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护肝醒酒软糖混合液对小鼠急性酒精性肝损伤的保护作用

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现代食品科技 2024年第5期40卷 8-14页

作者：李东海李立郎王瑜李雪张朝举李祖辉杨小生杨娟贵州医科大学药学院贵州贵阳550025 贵州省天然产物研究中心贵州贵阳550014 贵州中意食品有限责任公司贵州贵阳550025

探究护肝醒酒软糖混合液(LSSCM)对小鼠急性酒精性肝损伤的保护作用。建立急性酒精性肝损伤模型,计算肝脏指数,测定血清中甘油三酯(TG)、丙氨酸氨基转移酶(ALT)、谷草转氨酶(AST)和肝组织中超氧化物歧化酶(SOD)、丙二醛(MDA)、乙醇脱氢酶... 详细信息

探究护肝醒酒软糖混合液(LSSCM)对小鼠急性酒精性肝损伤的保护作用。建立急性酒精性肝损伤模型,计算肝脏指数,测定血清中甘油三酯(TG)、丙氨酸氨基转移酶(ALT)、谷草转氨酶(AST)和肝组织中超氧化物歧化酶(SOD)、丙二醛(MDA)、乙醇脱氢酶(ADH)、乙醛脱氢酶(ALDH)的水平变化及通过肝组织病理切片分析其形态变化。结果表明,与模型组相比,LSSCM高剂量组肝脏指数、TG含量、MDA含量显著降低12.33%、48.35%、39.10%;SOD、ALDH、ADH水平显著提高18.61%、44.59%、124.61%;AST、ALT水平显著降低32.26%、40.71%;小鼠肝组织病理切片结果显示,LSSCM各剂量组小鼠受损肝脏均得到不同程度改善。综上所述,LSSCM对酒精所致的急性肝损伤小鼠的肝脏肿大、脂质代谢紊乱、肝脏氧化应激具有显著改善效果,可有效预防和改善急性酒精性肝损伤。

关键词：葛根枳椇子车前草刺梨护肝急性酒精性肝损伤

车前草提取物对小鼠急性酒精性肝损伤的保护作用

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现代食品科技 2024年第9期40卷 20-26页

作者：李东海杨娟王瑜张朝举杨小生李祖辉李立郎贵州医科大学药学院贵州贵阳550025 贵州省天然产物研究中心贵州贵阳550014 贵州中意食品有限责任公司贵州贵阳550025

该实验研究了车前草提取物(Plantain Extract,PE)对急性酒精性肝损伤小鼠的保护作用。通过灌胃体积分数52%的食用酒精建立小鼠急性酒精性肝损伤模型,测定小鼠肝脏指数、血清谷丙转氨酶(Alanine Aminotransferase,ALT)、谷草转氨酶(Aspar... 详细信息

该实验研究了车前草提取物(Plantain Extract,PE)对急性酒精性肝损伤小鼠的保护作用。通过灌胃体积分数52%的食用酒精建立小鼠急性酒精性肝损伤模型,测定小鼠肝脏指数、血清谷丙转氨酶(Alanine Aminotransferase,ALT)、谷草转氨酶(Aspartate Aminotransferase,AST)活性和甘油三酯(Triglycerides,TG)的含量,以及肝组织中超氧化物歧化酶(Superoxide Dismutase,SOD)、过氧化氢酶(Catalase,CAT)活性和总谷胱甘肽(Total Glutathione,T-GSH)、丙二醛(Malondialdehyde,MDA)的含量,并对小鼠肝组织进行病理学观察。结果显示,与模型组相比,阳性对照组和给药组小鼠肝脏指数显著下降(P<0.01),给药组最大降幅为20.18%,高剂量组血清中ALT、AST和TG水平显著降低27.29%、36.03%、45.69%,肝组织中CAT和SOD活性、T-GSH含量均显著增加16.36%、18.42%、28.66%及MDA含量显著降低36.89%,且肝组织病理切片显示给药组小鼠肝损伤程度均有显著改善。由此可见,PE对急性酒精诱导的肝损伤具有明显的保护作用。

关键词：车前草提取物急性酒精肝损伤保护作用抗氧化病理切片

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大秦铁路助调台站场表示信息丢失原因分析与优化策略

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铁道通信信号 2024年第7期60卷 40-44页

作者：郝晓昀杨晓生冯振国费振豪卡斯柯信号有限公司上海市铁路智能调度指挥系统工程研究中心北京100070

为满足大秦铁路日益增长的业务需求,基于大秦线运输组织特点和CTC3.0系统数据流原理,结合现场故障排查流程,详细分析调度集中系统中心站场表示信息丢失的原因,最终确定在大秦线数据量瞬时较大的情况下,系统通信组件将数据分成包头、包尾... 详细信息

为满足大秦铁路日益增长的业务需求,基于大秦线运输组织特点和CTC3.0系统数据流原理,结合现场故障排查流程,详细分析调度集中系统中心站场表示信息丢失的原因,最终确定在大秦线数据量瞬时较大的情况下,系统通信组件将数据分成包头、包尾2次发送,导致助调工作站数据解析效率降低,引发中心站场表示信息丢失。为此提出采用合并发送数据帧的方式,提高系统的数据处理能力和整体性能,有效解决中心站场表示信息丢失问题;提出降低数据负载和建立预警机制等策略,进一步提升调度集中系统的稳定性和可靠性。经现场验证,该方法可有效提升大秦铁路的运输效率,为类似重载铁路调度集中系统功能优化提供参考。

关键词：调度集中重载铁路助调台站场表示信息通信组件通信队列进路序列

Source-configured symmetry-broken hyperbolic polaritons

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eLight 2023年第1期3卷 136-146页

作者： Caixing Hu Tian Sun Ying Zeng Weiliang Ma Zhigao Dai xiaosheng yang Xinliang Zhang Peining Li Wuhan National Laboratory for Optoelectronics and School of Optical and Electronic Information Huazhong University of Science and TechnologyWuhan 430074China Optics Valley Laboratory Hubei 430074China Faculty of Materials Science and Chemistry Engineering Research Center of NanoGeomaterials of Ministry of EducationChina University of GeosciencesWuhan 430074China Xidian University Xi’an 710126China

Polaritons are quasi-particles that combine light with matter,enabling precise control of light at deep subwavelength *** excitation and propagation of polaritons are closely linked to the structural symmetries of the host materials,resulting in symmetrical polariton propagation in high-symmetry ***,in low-symmetry crystals,symmetry-broken polaritons exist,exhibiting enhanced directionality of polariton propagation for nanoscale light manipulation and ***,we theoretically propose and experimentally demonstrate the existence of symmetry-broken polaritons,with hyperbolic dispersion,in a high-symmetry *** show that an optical disk-antenna positioned on the crystal surface can act as an in-plane polarized excitation source,enabling dynamic tailoring of the asymmetry of hyperbolic polariton propagation in the high-symmetry crystal over a broad frequency ***,we provide an intuitive analysis model that predicts the condition under which the asymmetric polaritonic behavior is maximized,which is corroborated by our simulations and *** results demonstrate that the directionality of polariton propagation can be conveniently configured,independent of the structure symmetry of crystals,providing a tuning knob for the polaritonic response and in-plane anisotropy in nanophotonic applications.

关键词： Hyperbolic polaritons Near-field excitation Crystal symmetry In-plane polarization Calcite

Beneficiation Studies of a Rare Earth Ore from the Olserum Deposit

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Natural Resources 2019年第9期10卷 346-357页

作者： xiaosheng yang Neea Heino Lassi Pakkanen GTK Mintec Geological Survey of Finland Outokumpu Finland Geological Survey of Finland Espoo Finland

The Olserum deposit located in Sweden hosts an indicated mineral resource of 4.5 million tonnes at 0.6% total rare earth oxides (TREO), exhibiting a relatively high proportion of heavy rare earth elements (HREE). The mineralogy and beneficiation of a composite drill core sample from the Olserum deposit were studied. Monazite and xenotime were found by the mineralogical analyses to be the target minerals for beneficiation of REEs and most (96.9%) of REEs in the ore are carried by monazite (68.5%) and xenotime (28.4%). Because xenotime carries 84.7% of heavy REEs (Y, Gd, Dy) in the ore it is more valuable mineral than monazite. A beneficiation process was developed which includes grinding, wet low intensity magnetic separation (WLIMS) for removal of magnetite and REEs flotation consisting of one stage of roughing and two stages of cleaning. Selective flotation collector of REE minerals and suitable grinding size of feed material were determined by testwork. The REE concentrate and tailings were chemically and mineralogically characterized. The studies of process mineralogy showed that the REE-bearing minerals, monazite and xenotime, and apatite were successfully enriched from the concentrations of 0.6%, 0.31% and 2.6% in the feed to those of 17.0%, 8.9% and 65.0% in the concentrate with the recoveries of 79.0%, 81.3% and 71.0%, respectively.

关键词： The Olserum Deposit Rare Earth Minerals Flotation

Mineralogy and Beneficiation of Lamujärvi Syenites

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Natural Resources 2016年第8期7卷 481-493页

作者： xiaosheng yang Jukka Laukkanen Akseli Torppa Neea Heino Geological Survey of Finland GTK Mintec Outokumpu Finland Geological Survey of Finland Kuopio Finland

The Lamujärvi syenites intrusions occur within Svecofennian (ca. 1.92 Ga) gneisses, ca. 70 km west of the Otanmaki alkaline area in central Finland. Previous studies have revealed zones in the syenites that display strong enrichment in Zr (1587 ppm), Nb (up to 685 ppm), Ta (up to 82 ppm), and REE (up to 5350 ppm). The major REE-bearing minerals in the Lamujarvi syenites are allanite and monazite. A sample of the Lamujärvi syenites with the REE content of 4700 ppm was studied on the mineralogy and beneficiation at GTK Mintec. The mineralogical analysis was conducted by MLA. The REE-bearing minerals allanite, parisite, zircon, and apatite were identified at significant concentrations and high contents of titanite (15.4%), biotite (30.9%) and magnetite (8.2%) were displayed in the sample. The beneficiation experiments by flotation, wet low and high gradient magnetic separations and gravity separation with a shaking table were carried out. A composite REE-Ti concentrate with REE 23,000 ppm, Zr 5000 ppm, Nb 3400 ppm and TiO2 25.5% at REE and Ti recoveries of 57% and 54% was obtained. In addition, biotite and magnetite concentrates were gained as by-products.

关键词： The Lamujärvi Syenites Mineralogy Beneficiation Allanite Titanite

Establishment of NaLuF_(4):15%Tb-based low dose X-PDT agent and its application on efficient antitumor therapy

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International Journal of Minerals,Metallurgy and Materials 2024年第3期31卷 599-610页

作者： Yi Tian Zhiguang Fu xiaosheng Zhu Chunjing Zhan Jinwei Hu Li Fan Chaojun Song Qian yang Yu Wang Mei Shi Department of Radiation Oncology Xijing HospitalThe Fourth Military Medical UniversityXi’an 710032China Department of Oncology Air Force Medical CenterPLAThe Fourth Military Medical UniversityBeijing 100142China Department of Tumor Radiotherapy Air Force Medical CenterPLAThe Fourth Military Medical UniversityBeijing 100142China Department of Gastroenterology Air Force Hospital of Southern Theater CommandGuangzhou 510062China Department of Pharmaceutical Chemistry and Analysis School of PharmacyThe Fourth Military Medical UniversityXi’an 710032China School of Life Sciences Northwestern Polytechnical UniversityXi’an 710072China Institue of Materia Medica School of PharmacyThe Fourth Military Medical UniversityXi’an 710032China

X-ray excited photodynamic therapy(X-PDT)is the bravo answer of photodynamic therapy(PDT)for deep-seated tumors,as it employs X-ray as the irradiation source to overcome the limitation of light penetration ***,high X-ray irradiation dose caused organ lesions and side effects became the major barrier to X-PDT *** address this issue,this work employed a classic-al co-precipitation reaction to synthesize NaLuF_(4):15%Tb^(3+)(NLF)with an average particle size of(23.48±0.91)nm,which was then coupled with the photosensitizer merocyanine 540(MC540)to form the X-PDT system NLF-MC540 with high production of singlet *** system could induce antitumor efficacy to about 24%in relative low dose X-ray irradiation range(0.1-0.3 Gy).In vivo,when NLF-MC540 irradiated by 0.1 Gy X-ray,the tumor inhibition percentage reached 89.5%±5.7%.The therapeutic mechanism of low dose X-PDT was found.A significant increase of neutrophils in serum was found on the third day after *** immunohistochemical staining of tumor sections,the Ly6G^(+),CD8^(+),and CD11c^(+)cells infiltrated in the tumor microenvironment were *** the bilat-eral tumor model,the NLF-MC540 with 0.1 Gy X-ray irradiation could inhibit both the primary tumor and the distant tumor ***-tected by enzyme linked immunosorbent assay(ELISA),two cytokines IFN-γand TNF-αin serum were upregulated 7 and 6 times than negative control,*** by enzyme linked immune spot assay(ELISPOT),the number of immune cells attributable to the IFN-γand TNF-αlevels in the group of low dose X-PDT were 14 and 6 times greater than that in the negative control group,***,it conclude that low dose X-PDT system could successfully upregulate the levels of immune cells,stimulate the secretion of cy-tokines(especially IFN-γand TNF-α),activate antitumor immunity,and finally inhibit colon tumor growth.

关键词： X-ray excited photodynamic therapy singlet oxygen low dose X-Ray irradiation efficient antitumor therapy anti-tumor immunity

Phosphogypsum Processing for Rare Earths Recovery—A Review

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Natural Resources 2019年第9期10卷 325-336页

作者： xiaosheng yang Dandara Salvador Hannu Tapani Makkonen Lassi Pakkanen GTK Mintec Geological Survey of Finland Outokumpu Finland Geological Survey of Finland Espoo Finland

As a by-product from the phosphate fertilizer industry Phosphogypsum (PG) was considered a potentially valuable source of the rare earth elements (REEs). Because of trace concentration of REEs in the PG (normally <0.1% wt) and also their tiny and complex occurrence phases the recovery process would be highly challenging in both technology and economy. The studies on occurrences of REEs, REE recovery by physical methods and leaching using different lixiviants such as inorganic acids, H2SO4, HCl and HNO3, and organic chemicals, the effects of mechanical treatment of PG by microwaving and grinding on leaching efficiency of REEs, and resin-in-leach process were reviewed in the paper.

关键词： Phosphogypsum Rare Earth Elements Phases of Rare Earth Elements Acid Leaching

Biomechanical energy harvesting technologies for wearable electronics:Theories and devices

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Friction 2024年第8期12卷 1655-1679页

作者： Xiaowen LI Xu ZENG Junwei LI Boyuan LI Yu CHEN xiaosheng ZHANG University of Electronic Science and Technology of China Chengdu 611731China

Wearable biomechanical energy harvesting devices have received a lot of attention recently,benefiting from the rapid advancement of theories and devices in the field of the micro electromechanical system(MEMS).They not only fulfil the requirements for powering wearable electronic devices but also provide an attractive prospect for powering self-powered flexible electronic devices when *** this article,we provide a review of the theories and devices of biomechanical energy harvesting technology for wearable *** different forms of biomechanical energy harvesting mechanisms,including the piezoelectric effect,electromagnetic effect,and electrostatic effect,are investigated in *** fundamental principle of converting other types of energy from the biomechanical environment into electrical energy,as well as the most commonly-used analytical theoretical models,are outlined for each ***,the features,properties,and applications of energy harvesting devices are *** addition,the coupled multi-effect hybrid energy harvesting devices are listed,showing the various possibilities of biomechanical energy harvesting devices for serving as sources,sensors,and ***,we present perspectives on the future trends of biomechanical energy harvesting devices for wearable electronics applications.

关键词： micro electromechanical system(MEMS) nanogenerators biomechanical energy harvesters wearable electronics