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World Journal of Gastrointestinal Oncology 2016年第3期8卷 282-288页

作者： Yuning Hou Xiaoqing Guan Zhe Yang Chunying Li Department of Biochemistry and Molecular Biology Karmanos Cancer Institute Wayne State University School of Medicine

Cystic fibrosis transmembrane conductance regulator(CFTR), a glycoprotein with 1480 amino acids, has been well established as a chloride channel mainly expressed in the epithelial cells of various tissues and organs such as lungs, sweat glands, gastrointestinal system, and reproductive organs. Although defective CFTR leads to cystic fibrosis, a common genetic disorder in the Caucasian population, there is accumulating evidence that suggests a novel role of CFTR in various cancers, especially in gastroenterological cancers, such as pancreatic cancer and colon cancer. In this review, we summarize the emerging findings that link CFTR with various cancers, with focus on the association between CFTR defects and gastrointestinal cancers as well as the underlying mechanisms. Further study of CFTR in cancer biology may help pave a new way for the diagnosis and treatment of gastrointestinal cancers.

关键词： Gastrointestinal cancer Protein interaction Cystic fibrosis transmembrane conductance regulator Nuclear factor k B Signaling molecule

Novel Real-Time Seam Tracking Algorithm Based on Vector Angle and Least Square Method

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Journal of Beijing Institute of Technology 2017年第2期26卷 150-157页

作者： guanhao Liang Qingsheng Luo Zhuo Ge Xiaoqing Guan School of Mechatronical Engineering Beijing Institute of TechnologyBeijing 100081China Academic Affairs Office Beijing PolytechnicBeijing 100176China

Real-time seam tracking can improve welding quality and enhance welding efficiency during the welding process in automobile manufacturing.However,the teaching-playing welding process,an off-line seam tracking method,is still dominant in automobile industry,which is less flexible when welding objects or situation change.A novel real-time algorithm consisting of seam detection and generation is proposed to track seam.Using captured 3D points,space vectors were created between two adjacent points along each laser line and then a vector angle based algorithm was developed to detect target points on the seam.Least square method was used to fit target points to a welding trajectory for seam tracking.Furthermore,the real-time seam tracking process was simulated in MATLAB/Simulink.The trend of joint angles vs.time was logged and a comparison between the off-line and the proposed seam tracking algorithm was conducted.Results show that the proposed real-time seam tracking algorithm can work in a real-time scenario and have high accuracy in welding point positioning.

关键词： real-time seam tracking real-time seam detection laser scanner vector angle leastsquare method algorithm research

Case report of rabies-induced persistent mental symptoms

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上海精神医学 2015年第1期27卷 52-54页

作者： xiaoqing WANG Xiaowen YU Yangtai guan DepartmentofNeurology ChanghaiHospitalShanghaiSecondMilitaryMedicalUniversity DepartmentofNeurology RenjiHospitalShanghaiJiaotongUniversitySchoolofMedicine

Summary:Rabies is a viral infection with a high case fatality rate. Typical symptoms of rabies include hydrophobia, pharynx muscle spasms, and progressive paralysis. Rabies-induced persistent mental disturbances are rare. Here we report a 22-year-old male who was infected with rabies after being attacked by a dog. He did not receive rabies vaccine immediately after the incident and was only provided with non- standard treatment at a local clinic. A week later he became disorientated, paranoid, and aggressive. One month after the attack, rabies antibody was found in his cerebrospinal fluid and a Magnetic Resonance Imaging (MRI) examination of his head revealed abnormal signals in the putamina, caudate nucleus, and insula. His mental symptoms persisted for six years and his daily functioning was severely impaired, but his vital signs were stable without signs of brain stem damage. Six years after the incident, a repeat MRI showed brain atrophy.

关键词：典型症状精神障碍狂犬病持续性病例报告病毒感染磁共振成像狂犬疫苗

Novel drug-delivery approaches to the blood-brain barrier

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Neuroscience Bulletin 2015年第2期31卷 257-264页

作者： xiaoqing Wang Xiaowen Yu William Vaughan Mingyuan Liu Yangtai guan Department of Neurology Changhai Hospital Second Military Medical University Stem Cells and Medical Research Center Second Military Medical University Department of Gerontology Changhai Hospital Second Military Medical University Department of Genetics Yale University

The blood-brain barrier （BBB） maintains homeostasis by blocking toxic molecules from the circulation, but drugs are blocked at the same time. When the dose is increased to enhance the drug concentration in the central nervous system, there are side-effects on peripheral organs. In recent years, genetic therapeutic agents and small molecules have been used in various strategies to penetrate the BBB while minimizing the damage to systemic organs. In this review, we describe several representative methods to circumvent or cross the BBB, including chemical and physical strategies.

关键词： drug delivery blood-brain barrier nanoparticles focused ultrasound

Complex regulatory network of Betula BplSPL8 in planta

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Journal of Forestry Research 2017年第5期28卷 881-890页

作者： Chuang Liu Minxiao guan xiaoqing Hu Jing Tian Xuemei Liu College of Life Science Northeast Forestry University Suzhou Micro Diag Biomedicine Co. LtdJiangsu Engineering Research Center for Tumor Molecular Diagnostics

SQUAMOSA-promoter binding protein-like (SPL) proteins are plant-specific transcription factors and participate in different pathways, including the vegetative to reproductive transition, male sterility, biosynthesis of gibberellic acid (GA), plant morphogenesis and response to environmental stress. In this study, we generated transgenic Arabidopsis that overexpressed Betula BplSPL8 and confirmed that BplSPL8 is a transcription factor with transcriptional activation activity and is located in the nucleus. Functional analysis of BplSPL8 showed that it is involved in regulating different development processes: (1) BplSPL8 can delay flowering by reducing sensitivity to GA under short days; (2) BplSPL8 controls the number and morphogenesis of leaves, including up-rolling leaves under long days and folded leaves mediated by GA under short days; (3) BplSPL8 can promote root elongation during late development of roots and inhibit lateral root formation; (4) BplSPL8 may be involved in regulating carotenoid biosynthesis and secretion metabolism. These results show that there is a complex regulatory network for the SPL family genes that is mediated by other components and may provide a new insights for the functional research of SPL genes.

关键词： Birch Root SQUAMOSA-promoter binding protein-like Transgenic Carotenoid

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农民工城镇化视角下职业教育精准扶贫的逻辑

职业技术教育 2018年第22期39卷 61-66页

作者：管小青广东省外语艺术职业学院思想政治理论课教学部广州510640

农民工在城镇化进程中,由于先天的经济资本、社会资本、文化资本劣势,导致其在城市中的脱贫能力较差,阻碍了其经济、身份及心理融入,并逐渐沦为城市边缘群体。职业教育在精准扶贫过程中,可以充分发挥其补偿性及发展性功能,通过提升农民... 详细信息

农民工在城镇化进程中,由于先天的经济资本、社会资本、文化资本劣势,导致其在城市中的脱贫能力较差,阻碍了其经济、身份及心理融入,并逐渐沦为城市边缘群体。职业教育在精准扶贫过程中,可以充分发挥其补偿性及发展性功能,通过提升农民工的人力资本、扩充社会关系网络及增强城市文化认同感来帮助农民工消除物质、能力及精神贫困。基于职业教育在精准扶贫中的显著作用,需要精准分析农民工实际需求,协同多方力量完善扶贫治理与监督机制,优化职业教育精准扶贫的供给,提升扶贫合力以及保障扶贫效能。

关键词：职业教育精准扶贫农民工城镇化

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高职思想政治理论课精准教学设计及实施探索

宁波职业技术学院学报 2021年第6期25卷 100-104页

作者：管小青广东省外语艺术职业学院广东广州510640

高职院校思想政治理论课教学存在课前对学情的把握不足、课中未体现个性化差异、课后任务未凸显专业特质等三大“不精准”问题。通过影视动画专业的“坚定文化自信”课例呈现,探索精准教学设计“明学情,析内容;定目标,讲策略;谈组织,说... 详细信息

高职院校思想政治理论课教学存在课前对学情的把握不足、课中未体现个性化差异、课后任务未凸显专业特质等三大“不精准”问题。通过影视动画专业的“坚定文化自信”课例呈现,探索精准教学设计“明学情,析内容;定目标,讲策略;谈组织,说过程;强效果,深反思”的逻辑进路。实施精准教学有四个原则:坚持“以学生为中心、知行合一”的教学理念;坚持整体的精准教学设计与协同运行;坚持内容为王和信息技术运用的适度原则;坚持“八个相统一”的教学具体要求。坚持这四个原则,打造有温度、有深度和有情怀的思想政治理论课堂。

关键词：思想政治理论课精准教学实施探索

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香港大澳海洋生态旅游发展的经验与启示

中国海洋经济 2019年第2期4卷 177-187页

作者：关晓青中国银行香港有限公司

海洋生态旅游是实现海洋经济和海洋旅游可持续发展的重要方式之一。它强调的是协调海洋旅游资源开发与环境保护之间的关系,最终的目标是追求经济效益、环境效益和社会效益的统一。本文以香港著名渔村大澳为例,对其海洋自然生态旅游资源... 详细信息

海洋生态旅游是实现海洋经济和海洋旅游可持续发展的重要方式之一。它强调的是协调海洋旅游资源开发与环境保护之间的关系,最终的目标是追求经济效益、环境效益和社会效益的统一。本文以香港著名渔村大澳为例,对其海洋自然生态旅游资源和海洋人文生态旅游资源开发的现状与实际进行了探讨和研究,总结了其主要做法与可供借鉴的经验,如尽量保持原生态的自然与人文环境,积极开展教育与体验相结合的生态旅游项目,秉承可持续发展理念并积极听取多方意见以促进渔村繁荣,减少对邻近区域造成的环保负担,协力保护共同资源,等等。

关键词：渔村海洋生态旅游可持续发展海洋经济海洋旅游资源

Energy band engineering via“Bite”defect located on N=8 armchair graphene nanoribbons

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Nano Research 2022年第1期15卷 653-658页

作者： Shijie Sun Yurou guan Zhenliang Hao Zilin Ruan Hui Zhang Jianchen Lu Lei Gao xiaoqing Zuo Jinming Cai Faculty of Materials Science and Engineering Kunming University of Science and TechnologyKunming 650000China Faculty of Science Kunming University of Science and TechnologyKunming 650000China

Graphene nanoribbons(GNRs)not only share many superlative properties of graphene but also display an exceptional degree of tunability of their electronic properties.The bandgaps of GNRs depend greatly on their widths,edges,etc.Herein,we report the synthesis path and the physical properties of atomic accuracy staggered narrow N=8 armchair graphene nanoribbons(sn-8AGNR)with alternating"Bite"defects on the opposite side.The intermediate structures in the surface physicochemical reactions from the precursors to the sn-8AGNR are characterized by scanning tunneling microscopy.The electronic properties of the sn-8AGNR are characterized by scanning tunneling spectroscopies and 6//6V mappings.Compared with the perfect N=8 armchair graphene nanoribbons(8AGNR),the sn-8AGNR has a larger bandgap,indicating that the liB\Xen edges can effectively regulate the electronic structures of GNRs.

关键词： graphene nanoribbons(GNRs) scanning tunneling spectroscopy(STS) non-contact atomic force microscopy(NC-AFM) density functional theory(DFT) energy band regulation

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新能源企业开展综合能源系统方案与建议

能源科技 2020年第12期18卷 66-70页

作者：关晓晴国华能源投资有限公司规划发展部北京100011

2015年新电改方案的出台逐渐催生出一批电力行业新业态,综合能源业务就是其中之一。本文以山东省青岛市某新建制造业园区为例,通过园区的用能需求分析以及各种能源模式的技术路线,提出了适用于新能源发电企业的综合能源系统方案,并结合... 详细信息

2015年新电改方案的出台逐渐催生出一批电力行业新业态,综合能源业务就是其中之一。本文以山东省青岛市某新建制造业园区为例,通过园区的用能需求分析以及各种能源模式的技术路线,提出了适用于新能源发电企业的综合能源系统方案,并结合新能源发电企业的优势与制约因素,提出其开展综合能源业务的建议。

关键词：综合能源储能峰谷电价