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Promotion effect of FOXCUT as a microRNA sponge for miR-24-3p on progression in triple-negative breast cancer through the p38 MAPK signaling pathway

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Chinese Medical Journal 2024年第1期137卷 105-114页

作者： Xiafei Yu Fangze Qian xiaoqiang zhang Yanhui Zhu Gao He Junzhe Yang Xian Wu Yi Zhou Li Shen Xiaoyue Shi Hongfei zhang Xiao’an Liu Department of Breast Surgery The First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu 210029China

Background:Triple-negative breast cancer(TNBC)is a type of highly invasive breast cancer with a poor prognosis.According to new research,long noncoding RNAs(lncRNAs)play a significant role in the progression of cancer.Although the role of lncRNAs in breast cancer has been well reported,few studies have focused on TNBC.This study aimed to explore the biological function and clinical significance of forkhead box C1 promoter upstream transcript(FOXCUT)in triple-negative breast cancer.Methods:Based on a bioinformatic analysis of the cancer genome atlas(TCGA)database,we detected that the lncRNA FOXCUT was overexpressed in TNBC tissues,which was further validated in an external cohort of tissues from the General Surgery Department of the First Affiliated Hospital of Nanjing Medical University.The functions of FOXCUT in proliferation,migration,and invasion were detected in vitro or in vivo.Luciferase assays and RNA immunoprecipitation(RIP)were performed to reveal that FOXCUT acted as a competitive endogenous RNA(ceRNA)for the microRNA miR-24-3p and consequently inhibited the degradation of p38.Results:lncRNA FOXCUT was markedly highly expressed in breast cancer,which was associated with poor prognosis in some cases.Knockdown of FOXCUT significantly inhibited cancer growth and metastasis in vitro or in vivo.Mechanistically,FOXCUT competitively bounded to miR-24-3p to prevent the degradation of p38,which might act as an oncogene in breast cancer.Conclusion:Collectively,this research revealed a novel FOXCUT/miR-24-3p/p38 axis that affected breast cancer progression and suggested that the lncRNA FOXCUT could be a diagnostic marker and therapeutic target for breast cancer.

关键词： Triple negative breast neoplasms RNA,long noncoding FOXCUT miR-24-3p p38 MAPK signaling pathway Disease progression

Effective Impulse for Fully Clamped Rectangular Plates Under Internal Blast Loading

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Acta Mechanica Solida Sinica 2022年第3期35卷 481-494页

作者： Xianben Ren xiaoqiang zhang Zhixin Huang Ying Li State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing 100081China Beijing Key Laboratory of Lightweight Multi-functional Composite Materials and Structures Institute of Advanced Structure TechnologyBeijing Institute of TechnologyBeijing 100081China

Under internal blast loading,the response of a beam or plate is highly correlated with the phenomenon of saturated impulse,which governs the deflection of the structure.This paper aims to investigate the phenomenon of saturated impulse for fully clamped rectangular plates subjected to internal blast loading.Based on the rigid,perfectly plastic assumption,the relationship between saturation duration and saturation deflection is derived.Influences of the peak shock wave,the duration of shock wave and the peak quasi-static pressure loading on saturation duration and saturation deflection are discussed.It is found that there is a critical duration for the internal blast impulse to reach saturation,and beyond this duration,the deflection of plate will no longer increase as the loading increases further.The saturation deflection and saturation duration both exhibit regular variation patterns with the changes of the dimensionless peak shock wave,the duration of shock wave and the peak quasi-static pressure loading.

关键词： Internal blast Effective impulse Rectangular plate Effective acting time Simplified model

Enhancing suspension vibration reduction by diagonal inerter

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Applied Mathematics and Mechanics(English Edition) 2022年第10期43卷 1531-1542页

作者： Meng YANG Xingjiu LUO xiaoqiang zhang Hu DING Liqun CHEN Naval Medical Center of PLA Shanghai 200433China School of Mechanics and Engineering Sciences Shanghai UniversityShanghai 200072China

The diagonal inerter is integrated into a suspension vibration reduction system(SVRS).The dynamic model of the SVRS with diagonal inerter and damping is established.The dynamic model is of strong geometric nonlinearity.The retaining nonlinearity up to cubic terms is validated under impact excitation.The conditions omitting the static deformation are determined.The effects of the diagonal inerter on the vibration reduction performance of the SVRS are explored under impact and random excitations.The vibration reduction performance of the proposed SVRS with both diagonal inerter and damping is better than that of either the SVRS without them or the SVRS with the diagonal damping only.

关键词： suspension vibration reduction system(SVRS) diagonal inerter verification calculation geometric nonlinearity

不确定需求下铁路集装箱班列开行方案与定价联合优化

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铁道学报 2024年第1期46卷 22-33页

作者：李琳张小强上海海事大学交通运输学院上海201306 西南交通大学交通运输与物流学院四川成都611756 西南交通大学综合交通大数据应用技术国家工程实验室四川成都611756 西南交通大学综合交通运输智能化国家地方联合工程实验室四川成都611756

铁路集装箱班列开行方案与运价是影响铁路集装箱运输企业盈利的两个关键因素,且这二者相互联系、相互影响,对其进行联合优化可以提升铁路集装箱运输的市场竞争力。以最大化铁路集装箱运输预期利润为目标,构建联合优化班列开行方案与定... 详细信息

铁路集装箱班列开行方案与运价是影响铁路集装箱运输企业盈利的两个关键因素,且这二者相互联系、相互影响,对其进行联合优化可以提升铁路集装箱运输的市场竞争力。以最大化铁路集装箱运输预期利润为目标,构建联合优化班列开行方案与定价的随机混合整数非线性规划(SMINP)模型。此模型以二项Logit模型描述托运人在铁路集装箱运输与公路集装箱运输之间的运输方式选择行为,在集装箱总运输需求概率分布形式、一阶矩与二阶矩均不确定的情形下,基于分布鲁棒优化方法将此SMINP模型转化为其确定性等价类,根据转化后模型特点进一步利用增量分段线性化以及McCormick包络法对模型线性化,使其可通过调用Gurobi求解器高效求解。以大朗至大红门铁路集装箱运输线路进行算例分析,在线路通过能力与运价可变动范围等信息已知的前提下,求得最优集装箱班列开行方案与运价。算例结果表明本文所提方法能够提升铁路集装箱运输效率与收益。

关键词：铁路集装箱运输开行方案定价分布鲁棒机会约束线性化

The Development Trend of and Suggestions for China’s Hydrogen Energy Industry

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Engineering 2021年第6期7卷 719-721页

作者： xiaoqiang zhang China Center for International Economic Exchanges Beijing 100050China

1.Introduction Driven by the current round of technological revolution and industrial transformation,and based on a consensus among countries around the world,the world’s energy landscape is undergoing profound adjustments to promote a transition to clean,low-carbon energy in order to cope with global climate change.As a clean and carbon-free secondary energy source,hydrogen energy is an important component of the energy strategy in various countries.Fuel cell technology is also of great importance in directing the current global energy technology revolution.

关键词： landscape Trend profound

Transportation characteristics of gas-solid two-phase flow in a long-distance pipeline

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Particuology 2015年第4期13卷 196-202页

作者： xiaoqiang zhang Dongfeng zhang An Wang Yide Geng College of Mining Engineering Taiyuan University of Technology China National Coal Group Corporation

In this study, experiments on fly ash conveying were carried out with a home-made long-distance positive-pressure pneumatic conveying system equipped with a high performance electrical capacitance tomography system to observe the transient characteristics of gas-solid two-phase flow. The experimen- tal results indicated that solids throughput increased with increasing solids-gas ratio when the conveying pipeline was not plugged. Moreover, the optimum operating state was determined for the 1000 m long conveying pipeline with a throttle plate of 26 orifices. At this state the solids throughput was about 12.97 t/h. Additionally, the transportation pattern of fly ash gradually changed from sparse-dense flow to partial and plug flows with increasing conveying distance because of the conveying pressure loss, These experimental results provide important reference data for the development of pneumatic conveying technology.

关键词： Pneumatic conveying Electrical capacitance tomography Fly ash Gas-solid two-phase flow Solid concentration

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考虑时间价值的中欧班列多级定价与舱位控制

交通运输工程与信息学报 2024年第2期22卷 77-89页

作者：徐如君张小强西南交通大学交通运输与物流学院成都611756 综合交通大数据应用技术国家工程实验室成都611756 综合交通运输智能化国家地方联合工程实验室成都611756

中欧班列运输需求高速增长,导致旺季时间偏长,运能供不应求。部分时间敏感型货物无法长时间等待,进而转向了其他运输方式。为满足时间敏感型货物的运输需求,本文考虑货物时间价值并提出多等级定价方案,以班列运营企业收益最大化为目标... 详细信息

中欧班列运输需求高速增长,导致旺季时间偏长,运能供不应求。部分时间敏感型货物无法长时间等待,进而转向了其他运输方式。为满足时间敏感型货物的运输需求,本文考虑货物时间价值并提出多等级定价方案,以班列运营企业收益最大化为目标建立了考虑货主选择行为的动态舱位控制模型。由于多维状态空间模型难以获得精确解,采用值函数近似方法近似求解动态规划模型,利用最小二乘近似策略迭代算法对线性近似、分段线性近似两种形式的近似值函数进行参数标定。应用学习得到的参数进行仿真实验,对比两种值函数近似方法与基准运价下先到先得、多级定价下先到先得方案的收益性能和舱位预订情况。结果表明,在需求旺季供不应求的场景下,本文提出的基于多级定价的舱位控制策略能把有限的运能分配给最需要的客户,同时可以有效提升铁路企业的运输收益,其中分段线性近似方法对收益提升的效果更佳。

关键词：铁路运输多级定价动态舱位控制货物时间价值选择行为

联合结构重参数和YOLOv5的航拍红外目标检测

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电子科技大学学报 2024年第3期53卷 382-389页

作者：邵延华张兴平张晓强楚红雨吴亚东西南科技大学信息工程学院绵阳621010 四川轻化工大学计算机科学与工程学院宜宾644000

无人机进行红外航拍目标检测在交通、农业和军事等方面有着广泛应用。该领域的主要挑战有目标较小、相互遮挡、非刚体形变大以及红外成像纹理信息少、边缘特征弱等。针对以上问题,基于YOLOv5和结构重参数化优化思想,提出了一种针对航拍... 详细信息

无人机进行红外航拍目标检测在交通、农业和军事等方面有着广泛应用。该领域的主要挑战有目标较小、相互遮挡、非刚体形变大以及红外成像纹理信息少、边缘特征弱等。针对以上问题,基于YOLOv5和结构重参数化优化思想,提出了一种针对航拍场景的目标检测模型Rep-YOLO。首先,在主干网络中引入RepVGG模块,提升模型特征提取能力;在模型推理时对RepVGG模块的多分支进行结构重参数化,减少网络分支和结构复杂度。其次,结合数据特征,改进检测网络颈部的路径聚合网络,提升检测算法在机载平台的精度-速度均衡能力。最后,在两个公开红外数据集进行对比实验,表明该算法的有效性。以南航ComNet航拍数据集为例,统计结果显示主要检测指标各类平均精度(mean Average Precision,mAP)提升5.9%,同时参数量和模型大小分别减少约29.7%和23.2%。另外,对Rep-YOLO在典型机载平台Jetson Nano上进行了模型部署验证,为航拍场景的检测算法改进和实际应用提供了可靠的技术支撑。

关键词：深度学习红外图像航拍目标检测 YOLOv5 结构重参数化

Discoloration mechanism,structures and recent applications of thermochromic materials via different methods:A review

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Journal of Materials Science & Technology 2018年第12期34卷 2225-2234页

作者： Youliang Cheng xiaoqiang zhang Changqing Fang Jing Chen Zhen Wang Faculty of Printing Packaging Engineering and Digital Media TechnologyXi'an University of Technology

Thermochromic material is a kind of smart material whose color will vary as the result of the phase transition caused by the temperature change. The characteristics of thermochromic materials are the memory functions to the temperature, having great potential applications in aerospace, military, anticounterfeiting technology, construction and other fields. In recent years, many kinds of thermochromic materials have been prepared by different methods and their discoloration mechanisms are various according to published literatures. In this paper, the classification, discoloration mechanism, preparation methods, application fields and development trend of thermochromic materials are reviewed.

关键词： Thermochromic materials Discoloration mechanism Transformation temperature Classification