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The cultivation of epilepsy neurosurgeons:requirements and challenges

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Chinese Neurosurgical Journal 2016年第3期2卷 -页

作者： Kai Zhang Jianguo Zhang Yanshan Ma Xiaoqiu Shao Wenhan Hu Baotian Zhao Department of Neurosurgery Epilepsy Center medical alliance of Beijing Tian Tan Hospital Peking University First Hospital Fengtai Hospital Beijing 100000 China Department of Neurology Beijing Tian Tan Hospital Capital Medical University Beijing 1000S0 ChinaEpilepsy Center medical alliance of Beijing Tian Tan Hospital Peking University First Hospital Fengtai Hospital Beijing 100000 China Beijing Key Laboratory of Neurostimulation Department of Neurosurgery Beijing Tian Tan Hospital Capital Medical University No.6 Tian Tan Xi Li Beijing 100050 China

Epilepsy surgery has been accepted as an effective treatment in drug-resistant focal epilepsy. However, the number of epilepsy neurosurgeons is not enough in China compared with the huge demand. The content of epilepsy neurosurgeon cultivation includes surgery itself as well as presurgical evaluation. In this article, we review not only different categories of epilepsy surgeries but also the presurgical evaluation approaches including non-invasive methods, such as semiology analysis, high-resolution structural and functional imaging techniques, scalp electroencephalography monitoring as well as invasive methods, such as electrocorticography (ECoG) and stereotactic electroencephalography (SEEG). We also discuss the importance of learning each method briefly. In addition, we suggest that epilepsy neurosurgeons should have a solid structural and functional anatomy basis as it plays pivotal role in localizing epileptogenic zone. Epilepsy neurosurgeons should also be familiar with the staged presurgical evaluation starting from the most preliminary examinations and progressing to more complex and invasive methods. During the diagnosis and therapeutic procedures, collaboration between epilepsy neurosurgeons and other specialists is essential. At last, the necessity of epilepsy neurosurgeon cultivation has been emphasized.

关键词： Epilepsy neurosurgeon cultivation Epilepsy surgery Presurgical evaluation learning

Expert consensus on clinical applications of high-frequency oscillations in epilepsy

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Acta Epileptologica 2020年第1期2卷 59-68页

作者： Yuping Wang Dong Zhou Xiaofeng Yang Xin Xu Liankun Ren Tao Yu Wenjing Zhou Xiaoqiu Shao Zhixian Yang Shuang Wang Dezhi Cao Chunyan Liu Shang Yeong Kwan Jing Xiang Department of Neurology Xuanwu HospitalCapital Medical UniversityBeijing 100000China. Beijing Key Laboratory of Neuromodulation Beijing 100000China. Center of Epilepsy Beijing Institute of Brain DisordersCapital Medical UniversityBeijing 100000China. Department of Neurology West China HospitalSichuan UniversityChengdu 610000China. Neuroelectrophysiological Laboratory Xuanwu HospitalCapital Medical UniversityBeijing 100000China. Department of Neurosurgery General Hospital of PLABeijing 100000China. Department of Functional Neurosurgery Xuanwu HospitalCapital Medical UniversityBeijing 100000China. Epilepsy Center Tsinghua University Yuquan HospitalBeijing 100000China. Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijing 100000China. China National Clinical Research Center for Neurological Disease NCRC-ND Beijing 100000China. Department of Pediatrics Peking University First HospitalBeijing 100000China. Epilepsy Center Second Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310000China. Department of Neurology Shenzhen Children’s HospitalShenzhen 518000China. Section of Epilepsy Neurological InstituteTaipei Veterans General HospitalTaipeiChina. MEG Center Cincinnati Children’s Hospital Medical CenterCincinnatiOH 45245USA. Division of Neurology Cincinnati Children’s Hospital Medical CenterCincinnatiOH 45245USA.

Studies in animal models of epilepsy and pre-surgical patients have unanimously found a strong correlation between high-frequency oscillations(HFOs,>80 Hz)and the epileptogenic zone,suggesting that HFOs can be a potential biomarker of epileptogenicity and epileptogenesis.This consensus includes the definition and standard detection techniques of HFOs,the localizing value of pathological HFOs for epileptic foci,and different ways to distinguish physiological from epileptic HFOs.The latest clinical applications of HFOs in epilepsy and the related findings are also discussed.HFOs will advance our understanding of the pathophysiology of epilepsy.

关键词： High-frequency oscillations Ripple Fast ripple Interictal spike Epilepsy Biomarker

Is intracranial electroencephalography mandatory for MRI-negative neocortical epilepsy surgery?

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Is intracranial electroencephalography mandatory for MRI-neg...

第十六届中国医师协会神经外科医师年会

作者： Zhihao Guo Chao Zhang Xiu Wang Chang Liu Baotian Zhao Jiajie Mo Zhong Zheng Xiaoqiu Shao Jianguo Zhang Kai Zhang Wenhan Hu Department of Neurosurgery Beijing Tiantan HospitalCapital Medical University Department of Neurosurgery Beijing Fengtai Hospital Department of Neurology Beijing Tiantan HospitalCapital Medical University Stereotactic and Functional Neurosurgery Laboratory Beijing Neurosurgical InstituteCapital Medical University Beijing Key Laboratory of Neurostimulation

Objective:MRI-negative focal epilepsy is one of the most challenging cases in epilepsy surgical treatment.Many epilepsy centers recommend intracranial electroencephalography for MRI-negative cases,especially neocortical epilepsy.This retrospective study aimed to explore whether intracranial monitoring is mandatory in MRI-negative neocortical epilepsy surgery and the factors that significantly influence the decision to perform intracranial recording or not.Methods:In this study,consecutive surgical patients with focal MRI-negative neocortical epilepsy were recruited.All patients underwent routine preoperative evaluation according to the dedicated protocol of our epilepsy center to determine the treatment plan.Patients were divided into two groups according to the surgical strategy:a direct group and a stereo-encephalography(SEEG)-guided group.History of epilepsy,seizure frequency,interictal and ictal EEG data,PET data,PET/MRI co-registration data,neuropathological findings,and surgical outcomes were compared between the two groups.Multivariate analysis was performed to identify factors influencing the decision to implement SEEG monitoring.Results:Sixty-four patients were included in this study,of whom 19 and 45 underwent direct and SEEG-guided cortical resection,respectively.At an average follow-up of 3.9 years postoperatively,56 patients(87.5%) had Engel class I results without permanent neurological deficits.Surgical outcomes were not significantly different between the direct and SEEG-guided groups(94.7% vs.84.4%).There were significant differences between the two groups in the degree of hypometabolism(focal vs.non-focal,p<0.01) and pathological subtype(FCD II vs.others,p=0.03).Multivariate analysis revealed that the degree of hypometabolism(OR 0.01,95% CI 0.00-0.15,p=0.001) was the only independent factor affecting surgical strategy.Conclusions:Careful selection of patients with MRI-negative neocortical epilepsy may yield favorable outcomes with direct cortical resection without intracranial monitoring;PET/MRI

关键词： Neocortical epilepsy MRI-negative FDG-PET Intracranial electroencephalography Stereo-electroencephalography

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心理治疗对青春期癫痫患者康复效用性研究

中国康复医学杂志 2012年第9期27卷 833-836页

作者：王艳云邵晓秋首都医科大学附属北京天坛医院神经内科北京100050

目的:探索心理治疗对青春期癫痫患者康复的有效性。方法:选取73例在我院就诊,年龄在11—17岁之间,明确诊断为癫痫,并正在接受抗癫痫药物治疗的青春期癫痫患者。分为心理治疗组(心理治疗合并抗癫痫药物治疗)和对照组(抗癫痫药物治疗,不... 详细信息

目的:探索心理治疗对青春期癫痫患者康复的有效性。方法:选取73例在我院就诊,年龄在11—17岁之间,明确诊断为癫痫,并正在接受抗癫痫药物治疗的青春期癫痫患者。分为心理治疗组(心理治疗合并抗癫痫药物治疗)和对照组(抗癫痫药物治疗,不给予心理行为干预),采用自我效能量表、青春期癫痫患者生存质量量表进行评定,评定分为初测、疗后测和随访,共计3次。结果:自我效能量表评定:心理治疗组初测为3.72±2.01,疗后测为8.03±2.33,初测与疗后测结果比较差异有显著性(P0.1);随访评定结果为193.08±13.06,与初测结果比较差异不明显(P>0.1);对照组患者生存质量提高不明显,与初测比较无显著性差异。结论:心理治疗合并抗癫痫药物治疗对于青春期癫痫患者康复效果明显,可提高患者的自我效能和生存质量。

关键词：心理治疗青春期癫痫

Effective connectivity among the hippocampus,amygdala and temporal neocortex in epilepsy patients:a cortico-cortical evoked potential study

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Effective connectivity among the hippocampus,amygdala and te...

第七届CAAE脑电图与神经电生理大会

作者： Zhihao Guo Baotian Zhao Wenhan Hua Chao Zhang Xiu Wang Yao Wang Chang Liu Jiajie Mo Lin Sang Yanshan Ma Xiaoqiu Shao Jianguo Zhang Kai Zhang Beijing Tian Tan Hospital Capital Medical University Beijing Key Laboratory of Neurostimulation Beijing Fengtai Hospital

＜正＞Objective Mesial temporal lobe epilepsy（MTLE） is one of the most common types of intractable epilepsy.The hippocampus and amygdala are two crucial structures of the mesial temporal lobe and play important roles in the epileptogenic network of MTLE.This study aimed to explore the effective connectivity among the hippocampus,amygdala and temporal neocortex and to determine whether differences in effective connectivity exist between MTLE patients and non-MTLE patients.

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南通芦扉花色织土布艺术特色与图案分析

毛纺科技 2018年第10期46卷 17-21页

作者：邵卓尔单筱秋张毅江南大学纺织服装学院江苏无锡214122 南京艺术学院设计学院江苏南京210013

针对南通芦扉花色织土布工艺面临绝迹失传的问题,运用文献查阅、田野调查等方法,探究南通色织土布历史发展轨迹,并搜集大量芦扉花布样进行归类,对芦扉花的艺术特色、图案特点、影响因素作了归纳研究。芦扉花布图案题材来源于日常生活,... 详细信息

针对南通芦扉花色织土布工艺面临绝迹失传的问题,运用文献查阅、田野调查等方法,探究南通色织土布历史发展轨迹,并搜集大量芦扉花布样进行归类,对芦扉花的艺术特色、图案特点、影响因素作了归纳研究。芦扉花布图案题材来源于日常生活,形式简单却变化多样,主要以点、线、简单的几何纹样组合而成,用色简单,主要选用蓝白2色,给人素净朴实之美。文章通过记录、整理、研究分析芦扉花布的特色,使传统文化得到更好的传承与发展。

关键词：南通色织土布艺术特色图案色彩

子宫肌瘤射频消融术后短期疗效评估的超声影响因素分析

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中华医学超声杂志（电子版） 2019年第4期16卷 275-280页

作者：苗阔董晓秋邵小慧孔德姣哈尔滨医科大学附属第四医院超声科

目的分析子宫肌瘤射频消融(RFA)术后超声指标和特征,探讨影响RFA术后短期疗效评估结果的超声相关因素。方法选取2015年6月至2018年3月于哈尔滨医科大学附属第四临床医学院接受子宫肌瘤RFA治疗的患者71例,依据术后3个月的临床症状、瘤体... 详细信息

目的分析子宫肌瘤射频消融(RFA)术后超声指标和特征,探讨影响RFA术后短期疗效评估结果的超声相关因素。方法选取2015年6月至2018年3月于哈尔滨医科大学附属第四临床医学院接受子宫肌瘤RFA治疗的患者71例,依据术后3个月的临床症状、瘤体直径减小率及超声造影结果将患者分为疗效优组46例,疗效良组25例。所有患者均于RFA前行常规二维超声、彩色多普勒血流成像(CDFI)、超声弹性成像及超声造影检查。对肌瘤位置、数目、大小、边界、内部回声、CDFI血流、造影模式及造影剂分布特征等相关因素进行统计,分析影响子宫肌瘤RFA短期疗效评估结果的术前超声特征。结果疗效优组与疗效良组比较,肌瘤回声强度、有无粗大供养血管、肌瘤CDFI血流分级、病灶弹性指数(E1)与周围肌层弹性指数(E2)比值(E1/E2)、超声造影增强模式、造影剂分布特征6项因素差异具有统计学意义(χ^2=10.87、4.70、12.81、8.23、10.99、3.92,P均1(OR=11.66,95%CI:2.73~70.50,P=0.002)、超声造影剂分布不均匀(OR=5.84,95%CI:1.45~30.29,P=0.020)是预测子宫肌瘤RFA术后疗效良的独立危险因素。结论术前超声检查可为子宫肌瘤RFA术前评估疗效及判断预后提供参考依据,对于存在术后疗效预测结果为良的危险因素的子宫肌瘤患者应合理优化RFA术前及术中治疗方案,以达到预期的治疗效果。

关键词：子宫平滑肌瘤消融技术超声检查危险因素

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社会主义核心价值体系构建的路径思考

新视野 2007年第5期 9-11页

作者：贺新元邵晓秋中国社会科学院马克思主义研究院江西师范大学政法学院

社会主义核心价值体系,合乎思想价值观念发展的内在逻辑和中国特色社会主义的建设规律。它具有先进性与广泛性相统一的层次性,有党和国家的指导思想层次,也有社会普遍思想层次。这些决定了社会主义核心价值体系构建除了要形成科学灌输... 详细信息

社会主义核心价值体系,合乎思想价值观念发展的内在逻辑和中国特色社会主义的建设规律。它具有先进性与广泛性相统一的层次性,有党和国家的指导思想层次,也有社会普遍思想层次。这些决定了社会主义核心价值体系构建除了要形成科学灌输理论的路径依赖外,还要有上下良性互动的路径创新,以及建立健全科学有效的机制以保证坚实的社会基础。

关键词：社会主义核心价值体系路径社会思潮

Patient,Diagnosis,and Treatment Delays Among Tuberculosis Patients Before and During COVID-19 Epidemic—China,2018-2022

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China CDC weekly 2023年第12期5卷 259-265页

作者： Tao Li Xin Du Jiaojie Kang Dan Luo xiaoqiu Liu Yanlin Zhao National Center for Tuberculosis Control and Prevention China CDCBeijingChina School of Public Health Peking UniversityBeijingChina Department of Public Health Hangzhou Medical CollegeHangzhou CityZhejiang ProvinceChina

Summary What is already known about this topic?The coronavirus disease(COVID-19)pandemic could have a damaging impact on access to tuberculosis(TB)diagnosis and treatment.What is added by this report?The overall delay experienced by TB patients during the COVID-19 pandemic has shown a modest decrease in comparison to the period before the pandemic.Notably,higher patient delays were observed among agricultural workers and those identified through passive case-finding methods.Furthermore,the patient delay in eastern regions was shorter compared to western and central regions.

关键词： diagnosis Patients delay