision seeding maize based on fuzzy PID

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International Journal of Agricultural and Biological Engineering 2024年第4期17卷 217-226页

作者： xiaoshun Zhao Hongpeng Zhao Zehe Wang Jincai Li Huali Yu Qing Yan State Key Laboratory of North China Crop Improvement and Regulation Hebei Agricultural UniversityBaoding 071001HebeiChina College of Mechanical and Electrical Engineering Hebei Agricultural UniversityBaoding 071001HebeiChina

Aiming at the problem of poor uniformity of maize sowing caused by ground wheel slip,an electronic control seed-metering system(ECSMS)for maize single seed precision sowing was designed and a mathematical model for motor control of the ECSMS was *** PID parameters were set by Z-N method and fuzzy *** fuzzy PID control design and Simulink simulation were completed by MATLAB,which reduced response time of the system by 0.23 s and improved the control *** on the JPS-12 test bench show that the qualification index(QI)of maize seed-metering device with the ECSMS increases by 4.47%,the multiples index(MI)decreases by 1.96%,the miss index(MIX)decreases by 2.81%,and the coefficient of variation(CV)of qualified seed spacing decreases by 5.06%,and the sowing uniformity has been greatly *** results of the soil-tank test bench show that the system has good sowing uniformity and *** the QI is 96.74%,the MI is 2.15%,the MIX is 1.10%,and the CV of qualified seed spacing is 16.24%.Under different setting seed spacing and different sowing operation speed,the change range of seeding quality index was within 10%.The results of field sowing test show that the QI was 84.21%,the MI was 2.63%,the MIX was 7.89%,and the CV of qualified seed spacing was 22.15%,which meet the requirements of JB/T 10293-2013‘Specification for single seed planters(precision planters)’and the agronomic requirements for maize precision *** system runs stably and reliably in practical operation and has good operation performance.

关键词： maize seed-metering system electronic control precision sowing parameters tuning fuzzy PID control simulink simulation

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Grouping-Based Optimal Design of Collector System Topology for a Large-Scale Offshore Wind Farm by Improved Simulated Annealing

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Protection and Control of Modern Power Systems 2024年第1期9卷 94-111页

作者： Ruilin Chen Zeyu Zhang Junxuan Hu Lei Zhao Chuangzhi Li xiaoshun Zhang Shantou University ShantouChina ZHONGNAN ENGINEERING CORPORATION LIMITED North China Electric Power University Department of Electronic and Information Engineering College of EngineeringShantouUniversityShantouChina Sichuan university ChengduChina Foshan Graduate School Northeastern UniversityFoshan 528311China College of Information Science and Engineering Northeastern UniversityShenyang 110819China

During the construction of an offshore wind farm(OWF),the capital cost of the collector cable system accounts for a large proportion of the total ***,the optimal design of the collector system topology(CST)is one of the most crucial tasks in OWF ***,for a large-scale OWF,the optimal design of CST is a complex integer programming problem with high-dimension variables and various ***,it is difficult to acquire a high-quality optimal design *** address this issue,this paper proposes a new grouping-based optimal design of CST for a large-scale ***,all the wind turbines are divided into multiple groups according to their geographical locations and the maximum allowed connected wind turbines by each *** not only reduces the optimization dimension and difficulty,but also effectively satisfies the‘no cross’constraint by putting the geographically closed wind turbines into the same ***,the electrical topology among different wind turbines in each group is initially generated by an improved dynamic minimum spanning tree(DMST).The division groups of the OWF are then adjusted to further reduce the capital cost by improved simulated *** verify the proposed technique,comparison case studies are carried out with five algorithms on two different OWF.

关键词： dimension Optimal initially

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