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CAF-derived exosome-miR-3124-5p promotes malignant biological processes in NSCLC via the TOLLIP/TLR4-MyD88-NF-κB pathway

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Oncology Research 2025年第1期33卷 133-148页

作者： TAO SUN QINGHUA song HUA LIU Department of Respiratory and Critical Care Medicine Affiliated Hospital of Nantong UniversityMedical School of Nantong UniversityNantong226001China Department of Emergency The People’s Hospital of RugaoNantong226500China Department of Haematology The People’s Hospital of RugaoNantong226500China

Background:Lung cancer is a life-threatening disease that occurs worldwide,but is especially common in *** crucial role of the tumour microenvironment(TME)in non-small cell lung cancer(NSCLC)has attracted recent ***-associated fibroblasts(CAFs)are the main factors that contribute to the TME function,and CAF exosomes are closely linked to ***:The expression levels of miR-3124-5p and Toll-interacting protein(TOLLIP)were analysed by bioinformatics prediction combined with RT-qPCR/Western Blot *** were isolated and identified from clinical NSCLC *** electron microscopy and Western Blot were used to identify exosomes from these *** in proliferation(CCK-8 and clone formation),migration(wound healing),and invasion(transwell)of NSCLC cells were *** Luciferase reporter test was applied to clarify the binding of miR-3124-5p to *** TOLLIP/TLR4/MyD88/NF-κB pathway proteins were determined using Western blot ***:MiR-3124-5p is overexpressed in clinical tissues and cells of ***-3124-5p was dramatically enriched in CAF-derived *** experiments revealed that CAFs delivered miR-3124-5p into NSCLC cells via exosomes,stimulating cancer cell ***-3124-5p acted as a sponge to negatively regulate TOLLIP expression,which activated the TLR4/MyD88/NF-κB axis to promote the occurrence and development of *** salvage tests were performed to determine whether CAF-exosome-derived miR-3124-5p plays a pro-cancer role in NSCLC by affecting the TOLLIP signalling ***:These results provide an interesting direction for the diagnosis and therapy of NSCLC.

关键词： Non-small cell lung cancer(NSCLC) Cancer-associated fibroblasts(CAFs) Exosomes miR-3124-5p Toll-interacting protein(TOLLIP)

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A Power Battery Fault Diagnosis Method Based on Long-Short Term Memory-Back Propagation

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Energy Engineering 2025年第2期122卷 709-731页

作者： Yuheng Yin Jiahao song Minghui Yang School of Automation Harbin University of Science and TechnologyHarbin150080China

The lithium battery is an essential component of electric cars;prompt and accurate problem detection is vital in guaranteeing electric cars’safe and dependable functioning and addressing the limitations of Back Propagation(BP)neural networks in terms of vanishing gradients and inability to effectively capture dependencies in time series,and the limitations of Long-Short Term Memory(LSTM)neural network models in terms of risk of overfitting.A method based on LSTM-BP is put forward for power battery fault diagnosis to improve the accuracy of lithium battery fault ***,a lithium battery model is constructed based on the second-order RC equivalent circuit and the electro-thermal coupling model,and various lithium battery failures are simulated to examine the fault ***,the lithium battery charging and discharging experiments collect,clean,and process the battery *** constructing a neural network LSTM-BP model,we verified the superiority and accuracy of the LSTM-BP neural network model by comparing the LSTM model and BP model vertically and by comparing the Recurrent Neural Network(RNN)model,the Gated Recurrent Unit(GRU)model,and the Residual Neural Network(ResNet)model of a more advanced architecture ***,the lithium battery fault diagnosis process is summarized through the threshold quantitative criteria,and different faults are diagnosed and *** show that the LSTM-BP neural network not only overcomes the limitations of the LSTMneural network and BP neural network but also improves the ability to process sequence data and reduces the risk of overfitting.

关键词： Lithium battery fault diagnosis BP neural network LSTM neural network

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基于SDN的高性能QoS保障低轨道卫星星间路由算法

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计算机工程 2022年第5期48卷 185-190,199页

作者：王奎宇宋晓勤缪娟娟张昕婷雷磊南京航空航天大学电子信息工程学院南京211106

低轨道卫星通信系统具有全球覆盖性、移动性、可扩展性等优势,在提供全球互联网服务、灾难应急处理等方面发挥重要作用,但由于星上有限的存储和计算资源,传统路由算法不适用于低轨道卫星通信网络。结合软件定义网络架构,提出一种支持服... 详细信息

低轨道卫星通信系统具有全球覆盖性、移动性、可扩展性等优势,在提供全球互联网服务、灾难应急处理等方面发挥重要作用,但由于星上有限的存储和计算资源,传统路由算法不适用于低轨道卫星通信网络。结合软件定义网络架构,提出一种支持服务质量(QoS)的高性能低轨道卫星星间路由算法。根据剩余链路持续时间定义星间链路生存时间,确定每条星间链路的稳定度,缓解由于链路切换导致的业务路径重构问题。基于高轨道卫星得到的星间链路的流量状态,定义链路负载矩阵,给出星间链路负载度函数,并利用标签交换路径集合获得每条路径的负载度,避免节点拥塞,实现网络负载均衡。针对不同要求的业务服务类型定义权重因子矩阵,通过调整因子来减小瓶颈节点对路由算法的影响,满足多用户的QoS要求。仿真结果表明,在不同的QoS要求下,该算法在业务时延、系统吞吐量、网络负载均衡等方面均具有明显优势,且算法复杂度低,大幅节省了有限的星上存储与计算资源。

关键词：低轨道卫星空天地一体化软件定义网络服务质量负载均衡

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HMGB2 knockdown ameliorates retinal ganglion cell injury by inhibiting NLRP3 inflammasome activation after retinal ischemia

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International Journal of Ophthalmology(English edition) 2025年第1期18卷 39-50页

作者： Lin-Ping Xue Hai-song Feng Hubei University of Chinese Medicine Wuhan 430065Hubei ProvinceChina Department of Encephalopathy Hubei Provincial Hospital of Traditional Chinese MedicineWuhan 430070Hubei ProvinceChina

AIM:To explore the neuroprotective effects of high mobility group box 2(HMGB2)knockdown on retinal ganglion cells(RGCs)in the retinal ischemia-reperfusion injury(RIRI).METHODS:Oxygen-glucose deprivation(OGD)-injured RGCs from postnatal three-day C57BL/6 mice pups and high intraocular pressure(IOP)-induced RIRI mice were used as cellular and animal models of *** expression of HMGB2 in the retina of RIRI mice and OGD-injured RGCs was detected through reverse transcription-polymerase chain reaction(RT-qPCR)and Western *** effects of HMGB2 silencing on the morphological changes,RGCs survival,and cell apoptosis in mouse retinal tissues were observed through H&E staining,immunofluorescence staining with RNA-binding protein with multiple splicing(RBPMS)antibody,and TUNEL staining,*** viability and apoptosis were examined by CCK-8 and flow cytometry *** levels of proteins associated with NOD-like receptor thermal protein domain associated protein 3(NLRP3)-mediated pyroptosis[NLRP3,Caspase-1,GSDMD-N,interleukin(IL)-1β,IL-18]in vivo and in vitro were measured by Western ***:HMGB2 protein and NLRP3 were upregulated in the retina of RIRI mice and OGD-injured RGCs(P<0.001).The retina was edematous,accompanied by disorganized cell arrangement and decreased thickness of all layers,and obvious vacuoles in ganglion cell ***2 silencing alleviated the reduction in total retinal thickness and the severity of retinal tissue damage as well as suppressed RGC loss and retinal cell apoptosis in RIRI ***-induced RGC apoptosis was ameliorated after downregulation of HMGB2 in *** injection of the AAV-sh-HMGB2 and si-HMGB2 resulted in significantly decrease of NLRP3,Caspase-1,GSDMD-N,IL-1β,and IL-18 protein levels in the retinal tissues of RIRI mice and OGD-injured RGCs,respectively(all P<0.001).CONCLUSION:HMGB2 knockdown protects against RGC apoptosis and pyroptosis after RIRI through suppressing NLRP3 inflammasome activ

关键词： HMGB2 retinal ischemia-reperfusion injury retinal ganglion cell apoptosis pyroptosis NLRP3 mice

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Inspires effective alternatives to backpropagation:predictive coding helps understand and build learning

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Neural Regeneration Research 2025年第11期20卷 3215-3216页

作者： Zhenghua Xu Miao Yu Yuhang song School of Health Sciences and Biomedical Engineering Hebei University of TechnologyTianjinChina Department of Computer Science University of OxfordOxfordUK

Artificial neural networks are capable of machine learning by simulating the hiera rchical structure of the human *** enable learning by brain and machine,it is essential to accurately identify and correct the prediction errors,referred to as credit assignment(Lillicrap et al.,2020).It is critical to develop artificial intelligence by understanding how the brain deals with credit assignment in neuroscience.

关键词： assignment learning enable

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天然气集输管道90°弯头冲蚀磨损规律研究

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润滑与密封 2018年第8期43卷 62-68页

作者：宋晓琴刘玲骆宋洋罗鹏王彦然西南石油大学石油与天然气工程学院四川成都610500 成都燃气集团股份有限公司生产部四川成都610041

针对输气管道中90°弯头冲蚀磨损失效的问题,依据现场实际工况,利用CFD仿真软件建立相应的模型,探究集输管道输送气固两相流介质时固体颗粒冲击弯头壁面的冲蚀磨损规律。采用RNG k-ε湍流模型、DPM模型和E/CRC冲蚀磨损模型研究集输压力... 详细信息

针对输气管道中90°弯头冲蚀磨损失效的问题,依据现场实际工况,利用CFD仿真软件建立相应的模型,探究集输管道输送气固两相流介质时固体颗粒冲击弯头壁面的冲蚀磨损规律。采用RNG k-ε湍流模型、DPM模型和E/CRC冲蚀磨损模型研究集输压力、不同重力方向、集输流速、集输管径以及颗粒大小对弯头冲蚀磨损的影响。结果表明:集输压力越大,弯头冲蚀磨损程度减轻,且磨损区域呈现由中部向出口、由外侧向内侧凹曲面移动的现象;重力会影响弯头冲蚀磨损程度以及磨损区域,重力场和气相主流场趋势相同时会加剧磨损;当气流速度超过临界集输流速时,冲蚀磨损情况加剧且最大磨损率出现区域后移;集输管径越小、颗粒直径越大时,冲蚀磨损越严重。

关键词：弯头冲蚀磨损固体颗粒集输管道

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管道油品泄漏原因及其对环境的影响

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油气储运 2011年第4期30卷 297-298,237页

作者：宋晓琴刘广文王雯娟西南石油大学四川成都610500 中国石油管道科技研究中心河北廊坊065000 中国石油管道公司兰成渝输油气分公司四川成都610000

根据多年油气管道性能的评价数据统计报告,总结了引起油气管道泄漏的起因,并根据导致的平均泄漏量大小对各种泄漏起因进行排序,依次为:机械损伤、第三方破坏、自然灾害、操作失误和腐蚀。对比分析了5种泄漏起因引起的泄漏量和环境污染... 详细信息

根据多年油气管道性能的评价数据统计报告,总结了引起油气管道泄漏的起因,并根据导致的平均泄漏量大小对各种泄漏起因进行排序,依次为:机械损伤、第三方破坏、自然灾害、操作失误和腐蚀。对比分析了5种泄漏起因引起的泄漏量和环境污染面积等情况。介绍了影响环境污染程度的因素,包括泄漏程度、泄漏处油品喷射方向和泄漏孔所在位置等。讨论了泄漏孔大小与泄漏量之间的关系。分析结果可为管道维抢修提供科学依据。

关键词：管道油品泄漏环境污染

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From Static and Dynamic Perspectives:A Survey on Historical Data Benchmarks of Control Performance Monitoring

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IEEE/CAA Journal of Automatica Sinica 2025年第2期12卷 300-316页

作者： Pengyu song Jie Wang Chunhui Zhao Biao Huang the State Key Laboratory of Industrial Control Technology College of Control Science and Engineering Zhejiang University IEEE the Department of Chemical and Materials Engineering University of Alberta

In recent decades, control performance monitoring(CPM) has experienced remarkable progress in research and industrial applications. While CPM research has been investigated using various benchmarks, the historical data benchmark(HIS) has garnered the most attention due to its practicality and effectiveness. However, existing CPM reviews usually focus on the theoretical benchmark, and there is a lack of an in-depth review that thoroughly explores HIS-based methods. In this article, a comprehensive overview of HIS-based CPM is provided. First, we provide a novel static-dynamic perspective on data-level manifestations of control performance underlying typical controller capacities including regulation and servo: static and dynamic properties. The static property portrays time-independent variability in system output, and the dynamic property describes temporal behavior driven by closed-loop feedback. Accordingly,existing HIS-based CPM approaches and their intrinsic motivations are classified and analyzed from these two ***, two mainstream solutions for CPM methods are summarized, including static analysis and dynamic analysis,which match data-driven techniques with actual controlling behavior. Furthermore, this paper also points out various opportunities and challenges faced in CPM for modern industry and provides promising directions in the context of artificial intelligence for inspiring future research.

关键词： Control performance monitoring (CPM) data-driven method historical data benchmark (HIS) industrial process performance index static and dynamic analysis

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Domain generalization with semi-supervised learning for people-centric activity recognition

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Science China(Information Sciences) 2025年第1期68卷 171-188页

作者： Jing LIU Wei ZHU Di LI Xing HU Liang song Academy for Engineering & Technology Fudan University Shanghai East-bund Research Institute on Networking Systems of AI School of Optoelectronic Information and Computer Engineering University of Shanghai for Science & Technology

People-centric activity recognition is one of the most critical technologies in a wide range of real-world applications,including intelligent transportation systems, healthcare services, and brain-computer interfaces. Large-scale data collection and annotation make the application of machine learning algorithms prohibitively expensive when adapting to new tasks. One way of circumventing this limitation is to train the model in a semi-supervised learning manner that utilizes a percentage of unlabeled data to reduce the labeling burden in prediction tasks. Despite their appeal, these models often assume that labeled and unlabeled data come from similar distributions, which leads to the domain shift problem caused by the presence of distribution gaps. To address these limitations, we propose herein a novel method for people-centric activity recognition,called domain generalization with semi-supervised learning(DGSSL), that effectively enhances the representation learning and domain alignment capabilities of a model. We first design a new autoregressive discriminator for adversarial training between unlabeled and labeled source domains, extracting domain-specific features to reduce the distribution gaps. Second, we introduce two reconstruction tasks to capture the task-specific features to avoid losing information related to representation learning while maintaining task-specific consistency. Finally, benefiting from the collaborative optimization of these two tasks, the model can accurately predict both the domain and category labels of the source domains for the classification task. We conduct extensive experiments on three real-world sensing datasets. The experimental results show that DGSSL surpasses the three state-of-the-art methods with better performance and generalization.

关键词： activity recognition deep learning domain generalization semi-supervised learning adversarial training

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Optimizing the ORR performance of PtMnM ternary intermetallics by tuning the surface strain

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Science China Chemistry 2025年第2期68卷 536-542页

作者： Min song Guanyu Luo Qian Zhang Hanyu Hu Deli Wang Key Laboratory of Material Chemistry for Energy Conversion and Storage Ministry of EducationSchool of Chemistry and Chemical EngineeringHuazhong University of Science and Technology(HUST)Wuhan 430074China

Identifying the descriptors that control catalytic performance is key to design catalysts with high activity and *** indirect descriptors related to catalytic activity,modulating the Pt–Pt interatomic distance and d-band center can effectively enhance the ORR *** is well recognized that the Pt–Pt interatomic distance is strongly correlated with the surface ***,PtMnM/C ternary intermetallics are constructed through partially replacing Mn in PtMn/C binary intermetallics with the other transition metal(M=Fe,Co,Ni,and Cu).The 3d-transition metal doping induces surface strain,and the ORR performance of PtMnM/C exhibits volcano relationship relative to both the Pt–Pt interatomic distance and d-band *** PtMnCo/C with optimum strain exhibits the highest mass activity(1.06 A mgPt^(−1))at 0.9 V,which is 2.6 and 4.6 times higher than that of PtMn/C and commercial Pt/C catalysts,*** addition,PtMnCo/C shows good durability with only 10 mV half-wave potential decay after 50,000 potential cycles.

关键词： oxygen reduction reaction electrocatalysts ternary intermetallics surface strain electronic structure

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