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鄂尔多斯盆地东南部山2段物源与曲流河三角洲沉积体系

2017年中国肿瘤标志物学术大会暨第十一届肿瘤标志物青年科学家论坛

作者： Zhaolei Cui xiaoqin xin Yan Chen Department of Clinical Laboratory Fujian Provincial Key Laboratory of Tumor BiotherapyFujian Cancer HospitalFujian Medical University Cancer Hospital

Objective: ARA55(androgen receptor coactivator 55 kDa protein) was first identified as a TGF β1-inducible protein and function as a molecular scaffold in coordinating protein-protein interactions. Herein, we focused on validating the functional role of ARA55 in TGF β1-induced epithelial-mesenchymal transition(EMT) in human CNE2 nasopharyngeal carcinoma cells. Methods: Expression of ARA55 in the CNE2 cells was stimulated by TGF β1(5 ng/ml), and a commercial RNA interference plasmid(siRNA-ARA55) was utilized to silence ARA55 expression in response to TGF β1 induction. Results: Our results manifested that forced expression of ARA55 enhances growth as well as migration and invasion of the CEN2 cells. In contrast, cells depleted of ARA55 resulted in suppressed cell proliferation and metastasis capability, along with a down-regulation of N-cadherin and up-regulation of Claudin-1. Further co-immunoprecipitation analysis exhibited that induced ARA55 yields a direct physical interaction with Smad7 in TGF β1 signaling. Conclusions: Our data demonstrate that ARA55 exerts a causative role and functions as a critical regulator in TGF β1-mediated EMT in CNE2 nasopharyngeal carcinoma cells through binding with Smad7.

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沉积学报 2017年第3期35卷 540-551页

作者：李亚龙于兴河周进松单新韩小琴史新胡鹏中国地质大学(北京)能源学院北京100083 陕西延长石油(集团)有限责任公司研究院西安710075

鄂尔多斯盆地东南部山2段是该盆地重要的天然气富集层位。通过重矿物分布、岩屑组分、砂岩岩屑类型及阴极发光特征分析山2段沉积物源体系,经研究认为盆地东南部山2段沉积同时受南、北部物源供源。山2段为曲流河三角洲前缘沉积亚相,碎屑... 详细信息

鄂尔多斯盆地东南部山2段是该盆地重要的天然气富集层位。通过重矿物分布、岩屑组分、砂岩岩屑类型及阴极发光特征分析山2段沉积物源体系,经研究认为盆地东南部山2段沉积同时受南、北部物源供源。山2段为曲流河三角洲前缘沉积亚相,碎屑颗粒分选中等偏好、磨圆较好、颗粒之间接触紧密,沉积构造主要为板、槽状交错层理、平行层理及浪成交错层理。本区山2段沉积物以跳跃组分和悬浮组分为主,水下分流河道微相粒度概率曲线呈现三段式和四段式;河口坝微相分选较好、粒度概率曲线形态为两段式和三段式。研究区北部、南部及中部志丹、甘泉等地区砂体发育较厚,剖面上河道砂体呈不对称式相互叠置,水动力条件中等—较强。通过物源体系重建、沉积特征分析与薄片特征鉴定,建立了鄂尔多斯盆地东南部山2段双物源曲流河三角洲沉积模式。该研究明确了盆地东南部山2段物源方向,明晰了山2段沉积特征,创建了典型曲流河三角洲沉积模式,为进一步勘探开发提供了理论支持。

关键词：曲流河三角洲物源沉积模式山2段鄂尔多斯盆地东南部

Recent progress in constructing fluorinated solid-electrolyte interphases for stable lithium metal anodes

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 270-291页

作者： Di Zhang Pengfei Lv Wei Qin xin He Yuanhua He Civil Aircraft Fire Science and Safety Engineering Key Laboratory of Sichuan Province College of Civil Aviation Safety EngineeringCivil Aviation Flight University of ChinaGuanghan 618307China School of Chemical Engineering Sichuan UniversityChengdu 610065China

Lithium metal batteries(LMBs)are emerging as a promising energy storage solution owing to their high energy density and specific ***,the non-uniform plating of lithium and the potential rupture of the solid-electrolyte interphase(SEI)during extended cycling use may result in dendrite growth,which can penetrate the separator and pose significant short-circuit *** a stable SEI is essential for the long-term operation of the ***-rich SEI has garnered significant attention for its ability to effectively passivate electrodes,regulate lithium deposition,and inhibit electrolyte *** the structural components and preparation methods of existing fluorinated SEI is crucial for optimizing lithium metal anode *** paper reviews the research on optimizing LiF passivation interfaces to protect lithium metal *** focuses on four types of compositions in fluorinated SEI that work synergistically to enhance SEI *** instance,combining compounds with LiF can further enhance the mechanical strength and ionic conductivity of the *** metals with LiF significantly improves electrochemical performance at the SEI/anode interface,with a necessary focus on reducing electron tunneling ***,incorporating polymers with LiF offers balanced improvements in interfacial toughness and ionic conductivity,though maintaining structural stability over long cycles remains a critical area for future *** alloys combined with LiF increase surface energy and lithium affinity,challenges such as dendrite growth and volume expansion *** summary,this paper emphasizes the crucial role of interfacial structures in LMBs and offers comprehensive guidance for future design and development efforts in battery technology.

关键词： LiF lithium metal anodes solid-electrolyte interphase interface cycling stability

超声波/紫外线一体化反应器用于污水消毒的中试研究

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环境工程学报 2016年第11期10卷 6185-6189页

作者：赵军嫄李子富周瑱周晓琴杨鑫王冬泠北京科技大学土木与环境工程学院北京100083

采用自行设计的超声波/紫外线一体化推流式反应器对污水厂二级出水进行消毒实验,考察了超声波协同紫外线消毒的消毒效率以及对消毒过程对水质和紫外灯管结垢的影响。结果表明:超声波协同紫外线消毒可以强化单独紫外线的消毒效率,且超声... 详细信息

采用自行设计的超声波/紫外线一体化推流式反应器对污水厂二级出水进行消毒实验,考察了超声波协同紫外线消毒的消毒效率以及对消毒过程对水质和紫外灯管结垢的影响。结果表明:超声波协同紫外线消毒可以强化单独紫外线的消毒效率,且超声波功率密度越大,水力停留时间越长,消毒效果越好;当超声波功率密度为70 W·L-1,水力停留时间60 s时,粪大肠杆菌的对数去除率可以达到3.85 log,比单独紫外消毒增加了40.7%。同时,超声波协同紫外线消毒还可以降低紫外灯管的结垢速率。虽然超声波的引入会对水质(COD、UV254和浊度)产生轻微波动,但是并不影响出水水质。

关键词：超声波/紫外线一体化消毒反应器二级出水消毒效率粪大肠杆菌

内蒙古农村牧区集体土地所有权确权登记发证成果应用现状与集成应用模式探索

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内蒙古师范大学学报（哲学社会科学版） 2015年第2期44卷 121-124页

作者：王蔷蒋一涵邢晓芹内蒙古自治区土地调查规划院内蒙古呼和浩特010010

为了促进内蒙古自治区农村集体土地所有权确权登记成果的应用转化,本文以全区总体水平为研究基础,应用实证分析法和文献研究法,系统地分析了集体土地确权登记发证成果应用的现状与问题。结果表明,目前农村牧区集体土地所有权确权登记成... 详细信息

为了促进内蒙古自治区农村集体土地所有权确权登记成果的应用转化,本文以全区总体水平为研究基础,应用实证分析法和文献研究法,系统地分析了集体土地确权登记发证成果应用的现状与问题。结果表明,目前农村牧区集体土地所有权确权登记成果在一定范围内已显示出重要的基础作用,但成果的应用领域及范围仍有待扩展。建议今后侧重在国土资源管理系统内部、外部及成果信息化建设等方面进行应用范围的进一步探索,同时,加强在城乡一体化地籍管理信息系统、集体土地征收后的权属管理及城乡建设用地增减挂钩等领域的应用模式研究。

关键词：所有权成果应用现状模式

Targeting TrkB–PSD-95 coupling to mitigate neurological disorders

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Neural Regeneration Research 2025年第3期20卷 715-724页

作者： xin Yang Yu-Wen Alvin Huang John Marshall Department of Molecular Biology Cell Biology and BiochemistryBrown UniversityProvidenceRIUSA Department of Neurology Warren Alpert Medical School of Brown UniversityProvidenceRIUSA Center for Translational Neuroscience Robert J.and Nancy D.Carney Institute for Brain Science and Brown Institute for Translational ScienceBrown UniversityProvidenceRIUSA

Tropomyosin receptor kinase B(TrkB)signaling plays a pivotal role in dendritic growth and dendritic spine formation to promote learning and *** activity-dependent release of brain-derived neurotrophic factor at synapses binds to pre-or postsynaptic TrkB resulting in the strengthening of synapses,reflected by long-term ***,the association of postsynaptic density protein-95 with TrkB enhances phospholipase Cγ-Ca^(2+)/calmodulin-dependent protein kinaseⅡand phosphatidylinositol 3-kinase-mechanistic target of rapamycin signaling required for long-term *** this review,we discuss TrkB-postsynaptic density protein-95 coupling as a promising strategy to magnify brain-derived neurotrophic factor signaling towards the development of novel therapeutics for specific neurological disorders.A reduction of TrkB signaling has been observed in neurodegenerative disorders,such as Alzheimer's disease and Huntington's disease,and enhancement of postsynaptic density protein-95 association with TrkB signaling could mitigate the observed deficiency of neuronal connectivity in schizophrenia and *** with brain-derived neurotrophic factor is problematic,due to poor pharmacokinetics,low brain penetration,and side effects resulting from activation of the p75 neurotrophin receptor or the truncated TrkB.T1 *** TrkB agonists and antibodies that activate TrkB are being intensively investigated,they cannot distinguish the multiple human TrkB splicing isoforms or cell type-specific *** TrkB–postsynaptic density protein-95 coupling provides an alternative approach to specifically boost TrkB signaling at localized synaptic sites versus global stimulation that risks many adverse side effects.

关键词： Angelman syndrome autism brain-derived neurotrophic factor depression neurodegenerative disorder neurodevelopmental disorder postsynaptic density protein-95 synaptic plasticity TrkB

From waste to wealth:Coal tar residue derived carbon materials as low-cost anodes for potassium-ion batteries

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 464-475页

作者： Zhonghua Lu Jun Shen xin Zhang Lingcong Chao Liang Chen Ding Zhang Tao Wei Shoudong Xu College of Chemical Engineering and Technology Taiyuan University of TechnologyTaiyuan 030024China College of Chemistry Taiyuan University of TechnologyTaiyuan 030024China School of Chemical Engineering and Pharmacy Wuhan Institute of TechnologyWuhan 430205China School of Energy and Power Jiangsu University of Science and TechnologyZhenjiang 212003China

Carbon materials are widely recognized as highly promising electrode materials for various energy storage system *** tar residues(CTR),as a type of carbon-rich solid waste with high value-added utilization,are crucially important for the development of a more sustainable *** this study,we employed a straightforward direct carbonization method within the temperature range of 700-1000℃to convert the worthless solid waste CTR into economically valuable carbon materials as anodes for potassium-ion batteries(PIBs).The effect of carbonization temperature on the microstructure and the potassium ions storage properties of CTR-derived carbons(CTRCs)were systematically explored by structural and morphological characterization,alongside electrochemical performances *** on the co-regulation between the turbine layers,crystal structure,pore structure,functional groups,and electrical conductivity of CTR-derived carbon carbonized at 900℃(CTRC-900H),the electrode material with high reversible capacity of 265.6m Ah·g^(-1)at 50 m A·g^(-1),a desirable cycling stability with 93.8%capacity retention even after 100 cycles,and the remarkable rate performance for PIBs were ***,cyclic voltammetry(CV)at different scan rates and galvanostatic intermittent titration technique(GITT)have been employed to explore the potassium ions storage mechanism and electrochemical kinetics of *** indicate that the electrode behavior is predominantly governed by surface-induced capacitive processes,particularly under high current densities,with the potassium storage mechanism characterized by an“adsorption-weak intercalation”*** work highlights the potential of CTR-based carbon as a promising electrode material category suitable for high-performance PIBs electrodes,while also provides valuable insights into the new avenues for the high value-added utilization of CTR.

关键词： coal tar residue carbon materials anode potassium-ion batteries high value-added

Research status and prospects of the fractal analysis of metal material surfaces and interfaces

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 20-38页

作者： Qinjin Dai Xuefeng Liu xin Ma Shaojie Tian Qinghe Cui Beijing Advanced Innovation Center for Materials Genome Engineering University of Science and Technology BeijingBeijing 100083China Beijing Laboratory of Metallic Materials and Processing for Modern Transportation University of Science and Technology BeijingBeijing 100083China Laboratory for Advanced Materials Processing of Ministry of Education University of Science and Technology BeijingBeijing 100083China School of Mechanical and Electrical Engineering Xinjiang Institute of EngineeringUrumqi 830023China

As a mathematical analysis method,fractal analysis can be used to quantitatively describe irregular shapes with self-similar or self-affine *** analysis has been used to characterize the shapes of metal materials at various scales and *** methods make it difficult to quantitatively describe the relationship between the regular characteristics and properties of metal material surfaces and ***,fractal analysis can be used to quantitatively describe the shape characteristics of metal materials and to establish the quantitative relationships between the shape characteristics and various properties of metal *** the perspective of two-dimensional planes and three-dimensional curved surfaces,this paper reviews the current research status of the fractal analysis of metal precipitate interfaces,metal grain boundary interfaces,metal-deposited film surfaces,metal fracture surfaces,metal machined surfaces,and metal wear *** relationship between the fractal dimensions and properties of metal material surfaces and interfaces is *** from three perspectives of fractal analysis,namely,research scope,image acquisition methods,and calculation methods,this paper identifies the direction of research on fractal analysis of metal material surfaces and interfaces that need to be *** is believed that revealing the deep influence mechanism between the fractal dimensions and properties of metal material surfaces and interfaces will be the key research direction of the fractal analysis of metal materials in the future.

关键词： metal material surfaces and interfaces fractal analysis fractal dimension homogeneity

Single-cell omics: experimental workflow, data analyses and applications

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Science China Life Sciences 2025年第1期68卷 5-102页

作者： Fengying Sun Haoyan Li Dongqing Sun Shaliu Fu Lei Gu xin Shao Qinqin Wang xin Dong Bin Duan Feiyang xing Jun Wu Minmin Xiao Fangqing Zhao Jing-Dong J.Han Qi Liu Xiaohui Fan Chen Li Chenfei Wang Tieliu Shi Department of Clinical Laboratory the Affiliated Wuhu Hospital of East China Normal University (The Second People's Hospital of Wuhu City) Pharmaceutical Informatics Institute College of Pharmaceutical SciencesZhejiang University Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration (Tongji University) Ministry of EducationOrthopaedic DepartmentTongji HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Frontier Science Center for Stem Cells School of Life Sciences and TechnologyTongji University Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine Shanghai East HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Research Institute of Intelligent Computing Zhejiang Lab Shanghai Research Institute for Intelligent Autonomous Systems Center for Single-cell Omics School of Public HealthShanghai Jiao Tong University School of Medicine National Key Laboratory of Chinese Medicine Modernization Innovation Center of Yangtze River DeltaZhejiang University Center for Bioinformatics and Computational Biology Shanghai Key Laboratory of Regulatory Biologythe Institute of Biomedical Sciences and School of Life SciencesEast China Normal University Beijing Institutes of Life Science Chinese Academy of Sciences Peking-Tsinghua Center for Life Sciences Academy for Advanced Interdisciplinary StudiesCenter for Quantitative Biology (CQB)Peking University Zhejiang Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases Women's HospitalZhejiang University School of Medicine Key Laboratory of Advanced Theory and Application in Statistics and Data Science-MOE School of StatisticsEast China Normal University

Cells are the fundamental units of biological systems and exhibit unique development trajectories and molecular features. Our exploration of how the genomes orchestrate the formation and maintenance of each cell, and control the cellular phenotypes of various organismsis, is both captivating and intricate. Since the inception of the first single-cell RNA technology, technologies related to single-cell sequencing have experienced rapid advancements in recent years. These technologies have expanded horizontally to include single-cell genome, epigenome,proteome, and metabolome, while vertically, they have progressed to integrate multiple omics data and incorporate additional information such as spatial sc RNA-seq and CRISPR screening. Single-cell omics represent a groundbreaking advancement in the biomedical field,offering profound insights into the understanding of complex diseases, including cancers. Here, we comprehensively summarize recent advances in single-cell omics technologies, with a specific focus on the methodology section. This overview aims to guide researchers in selecting appropriate methods for single-cell sequencing and related data analysis.

关键词： single-cell sequencing genome epigenome proteomics metabolomics multimodal spatial transcriptomics CRISPR screening