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Plasmon Bi in-situ anchored on BiOCl nanosheets assembled microspheres towards optimized photothermal-photocatalytic performance

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Chinese Chemical Letters 2024年第2期35卷 469-476页

作者： Dongxue Song Mingxia Li Fan Yang Menghan Yu Zhenzi Li Jie Chen xiaoshuang zhang Wei Zhou School of Chemistry and Materials Science Key Laboratory of Functional Inorganic Material ChemistryMinistry of Education of the People's Republic of ChinaHeilongjiang UniversityHarbin 150080China Shandong Provincial Key Laboratory of Molecular Engineering School of Chemistry and Chemical EngineeringQilu University of Technology (Shandong Academy of Sciences)Ji'nan 250353China

Interface engineering is of great importance to improve the photocatalytic performance.Herein,in-situ formation plasmon Bi/BiOCl nanosheets assembled heterojunction microspheres are fabricated via facile reductive solvothermal approach.The aldehyde group in the DMF structure is used to exert the weak reducing property of the solvent and thus strip out the metal Bi in BiOCl.The metal Bi is anchored on surface of BiOCl firmly due to in-situ formation engineered interface,which could realize efficient charge transfer channel.The resultant Bi/BiOCl heterojunctions assemblies with narrow bandgap of 3.05 eV and mesoporous structure extend the photoresponse to visible light region and could provide sufficient surface active sites.The visible-light-driven photocatalytic degradation of high-toxic norfloxacin for Bi/BiOCl heterojunctions is up to 95.5%within 20 min,representing several times that of pristine BiOCl nanosheets and the physical mixture.It is attributed to the in-situ formation of Bi/BiOCl heterojunctions and surface plasmon resonance(SPR)effect of plasmon Bi promoting charge transfer,and the obvious photothermal effect promoting the photocatalytic reaction,which are verified by experimental and density functional theory(DFT)calculations.This strategy provides ideal perspectives for fabricating metal/semiconductor heterojunctions photocatalysts with high-performance.

关键词： Photocatalysis BiOCl Heterojunction Plasmon Bi Mesoporous structure

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MOF-derived Zn-Co-Ni sulfides with hollow nanosword arrays for high-efficiency overall water and urea electrolysis

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Green Energy & Environment 2023年第3期8卷 798-811页

作者： Xiaoqiang Du Yangyang Ding xiaoshuang zhang School of Chemical Engineering and Technology North University of ChinaTaiyuan030051China School of Science North University of ChinaTaiyuan030051China

Water electrolysis is a promising technology to produce hydrogen but it was severely restricted by the slow oxygen evolution reaction(OER).Herein,we firstly reported an advanced electrocatalyst of MOF-derived hollow Zn-Co-Ni sulfides(ZnS@Co_(9)S_(8)@Ni_(3)S_(2)-1/2,abbreviated as ZCNS-1/2)nanosword arrays(NSAs)with remarkable hydrogen evolution reaction(HER),OER and corresponding water electrolysis performance.To reach a current density of 10 mA cm^(-2),the cell voltage of assembled ZCNS-1/2//ZCNS-1/2 for urea electrolysis(1.314 V)is 208 mV lower than that for water electrolysis(1.522 V)and stably catalyzed for over 15 h,substantially outperforming the most reported water and urea electrolysis electrocatalysts.Density functional theory calculations and experimental result clearly reveal that the properties of large electrochemical active surface area(ECSA)caused by hollow NSAs and fast charge transfer resulted from the Co_(9)S_(8)@Ni_(3)S_(2) heterostructure endow the ZCNS-1/2 electrode with an enhanced electrocatalytic performance.

关键词： Water electrolysis Urea electrolysis MOF Multi-metal sulfides Density functional theory

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Highly efficient tunable photodetector with a bipolar response in van der Waals heterojunctions

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Science China(Technological Sciences) 2024年第2期67卷 639-646页

作者： SHI ChaoFan zhang Shi XIAO KeNing zhang LiBo HAN Li ZHU YuLin TANG WeiWei LIU ChangLong LI GuanHai CHEN xiaoshuang College of Physics and Optoelectronic Engineering Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of Sciences Hangzhou310024China State Key Laboratory of Infrared Physics Shanghai Institute of Technical PhysicsChinese Academy of SciencesShanghai 200083China

The heterojunction integration of two-dimensional(2D)materials via van der Waals(vdW)forces,unencumbered by lattice and processing constraints,constitutes an efficacious approach to enhance the overall optoelectronic performance of photodetectors,due to an assortment of distinctive light-matter interactions.Nonetheless,vdW heterojunction photodetectors based on transition metal dichalcogenides(TMDs)face an inevitable trade-off between low dark currents and high responsivity,curtailing the application potential of myriad novel optoelectronic components in sensing,spectral,and communication systems.In this study,we present the successful actualization of a highly sensitive,self-powered,and gate-tunable bipolar response photodetector.The mechanisms underlying photocurrent generation were scrutinized via bias-,power-,and position-dependent mapping photoresponse measurements,identifying the photovoltaic effect,which is attributable to the Schottky junction’s built-in electric field,as the predominant mechanism.The prototype Au-WS2-graphene photodetector exhibits a remarkable light on/off ratio of 1.2×10^(6),a specific detectivity of 6.12×10^(11)cm H^(z1/2)W^(-1)with 20μs response time at 638 nm.The wide gate-tunable responsivity provides an adjustability scope,ranging from 0.9 to 3.1 A W^(-1).Notably,the device demonstrates an exceptional linear photocurrent response,with a linear dynamic range(LDR)value approximating 130 dB,which significantly surpasses that of other photodetectors based on TMDs.

关键词： WS2/graphene van der Waals heterojunction gate-tunable bipolar response

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Internal m6A and m7G RNA modifications in hematopoietic system and acute myeloid leukemia

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中华医学杂志(英文版) 2024年第9期137卷 2024 Mar 28页

作者： zhang Xiaoxu Ma Yanni Yu Jia Su Rui Wang xiaoshuang State Key Laboratory of Common Mechanism Research for Major Diseases State Key Laboratory for Complex Severe and Rare Diseases Institute of Basic Medical Sciences Chinese Academy of Medical Sciences / Peking Union Medical College Beijing China Department of Systems Biology Beckman Research Institute of City of Hope Monrovia CA USA The Institute of Blood Transfusion Chinese Academy of Medical Sciences / Peking Union Medical College Chengdu Sichuan China Key Laboratory of RNA and Hematopoietic Regulation Chinese Academy of Medical Sciences Beijing China Department of Biochemistry and Molecular Biology Chinese Academy of Medical Sciences School of Basic Medicine Peking Union Medical College Beijing China

Epitranscriptomics focuses on the RNA-modification-mediated post-transcriptional regulation of gene expression. The past decade has witnessed tremendous progress in our understanding of the landscapes and biological functions of RNA modifications, as prompted by the emergence of potent analytical approaches. The hematopoietic system provides a lifelong supply of blood cells, and gene expression is tightly controlled during the differentiation of hematopoietic stem cells (HSCs). The dysregulation of gene expression during hematopoiesis may lead to severe disorders, including acute myeloid leukemia (AML). Emerging evidence supports the involvement of the mRNA modification system in normal hematopoiesis and AML pathogenesis, which has led to the development of small-molecule inhibitors that target N6-methyladenosine (m6A) modification machinery as treatments. Here, we summarize the latest findings and our most up-to-date information on the roles of m6A and N7-methylguanine in both physiological and pathological conditions in the hematopoietic system. Furthermore, we will discuss the therapeutic potential and limitations of cancer treatments targeting m6A.

关键词： N6-methyladenosine N7-methylguanine Hematopoiesis Acute myeloid leukemia Therapeutic target RNA modifications

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Development of LAG-3/FGL1 blocking peptide and combination with radiotherapy for cancer immunotherapy

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Acta Pharmaceutica Sinica B 2024年第3期14卷 1150-1165页

作者： Yuzhen Qian Yixuan Sun Peishang Shi Xiuman Zhou Qiongqiong zhang Qingyu Dong Shengzhe Jin Lu Qiu xiaoshuang Niu Xiaowen Zhou Wenshan Zhao Yahong Wu Wenjie Zhai Yanfeng Gao School of Life Sciences Zhengzhou UniversityZhengzhou 450001China School of Pharmaceutical Sciences(Shenzhen) Shenzhen Campus of Sun Yat-sen UniversityShenzhen 518107China International Joint Laboratory for Protein and Peptide Drugs of Henan Province Zhengzhou UniversityZhengzhou 450001China

Aside from antibodies,peptides show great potential as immune checkpoint inhibitors(ICIs)due to several advantages,such as better tumor penetration and lower cost.Lymphocyte-activation gene 3(LAG-3)is an immune checkpoint which can induce T cell dysfunction through interaction with its soluble ligand fibrinogen like protein-1(FGL1).Here,we found that LAG-3 expression was higher than programmed cell death protein 1(PD-1)in multiple human cancers by TCGA databases,and successfully identified a LAG-3 binding peptide LFP-6 by phage display bio-panning,which specifically blocks the interaction of LAG-3/FGL1 but not LAG-3/MHC-II.Subsequently,D-amino acids were introduced to substitute the N-and C-terminus of LFP-6 to obtain the proteolysis-resistant peptide LFP-D1,which restores T cell function in vitro and inhibits tumor growth in vivo.Further,a bispecific peptide LFOP targeting both PD-1/PD-L1 and LAG-3/FGL1 was designed by conjugating LFP-D1 with PD-1/PD-L1blocking peptide OPBP-1(8-12),which activates T cell with enhanced proliferation and IFN-γ production.More importantly,LFOP combined with radiotherapy significantly improve the T cell infiltration in tumor and elevate systemic antitumor immune response.In conclusion,we developed a novel peptide blocking LAG-3/FGL1 which can restore T cell function,and the bispecific peptide synergizes with radiotherapy to further enhance the antitumor immune response.

关键词： LAG-3 FGL1 PD-1 PD-L1 Peptide Immune checkpoint Radiotherapy Cancer immunotherapy

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Photobiomodulation inhibits the expression of chondroitin sulfate proteoglycans after spinal cord injury via the Sox9 pathway

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Neural Regeneration Research 2024年第1期19卷 180-189页

作者： Zhihao zhang Zhiwen Song Liang Luo Zhijie Zhu xiaoshuang Zuo Cheng Ju Xuankang Wang Yangguang Ma Tingyu Wu Zhou Yao Jie Zhou Beiyu Chen Tan Ding Zhe Wang Xueyu Hu Department of Orthopedics Xijing HospitalFourth Military Medical UniversityXi’anShaanxi ProvinceChina

Both glial cells and glia scar greatly affect the development of spinal cord injury and have become hot spots in research on spinal cord injury treatment.The cellular deposition of dense extracellular matrix proteins such as chondroitin sulfate proteoglycans inside and around the glial scar is known to affect axonal growth and be a major obstacle to autogenous repair.These proteins are thus candidate targets for spinal cord injury therapy.Our previous studies demonstrated that 810 nm photo biomodulation inhibited the formation of chondroitin sulfate proteoglycans after spinal cord injury and greatly improved motor function in model animals.However,the specific mechanism and potential targets involved remain to be clarified.In this study,to investigate the therapeutic effect of photo biomodulation,we established a mouse model of spinal cord injury by T9 clamping and irradiated the injury site at a power density of 50 mW/cm~2 for 50 minutes once a day for 7 consecutive days.We found that photobiomodulation greatly restored motor function in mice and down regulated chondroitin sulfate proteoglycan expression in the injured spinal cord.Bioinformatics analysis revealed that photobiomodulation inhibited the expression of proteoglycan-related genes induced by spinal cord injury,and versican,a type of proteoglycan,was one of the most markedly changed molecules.Immunofluorescence staining showed that after spinal cord injury,versican was present in astrocytes in spinal cord tissue.The expression of versican in primary astrocytes cultured in vitro increased after inflammation induction,whereas photobiomodulation inhibited the expression of ve rsican.Furthermore,we found that the increased levels of p-Smad3,p-P38 and p-Erk in inflammatory astrocytes were reduced after photobiomodulation treatment and after delivery of inhibitors including FR 180204,(E)-SIS3,and SB 202190.This suggests that Sma d 3/Sox9 and MAP K/Sox9 pathways may be involved in the effects of photobiomodulation.In summary,our findings show that photobiomodu

关键词： chondroitin sulfate proteoglycans Erk MAPK P38 photobiomodulation principal component analysis Smad3 Sox9 spinal cord injury versican

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Highly stable aqueous phase black phosphorus quantum dots with enhanced fluorescence property

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Journal of Materials Science & Technology 2022年第21期116卷 50-57页

作者： Yingli Ma Xiaoguang Xu xiaoshuang zhang Mayifei Rong Liying Lu Yan Li Wenhao Dai Hongwu Du Yong Jiang School of Materials Science and Engineering University of Science and Technology BeijingBeijing 100083China School of Chemistry and Biological Engineering University of Science and Technology BeijingBeijing 100083China

Black phosphorus quantum dots(BPQDs)are a kind of outstanding optical material due to the tunable band structure.However,their fluorescence property and stability are obviously weakened in the aqueous phase,which extremely restricts the development of BPQDs.Here,we propose a new method to prepare stable BPQDs in an aqueous solution directly with high absolute fluorescence quantum yield.Aqueous phase BPQDs are synthesized by liquid exfoliation and hydrothermal with NH_(2)-polyethylene glycol(PEG)-NH_(2) as the modification agent to protect the BPQDs,which have high stability more than six months.In addition,NH_(2)-PEG-NH_(2) is also a surface passivation agent to enhance the emission of BPQDs by forming P-N bonds,which is confirmed by an absolute fluorescent quantum yield of 11.5%.Moreover,BPQDs show excellent resistance to a strong acid environment and high ionic strengths except for Fe^(3+).Therefore,the BPQDs are a kind of highly selective and linear response fluorescence probe for Fe^(3+).Considering the good biocompatibility of BPQDs,they are employed as cell fluorescent label probes and show excellent fluorescence imaging contrast.Based on the unique structural stability and fluorescence performance in the aqueous phase,BPQDs are potential candidates for Fe^(3+)detection and optical bio-imaging.

关键词： Black phosphorus Quantum dots Fluorescence Iron detection Cell imaging

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采用融合ResNet和Transformer的U-Net进行疟疾感染红细胞分割

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中国医学物理学杂志 2024年第2期41卷 191-197页

作者：刘潇霜张伟甘肃中医药大学信息工程学院甘肃兰州730000

针对疟疾感染红细胞图像分割模型分割性能不高的问题,提出一种改进的U-Net网络模型,融合ResNet和Transformer。首先编码器部分使用ResNet,加深特征提取网络,以提取更深层次的特征;然后将ResNet输出传入Transformer模块进行目标区域特征... 详细信息

针对疟疾感染红细胞图像分割模型分割性能不高的问题,提出一种改进的U-Net网络模型,融合ResNet和Transformer。首先编码器部分使用ResNet,加深特征提取网络,以提取更深层次的特征;然后将ResNet输出传入Transformer模块进行目标区域特征的加强;最后通过解码器模块进行特征融合并输出结果。在疟疾显微图像数据集上,本文方法的Dice相似系数、平均交并比、类别平均像素准确率均优于U-Net网络,分别达到了87.40%、76.85%、85.28%。本文方法可以提高疟疾感染红细胞图像的分割精度,为疟疾诊断提供更有效和准确的解决方案。

关键词：疟疾 U-Net Transformer 语义分割

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PEDOT:PSS:From conductive polymers to sensors

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Nanotechnology and Precision Engineering 2021年第4期4卷 89-107页

作者： xiaoshuang zhang Wentuo Yang Hainan zhang Mengying Xie Xuexin Duan State Key Laboratory of Precision Measuring Technology and Instruments Tianjin UniversityTianjin 300072China

PEDOT:PSS conductive polymers have received tremendous attention over the last two decades owing to their high conductivity,ease of processing,and biocompatibility.As a flexible versatile material,PEDOT:PSS can be developed into various forms and has had a significant impact on emerging sensing applications.This review covers the development of PEDOT:PSS from material to physical sensors.We focus on the morphology of PEDOT:PSS in the forms of aqueous dispersions,solid films,and hydrogels.Manufacturing processes are summarized,including coating,printing,and lithography,and there is particular emphasis on nanoimprinting lithography that enables the production of PEDOT:PSS nanowires with superior sensing performance.Applications to various physical sensors,for humidity,temperature,pressure,and strain,are demonstrated.Finally,we discuss the challenges and propose new directions for the development of PEDOT:PSS.

关键词： PEDOT:PSS Conductive polymer Sensor Physical sensor Manufacturing process Morphology

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Prunus sunhangii: A new species of Prunus from central China

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Plant Diversity 2019年第1期41卷 19-25页

作者： xiaoshuang zhang Zhilin Jiang Ziyoviddin Yusupov Menghua zhang Daigui zhang Komiljon Tojibaev Ying Meng Tao Deng Key Laboratory of Plant Resources Conservation and Utilization Jishou University Puer University Institute of Comparative Study of Traditional Materia Medica Institutes of Integrative Medicine Fudan University Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of Botany Chinese Academy of Sciences Central Herbarium of Uzbekistan Institute of Botany Academy Sciences of Uzbekistan

A new species of Rosaceae from Central China, Prunus sunhangii D. G. zhang & T. Deng, sp. nov., is described and illustrated. The new species is placed in Prunus subgenus Cerasus by flower and fruit characteristics. It is most similar to Prunus cerasoides, but differs by having longitudinally 2-lobed apical petals, an acuminate leaf apex, 17—25 stamens, white petals, dark black drupes, brown hypanthium, and different phenology. The phylogenetic placement of this species was assessed based on morphological and molecular data. Molecular analysis(cp DNA + ITS) corroborated its placement in subgenus Cerasus,specifically Prunus section Serrula.

关键词： Phylogenetic analyses Taxonomy Cerasus Section Serrula

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