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The emerging role of nitric oxide in the synaptic dysfunction of vascular dementia

Neural Regeneration Research 2025年第2期20卷 402-415页

作者： xiaorong zhang Zhiying Chen Yinyi Xiong Qin Zhou Ling-Qiang Zhu Dan Liu Department of Pathology Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Jiujiang Clinical Precision Medicine Research Center JiujiangJiangxi ProvinceChina Center for Cognitive Science and Transdisciplinary Studies Jiujiang UniversityJiangxi ProvinceChina Department of Neurology Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Department of Rehabilitation Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Department of Pathophysiology School of Basic MedicineTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

With an increase in global aging,the number of people affected by cerebrovascular diseases is also increasing,and the incidence of vascular dementia-closely related to cerebrovascular risk-is increasing at an epidemic ***,few therapeutic options exist that can markedly improve the cognitive impairment and prognosis of vascular dementia *** in Alzheimer’s disease and other neurological disorders,synaptic dysfunction is recognized as the main reason for cognitive *** oxide is one of the ubiquitous gaseous cellular messengers involved in multiple physiological and pathological processes of the central nervous ***,nitric oxide has been implicated in regulating synaptic plasticity and plays an important role in the pathogenesis of vascular *** review introduces in detail the emerging role of nitric oxide in physiological and pathological states of vascular dementia and summarizes the diverse effects of nitric oxide on different aspects of synaptic dysfunction,neuroinflammation,oxidative stress,and blood-brain barrier dysfunction that underlie the progress of vascular ***,we propose that targeting the nitric oxide-sGC-cGMP pathway using certain specific approaches may provide a novel therapeutic strategy for vascular dementia.

关键词： endoplasmic reticulum stress endothelial nitric oxide synthase gene therapy nitric oxide NO-sGC-cGMP pathway synaptic dysfunction vascular dementia

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1.56 kV/30 A vertical β-Ga2O3 Schottky barrier diodes with composite edge terminations

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Science China(Information Sciences) 2025年

作者： Yitao FENG Hong ZHOU Sami ALGHAMDI Hao FANG xiaorong zhang Yanbo CHEN Guotao TIAN Saud WASLY Yue HAO Jincheng zhang Key Lab of Wide Band Gap Semiconductor Materials and Devices School of MicroelectronicsXidian University Center of Excellence in Intelligent Engineering Systems (CEIES) King Abdulaziz University China Resources Microelectronics Limited(Wuxi)

In recent years, large-area wide-bandgap (WBG) semiconductor materials have achieved numerous notable breakthroughs [1, 2]. The ultra-WBG semiconductor β-Ga2O3,with its excellent material properties, is ideally suited for the fabrication of power devices. Moreover, it offers easily obtainable large-area substrates, with reported sizes up to 6 inches, produced through melt-grown crystal growth methods. These characteristics make β-Ga2O3 highly attractive for future low-cost commercialization. Despite these advances, most research has focused on low-current and small-size diodes, with few studies addressing high-current and large-size diodes.

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A Self-Healing and Nonflammable Cross-Linked Network Polymer Electrolyte with the Combination of Hydrogen Bonds and Dynamic Disulfide Bonds for Lithium Metal Batteries

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Energy & Environmental Materials 2023年第4期6卷 106-113页

作者： Kai Chen Yuxue Sun xiaorong zhang Jun Liu Haiming Xie Department of Chemistry National&Local United Engineering Laboratory for Power BatteryNortheast Normal UniversityChangchun 130024China

The self-healing solid polymer electrolytes(SHSPEs)can spontaneously eliminate mechanical damages or micro-cracks generated during the assembly or operation of lithium-ion batteries(LIBs),significantly improving cycling performance and extending service life of ***,we report a novel cross-linked network SHSPE(PDDP)containing hydrogen bonds and dynamic disulfide bonds with excellent self-healing properties and *** combination of hydrogen bonding between urea groups and the metathesis reaction of dynamic disulfide bonds endows PDDP with rapid self-healing capacity at 28°C without external ***,the addition of 1-ethyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide(EMIMTFSI)improves the ionic conductivity(1.13×10^(−4)S cm^(−1)at 28°C)and non-flammability of *** assembled Li/PDDP/LiFePO_(4)cell exhibits excellent cycling performance with a discharge capacity of 137 mA h g^(−1)after 300 cycles at 0.2 *** importantly,the self-healed PDDP can recover almost the same ionic conductivity and cycling performance as the original PDDP.

关键词： cross-linked network dynamic disulfide bonds lithium-ion batteries nonflammable self-healing solid polymer electrolytes

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Applications of M/N/C analogue catalysts in PEM fuel cells and metal-air/oxygen batteries: Status quo, challenges and perspectives

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Progress in Natural Science:Materials International 2020年第6期30卷 807-814页

作者： Bin Chi xiaorong zhang Mingrui Liu Shijie Jiang Shijun Liao The Key Laboratory of Fuel Cell Technology of Guangdong Province & The Key Laboratory of New Energy Technology of Guangdong Universities School of Chemistry and Chemical Engineering South China University of Technology

To meet the sharp increase in demand for clean and renewable energy, it is necessary to develop new energyconversion and storage technologies, such as proton exchange membrane fuel cells(PEMFCs) and metal-air/oxygen batteries(MABs). Due to the sluggish reaction kinetics of the oxygen reduction reaction(ORR) and the oxygen evolution reaction(OER) in the cathodes of PEMFCs and MABs, significant amounts of precious metal catalysts need to be used, driving up the cost of fuel cells and MABs and thereby hindering their commercialization on a large scale. Transition metal and nitrogen co-doped carbonaceous catalysts(M/N/C) have high catalytic activity towards the ORR and OER once the catalysts are modified with certain promoters/additives. In addition, M/N/C catalysts can be prepared from abundant, inexpensive materials, making their cost negligible compared with precious metal catalysts, a development that would efficiently decrease the cost of PEMFCs and MABs. In last decade, numerous researchers have attempted to realize these applications of M/N/C catalysts, and some exciting results have been achieved, making these promising replacements for precious metal ***, some serious problems and significant challenges remain. In this paper, we review the research on the application of M/N/C analogue catalysts in PEMFCs and MABs in the last 10 years, indicate the remaining challenges, and suggest the future research directions.

关键词： PEM fuel cell MABs M/N/C catalysts Oxygen reaction

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Protective effects of Humanin on hypoxia-induced neuronal death

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Neural Regeneration Research 2009年第1期4卷 5-9页

作者： Yunqi Zhu Yanli Li Jingyi Liu xiaorong Yang Ce zhang Department of Physiology and Neurobiology Shanxi Medical University Taiyuan 030001 Shanxi Province China

BACKGROUND： Humanin is a 24-amino acid peptide isolated from the brain of an Alzheimer’s disease patient. Several studies have indicated that Humanin can protect cells against cytotoxicity induced by various insults. OBJECTIVE： To investigate the protective role of Humanin on hypoxia-induced neuronal death, and to determine the most appropriate therapeutic concentration of Humanin. DESIGN, TIME AND SETTING： Neuropathophysiological, randomized, controlled experiment, conducted at the Department of Physiology and Neurobiology, Shanxi Medical University, between March 2007 and October 2007. MATERIALS： Newborn Wistar rats, 5,5＇,6,6＇ tetrachloro-1,1＇,3,3＇-tetraethyl- benzimidazolylcarbo- cyanine iodide （JC-1, USA）, calcein-acetoxymethylester （calcein-AM, USA）, and Humanin （Shanghai, China） were used in this study. METHODS： Primary cortical neurons were cultured with dulbecco＇s modified eagle＇s medium containing 15% fetal bovine serum. Cultures were divided into three groups： control, hypoxia, and hypoxia ＋ Humanin. Various concentrations of Humanin （1, 10, and 20 μmol/L） were added to the cultures 16 hours prior to hypoxia induction. For hypoxic conditions, cells were maintained at 37 ℃ within an incubator chamber filled with 95% N2 and 5% CO2 for 24 hours. Cells in the control group were cultured in normal oxygen. MAIN OUTCOME MEASURES： Cell viability was determined through the use of the vital dye calcein-AM, and the number of live cells was determined. Mitochondrial membrane potential （△Ψm） was assessed using the fluorescent probe JC-1. Mitochondrial permeability transition pore （mPTP） opening was determined with calcein-AM in the presence of cobalt chloride.RESULTS：（1） Cell viability： Hypoxia for 24 hours induced death in a large number of neurons. Pre- treatment with 10 μmol/L and 20 μmol/L Humanin, 16 hours prior to hypoxia, protected cells against hypoxia. However, 1 μmol/L Humanin provided little protection. （2） △Ψm： △Ψm was re-duced after 24-hour hypo

关键词： hypoxia Humanin protection mitochondria

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Preparation and toughening mechanism of Al_(2)O_(3) composite ceramics toughened by B_(4)C@TiB_(2) core–shell units

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Journal of Advanced Ceramics 2023年第12期12卷 2371-2381页

作者： Yingjie Shi Weixing Li xiaorong zhang Jiachao Jin Jilin Wang Yu Dong Jingbo Mu Guangsuo Wang Xiaoliang zhang Zhixiao zhang Key Laboratory of New Inorganic Nonmetallic Composites of Handan College of Materials Science and EngineeringHebei University of EngineeringHandan 056038China Key Laboratory of Intelligent Industrial Equipment Technology of Hebei Province College of Mechanical and Equipment EngineeringHebei University of EngineeringHandan 056038China College of Materials Science and Engineering Guilin University of TechnologyGuilin 532100China School of Civil and Mechanical Engineering Curtin UniversityPerth 6845Australia

In this paper, the concept of incorporating core–shell structured units as secondary phases totoughen Al_(2)O_(3) ceramics is proposed. Al_(2)O_(3) composite ceramics toughened by B_(4)C@TiB_(2) core–shellunits are successfully synthesized using a combination of molten salt methodology and spark plasmasintering. The synthesis of B_(4)C@TiB_(2) core–shell toughening units stems from the prior production ofcore–shell structural B_(4)C@TiB_(2) powders, and this core–shell structure is effectively preserved withinthe Al_(2)O_(3) matrix after sintering. The B_(4)C@TiB_(2) core–shell toughening unit consists of a micron-sizedB4C core enclosed by a shell approximately 500 nm in thickness, composed of numerous nanosizedTiB2 grains. The regions surrounding these core–shell units exhibit distinct geometric structures andencompass multidimensional variations in phase composition, grain dimensions, and thermal expansioncoefficients. Consequently, intricate stress distributions emerge, fostering the propagation of cracks inmultiple dimensions. This behavior consumes a considerable amount of crack propagation energy,thereby enhancing the fracture toughness of the Al_(2)O_(3) matrix. The resulting Al_(2)O_(3) composite ceramicsdisplay relative density of 99.7%±0.2%, Vickers hardness of 21.5±0.8 GPa, and fracture toughness6.92±0.22 MPa·m1/2.

关键词： Al_(2)O_(3)composite ceramics microstructure design core-shell structure toughening mechanism spark plasma sintering(SPS)

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Interactive Web-based Annotation of Plant MicroRNAs with iwa-miRNA

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Genomics, Proteomics & Bioinformatics 2022年第3期20卷 557-567页

作者： Ting zhang Jingjing Zhai xiaorong zhang Lei Ling Menghan Li Shang Xie Minggui Song Chuang Ma State Key Laboratory of Crop Stress Biology for Arid Areas Center of BioinformaticsCollege of Life SciencesNorthwest A&F UniversityYangling 712100China Key Laboratory of Biology and Genetics Improvement of Maize in Arid Area of Northwest Region Ministry of Agriculture and Rural AffairsNorthwest A&F UniversityYangling 712100China College of Plant Science Tibet Agricultural and Animal Husbandry UniversityLinzhi 860006China College of Information Engineering Northwest A&F UniversityYangling 712100China

MicroRNAs(miRNAs) are important regulators of gene expression. The large-scale detection and profiling of miRNAs have been accelerated with the development of highthroughput small RNA sequencing(sRNA-Seq) techniques and bioinformatics tools. However,generating high-quality comprehensive miRNA annotations remains challenging due to the intrinsic complexity of sRNA-Seq data and inherent limitations of existing miRNA prediction tools. Here,we present iwa-miRNA, a Galaxy-based framework that can facilitate miRNA annotation in plant species by combining computational analysis and manual curation. iwa-miRNA is specifically designed to generate a comprehensive list of miRNA candidates, bridging the gap between already annotated miRNAs provided by public miRNA databases and new predictions from sRNA-Seq datasets. It can also assist users in selecting promising miRNA candidates in an interactive mode,contributing to the accessibility and reproducibility of genome-wide miRNA annotation. iwamiRNA is user-friendly and can be easily deployed as a web application for researchers without programming experience. With fexible, interactive, and easy-to-use features, iwa-miRNA is a valuable tool for the annotation of miRNAs in plant species with reference genomes. We also illustrate the application of iwa-miRNA for miRNA annotation using data from plant species with varying genomic complexity. The source codes and web server of iwa-miRNA are freely accessible at http://***/.

关键词： Galaxy Interactive annotation Manual inspection MicroRNA Platform

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Intrathecal MK-801 inhibits formalin-induced activation of spinal p38-MAPK in rats

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Neural Regeneration Research 2008年第11期3卷 1168-1171页

作者： Zhifeng Peng Xin Zhao Xing Jin Xiaochun Yan xiaorong Yang Ce zhang Department of Physiology and Neurology Shanxi Medical University Taiyuan 030001 Shanxi Province China

BACKGROUND： p38 mitogen-activated protein kinase （MAPK） plays an instrumental role in signal transduction from the cell surface to the nucleus, while subcutaneous injection of formalin can induce increased activation of spinal p38 MAPK. However, the mechanisms underlying the formalin-induced activation of spinal p38 MAPK in rats are unclear. OBJECTIVE： To observe the effects of N-methyl-D-aspartic acid （NMDA） receptor antagonist MK-801 on the formalin-induced activation of spinal p38 MAPK in rats. DESIGN, TIME AND SETTING： This randomized grouping, controlled animal experiment was performed at the Department of Physiology and Neurobiology, Shanxi Medical University between May and November 2007. MATERIALS： Forty eight healthy, adult Wistar rats were randomly divided into two groups： formalin ＋ normal saline （n = 12） and formalin ＋ MK-801 （n = 36）. The formalin ＋ MK-801 group was further divided into three subgroups according to the dosage of MK-801 （10, 50, and 100 nmol/L, 12 rats for each subgroup） METHODS： Following anesthesia, polyethylene tubing filled with sterile normal saline was implanted into the subarachnoid cavity. On postoperative days 5-8, rats received a 15 minute perfusion of normal saline or MK-801 （10, 50, and 100 nmol/L） in the formalin ＋ normal saline and formalin ＋ MK-801 groups, respectively, followed by formalin injection for the induction of nociceptive behavior. MAIN OUTCOME MEASURES： Detection of total p38 MAPK and of phosphorylated p38 MAPK by western Blot analysis; observation of nociceptive behaviors in the 1 hour after formalin injection. RESULTS： Western Blot analysis revealed that injection of formalin had no effect on total p38 MAPK expression but resulted in increased phosphorylation of p38 MAPK in the spinal cord. This increase was apparent after 5 minutes, peaked at 20 minutes, and thereafter descended and reached control levels after 45 minutes. Pretreatment with MK-801 （10, 50, 100 nmol/L） resulted in a dose-dependent reduction o

关键词： NMDA receptor antagonist MK-801 formalin nociceptive behavior phosphorylation p38 MAPK

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Numerical modeling of secondary migration and its applications to Chang-6 Member of Yanchang Formation (Upper Triassic), Longdong area, Ordos Basin, China

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Science China Earth Sciences 2007年第Z2期50卷 91-102页

作者： LUO xiaorong YU Jian zhang LiuPing YANG Yang CHEN RuiYin CHEN ZhanKun ZHOU Bo Key Laboratory of Petroleum Resources Researches Institute of Geology and Geophysics Chinese Academy of Sciences Beijing 100029 China Institute of Petroleum Exploration and Development Changqing Oil Company PetroChina Company Limited Xi'an 710021 China Key Laboratory of Petroleum Resources Researches Institute of Geology and Geophysics Chinese Academy of Sciences Beijing 100029 China Institute of Petroleum Exploration and Development Changqing Oil Company PetroChina Company Limited Xi'an 710021 China Key Laboratory of Petroleum Resources Researches Institute of Geology and Geophysics Chinese Academy of Sciences Beijing 100029 China Key Laboratory of Petroleum Resources Researches Institute of Geology and Geophysics Chinese Academy of Sciences Beijing 100029 China Key Laboratory of Petroleum Resources Researches Institute of Geology and Geophysics Chinese Academy of Sciences Beijing 100029 China

Mathematic modeling, established on the basis of physical experiments, is becoming an increasingly important tool in oil and gas migration studies. This technique is based on the observation that hydrocarbon migration tends to take relative narrow pathways. A mathematical model of hydrocarbon migration and accumulation is constructed using the percolation theory. It is then calibrated using physical experimental results, and is tested under a variety of conditions, to understand the applicability of the model in different migration cases. Through modeling, dynamic conditions of large-scale migration pathways within homogeneous formations can be evaluated. Basin-scale hydrocarbon migration pathways and their characteristics are analyzed during the model application to the Chang-8 Member of the Triassic Yanchang Formation in Longdong area of Ordos Basin. In heterogeneous formations, spatial changes in fluid potential determine the direction of secondary migration, and heterogeneity controls the characteristics and geometry of secondary migration pathways.

关键词： hydrocarbon migration, percolation theory, numerical model, migration pathway, migration carrier, heterogeneity

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Natural multimodal interaction in immersive flow visualization

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Visual Informatics 2021年第4期5卷 56-66页

作者： Chengyu Su Chao Yang Yonghui Chen Fupan Wang Fang Wang Yadong Wu xiaorong zhang Southwest University of Science and Technology School of Computer Science and Tecnonology China Computational Aerodynamics Institute at China Aerodynamics Research and Development Center China SiChuan University of Science&Engineering China

In the immersive flow visualization based on virtual reality,how to meet the needs of complex professional flow visualization analysis by natural human–computer interaction is a pressing *** order to achieve the natural and efficient human–computer interaction,we analyze the interaction requirements of flow visualization and study the characteristics of four human–computer interaction channels:hand,head,eye and *** give out some multimodal interaction design suggestions and then propose three multimodal interaction methods:head&hand,head&hand&eye and head&hand&eye&*** freedom of gestures,the stability of the head,the convenience of eyes and the rapid retrieval of voices are used to improve the accuracy and efficiency of *** interaction load is balanced by multimodal interaction to reduce *** evaluation shows that our multimodal interaction has higher accuracy,faster time efficiency and much lower fatigue than the traditional joystick interaction.

关键词： Flow visualization Virtual reality Multimodal interaction Human-computer interaction

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