检索结果-南通市图书馆

A deep learning-driven discovery of berberine derivatives as novel antibacterial against multidrug-resistant Helicobacter pylori

引用

Signal Transduction and Targeted Therapy 2024年第8期9卷 3449-3466页

作者： Xixi Guo xiaosa zhao Xi Lu Liping zhao Qingxuan Zeng Fenbei Chen Zhimeng Zhang Mengyi Xu Shijiao Feng Tianyun Fan Wei Wei Xin Zhang Jing Pang xuefu You Danqing Song Yanxiang Wang Jiandong Jiang Institute of Medicinal Biotechnology Chinese Academy of Medical Sciences and Peking Union Medical College100050 BeijingChina School of Information Science and Technology Northeast Normal UniversityChangchun 130117China Department of Pharmacy Affiliated Hospital of Jining Medical UniversityJining Medical UniversityJining 272029 ShandongChina Institute of Health and Medicine Hefei Comprehensive National Science CenterHefei230601AnhuiChina

Helicobacter pylori(***)is currently recognized as the primary carcinogenic pathogen associated with gastric tumorigenesis,and its high prevalence and resistance make it difficult to tackle.A graph neural network-based deep learning model,employing different training sets of 13,638 molecules for pre-training and fine-tuning,was aided in predicting and exploring novel molecules against ***.A positively predicted novel berberine derivative 8 with 3,13-disubstituted alkene exhibited a potency against all tested drug-susceptible and resistant *** strains with minimum inhibitory concentrations(MICs)of 0.25-0.5μg/*** studies demonstrated an ideal gastric retention of 8,with the stomach concentration significantly higher than its MIC at 24 h post *** administration of 8 and omeprazole(OPZ)showed a comparable gastric bacterial reduction(2.2-log reduction)to the triple-therapy,namely OPZ+amoxicillin(AMX)+clarithromycin(CLA)without obvious disturbance on the intestinal flora.A combination of OPZ,AMX,CLA,and 8 could further decrease the bacteria load(2.8-log reduction).More importantly,the mono-therapy of 8 exhibited comparable eradication to both triple-therapy(OPZ+AMX+CLA)and quadrupletherapy(OPZ+AMX+CLA+bismuth citrate)*** and BamD,playing a major role in outer membrane protein(OMP)transport and assembling,were identified and verified as the direct targets of 8 by employing the chemoproteomics technique.n summary,by targeting the relatively conserved OMPs transport and assembling system,8 has the potential to be developed as a novel *** candidate,especially for the eradication of drug-resistant strains.

关键词： berberine stomach retention

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

非线性水动力导数的数值计算与研究

引用

武汉理工大学学报（交通科学与工程版） 2017年第1期41卷 70-75,81页

作者：赵小仨徐海祥高性能船舶技术教育部重点实验室武汉430063 武汉理工大学交通学院武汉430063

针对船舶的非线性运动难以界定和非线性运动难以预报的问题,以供应船为研究对象,采用CFD商用软件FLUENT,结合动网格技术对大振幅平面运动机构试验进行数值模拟,通过对比不同工况的流场压力云图,分析得出供应船水动力达到非线性的振幅范... 详细信息

针对船舶的非线性运动难以界定和非线性运动难以预报的问题,以供应船为研究对象,采用CFD商用软件FLUENT,结合动网格技术对大振幅平面运动机构试验进行数值模拟,通过对比不同工况的流场压力云图,分析得出供应船水动力达到非线性的振幅范围.设计供应船非线性运动的试验方案,分别模拟不同频率时的大漂角斜航运动及大振幅的纯纵荡、纯横荡、纯首摇、组合运动,拟合得到接近零频率的非线性水动力导数.

关键词：非线性水动力大振幅PMM试验数值计算供应船

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Recycling arsenic-containing bio-leaching residue after thermal treatment in cemented paste backfill:Structure modification,binder properties and environmental assessment

引用

International Journal of Minerals,Metallurgy and Materials 2024年第10期31卷 2136-2147页

作者： Dengfeng zhao Shiyu Zhang Yingliang zhao Department of Mining Engineering Lyuliang UniversityLvliang 033000China School of Civil and Environmental Engineering University of Science and Technology BeijingBeijing 100083China School of Mining Engineering Taiyuan University of TechnologyTaiyuan 030024China Department of Civil and Environmental Engineering The Hong Kong Polytechnic UniversityHong Kong 00852China

The substantial arsenic(As)content present in arsenic-containing bio-leaching residue(ABR)presents noteworthy environ-mental challenges attributable to its inherent instability and susceptibility to *** its elevated calcium sulfate content,ABR exhibits considerable promise for industrial *** study delved into the feasibility of utilizing ABR as a source of sulfates for producing super sulfated cement(SSC),offering an innovative binder for cemented paste backfill(CPB).Thermal treatment at varying temperatures of 150,350,600,and 800℃ was employed to modify ABR’s *** investigation encompassed the examination of phase transformations and alterations in the chemical composition of As within ***,the hydration characteristics of SSC utilizing ABR,with or without thermal treatment,were studied,encompassing reaction kinetics,setting time,strength development,and *** findings revealed that thermal treatment changed the calcium sulfate structure in ABR,consequently impacting the resultant sample ***,calcination at 600℃ demonstrated optimal modification effects on both early and long-term strength *** enhanced performance can be attributed to the augmented formation of reaction products and a densified ***,the thermal treatment elicited modifications in the chemical As fractions within ABR,with limited impact on the As immobilization capacity of the prepared binders.

关键词： cemented paste backfill bio-leaching residue arsenic immobilization binder hydration calcination

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

融合改进SURF和Cell加速的幂函数加权图像拼接方法

引用

激光与光电子学进展 2020年第24期57卷 190-200页

作者：赵潇洒陈西江班亚张丹丹徐乐先武汉理工大学安全科学与应急管理学院湖北武汉430079 重庆市计量质量检测研究院重庆401120

针对图像拼接过程中传统算法存在特征点匹配正确率低和图像融合过程中出现重影、色差及拼接缝隙等问题,提出一种融合改进SURF(Speeded Up Robust Feature)和Cell加速的幂函数加权图像拼接方法。首先利用余弦相似度初步判断特征点的相似... 详细信息

针对图像拼接过程中传统算法存在特征点匹配正确率低和图像融合过程中出现重影、色差及拼接缝隙等问题,提出一种融合改进SURF(Speeded Up Robust Feature)和Cell加速的幂函数加权图像拼接方法。首先利用余弦相似度初步判断特征点的相似性,然后结合双向一致性算法和MSAC算法对粗匹配点进行精匹配,最后使用Cell加速的幂函数权重对图像进行融合,从而完成图像拼接。实验结果表明,相比于其他算法,所提算法的特征点匹配正确率高出约为11个百分点,均方误差缩小约为1.32%~1.48%,信息熵提升约为0.98%~1.70%,拼接总时间消耗减少约为2 s。所提算法在匹配正确率和融合效果上有较好的效果,且同时拥有较好的拼接图像质量,具有更好的普适性。

关键词：图像处理图像拼接余弦相似性 MSAC算法加权融合 Cell加速

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Automatic modeling algorithm of stochastic error for inertial sensors

引用

Control Theory and Technology 2024年第1期22卷 81-91页

作者： Luodi zhao Long zhao School of Automation Science and Electrical Engineering Beihang UniversityBeijing100191China Digital Navigation Center Beihang UniversityBeijing100191China Science and Technology on Aircraft Control Laboratory Beihang UniversityBeijing100191China

This paper proposes an automatic algorithm to determine the properties of stochastic processes and their parameters for inertial error. The proposed approach is based on a recently developed method called the generalized method of wavelet moments (GMWM), whose estimator was proven to be consistent and asymptotically normally distributed. This algorithm is suitable mainly (but not only) for the combination of several stochastic processes, where the model identification and parameter estimation are quite difficult for the traditional methods, such as the Allan variance and the power spectral density analysis. This algorithm further explores the complete stochastic error models and the candidate model ranking criterion to realize automatic model identification and determination. The best model is selected by making the trade-off between the model accuracy and the model complexity. The validation of this approach is verified by practical examples of model selection for MEMS-IMUs (micro-electro-mechanical system inertial measurement units) in varying dynamic conditions.

关键词： GMWM Stochastic process Inertial sensor Sensor calibration Error model Allan variance

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Meeting the challenges of invasive alien species

引用

National Science Review 2024年第3期11卷 296-298页

作者： Weijie zhao NSR news

The Xinjiang Uygur Autonomous Region of China is famous for its tomato production. Abundant sunshine, large day–night temperature difference and the abundant irrigation by snowmelt from the Tianshan Mountains produce...

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Ling-Ling Chen: RNA has its own features;don't study it as a protein

引用

National Science Review 2024年第2期11卷 301-305页

作者： Weijie zhao NSR

Non-coding RNA(ncRNA) has been a very active research area over the past 30 years. From small nc RNA – the discovery of RNA interference won the lead researchers the Nobel Prize, to long ncRNA(lncRNA), which has attracted much attention in recent years, various nc RNAs participate in all kinds of biological processes and show a variety of biomedical application prospects.

关键词： RNA

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

改进YCbCr和区域生长的多特征融合的火焰精准识别算法

引用

激光与光电子学进展 2020年第6期57卷 226-237页

作者：张丹丹章光陈西江班亚赵潇洒徐乐先武汉理工大学安全科学与应急管理学院湖北武汉430079 重庆市计量质量检测研究院重庆401120

提出一种融合RGB、YCbCr和区域生长的火焰前景提取算法。首先,在YCbCr算法的基础上,从反光和非反光区域考虑R通道和Y通道之间的关系,避免反光和非反光区域中过多噪声对初始分割的干扰;然后,计算连通区域质心权重,自动确定种子点,对完成... 详细信息

提出一种融合RGB、YCbCr和区域生长的火焰前景提取算法。首先,在YCbCr算法的基础上,从反光和非反光区域考虑R通道和Y通道之间的关系,避免反光和非反光区域中过多噪声对初始分割的干扰;然后,计算连通区域质心权重,自动确定种子点,对完成颜色分割的图像进行区域生长,达到精细分割的目的;最后,全面分析火焰的静态和动态特征,给出面积和周长变异系数及质心运动距离变化比等,进而将火焰与路灯、蜡烛等干扰源区分开。实验结果表明:所提方法克服了单个算法对火焰场景分析中出现的识别精度不高的缺点,同时能识别出反光和非反光区域并快速排除干扰物,减少误判。

关键词：图像处理 YCbCr颜色空间区域生长前景提取特征分析

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Giant Flexoelectric Effect in Snapping Surfaces Enhanced by Graded Stiffness

引用

Acta Mechanica Solida Sinica 2024年第4期37卷 528-540页

作者： Chuo zhao Department of Aeronautics Imperial College LondonSouth Kensington CampusLondonSW72AZUK

Flexoelectricity is present in nonuniformly deformed dielectric materials and has size-dependent properties, making it useful for microelectromechanical systems. Flexoelectricity is small compared to piezoelectricity;therefore, producing a large-scale flexoelectric effect is of great interest. In this paper, we explore a way to enhance the flexoelectric effect by utilizing the snap-through instability and a stiffness gradient present along the length of a curved dielectric plate. To analyze the effect of stiffness profiles on the plate, we employ numerical parameter continuation. Our analysis reveals a nonlinear relationship between the effective electromechanical coupling coefficient and the gradient of Young’s modulus. Moreover, we demonstrate that the quadratic profile is more advantageous than the linear profile. For a dielectric plate with a quadratic profile and a modulus gradient of − 0.9, the effective coefficient can reach as high as 15.74 pC/N, which is over three times the conventional coupling coefficient of piezoelectric material. This paper contributes to our understanding of the amplification of flexoelectric effects by harnessing snapping surfaces and stiffness gradient design.

关键词： Functionally graded material Flexoelectricity Numerical continuation Snap-through instability

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

One dimensional CeO_(2) nanorods/poly(ethylene oxide) solid composite electrolyte for all-solid-state lithium-ion batteries

引用

Journal of Rare Earths 2024年第3期42卷 570-577,I0005页

作者： Yudi Guo Erqing zhao Xiaofang zhao Shuailei Liu School of Chemistry and Materials Engineering Xinxiang UniversityXinxiang453003China School of Chemistry and Chemical Engineering Henan Institute of Science and TechnologyXinxiang453003China

The research of poly(ethylene oxide)(PEO)-based solid composite electrolyte with high ionic conductivity and excellent interfacial stability is the key to the development of all-solid-state lithium-ion batteries(ASSLIBs). Herein, uniform nanorod structured CeO_(2) fillers were controllably synthesized by electrospinning, which were subsequently filled into PEO polymer to prepare CeO_(2)/PEO solid composite electrolyte. The addition of CeO_(2) nanorods can reduce both the glass transition temperature and the melting point of PEO polymer, and also interact with PEO and lithium bis(trifluoromethanesulphonyl)imide(LITFSI) by Lewis acid—base reaction. Therefore, the solid composite electrolyte exhibits a high ionic conductivity of 4.52 × 10^(-4)S/cm, a wide electrochemical stability window of about 4.8 V, and a good interfacial stability with Li at 55℃. Moreover, the LiFePO_4/Li ASSLIB divulges the discharging specific capacity of 165, 162, 156 and 146 mA,h/g at 0.2, 0.5, 1 and 2 C, respectively, and achieves the capacity retention of 90.3% after 150 cycles at 0.5 C. Consequently, one dimensional CeO_(2) nanorods can be considered as an alternative filler for polymeric solid electrolyte.

关键词： Poly(ethylene oxide) Solid composite electrolyte CeO_(2)nanorods Ionic conductivity Rare earths

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：