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The vegetation feature and palaeoenvironment significance in the mountainous interior of southern China from the Last Glacial Maximum

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Science China Earth Sciences 2018年第1期61卷 71-81页

作者： XIAO JiaYi SHANG ZhiYuan SHU Qiang YIN JianJi wu xiaoshuang Jiangsu Center for Collaborative Innovation in Geographical Information Resource Development and Application Nanjing Normal University School of Geographical Sciences Nanjing Normal University

Palynological records were selected from the profiles of three research sites in the mountainous interior of southern China(Dajiuhu at Shennongjia in the western part of Hubei Province, Dahu in the Nanling Mountains, and Gantang in the northern part of Fujian Province). It can be inferred that the forest vegetation growing in the south of the Qinling Mountains-Huaihe River was luxuriant during the late glaciation. The species succession with ecological significance in palaeoflora(Abies sp., Fagus sp. and Alnus sp.) revealed that there was a certain amount of precipitation and effective humidity in the mountain lands between Qinling Mountains-Huaihe River and Nanling Mountains. This ecological environment favored the zonal distribution of mountainous forest vegetation. The late glacial maximum featured a cold, wet climate that completely differed from the cold-dry climate on the Loess Plateau, and on the steppe and desert steppe of the Qinghai-Tibet Plateau. Besides being influenced by the predominant factors driving the Northern Hemisphere climate, the cold-wet climate feature of the mountainous interior of southern China was closely associated with some geographical factors such as the latitudinal position, proximity to the ocean, and the topography and landforms.

关键词： Southern China Mountainous vegetation Last Glacial Period Pollen record Palaeoenvironment

致敏红细胞BPGM酶活性降低对红细胞携氧/释氧能力的影响研究

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临床输血与检验 2024年第3期26卷 308-314页

作者：孟炜程陈要臻王雅芬安宁刘志新吴晓双王斐胡兴斌空军军医大学第一附属医院输血科陕西西安710032

目的分析致敏红细胞的携氧/释氧能力并初步探讨出现异常的原因。方法用微柱凝胶卡检测致敏红细胞,用携氧/释氧功能评价装置分析自身免疫性溶血性贫血(AIHA)和新生儿溶血病(HDN)患者的致敏红细胞的携氧/释氧能力。使用健康成人的血浆... 详细信息

目的分析致敏红细胞的携氧/释氧能力并初步探讨出现异常的原因。方法用微柱凝胶卡检测致敏红细胞,用携氧/释氧功能评价装置分析自身免疫性溶血性贫血(AIHA)和新生儿溶血病(HDN)患者的致敏红细胞的携氧/释氧能力。使用健康成人的血浆构建输血性溶血反应小鼠模型,对照组给予PBS,记录小鼠负重游泳至力竭的时间,分离小鼠红细胞并分析其携氧/释氧能力,利用蛋白组学对小鼠溶血组与正常组血浆中差异蛋白进行GO和KEGG富集分析。采用ELISA方法检测致敏红细胞BPGM酶活性和2,3-DPG含量。结果与相应对照组相比,AIHA、HDN和输血性溶血反应模型小鼠的红细胞的氧解离曲线均发生左移和P50下降。溶血模型小鼠的负重游泳时间明显缩短,蛋白组学筛选结果发现红细胞BPGM异常,致敏红细胞BPGM酶活性降低且细胞内2,3-DPG含量下降。结论致敏红细胞BPGM酶活性降低导致红细胞释放氧气能力下降。

关键词：红细胞溶血 BPGM 2 3-DPG

Development of LAG-3/FGL1 blocking peptide and combination with radiotherapy for cancer immunotherapy

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Acta Pharmaceutica Sinica B 2024年第3期14卷 1150-1165页

作者： Yuzhen Qian Yixuan Sun Peishang Shi Xiuman Zhou Qiongqiong Zhang Qingyu Dong Shengzhe Jin Lu Qiu xiaoshuang Niu Xiaowen Zhou Wenshan Zhao Yahong wu Wenjie Zhai Yanfeng Gao School of Life Sciences Zhengzhou UniversityZhengzhou 450001China School of Pharmaceutical Sciences(Shenzhen) Shenzhen Campus of Sun Yat-sen UniversityShenzhen 518107China International Joint Laboratory for Protein and Peptide Drugs of Henan Province Zhengzhou UniversityZhengzhou 450001China

Aside from antibodies,peptides show great potential as immune checkpoint inhibitors(ICIs)due to several advantages,such as better tumor penetration and lower ***-activation gene 3(LAG-3)is an immune checkpoint which can induce T cell dysfunction through interaction with its soluble ligand fibrinogen like protein-1(FGL1).Here,we found that LAG-3 expression was higher than programmed cell death protein 1(PD-1)in multiple human cancers by TCGA databases,and successfully identified a LAG-3 binding peptide LFP-6 by phage display bio-panning,which specifically blocks the interaction of LAG-3/FGL1 but not LAG-3/***,D-amino acids were introduced to substitute the N-and C-terminus of LFP-6 to obtain the proteolysis-resistant peptide LFP-D1,which restores T cell function in vitro and inhibits tumor growth in ***,a bispecific peptide LFOP targeting both PD-1/PD-L1 and LAG-3/FGL1 was designed by conjugating LFP-D1 with PD-1/PD-L1blocking peptide OPBP-1(8-12),which activates T cell with enhanced proliferation and IFN-γ *** importantly,LFOP combined with radiotherapy significantly improve the T cell infiltration in tumor and elevate systemic antitumor immune *** conclusion,we developed a novel peptide blocking LAG-3/FGL1 which can restore T cell function,and the bispecific peptide synergizes with radiotherapy to further enhance the antitumor immune response.

关键词： LAG-3 FGL1 PD-1 PD-L1 Peptide Immune checkpoint Radiotherapy Cancer immunotherapy

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海南岛主要农田耕层土壤磷的空间分布特征

热带生物学报 2024年第5期15卷 520-530页

作者：张善恒王文斌张永发罗雪华薛欣欣赵春梅任常琦王禹吴晓霜耿建梅海南大学热带农林学院海口570228 中国热带农业科学院橡胶所海口571101 中国热带农业科学院土壤肥料研究中心海口571101

为了探究农田耕层土壤磷素含量的空间分布特征,了解土壤磷素积累状况,为农田磷肥的合理施用提供依据,以海南岛主要农田为研究对象,采集耕层土壤混合样品2386个,分析检测土壤全磷、有效磷和有机质等指标,运用地统计学方法分析了土壤全磷... 详细信息

为了探究农田耕层土壤磷素含量的空间分布特征,了解土壤磷素积累状况,为农田磷肥的合理施用提供依据,以海南岛主要农田为研究对象,采集耕层土壤混合样品2386个,分析检测土壤全磷、有效磷和有机质等指标,运用地统计学方法分析了土壤全磷和有效磷的空间自相关性,采用普通克里格插值法预测了海南岛主要农田耕层土壤全磷和有效磷的空间分布情况。结果表明:海南岛主要农田耕层土壤全磷和有效磷含量较高且变异性较强,土壤全磷含量为0.06~4.61 g·kg^(-1),均值达1.02 g·kg^(-1),变异系数为64%;土壤有效磷含量为3.16~478.88 mg·kg^(-1),均值为106.51 mg·kg^(-1),变异系数高达91%。土壤全磷和有效磷的块金系数分别为0.918和0.928,都属于较弱的空间自相关性,主要受随机因素影响。克里格插值预测图显示,海南岛北部和南部地区的土壤全磷含量较高,主要集中在0.8~4.61 g·kg^(-1)之间;东部和西部地区的土壤全磷含量相对偏低,主要分布范围为0.4~0.8 g·kg^(-1);土壤的有效磷含量整体偏高,北部地区土壤有效磷含量为3.16~478.88 mg·kg^(-1),土壤有效磷分布不均衡;南部地区土壤的有效磷集中分布在90~240 mg·kg^(-1)之间,东部和西部地区的土壤有效磷含量相对较低,集中分布在20~90 mg·kg^(-1)之间。海南岛农田土壤全磷和有效磷的含量多处于较高水平,受人为施肥影响较大,农田周边水体面临较大的污染风险,在农业生产中应控制磷肥的施用。

关键词：地理信息系统有效磷地统计分析空间分布土地利用类型

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Photobiomodulation inhibits the expression of chondroitin sulfate proteoglycans after spinal cord injury via the Sox9 pathway

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Neural Regeneration Research 2024年第1期19卷 180-189页

作者： Zhihao Zhang Zhiwen Song Liang Luo Zhijie Zhu xiaoshuang Zuo Cheng Ju Xuankang Wang Yangguang Ma Tingyu wu Zhou Yao Jie Zhou Beiyu Chen Tan Ding Zhe Wang Xueyu Hu Department of Orthopedics Xijing HospitalFourth Military Medical UniversityXi’anShaanxi ProvinceChina

Both glial cells and glia scar greatly affect the development of spinal cord injury and have become hot spots in research on spinal cord injury *** cellular deposition of dense extracellular matrix proteins such as chondroitin sulfate proteoglycans inside and around the glial scar is known to affect axonal growth and be a major obstacle to autogenous *** proteins are thus candidate targets for spinal cord injury *** previous studies demonstrated that 810 nm photo biomodulation inhibited the formation of chondroitin sulfate proteoglycans after spinal cord injury and greatly improved motor function in model ***,the specific mechanism and potential targets involved remain to be *** this study,to investigate the therapeutic effect of photo biomodulation,we established a mouse model of spinal cord injury by T9 clamping and irradiated the injury site at a power density of 50 mW/cm~2 for 50 minutes once a day for 7 consecutive *** found that photobiomodulation greatly restored motor function in mice and down regulated chondroitin sulfate proteoglycan expression in the injured spinal *** analysis revealed that photobiomodulation inhibited the expression of proteoglycan-related genes induced by spinal cord injury,and versican,a type of proteoglycan,was one of the most markedly changed *** staining showed that after spinal cord injury,versican was present in astrocytes in spinal cord *** expression of versican in primary astrocytes cultured in vitro increased after inflammation induction,whereas photobiomodulation inhibited the expression of ve ***,we found that the increased levels of p-Smad3,p-P38 and p-Erk in inflammatory astrocytes were reduced after photobiomodulation treatment and after delivery of inhibitors including FR 180204,(E)-SIS3,and SB *** suggests that Sma d 3/Sox9 and MAP K/Sox9 pathways may be involved in the effects of photobiomodulatio

关键词： chondroitin sulfate proteoglycans Erk MAPK P38 photobiomodulation principal component analysis Smad3 Sox9 spinal cord injury versican

平台经济发展对就业质量的影响研究——产业结构升级的中介效应

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工业技术经济 2021年第10期40卷 62-69页

作者：李敏吴丽兰吴晓霜华南理工大学工商管理学院广州510640 华南理工大学公共管理学院广州510640

平台经济正在为我国经济高质量发展赋能,且经济高质量发展的内在要求是劳动者高质量就业,现有研究结果表明平台经济对就业“量”的扩大作用明显,但对就业“质”的影响还有待研究。本文基于宏观视角,结合社会分工理论、人力资本理论和“... 详细信息

平台经济正在为我国经济高质量发展赋能,且经济高质量发展的内在要求是劳动者高质量就业,现有研究结果表明平台经济对就业“量”的扩大作用明显,但对就业“质”的影响还有待研究。本文基于宏观视角,结合社会分工理论、人力资本理论和“配第—克拉克”定理分析了平台经济发展对就业质量的影响及作用机制,同时利用2013~2019年我国16个行业的面板数据进行实证检验。结果发现,不同行业间的平台经济水平差异较大,行业整体就业质量还有待提升;平台经济的发展显著促进就业质量的提升,产业结构升级在其中的中介效应显著。通过对控制变量的研究发现,教育水平正向影响就业质量。

关键词：平台经济就业质量产业结构升级行业面板数据中介效应教育水平

典型外墙外保温系统湿气迁移对其耐久性影响研究

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新型建筑材料 2021年第10期48卷 125-129页

作者：吴小双上海全筑控股集团股份有限公司上海200235 上海全筑住宅装饰工程有限公司上海200235

利用wuFI Pro 6.0热湿模拟软件对瓷砖饰面无机保温砂浆外墙外保温系统进行湿气迁移研究,其中稳态模拟分为夏热冬冷地区(典型城市上海)的夏季工况和冬季工况。3年稳态模拟结果表明,夏季工况下系统不会出现冷凝,只有小部分瓷砖出现毛细凝... 详细信息

利用wuFI Pro 6.0热湿模拟软件对瓷砖饰面无机保温砂浆外墙外保温系统进行湿气迁移研究,其中稳态模拟分为夏热冬冷地区(典型城市上海)的夏季工况和冬季工况。3年稳态模拟结果表明,夏季工况下系统不会出现冷凝,只有小部分瓷砖出现毛细凝结;冬季工况下系统不会出现冷凝,但近1/2厚度的墙体出现了比较严重的毛细凝结现象,瓷砖易导致墙体出现湿累积的现象。非稳态模拟结果表明,无机保温砂浆外墙外保温系统保温层外表面内侧的部分不会出现冷凝或毛细凝结,然而保温层外侧的部分有可能出现毛细凝结。

关键词：无机保温砂浆外墙外保温系统温湿耦合模拟湿气迁移

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寒冷地区沥青路面老化材料的低温性能评价

功能材料 2015年第24期46卷 24074-24077,24082页

作者：马宏岩王东升冯德成吴小双哈尔滨工业大学交通科学与工程学院哈尔滨150090

沥青路面的低温开裂是道路破坏的主要形式之一,在寒冷地区普遍存在。沥青和沥青混合料的低温性能是反映沥青路面抗低温开裂能力的主要指标。本文依托于长平高速公路实体工程,通过现场调查路面的实际开裂情况,以及室内低温劈裂蠕变实验... 详细信息

沥青路面的低温开裂是道路破坏的主要形式之一,在寒冷地区普遍存在。沥青和沥青混合料的低温性能是反映沥青路面抗低温开裂能力的主要指标。本文依托于长平高速公路实体工程,通过现场调查路面的实际开裂情况,以及室内低温劈裂蠕变实验和弯曲梁流变仪实验,评价沥青路面老化材料的低温性能。同时分析路面实际开裂情况与路面老化材料低温性能间的相关性,验证沥青及沥青混合料低温性能评价标准的有效性。

关键词：沥青路面低温开裂开裂指数劈裂蠕变实验弯曲梁流变实验

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王思顺推介词 500多块石头肖像的启示

美术文献 2016年第6期 42-47页

作者：吴小霜

在长征空间最新的展览《启示》中，参观者将会见到艺术家王思顺从世界各地搜集来的“石头肖像”。艺术家缘伺要开始收集这些具有人类特征的石头？它们又和“启示”之间有着怎样微妙的关联？

关键词：石头肖像介词《启示》艺术家参观者