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Nepheloid layer generation by gas eruption:unexpected experimental results

Journal of Oceanology and limnology 2023年第2期41卷 769-777页

作者： Chaoqi ZHU Sanzhong li Jiangxin CHEN Dawei WANG xiaoshuai SONG Zhenghui li Bo CHEN Hongxian SHAN Yonggang JIA Shandong Provincial Key Laboratory of Marine Environment and Geological Engineering Key Lab of Submarine Geosciences and Prospecting TechniquesMinistry of Education(MOE)Ocean University of ChinaQingdao 266100China Laboratory for Marine Geology Qingdao National Laboratory for Marine Science and TechnologyQingdao 266061China Frontiers Science Center for Deep Ocean Multispheres and Earth System and College of Marine GeosciencesOcean University of ChinaQingdao 266100China Hainan Key Laboratory of Marine Geological Resources and Environment Haikou 570206China Laboratory for Marine Mineral Resources Qingdao National Laboratory for Marine Science and TechnologyQingdao 266061China Key Laboratory of Gas Hydrate Ministry of Natural ResourcesQingdao Institute of Marine GeologyQingdao 266061China Laboratory of Marine Geophysics and Georeource Institute of Deep-Sea Science and EngineeringChinese Academy of SciencesSanya 572000China

Knowledge of nepheloid layers is important to improve the understanding of physical,geological,and sedimentary processes from continental shelf to abyssal *** had not tried to study the nepheloid layers in a hydrate-associated tank until unexpected results *** experimental results show that gas eruptions triggered intermediate nepheloid ***,we proposed a new mechanism of intermediate nepheloid layer generation by *** intermediate nepheloid layers were generated in uniform-density fluid,which indicated that stratified fluid is not a necessary condition for intermediate nepheloid *** space for advection and an oblique slope for detachment are the key ingredients for intermediate nepheloid layer generation by *** experiments also offer a new experimental evidence for bottom nepheloid layer generation by *** the scale effects of laboratory experiment,it is important to determine whether submarine volcanic eruption or hydrate-associated venting causes intermediate nepheloid layer in the nature.

关键词： intermediate nepheloid layer gas eruption bottom nepheloid layer gas hydrate tank experiment seafloor instability

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风筛式油莎豆清选装置设计分析与试验

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农机化研究 2024年第5期46卷 146-153,159页

作者：郑效帅尚书旗王东伟李成鹏李明辉申世龙赵泽龙何晓宁青岛农业大学机电工程学院山东青岛266109

作为一种新型油料作物,油莎豆清选损失率高、含杂率高的问题严重阻碍了其机械化收获进程。针对此问题,采用CFD-EDEM耦合方法进行了仿真试验、参数优化、规律解析和试验验证,结果表明:损失率影响程度从大到小为气流速度、振幅、频率,含... 详细信息

作为一种新型油料作物,油莎豆清选损失率高、含杂率高的问题严重阻碍了其机械化收获进程。针对此问题,采用CFD-EDEM耦合方法进行了仿真试验、参数优化、规律解析和试验验证,结果表明:损失率影响程度从大到小为气流速度、振幅、频率,含杂率影响程度从大到小为气流速度、频率、振幅;气流速度为10.52m/s、振幅为20.61mm,振频为6.93Hz时,清选损失率为3.65%,含杂率为5.26%,清选综合性能指标最优为4.46%;台架性能试验损失率为3.77%,较仿真结果误差为3.19%;含杂率为5.52%,较仿真结果误差为2.84%;仿真试验误差较小,比较可靠。研究所得的最优工作参数组合可为油莎豆优质清选提供理论支撑。

关键词：油莎豆清选流固耦合

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血清白细胞介素1β、半胱胺酸天冬氨酸蛋白水解酶3水平与颅内动脉瘤患者术后发生脑血管痉挛的关系

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血管与腔内血管外科杂志 2024年第1期10卷 88-92页

作者：张云鹏陈小帅王岩李玉明李昊北京市平谷区医院神经外科北京101200 首都医科大学附属北京天坛医院神经血管一病区北京100070

目的探讨血清白细胞介素1β(IL-1β)、半胱胺酸天冬氨酸蛋白水解酶3(Caspase-3)水平与颅内动脉瘤患者术后发生脑血管痉挛的关系。方法选取2020年1月至2022年1月于北京市平谷区医院及首都医科大学附属北京天坛医院拟行介入栓塞术手术治疗... 详细信息

目的探讨血清白细胞介素1β(IL-1β)、半胱胺酸天冬氨酸蛋白水解酶3(Caspase-3)水平与颅内动脉瘤患者术后发生脑血管痉挛的关系。方法选取2020年1月至2022年1月于北京市平谷区医院及首都医科大学附属北京天坛医院拟行介入栓塞术手术治疗的80例颅内动脉瘤患者,根据术后脑血管痉挛发生情况将其分为发生组(n=33)和未发生组(n=47)。收集所有患者的基线资料,记录所有患者的实验室指标,采用Pearson相关性检验分析血清IL-1β、Caspase-3之间的相关性,采用Logistic回归模型分析颅内动脉瘤患者术后发生脑血管痉挛的影响因素,绘制受试者工作特征曲线(ROC)分析血清IL-1β、Caspase-3对颅内动脉瘤患者术后发生脑血管痉挛的预测价值。结果发生组患者血清IL-1β、Caspase-3水平、白细胞计数均高于未发生组患者,差异均有统计学意义(P﹤0.05)。多因素分析结果显示,血清IL-1β、Caspase-3及白细胞计数水平升高均是颅内动脉瘤患者术后脑血管痉挛发生的危险因素(OR﹥1,P﹤0.05)。Pearson相关性检验结果显示,血清IL-1β与血清Caspase-3之间呈正相关(r=0.853,P﹤0.01)。血清IL-1β、Caspase-3及两者联合预测颅内动脉瘤患者术后发生脑血管痉挛的曲线下面积(AUC)分别为0.784、0.783、0.845,预测价值均较高,两者联合预测的AUC最大。结论颅内动脉瘤患者术后脑血管痉挛发生风险较高,血清IL-1β、Caspase-3水平升高与颅内动脉瘤患者术后脑血管痉挛发生有关,且两者联合预测术后脑血管痉挛发生的效能较高,可能成为临床预测术后发生脑血管痉挛及治疗靶点的生物学指标。

关键词：颅内动脉瘤脑血管痉挛血清白细胞介素1β 半胱胺酸天冬氨酸蛋白水解酶3

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膝骨关节炎患者SFRP与玻璃酸钠治疗效果的关系

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中国现代医生 2024年第21期62卷 66-69页

作者：曾笑帅李慧辉吴惠明刘海峰浙江中医药大学附属温州市中医院骨伤科浙江温州325000 瑞安市人民医院中医骨伤科浙江瑞安325200

目的探讨膝骨关节炎(knee osteoarthritis,KOA)患者分泌型卷曲相关蛋白(secretory curl related protein,SFRP)水平与玻璃酸钠治疗效果的关系。方法选取2021年5月至2023年6月温州市中医院收治的KOA患者89例纳入观察组,所有患者均采用玻... 详细信息

目的探讨膝骨关节炎(knee osteoarthritis,KOA)患者分泌型卷曲相关蛋白(secretory curl related protein,SFRP)水平与玻璃酸钠治疗效果的关系。方法选取2021年5月至2023年6月温州市中医院收治的KOA患者89例纳入观察组,所有患者均采用玻璃酸钠治疗,根据治疗效果分为显效/好转组和效果差组;同期选取67名健康体检者纳入对照组。采用酶联免疫吸附试验测定各组纳入者的SFRP1、SFRP2和SFRP5水平,并对KOA患者玻璃酸钠治疗效果进行多因素Logistic回归分析;绘制受试者操作特征曲线(receiver operating characteristic curve,ROC曲线),分析SFRP水平在KOA患者治疗效果中的评价效能。结果观察组患者的SFRP1、SFRP2及SFRP5水平低于对照组(P<0.05);89例KOA患者经玻璃酸钠治疗后,67例治疗效果良好(75.28%),显效/好转组患者的SFRP1、SFRP2及SFRP5水平高于效果差组(P<0.05);多因素分析结果表明,SFRP1、SFRP2、SFRP5水平及西安大略和麦克马斯特大学骨关节炎指数均为KOA患者治疗效果的影响因素(P<0.05);ROC曲线结果表明,SFRP1、SFRP2联合SFRP5对KOA患者治疗效果评价的敏感度和特异性高于单一指标(P<0.05)。结论SFRP1、SFRP2和SFRP5在KOA患者中呈低表达,其表达水平与患者玻璃酸钠治疗效果存在紧密联系,不同指标联合测定可提高预测的敏感度和特异性。

关键词：膝骨关节炎分泌型卷曲相关蛋白玻璃酸钠

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The shift in the abundance of two Stipa species in response to land use change is associated with their divergent reproductive strategies

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Journal of Plant Ecology 2019年第4期12卷 722-729页

作者： xiaoshuai Wang Frank Yonghong li Yuanheng li Xin Song Xudong Guo Xiangyang Hou Taogetao Baoyin Ministry of Education Key Laboratory of Ecology and Resource Use of the Mongolian Plateau&Inner Mongolia Key Laboratory of Grassland Ecology School of Ecology and EnvironmentInner Mongolia UniversityHohhot 010021China Grassland Research Institute of the Chinese Academy of Agricultural Sciences Hohhot 010020China

Aims The divergent changes of plant species under land use changes are key mechanisms underlying vegetation *** grandis steppe and Stipa krylovii steppe are two plant commu-nities widely distributed on the Mongolian *** have been speculated to be able to succeed into each other under different land use types and intensities based on the observa-tions on their presence and abundance at the sites with dif-ferent land use ***,no direct evidence,neither the underlying mechanisms,have been reported for this ***,we verified this speculation and explored the underlying mechanisms in the typical steppe region of Inner *** We investigated the abundance and reproductive behavior of ***-lovii and *** under different land use types and *** used 18 grassland paddocks to run a 6-year experiment with 6 management treatments(T0-unused,T1-grazing monthly in plant growing season,T2,T4,T6-grazing in different months in plant growing season,and T8-mowing)replicated three *** measured the relative density and cover of *** and *** using line sampling method and examined their number and bio-mass of vegetative and reproductive tillers using quadrat method in each paddock after treatments for 4 and 6 *** also de-termined these plant attributes in 14 pairs of heavily versus lightly used grassland plots in a wide area(150 km×200 km)of the typical steppe *** Findings *** largely and mowing moderately decreased the density ratio and coverage ratio of *** to *** in grasslands(P<0.05),and the differences in these ratios between grazed and unused grasslands increased with ***,but not mowing,significantly enhanced the relative density(N_(rep)=reproductive tiller number/total tiller number)of,and biomass allocation(B_(rep)=reproductive tiller biomass/total bio-mass)to,reproductive tillers of ***(P<0.05),but not *** grazing enhancement t

关键词： reproductive tiller vegetative tiller succession grazing mowing

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Single-cell biomagnifier for optical nanoscopes and nanotweezers

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light(Science & Applications) 2019年第1期8卷 651-662页

作者： Yuchao li xiaoshuai liu Baojun li Institute of Nanophotonics Jinan University511443 GuangzhouChina

Optical microscopes and optical tweezers,which were invented to image and manipulate microscale objects,have revolutionized cellular and molecular ***,the optical resolution is hampered by the diffraction limit;thus,optical microscopes and optical tweezers cannot be directly used to image and manipulate *** emerging plasmonic/photonic nanoscopes and nanotweezers can achieve nanometer resolution,but the high-index material structures will easily cause mechanical and photothermal damage to ***,we demonstrate subdiffraction-limit imaging and manipulation of nano-objects by a noninvasive device that was constructed by trapping a cell on a fiber *** trapped cell,acting as a biomagnifier,could magnify nanostructures with a resolution of 100 nm(λ/5.5)under white-light *** focus of the biomagnifier formed a nano-optical trap that allowed precise manipulation of an individual nanoparticle with a radius of 50 *** biomagnifier provides a high-precision tool for optical imaging,sensing,and assembly of bionanomaterials.

关键词： limit optical resolution

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The transcriptome analysis of cleft lip/palate-related PTCH1 variants in GMSM-K cells show carcinogenic potential

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BIOCELL 2023年第1期47卷 205-214页

作者： MINGZHAO li QIAN ZHANG WENBIN HUANG SHIYING ZHANG NAN JIANG xiaoshuai HUANG FENG CHEN Department of Orthodontics Peking University School and Hospital of StomatologyBeijingChina Central Laboratory Peking University School and Hospital of StomatologyBeijingChina Biomedical Engineering Department Peking UniversityBeijingChina

Cancer progression involves the sonic hedgehog(SHH)pathway,in which the receptor PTCH1 actives the downstream *** of PTCH1 can lead to nevoid basal cell carcinoma Syndrome(NBCCs)including neoplastic disease and congenital *** evaluate the relationship between PTCH1 and cancer,we applied the CRISPR/Cas9 system to knock out PTCH1 in oral nontumorous epithelial cells(GMSM-K).Then we screened six PTCH1 variants associated with cleft lip/palate(CL/P),one of the congenital disorders in NBCCs,and generated PTCH1 variant and wild-type recombinant PTCH1^(−/−)GMSM-K cell *** sequencing was conducted in these cell *** results revealed that differentially expressed genes(DEGs)in PTCH1^(−/−)GMSM-K were enriched in extracellular compartments,contributing epithelial diseases by pathway enrichment ***-PCR confirmed that KRT34,KRT81,KRT86,PDGFB,and WNT10B genes,associated with extracellular compartments were highly expressed in PTCH1^(−/−).The Kyoto Encyclopedia of Genes and Genomes analysis also suggested that DEGs are closely related to focal adhesion,transcriptional misregulation,and proteoglycans in breast and gastric *** analysis of samples revealed that the CL/P-associated PTCH1 variants A443G and V908G are potentially *** findings provide new insights into the carcinogenic potential of PTCH1 dysfunction.

关键词： CRISPR/Cas9 PTCH1 variant Carcinogenic potential Transcriptome sequencing

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Cellular mechanotransduction in health and diseases:from molecular mechanism to therapeutic targets

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Signal Transduction and Targeted Therapy 2023年第8期8卷 3705-3736页

作者： Xingpeng Di xiaoshuai Gao liao Peng Jianzhong Ai Xi Jin Shiqian Qi Hong li Kunjie Wang Deyi Luo Department of Urology and Institute of Urology National Clinical Research Center for GeriatricsWest China HospitalSichuan UniversityChengduP.R.China State Key Laboratory of Biotherapy and Cancer Center West China HospitalSichuan UniversityChengduP.R.China

Cellular mechanotransduction,a critical regulator of numerous biological processes,is the conversion from mechanical signals to biochemical signals regarding cell activities and *** mechanical cues in organisms include hydrostatic pressure,fluid shear stress,tensile force,extracellular matrix stiffness or tissue elasticity,and extracellular fluid *** has been expected to trigger multiple biological processes,such as embryonic development,tissue repair and ***,prolonged excessive mechanical stimulation can result in pathological processes,such as multi-organ fibrosis,tumorigenesis,and cancer immunotherapy *** the associations between mechanical cues and normal tissue homeostasis or diseases have been identified,the regulatory mechanisms among different mechanical cues are not yet comprehensively illustrated,and no effective therapies are currently available targeting mechanical cue-related *** review systematically summarizes the characteristics and regulatory mechanisms of typical mechanical cues in normal conditions and diseases with the updated *** key effectors responding to mechanical stimulations are listed,such as Piezo channels,integrins,Yes-associated protein(YAP)/transcriptional coactivator with PDZ-binding motif(TAZ),and transient receptor potential vanilloid 4(TRPV4).We also reviewed the key signaling pathways,therapeutic targets and cutting-edge clinical applications of diseases related to mechanical cues.

关键词： diseases stimulation therapeutic

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Physiological and molecular mechanisms of insect appendage regeneration

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Cell Regeneration 2023年第1期12卷 351-362页

作者： Jiru Zhong Andi Jing Shaojuan Zheng Sheng li xiaoshuai Zhang Chonghua Ren Guangdong Provincial Key Laboratory of Insect Developmental Biology and Applied Technology Guangzhou Key Laboratory of Insect Development Regulation and Application ResearchInstitute of Insect Science and TechnologySchool of Life SciencesSouth China Normal UniversityGuangzhou 510631China Guangmeiyuan R&D Center Guangdong Provincial Key Laboratory of Insect Developmental Biology and Applied TechnologySouth China Normal UniversityMeizhou 514779China

Regeneration,as a fascinating scientific field,refers to the ability of animals replacing lost tissue or body *** metazoan organisms have been reported with the regeneration phenomena,but showing evolutionarily variable *** the most diverse metazoan taxon,hundreds of insects show strong appendage regeneration *** regeneration process and ability are dependent on many factors,including macroscopic physiological conditions and microscopic molecular *** article reviews research progress on the physiological conditions and internal underlying mechanisms controlling appendage regeneration in insects.

关键词： Appendage regeneration Physiological condition Molecular mechanism Signaling pathways Epigenetics Insects

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Defect passivation with potassium trifluoroborate for efficient spray-coated perovskite solar cells in air

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Journal of Semiconductors 2022年第9期43卷 25-33页

作者： Chen Gao Hui Wang Pang Wang Jinlong Cai Yuandong Sun Cong Yu Teng li xiaoshuai Zhang Dan liu Tao Wang School of Materials Science and Engineering Wuhan University of TechnologyWuhan 430070China

Defects as non-radiative recombination centers hinder the further efficiency improvements of perovskite solar cells(PSCs).Additive engineering has been demonstrated to be an effective method for defect passivation in perovskite ***,we employed(4-methoxyphenyl)potassium trifluoroborate(C_(7)H_(7)BF_(3)KO)with and K+functional groups to passivate spray-coated(FAPbI_(3))_(x)(MAPbBr_(3))_(1-x) perovskite and eliminate *** is shown that the F of can form hydrogen bonds with the H atom in the amino group of MA+/FA+ions of perovskite,thus reducing the generation of MA+/FA+vacancies and improving device ***,K+and reduced MA+/FA+vacancies can inhibit ion migration,thereby eliminating *** the aid of C_(7)H_(7)BF_(3)KO,we obtained hysteresis-free PSCs with the maximum efficiency of 19.5%by spray-coating in *** work demonstrates that additive engineering is promising to improve the performance of spray-coated PSCs.

关键词： perovskite solar cells spray-coating additive engineering defect passivation hysteresis

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