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lncRNA Gm20257 alleviates pathological cardiac hypertrophy by modulating the PGC-1α–mitochondrial complexⅣaxis

Frontiers of Medicine 2024年第4期18卷 664-677页

作者： Tong Yu Qiang Gao Guofang Zhang Tianyu Li xiaoshan liu Chao Li Lan Zheng Xiang Sun Jianbo Wu Huiying Cao Fangfang Bi Ruifeng Wang Haihai Liang Xuelian Li Yuhong Zhou Lifang Lv Hongli Shan Department of Physiology School of Basic MedicineHarbin Medical UniversityHarbin150081China State Key Laboratory of Frigid Zone Cardiovascular Disease Department of Pharmacology(State-Province Key Laboratories of Biomedicine-Pharmaceutics of China Key Laboratory of Cardiovascular Research Ministry of Education)College of PharmacyHarbin Medical UniversityHarbin150081China The Center of Functional Experiment Teaching School of Basic MedicineHarbin Medical UniversityHarbin150081China

Pathological cardiac hypertrophy,a major contributor to heart failure,is closely linked to mitochondrial *** roles of long noncoding RNAs(lncRNAs),which regulate mitochondrial function,remain largely unexplored in this ***,a previously unknown lncRNA,Gm20257,was *** markedly increased under hypertrophic stress in vivo and in *** suppression of Gm20257 by using small interfering RNAs significantly induced cardiomyocyte ***,the overexpression of Gm20257 through plasmid transfection or adeno-associated viral vector-9 mitigated angiotensinⅡ-induced hypertrophic phenotypes in neonatal mouse ventricular cells or alleviated cardiac hypertrophy in a mouse TAC model respectively,thus restoring cardiac ***,Gm20257 restored mitochondrial complexⅣlevel and enhanced mitochondrial *** prediction showed that Gm20257 had a high binding score with peroxisome proliferator–activated receptor coactivator-1(PGC-1α),which could increase mitochondrial complex ***,Western blot analysis results revealed that Gm20257 substantially affected the expression of PGC-1α.Further analyses through RNA immunoprecipitation and immunoblotting following RNA pull-down indicated that PGC-1αwas a direct downstream target of *** interaction was demonstrated to rescue the reduction of mitochondrial complex IV induced by hypertrophic stress and promote the generation of mitochondrial *** findings suggest that Gm20257 improves mitochondrial function through the PGC-1α-mitochondrial complexⅣaxis,offering a novel approach for attenuating pathological cardiac hypertrophy.

关键词： lncRNA Gm20257 cardiac hypertrophy PGC-1α mitochondrial complexⅣ ATP

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大学生犯罪成因的压力整合理论实证研究——以调查访谈方法为例

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预防青少年犯罪研究 2024年第2期 19-26页

作者：刘晓善天津财经大学马克思主义学院天津300221

“压力整合”理论模型是在一般压力理论、社会支持理论和社会控制理论的基础上,进行抽选、修正与补充,整合建构而成的研究转型期大学生犯罪的成因理论。理论建构离不开实证研究,为验证“压力整合”理论模型在大学生犯罪成因理论分析上... 详细信息

“压力整合”理论模型是在一般压力理论、社会支持理论和社会控制理论的基础上,进行抽选、修正与补充,整合建构而成的研究转型期大学生犯罪的成因理论。理论建构离不开实证研究,为验证“压力整合”理论模型在大学生犯罪成因理论分析上的适用性,在遵循实证研究基本原则和主要目标的前提下,选取代表性案例,选择调查访谈方法即个别访问进行实证分析研究。

关键词：大学生犯罪压力整合理论实证研究调查访谈

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压力整合理论模型下大学生犯罪防治机制研究

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预防青少年犯罪研究 2024年第1期 4-9页

作者：刘晓善林苗天津财经大学天津300221

压力整合理论模型虽肇始于大学生犯罪的成因分析,但落脚点还是在于对大学生犯罪的防范和矫治。根据压力整合理论模型中大学生犯罪成因的两个系统来建构大学生犯罪防治的机制体系,一个是以一般压力理论为主线的中介系统,另一个是以社会... 详细信息

压力整合理论模型虽肇始于大学生犯罪的成因分析,但落脚点还是在于对大学生犯罪的防范和矫治。根据压力整合理论模型中大学生犯罪成因的两个系统来建构大学生犯罪防治的机制体系,一个是以一般压力理论为主线的中介系统,另一个是以社会支持和社会控制为两翼的条件系统。大学生犯罪防治的机制体系即以这两个系统为重要参照,构筑起制度、文化、教育和社会四位一体的立体防线,最终以期达到防治大学生犯罪的目的。

关键词：压力整合理论大学生犯罪防治机制

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热处理和泡沫铁对A356-SiC_(p)/Fe干滑动摩擦学性能的影响

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功能材料 2024年第3期55卷 3035-3041,3101页

作者：黎若芸何国球刘晓山刘胤孚周志强廖逸平同济大学材料科学与工程学院上海201800

采用真空辅助熔渗工艺制备泡沫铁骨架作为增强SiC_(p)/A359复合材料A359-SiC_(p)/Fe,对比进行泡沫铁增强前后和T6热处理前后,两种材料的显微硬度和高温磨损性能,明确泡沫铁和T6热处理对A359-SiC_(p)/Fe复合材料高温磨损性能增强的效果,... 详细信息

采用真空辅助熔渗工艺制备泡沫铁骨架作为增强SiC_(p)/A359复合材料A359-SiC_(p)/Fe,对比进行泡沫铁增强前后和T6热处理前后,两种材料的显微硬度和高温磨损性能,明确泡沫铁和T6热处理对A359-SiC_(p)/Fe复合材料高温磨损性能增强的效果,并结合使用SEM与EDS对表面磨损形貌、磨屑形貌的观察表征,以探究该材料在不同温度下的高温磨损机理。结果表示,使用真空辅助熔渗工艺制备A359-SiC_(p)/Fe, Al-Fe界面结合良好,不仅形成了机械结合,还形成了化学冶金结合(靠近铝基体界面的相为Al_(12)Fe_(5)Si_(3);靠近泡沫铁基体处为Fe_(2)Al_(5)相;远离泡沫铁组织,呈游离状态的合金相为Al_(4)FeSi)。A359-SiC_(p)/Fe在300~500℃的磨损量仅为未增强合金的25%~75%,有效将高温环境下的使用温度提升50~100℃以上。T6热处理能够明显提高Al基体的硬度以及Al-Fe界面的冶金结合程度,且在300~500℃时效果更明显,有效提高材料的高温耐磨性能。材料的磨削形式受温度影响,100℃时为磨粒磨损,摩擦温度到达350℃时表面出现分层和剥落,500℃时,开始粘着磨损。

关键词： A356-SiC_(p)/Fe SiC_(p)/A359 T6热处理摩擦温度磨损机制

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Experimental Study on Effects of Fuel Injection on Scramjet Combustor Performance

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Chinese Journal of Aeronautics 2007年第6期20卷 488-494页

作者： Wu Xianyu Li xiaoshan Ding Meng liu Weidong Wang Zhenguo College of Aerospace and Material Engineering National University of Defense Technology ChangSha 410073 China

In order to investigate the effects of fuel injection distribution on the scrarnjet combustor performance, there are conducted three sets of test on a hydrocarbon fueled direct-connect scramjet test facility. The results of Test A, whose fuel injection is carried out with injectors located on the top-wall and the bottom-wall, show that the fuel injection with an appropriate close-front and centralized distribution would be of much help to optimize combustor performances. The results of Test B, whose fuel injection is performed at the optimal injection locations found in Test A, with a given equivalence ratio and different injection proportions for each injector, show that this injection mode is of little benefit to improve combustor performances. The results of Test C with a circumferential fuel injection distribution displaies the possibility of ameliorating combustor performance. By analyzing the effects of injection location parameters on combustor performances on the base of the data of Test C, it is clear that the injector location has strong coupled influences on combustor performances. In addition, an irmer-force synthesis specific impulse is used to reduce the errors caused by the disturbance of fuel supply and working state of air heater while assessing combustor performances.

关键词： scramjet combustor fuel injection direct-cormect test

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Solar energy full-spectrum perfect absorption and efficient photo-thermal generation

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Chinese Physics B 2021年第8期30卷 381-387页

作者： Zhefu Liao Zhengqi liu Qizhao Wu xiaoshan liu Xuefeng Zhan Gaorong Zeng Guiqiang liu College of Physics and Communication Electronics Jiangxi Normal UniversityNanchang 330022China

Designing and manufacturing cost-effective absorbers that can cover the full-spectrum of solar irradiation is still critically important for solar *** control of the lightwave reflection and transmission,metamaterials realize high absorption over a relatively wide ***,a truncated circular cone metasurface(TCCM)composed of alternating multiple layers of titanium(Ti)and silicon dioxide(SiO_(2))is *** by the synergetic of surface plasmon resonances and Fabry-Pérot resonances,the TCCM simultaneously achieves high absorptivity(exceed 90%),and absorption broadband covers almost the entire solar irradiation *** addition,the novel absorber exhibits great photo-thermal *** exploiting the ultrahigh melting point of Ti and SiO_(2),high-efficiency solar irradiation absorption and heat release have been achieved at 700℃when the solar concentration ratio is 500(i.e.,incident light intensity at 5×10^(5) W/m^(2)).It is worth noting that the photo-thermal efficiency is almost unchanged when the incident angle increases from 0°to 45°.The outstanding capacity for solar harvesting and light-to-heat reported in this paper suggests that TCCM has great potential in photothermal therapies,solar desalination,and radiative cooling,etc.

关键词： solar energy photo-thermal generation perfect absorption plasmonic

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基于成果导向教育理念的卫生毒理学课程思政示范课堂设计及实施

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中国医药导报 2024年第19期21卷 86-90页

作者：陈玉婷高羽亭刘小山孙倩唐焕文广东医科大学公共卫生学院广东东莞523808

强调“以学生为中心”的成果导向教育(OBE)教学方法为人才培养和教学模式改革提供新思路。本文结合卫生毒理学课程特点,基于OBE理念研究案例为切入点的课程思政课堂教学的设计及实施。以第一章绪论的第三节“毒理学基本概念”内容为例,... 详细信息

强调“以学生为中心”的成果导向教育(OBE)教学方法为人才培养和教学模式改革提供新思路。本文结合卫生毒理学课程特点,基于OBE理念研究案例为切入点的课程思政课堂教学的设计及实施。以第一章绪论的第三节“毒理学基本概念”内容为例,针对学生特点和教学内容设计契合的实际案例,以思政案例为导向,构建“课前自主学习(基础)-课中深度学习(提升)-课后延伸拓展(拓展)”3个进阶式教学层次授课模式。实践表明,该教学设计有效引导学生自主学习,实现教学目标从知识传授型向能力和价值培养型转变,有助于培养胜任公共卫生岗位的高素质应用型预防医学专业人才。

关键词：卫生毒理学成果导向教育理念课程思政案例教学设计

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Predicting microbial extracellular electron transfer activity in paddy soils with soil physicochemical properties using machine learning

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Science China(Technological Sciences) 2024年第1期67卷 259-270页

作者： OU JiaJun LUO xiaoshan liu JunYang HUANG LinYan ZHOU LiHua YUAN Yong School of Automation Guangdong University of TechnologyGuangzhou 510006China Guangdong Key Laboratory of Environmental Catalysis and Health Risk Control Guangzhou Key Laboratory Environmental Catalysis and Pollution ControlSchool of Environmental Science and EngineeringInstitute of Environmental Health and Pollution ControlGuangdong University of TechnologyGuangzhou 510006China School of Biomedical and Pharmaceutical Sciences Guangdong University of TechnologyGuangzhou 510006China

Soil extracellular electron transfer(EET)is a pivotal biological process within the realm of ***,EET suffers from a lack of predictive ***,an intricately crafted machine learning model has been developed for the purpose of predicting soil EET by using the physicochemical properties of soil as independent input variables and the EET capabilities in terms of current density(j_(max))and Coulombic charge(C_(out))as dependent output *** autoencoder ensemble stacking(AES)model was developed to address the aforementioned issue by integrating support vector machine,multilayer perceptron,extreme gradient boosting,and light gradient boosting machine algorithms as the stacking *** 10-fold crossvalidation,the AES model exhibited notable improvements in predicting j_(max)and C_(out),with average test R^(2)values of 0.83 and 0.84,respectively,surpassing those of single machine learning(ML)models and the basic ensemble *** utilizing partial correlation plots(PDPs),Shapley Additive explanations(SHAP)values,and SHAP decision plots,we quantitatively explained the impact and contribution of the input molecules on the AES model’s predictions of j_(max)and C_(out).In the context of the SHAP method for the AES model,total carbon(TC)was identified as the most correlated descriptor for j_(max),while total organic carbon(TOC)stood out as the most relevant descriptor for C_(out).In the prediction tasks of j_(max)and C_(out)within the AES model,employing a multitask ML approach allowed the model to benefit from the shared information of input variables,thereby enhancing its overall *** study provides a feasible tool for the prediction of soil EET from soil physiochemical properties and an advanced understanding of the relationship between soil physiochemical properties and EET capability.

关键词： extracellular electron transfer paddy soil machine learning prediction autoencoder ensemble stacking model

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Effects of long-term exposure to TDCPP in zebrafish( Danio rerio )–Alternations of hormone balance and gene transcriptions along hypothalamus-pituitary axes

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Animal Models and Experimental Medicine 2022年第3期5卷 239-247页

作者： xiaoshan liu Xiaoxun Lu Jiabin Hong Jing Zhang Juntong Lin Mengzhu Jiang Qian liu Kyungho Choi Jingjing Zhang School of Public Health Dongguan Key Laboratory of Environmental MedicineGuangdong Medical UniversityGuangdongChina Graduate School of Public Health and Institute of Health and Environment Seoul National UniversitySeoulKorea Affiliated Hospital of Guangdong Medical University&Key Laboratory of Zebrafish Model for Development and Disease Guangdong Medical UniversityZhanjiangChina The Marine Biomedical Research Institute of Guangdong Zhanjiang ZhanjiangGuangdongChina

Background : TDCPP is one of the major chemical of organophosphate flame retardants(OPFRs) that has been detected ubiquitously in both the environment and biota. Previously we observed that it influenced the concentrations of sex and thyroid hormones in a sex-dependent pattern, leading to reproductive impairments after short-term exposure in zebrafish. Here we investigate the consequences of longerterm exposure to TDCPP on the hypothalamic-pituitary-gonad(HPG), hypothalamicpituitary-i nterrenal(HPI), and hypothalamic-pituitary-thyroid(HPT) axes of zebrafish( Danio rerio).Methods : A 120-day exposure test to 0.005, 0.05 and 0.5 mg/L TDCPP was initiated with fertilized eggs. Sex steroid hormones in the treated fishes were measured and transcriptional changes were *** : In female fish, exposure to TDCPP resulted in increases in plasma cortisol,follicle stimulating hormone(FSH), luteinizing hormone(LH), 17β-estradiol(E2), cortisol, thyroxine(T4), and triiodothyronine(T3). Transcription of most target genes along HPG, HPI and HPT axes were increased by the exposure. While in male fish the exposure led to decreases in cortisol, FSH, LH, T4, T3, testosterone(T), and 11-ketotestosterone(11-KT). Transcription of genes along HPG, HPI and HPT axes,especially steroidogenic genes, were inhibited in male zebrafish. While, E2/T or E2/11-KT ratio was increased in both female and females. The sex-dependent changes in hormones might be due to differential responses to TDCPP induced stresses. An increase in cortisol level coincided with increases in E2 and THs in female fish, while in males decreases in cortisol as well as T, 11-KT and THs were observed. Long-term exposure to TDCPP at very low(μg/L) concentrations could disrupt hormone balances in a sex dependent *** : This study revealed that TDCPP could affect endocrine axes – HPG, HPI and HPT – in zebrafish, and impair zebrafish development.

关键词： hypothalamus-pituitary-gonad hypothalamus-pituitary-i nterrenal hypothalamus-pituitarythyroid organophosphate flame retardants Zebrafish

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公路沥青路面水损坏分析与处治研究

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市政技术 2024年第1期42卷 25-29页

作者：刘晓姗于海臣陆旭明姚敬宇薛立军北京国道通公路设计研究院股份有限公司北京100073 北京市政路桥股份有限公司北京100045 北京建工集团有限责任公司北京100055 北京市公联公路联络线有限责任公司北京100161

水损坏是我国高速公路沥青路面损坏的主要原因之一,但在实际工程中,对于水损坏原因的判断并没有成熟的方法,相应病害的治理措施也没有针对性的方法和流程。因此,以某高速公路北京段病害处理专项工程为实例,探讨了水损坏原因的判断方法... 详细信息

水损坏是我国高速公路沥青路面损坏的主要原因之一,但在实际工程中,对于水损坏原因的判断并没有成熟的方法,相应病害的治理措施也没有针对性的方法和流程。因此,以某高速公路北京段病害处理专项工程为实例,探讨了水损坏原因的判断方法以及处治措施,提出了应通过病害破损调查,同时结合钻芯取样与室内试验等方法,对病害原因进行分析;明确了滞水的位置与状态,并采用开挖盲沟加排水管排除沥青路面结构层间滞水的方法,对水损坏进行了处治。研究结果表明,该方法可以有效汇集并排除沥青路面层间滞水,彻底解决路面水损坏问题,可为沥青路面水损坏维修设计提供一定的参考。

关键词：沥青路面水损坏原因分析处治措施

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