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Intelligent lesion blood–brain barrier targeting nano-missiles for Alzheimer's disease treatment by anti-neuroinflammation and neuroprotection

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Acta Pharmaceutica Sinica B 2022年第4期12卷 1987-1999页

作者： Xueqin He xiaorong wang Lianyi Yang Zhihang Yang Wenqi Yu Yazhen wang Rui Liu Meiwan Chen Huile Gao Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial TechnologyWest China School of PharmacySichuan UniversityChengdu 610041China State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoMacao 999078China

The treatment of Alzheimer's disease(AD)is one of the most difficult challenges in neurodegenerative diseases due to the insufficient blood‒brain barrier(BBB)permeability and unsatisfactory intra-brain distribution of ***,we established an ibuprofen and FK506 encapsulated drug co-delivery system(Ibu&FK@RNPs),which can target the receptor of advanced glycation endproducts(RAGE)and response to the high level of reactive oxygen species(ROS)in *** is highly and specifically expressed on the lesion neurovascular unit of AD,this property helps to improve targeting specificity of the system and reduce unselective distribution in normal ***,these two drugs can be specifically released in astrocytes of AD lesion in response to high levels of *** a result,the cognition of AD mice was significantly improved and the quantity of Aβplaques was *** was also alleviated with structural regeneration and functional recovery of ***,the neuroinflammation dominated by NF-κB pathway was significantly inhibited with decreased NF-κB and IL-1βin the ***,Ibu&FK@RNPs can efficiently and successively target diseased BBB and astrocytes in AD *** it significantly enhances intracephalic accumulation of drugs and efficiently treats AD by anti-neuroinflammation and neuroprotection.

关键词： Receptor for advanced glycation end products ROS-responsive Blood‒brain barrier transcytosis Alzheimer’s disease Drug combination Anti-neuroinflammation Neuroprotection Nano drug delivery system

武汉城市森林空气环境效应研究——以九峰国家森林公园为例

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湖北林业科技 2024年第4期53卷 1-8页

作者：黄发新胡文杰崔鸿侠王晓荣潘磊王祥湖北省林业科学研究院武汉430075 湖北神农架森林生态系统国家定位观测研究站神农架442421 荆门市十里牌林场荆门448000

为探究城市森林空气环境的变化规律,以九峰国家森林公园为研究对象,以空气负离子浓度为主要监测指标,同步监测空气温、湿度,空气颗粒物浓度等,阐明其季节性变化规律,探索影响空气负离子浓度的主要因素。结果表明:森林环境可以显著改善... 详细信息

为探究城市森林空气环境的变化规律,以九峰国家森林公园为研究对象,以空气负离子浓度为主要监测指标,同步监测空气温、湿度,空气颗粒物浓度等,阐明其季节性变化规律,探索影响空气负离子浓度的主要因素。结果表明:森林环境可以显著改善空气温度、湿度,春季和秋季各林分的林内环境均达到“体感舒适”等级;与对照相比,各林分类型对PM_(1.0)、PM_(2.5)和PM_(10)有明显净化效果,其中秋季林分净化率高于夏季,春季最低,针叶+常绿阔叶林的颗粒物净化率相对较高;空气负离子浓度总体表现为夏季>春季>秋季,春季和秋季各林分空气负离子浓度的峰值出现时间主要集中在16∶00,夏季则是在10∶00;影响空气负离子浓度的主要因素在不同季节存在差异,各类型颗粒物浓度、天空开阔度在各季节均与负离子浓度呈极显著或显著负相关关系;空气负离子浓度在春季与空气湿度呈显著正相关,在夏季与树高呈显著正相关,在秋季则与空气温度、叶面积指数和树高表现出显著正相关关系。

关键词：森林公园体感指数颗粒物浓度空气负离子浓度季节性影响因素

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机器上甑在固态白酒蒸馏中的研究进展

酿酒 2024年第1期51卷 32-35页

作者：王孝荣蒋智杨甲平秦辉雷磊泸州老窖股份有限公司四川泸州646000

传统人工上甑过度依赖上甑工人的经验和手法,长时间连续作业下人工上甑的上甑质量和基酒产质量易产生波动,近年来逐渐被机械上甑替代,成为技术进步和发展的必然。基于机器人上甑实践,对生产现状进行了归纳总结,找出了其存在的痛点和难点... 详细信息

传统人工上甑过度依赖上甑工人的经验和手法,长时间连续作业下人工上甑的上甑质量和基酒产质量易产生波动,近年来逐渐被机械上甑替代,成为技术进步和发展的必然。基于机器人上甑实践,对生产现状进行了归纳总结,找出了其存在的痛点和难点,并就其未来重点突破方向和发展趋势进行了展望,为提升白酒固态蒸馏理论和机器上甑技术、提高上甑质量和蒸馏效率提供参考。

关键词：上甑机器固态蒸馏白酒研究进展

Multi-Component Model of Diesel Sprays Under High Injection Pressure

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Journal of Shanghai Jiaotong university(Science) 2018年第2期23卷 264-268页

作者： wang xiaorong wang Jigang JIN Zhangliang REN Guilong MA Hu School of Mechanical Engineering Jiangsu University of Science and Technology Zhenjiang 212003 Jiangsu China School of Mechanical Engineering Nanjing University of Science and Technology Nanjing 210094 China

The combustion efficiency of a diesel engine depends not only on spray characteristics but also on fuel-air mixing characteristics. Based on the original spray model, a new spray model is established in this paper to accurately predict the diesel spray, and then a multi-component evaporation model is added into it. The model takes the influence of component concentration gradient and species on its evaporation rate in the liquid phase into account. This paper studies the spray characteristics(spray penetration, spray angle and spray morphology) and fuel-air mixing characteristics(spray area, spray volume and air entrainment mass) using the spray model, and the results are compared with the experimental results. The comparison shows that the simulated spray penetration and spray angle are close to the experimental results with the average deviations less than 3%. Moreover, this paper studies the spray area, spray volume and air entrainment using empirical formula under different conditions. And the maximum deviations of the spray volume, spray area and air entrainment mass are less than 5% as compared with the test values. Overall, this spray model can predict the diesel spray characteristics and fuel-air mixing characteristics under high injection pressure accurately.

关键词： fuel-air mixing characteristics multi-component evaporation model diesel spray equivalence ratio

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日本汉方医腹诊探析

中国中医基础医学杂志 2024年第9期30卷 1526-1529页

作者：李凤王小荣赵哲李敏马秀兰甘肃中医药大学兰州730000

腹诊是通过诊察患者胸腹部病变征象以判断内在病理变化的一种诊察方法,起源于我国,受封建礼教的束缚,在我国的发展受到限制,后传入日本,逐渐形成日本汉方医学难经派、伤寒派、折衷派;三大腹诊流派内容丰富,其腹诊内容各具特色;纵观三派... 详细信息

腹诊是通过诊察患者胸腹部病变征象以判断内在病理变化的一种诊察方法,起源于我国,受封建礼教的束缚,在我国的发展受到限制,后传入日本,逐渐形成日本汉方医学难经派、伤寒派、折衷派;三大腹诊流派内容丰富,其腹诊内容各具特色;纵观三派腹诊,均有以常达变、切按为要,腹脉互参、整体审查的特点。基于此,本文对日本汉方医腹诊起源、内容、特色进行探析,以期进一步加深对日本汉方医腹诊的认识,提高中医临床诊疗水平。

关键词：腹诊汉方医难经派伤寒派折衷派

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糖尿病足病人生前预嘱知信行现状及影响因素

循证护理 2024年第5期10卷 898-902页

作者：张子晗钱新毅郑洁王晓蓉华中科技大学同济医学院附属梨园医院湖北430077 华中科技大学同济医学院

目的:调查糖尿病足病人生前预嘱的知信行现状并分析其影响因素。方法:采用便利抽样法,于2021年7月—12月对武汉某三级甲等医院住院的160例糖尿病足病人进行问卷调查。结果:糖尿病足病人生前预嘱知信行总分为(99.96±19.84)分,知识维度为... 详细信息

目的:调查糖尿病足病人生前预嘱的知信行现状并分析其影响因素。方法:采用便利抽样法,于2021年7月—12月对武汉某三级甲等医院住院的160例糖尿病足病人进行问卷调查。结果:糖尿病足病人生前预嘱知信行总分为(99.96±19.84)分,知识维度为(3.74±0.82)分,态度维度为(57.14±10.25)分,行为维度为(39.07±10.73)分;多元线性回归分析结果显示,糖尿病足病人生前预嘱知识的影响因素是文化程度、职业、糖尿病足分级;态度的影响因素是职业、医疗费用支付方式;行为的影响因素是医疗费用支付方式;知信行总分的影响因素是职业和医疗费用支付方式。结论:糖尿病足病人生前预嘱态度、行为维度处于中等水平,认知水平较低。医护人员根据糖尿病足病人的不同特征加强生前预嘱相关知识的普及,以提高糖尿病足病人生前预嘱的知信行水平。

关键词：糖尿病足生前预嘱知识态度行为影响因素护理

Evaporation Characteristics of Ethanol Diesel Droplets Containing Nanoparticles

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Journal of Shanghai Jiaotong university(Science) 2021年第2期26卷 201-209页

作者： wang xiaorong WEI Ning GAO Ji YAN Jun JIANG Genzhu School of Mechanical Engineering Jiangsu University of Science and TechnologyZhenjiang 212100JiangsuChina

Evaporation plavs an important role in the cylinder combustion *** the study of fiel evaporation characteristics is very important to improve the combustion performance of internal combustion *** this study,ethanol diesel was used as the base *** evaporation characteristics of droplets at different ambient temperatures(623 K.923 K)were investigated by adding alumina nanoparticles with different mass fractions(1%,2.5%)to ethanol *** results show that the evaporation states of three kinds of droplets(et hanol diesel,base fuel with 1%alumina nanoparticles,base fuel with 2.5%alumina nanoparticles)are similar in the low temperature environment,and nanoparticles inhibit the evaporation of the *** low temperature,the higher the concentration of nanoparticles is,the slower the evaporation rate *** the high temperature environment,nanoparticles significantly promote droplet *** the phenomenon of micro explosion is *** analvzine the evaporation processes of two different temperatures,we kuow that nanoparticles *** on the surface of the droplet,theu form a protective shell,and finally reduce the evaporation rate of the droplet at low *** the high temperature environment,mucleation sites and bubbles are formed in the interior of the droplet:as the droplet is heated further,mucleation sites and bubbles first gather and then fuse:the bubbles gradually expand and burst *** micro explosion of the *** most of them are evaporated in the micro explosion.

关键词： eio capiosion ethanol diesel nanoparticles droplet evaporation bubble micro explosion

Comparative metabolomics provides novel insights into the basis of petiole color differences in celery(Apium graveolens L.)

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2022年第4期23卷 300-314页

作者： Mengyao LI Jie LI Haohan TAN Ya LUO Yong ZHANG Qing CHEN Yan wang Yuanxiu LIN Yunting ZHANG xiaorong wang Haoru TANG College of Horticulture Sichuan Agricultural UniversityChengdu 611130China Institute of Pomology and Olericulture Sichuan Agricultural UniversityChengdu 611130China

Plant metabolites are important for plant development and human *** of celery(Apium graveolens L.)with different-colored petioles have been formed in the course of long-term ***,the composition,content distribution,and mechanisms of accumulation of metabolites in different-colored petioles remain *** ultra-high performance liquid chromatography-tandem mass spectrometry(UHPLC-MS/MS),1159 metabolites,including 100 lipids,72 organic acids and derivatives,83 phenylpropanoids and polyketides,and several alkaloids and terpenoids,were quantified in four celery cultivars,each with a different petiole *** were significant differences in the types and contents of metabolites in celery with different-colored petioles,with the most striking difference between green celery and purple celery,followed by white celery and green *** analysis of metabolic pathways showed that the metabolites of the different-colored petioles were significantly enriched in biosynthetic pathways such as anthocyanin,flavonoid,and chlorophyll pathways,suggesting that these metabolic pathways may play a key role in determining petiole color in *** content of chlorophyll in green celery was significantly higher than that in other celery cultivars,yellow celery was rich in carotenoids,and the content of anthocyanin in purple celery was significantly higher than that in the other celery *** color of the celery petioles was significantly correlated with the content of related *** the four celery cultivars,the metabolites of the anthocyanin biosynthesis pathway were enriched in purple *** results of quantitative real-time polymerase chain reaction(q RT-PCR)suggested that the differential expression of the chalcone synthase(CHS)gene in the anthocyanin biosynthesis pathway might affect the biosynthesis of anthocyanin in *** addition,HPLC analysis revealed that cyanidin is the main pigment in purple *** stud

关键词： Celery Metabolite Anthocyanin Chlorophyll Petiole color

Genetic environment of β-lactamase genes of extended-spectrum β-lactamase-producing Klebsiella pneumoniae isolates from patients with lower respiratory tract infection in China

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Chinese Medical Journal 2014年第13期127卷 2445-2450页

作者： Liu Lin wang xiaorong An Shuchang Zhang Xiangyan Chen Lin Li Yuqian Xu Li Zhang Yijie Gao Zhancheng Department of Respiratory & Critical Care Medicine PekingUniversity People's Hospital Beijing 100044 China Department of Respiratory Medicine Affiliated Union HospitalHuazhong University of Science and Technology Wuhan 430022Hubei China Department of Respiratory Medicine First Affiliated Hospital ofTsinghua University Beijing 100016 China Department of Respiratory & Critical Care Medicine GuizhouProvince People's Hospital Guiyang Guizhou 550002 China

Background Extended-spectrum β-lactamase （ESBL）-producing Klebsiella pneumoniae （***） is one of the most popular pathogens that cause refractory respiratory tract *** genetic environment,including insertion sequences and the types of promoter,plays a key role in exploration of the mechanism of prevalence and dismission of the ESBL-producing *** *** aim of the investigation was to target analysis the genetic environment and promoter sequences of blaCTX-M,blaSHV and blaTEM,the most popular β-lactamase genes harbored by ESBL-producing *** *** From February 2010 to July 2011,158 of 416 *** isolates producing ESBL from patients with lower respiratory tract infection were collected from seven tertiary hospitals from Beijing,Anhui,Fujian,Liaoning,Hebei and Inner Mongolia Autonomous Region in *** genetic environment including promoters of 10 types of blaCTX-M,18 types of blaSHVand 2 types of blaTEM were analyzed by amplification and direct sequencing with various sets of PCR *** ISEcp1 was located upstream of the 5＇ end of the blaCTX-M gene in 130 （97.0％） out of 134 *** isolates harboring blaCTX-M and provided a conserved promoter to blaCTX-M.A non-coding sequence preceded by kdpC and recF was identified in all of the blaSHV genes except blaSHV-12 and ***26 was also found upstream of 1 blaCTX-M-15,10 blaSHV-1 strains,4 blaTEM-1 and all of the blaSHV-2,blaSHV-2a,blaSHV-5 and ***-seven of 91 strains harboring blaTEM-1 carried a copy of Tn2 and IS26-blaTEM-1 fragments were also detected in 4 *** respect to ***,the genetic environment of blaCTX-M-38,blaSHV-142 and blaTEM-135 were firstly elaborated,and four kinds of novel genetic environment of blaCTX-M-3,blaCTX-M-15 and blaTEM-1 have been detected as *** Perfective implementation of the genetic environment information of β-lactamase gene needs to be further explored and supplemente

关键词： Klebsiella pneumoniae promoter β-lactamase insertion sequence