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Frontiers of Mechanical Engineering 2023年第4期18卷 97-117页

作者： Yuheng WANG Xiaoqiang Tang State Key Laboratory of Tribology Department of Mechanical EngineeringTsinghua UniversityBeijing 100084China Beijing Key Laboratory of Precision/Ultra-Precision Manufacturing Equipment and Control Tsinghua UniversityBeijing 100084China

The internal force antagonism(IFA)problem is one of the most important issues limiting the applications and popularization of redundant parallel robots in industry.Redundant cable-driven parallel robots(RCDPRs)and redundant rigid parallel robots(RRPRs)behave very differently in this problem.To clarify the essence of IFA,this study first analyzes the causes and influencing factors of IFA.Next,an evaluation index for IFA is proposed,and its calculating algorithm is developed.Then,three graphical analysis methods based on this index are proposed.Finally,the performance of RCDPRs and RRPRs in IFA under three configurations are analyzed.Results show that RRPRs produce IFA in nearly all the areas of the workspace,whereas RCDPRs produce IFA in only some areas of the workspace,and the IFA in RCDPRs is milder than that RRPRs.Thus,RCDPRs more fault-tolerant and easier to control and thus more conducive for industrial application and popularization than RRPRs.Furthermore,the proposed analysis methods can be used for the configuration optimization design of RCDPRs.

关键词： cable-driven parallel robots parallel robots redundant robots evaluation index force solution space

Acylations in cardiovascular diseases:advances and perspectives

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Chinese Medical Journal 2022年第13期135卷 1525-1527页

作者： Xiaofeng Chen Cechuan Deng Han Wang Xiaoqiang Tang Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE State Key Laboratory of BiotherapyWest China Second University HospitalSichuan UniversityChengduSichuan 610041China Department of Biochemistry and Molecular Biology School of Basic Medical SciencesChengdu University of Traditional Chinese MedicineChengduSichuan 610075China Department of Medical Genetics Prenatal Diagnostic CenterWest China Second University HospiaSichuan UniversitySichuan Chengdu610041China.

Cardiovascular diseases(CVD)have become..the leading cause of morbidity and mortality worldwide.Duringthe past two,decades,many experimental and preclinical studies have highlighted the critical roles of histone modifications(eg,acetylations and methylations)in regulating cardiovas-cular development,homeostasis,and disease progression by regulating gene transcription.The well studied histone acetylations such as H3K9ac and H3K27ac activate gene transcription and have shown critical functions in cardio-vascular homeostasis and remodeling. For instance,while class Ⅰ and Ⅱ histone deacetylases(HDACs)generally promote the development of cardiac hypertrophy and diabetic cardiomyopathy,most class Ⅱ HDACs(Sirtuins)exhibit cardioprotective capacity.The inhibitors of class Ⅲ HDACs have been proven to repress cardiac remodeling and heart failure.

关键词： homeostasis diseases protective

Histone crotonylation in neurobiology:to be or not to be?

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Chinese Medical Journal 2022年第9期135卷 1036-1038页

作者： Cechuan Deng Jia-Hua Qu InKyeom Kim Xiaoqiang Tang Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE State Key Laboratory of BiotherapyWest China Second University HospitalSichuan UniversityChengduSichuan 610041China Department of Medical Genetics Prenatal Diagnostic CenterWest China Second University HospitalSichuan UniversityChengduSichuan 610041China Laboratory of Cardiovascular Science Intramural Research ProgramNational Institute on AgingNational Institutes of HealthBaltimoreMaryland 21224USA Department of Pharmacology School of MedicineKyungpook National UniversityDaeguRepublic of Korea Cardiovascular Research Institute School of MedicineKyungpook National UniversityDaeguRepublic of Korea Department of Biomedical Science BK21 Plus KNU Biomedical Convergence ProgramSchool of MedicineKyungpook National UniversityDaeguRepublic of Korea

Epigenetic regulation is a pivotal mechanism that controls gene transcription and cell fate.During the past decades,it has been observed that histone,DNA,and RNA modifications participate in determining the fate of neural stem cells(NSCs).These modifications include histone acetylation and methylation,as well as DNA and RNA methylation.Of note,non-coding RNAs also participate in neural differentiation.[1]In addition to acetylation,many other types of acylations to histone lysines,including crotonylation,propionylation,succinylation,and malonylation,have been identified.[2]The roles of these histone acylations in neuroscience remain elusive.

关键词： neural differentiation. modification

Gut microbiota and microbiota-derived metabolites in cardiovascular diseases

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中华医学杂志（英文版） 2023年第19期136卷 2269-2284页

作者： Xiaofeng Chen Hua Zhang Sichong Ren Yangnan Ding Naznin Sultana Remex Md. Shenuarin Bhuiyan Jiahua Qu xiaoqiang tang China 611137 China Key Laboratory of Chronobiology (Sichuan University) National Health Commission of China Chengdu Sichuan 610041 China Sichuan Birth Defects Clinical Research Center West China Second University Hospital Sichuan University Chengdu Sichuan 610041 China610041 China 610500 China 450052 Department of Molecular and Cellular Physiology Louisiana State University Health Sciences Center Shreveport LA 71103 USA Department of Molecular and Cellular Physiology Louisiana State University Health Sciences Center Shreveport LA 71103 USA Department of Pathology and Translational Pathobiology Louisiana State University Health Sciences Center Shreveport LA 71103 USA Department of Pathology University of California San Francisco CA 94117 USA

Cardiovascular diseases, including heart failure, coronary artery disease, atherosclerosis, aneurysm, thrombosis, and hypertension, are a great economic burden and threat to human health and are the major cause of death worldwide. Recently, researchers have begun to appreciate the role of microbial ecosystems within the human body in contributing to metabolic and cardiovascular disorders. Accumulating evidence has demonstrated that the gut microbiota is closely associated with the occurrence and development of cardiovascular diseases. The gut microbiota functions as an endocrine organ that secretes bioactive metabolites that participate in the maintenance of cardiovascular homeostasis, and their dysfunction can directly influence the progression of cardiovascular disease. This review summarizes the current literature demonstrating the role of the gut microbiota in the development of cardiovascular diseases. We also highlight the mechanism by which well-documented gut microbiota-derived metabolites, especially trimethylamine N-oxide, short-chain fatty acids, and phenylacetylglutamine, promote or inhibit the pathogenesis of cardiovascular diseases. We also discuss the therapeutic potential of altering the gut microbiota and microbiota-derived metabolites to improve or prevent cardiovascular diseases.

关键词： Gut microbiota Metabolites Heart failure Coronary artery disease Atherosclerosis Aneurysm Thrombosis Hypertension

State-of-the-art on theories and applications of cable-driven parallel robots

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Frontiers of Mechanical Engineering 2022年第3期17卷 35-57页

作者： Zhaokun ZHANG Zhufeng SHAO Zheng YOU Xiaoqiang Tang Bin ZI Guilin YANG Clément GOSSELIN Stéphane CARO State Key Laboratory of Tribology Department of Mechanical EngineeringTsinghua UniversityBeijing 100084China Beijing Key Laboratory of Precision/Ultra-Precision Manufacturing Equipment and Control Tsinghua UniversityBeijing 100084China Department of Mechanical Engineering University of MichiganAnn ArborMI 48109USA Department of Precision Instrument Tsinghua UniversityBeijing 100084China School of Mechanical Engineering Hefei University of TechnologyHefei 230009China Ningbo Institute of Industrial Technology Chinese Academy of Sciences(CAS)Ningbo 315201China Department of Mechanical Engineering UniversitéLavalQuebec QC G1V 0A6Canada Laboratory of Digital Sciences of Nantes National Centre for Scientific ResearchNantes 44321France

Cable-driven parallel robot(CDPR)is a type of high-performance robot that integrates cable-driven kinematic chains and parallel mechanism theory.It inherits the high dynamics and heavy load capacities of the parallel mechanism and significantly improves the workspace,cost and energy efficiency simultaneously.As a result,CDPRs have had irreplaceable roles in industrial and technological fields,such as astronomy,aerospace,logistics,simulators,and rehabilitation.CDPRs follow the cutting-edge trend of rigid-flexible fusion,reflect advanced lightweight design concepts,and have become a frontier topic in robotics research.This paper summarizes the kernel theories and developments of CDPRs,covering configuration design,cable-force distribution,workspace and stiffness,performance evaluation,optimization,and motion control.Kinematic modeling,workspace analysis,and cable-force solution are illustrated.Stiffness and dynamic modeling methods are discussed.To further promote the development,researchers should strengthen the investigation in configuration innovation,rapid calculation of workspace,performance evaluation,stiffness control,and rigid-flexible coupling dynamics.In addition,engineering problems such as cable materials,reliability design,and a unified control framework require attention.

关键词： cable-driven parallel robot kinematics optimization dynamics control

Atlas Based Kinematic Optimum Design of the Stewart Parallel Manipulator

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Chinese Journal of Mechanical Engineering 2015年第1期28卷 20-28页

作者： SHAO Zhufeng tang xiaoqiang WANG Liping SUN Dengfeng State Key Laboratory of Tribology Department of Mechanical EngineeringTsinghua University Beijing Key Lab of Precision/Ultra-precision Manufacturing Equipments and Control Tsinghua University School of Aeronautics and Astronautics Engineering Purdue University

Optimum design is a key approach to make full use of potential advantages of a parallel manipulator. The optimum design of multi-parameter parallel manipulators（more than three design parameters）, such as Stewart manipulator, relies on analysis based and algorithm based optimum design methods, which fall to be accurate or intuitive. To solve this problem and achieve both accurate and intuition, atlas based optimum design of a general Stewart parallel manipulator is established, with rational selection of design parameters. Based on the defined spherical usable workspace（SUW）, primary kinematic performance indices of the Stewart manipulator involving workspace and condition number are introduced and analyzed. Then, corresponding performance atlases are drawn with the established non-dimensional design space, and impact of joint distribution angles on the manipulator performance is analyzed and illustrated. At last, an example on atlas based optimum design of the Stewart manipulator is accomplished to illustrate the optimum design process, considering the end-effector posture. Deduced atlases can be flexibly applied to both quantitative and qualitative analysis to get the desired optimal design for the Stewart manipulator with respect to related performance requirements. Besides, the established optimum design method can be further applied to other multi-parameter parallel manipulators.

关键词： optimum design performance atlas parallel mechanism Stewart

Increasing the greenness of an organic acid through deep eutectic solvation and further polymerisation

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Green Energy & Environment 2022年第4期7卷 840-853页

作者： Liteng Li Xiaofang Li Susu Zhang Hongyuan Yan xiaoqiang Qiao Hongyan He Tao Zhu Baokun tang College of Pharmaceutical Science Institute of Life Science and Green DevelopmentKey Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of EducationHebei UniversityBaoding071002China CAS Key Laboratory of Green Process and Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing010190China

Acrylic acid(AA)is an important and widely used industrial chemical,but its high toxicity renders its use incompatible with the concept of green development.By leveraging its terminal carboxyl group and unsaturated bond,we designed and explored a new strategy to increase the greenness of AA via its eutectic melting using a quaternary ammonium salt(choline chloride)to form a deep eutectic solvent(DES),followed by polymerisation of the DES to form a polymer(poly(DES)).The greenness of AA,DES,and poly(DES)was evaluated via an in vitro test using MGC80-3 cells and an in vivo test using Kunming mice.The toxicity improved from Grade 2(moderately toxic)for AA to Grade 1(slightly toxic)for DESs and Grade 0(non-toxic)for poly(DES)in the in vitro test.Moreover,the poly(DES)s showed a lower toxicity in mice than the DESs in the in vivo test.Thus,greenness enhancement was successfully achieved,with the greenness following the order AA

关键词： Greenness Deep eutectic solvent Polymer Toxicity Application

Construction of ternary PEG200-based DESs lubrication systems via tailoring tribo-chemistry

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Friction 2024年第4期12卷 655-669页

作者： Yuting LI Songyu LAN Yazhou LIU Cheng CAO Zicheng tang Deyin DENG Fuyuan LIU Hao LI xiaoqiang FAN Minhao ZHU Key Laboratory of Advanced Technologies of Materials(Ministry of Education) School of Materials Science and EngineeringSouthwest Jiaotong UniversityChengdu 610031China Tribology Research Institute School of Mechanical EngineeringSouthwest Jiaotong UniversityChengdu 610031China

Designing novel lubricants with easily customized structures,devisable compositions,and simple and economic synthesis over traditional lubricants is critical to fulfilling complex applications,prolonging machine lifetime,and saving energy.Deep eutectic solvents(DESs),which show tunable composition,adjustable structure,easy fabrication,and environmental friendliness,are promising candidates for variable and complicated lubricants applications.To promote the use of DESs as lubricants,a series of PEG200-based DESs with active heteroatoms were fabricated to tailor the tribological performance via tribo-chemistry.Thereinto,PEG200/boric acid(BA)DES shows optimal lubrication performance by forming tribo-chemical reaction film composited of B2O3,iron oxides,and FeOOH,and PEG200/thiourea(TU)DES displays abrasive wear-reducing property by producing FeS tribo-chemical film.Given the excellent abrasive wear-resistance of PEG200/TU DES and friction reduction of PEG200/BA DES,ternary PEG200/BA/TU DESs,composited of PEG200/TU DES and PEG200/BA DES,are first exploited.The ternary DESs possess superior wettability and thermal stability,which render them potential lubricants.Tribological tests of the ternary DESs demonstrate that synergistic lubrication is achieved by forming a transfer film consisting of FexBy,BN,B2O3,and FeS.Wherein FexBy,BN,and B2O3 increase load bearing of the film,and FeS mitigates severe abrasive wear.The proposed design philosophy of novel DESs as lubricants opens up a unique realm that is unattainable by traditional DESs lubrication mechanisms and provides a platform to design next-generation DESs lubrication systems.

关键词： deep eutectic solvents(DESs) PEG200/boric acid DES PEG200/thiourea DES ternary DESs synergistic lubrication tribo-chemistry

Hepatic Zbtb18 (Zinc Finger and BTB Domain Containing 18) alleviates hepatic steatohepatitis via FXR (Farnesoid X Receptor)

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Signal Transduction and Targeted Therapy 2024年第2期9卷 766-781页

作者： Lei Zhang Jiabing Chen Xiaoying Yang Chuangpeng Shen Jiawen Huang Dong Zhang Naihua Liu Chaonan Liu Yadi Zhong Yingjian Chen Kaijia tang Jingyi Guo Tianqi Cui Siwei Duan Jiayu Li Shangyi Huang Huafeng Pan Huabing Zhang Xiaoqiang Tang Yongsheng Chang Yong Gao State Key Laboratory of Traditional Chinese Medicine Syndrome Science and Technology Innovation CenterGuangzhou University of Chinese MedicineGuangzhouChina Key Laboratory of Immune Microenvironment and Disease(Ministry of Education) Tianjin Key Laboratory of Cellular Homeostasis and DiseaseDepartment of Physiology and PathophysiologyTianjin Medical UniversityTianjinChina Jiangsu Key Laboratory of Immunity and Metabolism Department of Pathogen Biology and ImmunologyJiangsu International Laboratory of Immunity and MetabolismXuzhou Medical UniversityXuzhouChina Department of Endocrinology The First Clinical CollegeGuangzhou University of Chinese MedicineGuangdongChina The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine ShenzhenChina Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine in Prevention and Treatment of Tumor Nanjing University of Chinese MedicineNanjingChina Department of Biochemistry and Molecular Biology Metabolic Disease Research CenterSchool of Basic MedicineAnhui Medical UniversityHefeiChina Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE State Key Laboratory of BiotherapyWest China Second University HospitalSichuan UniversityChengduChina

A lasting imbalance between fatty acid synthesis and consumption leads to non-alcoholic fatty liver disease(NAFLD),coupled with hepatitis and insulin resistance.Yet the details of the underlying mechanisms are not fully understood.Here,we unraveled that the expression of the transcription factor Zbtb18 is markedly decreased in the livers of both patients and murine models of NAFLD.Hepatic Zbtb18 knockout promoted NAFLD features like impaired energy expenditure and fatty acid oxidation(FAO),and induced insulin resistance.Conversely,hepatic Zbtb18 overexpression alleviated hepato-steatosis,insulin resistance,and hyperglycemia in mice fed on a high-fat diet(HFD)or in diabetic mice.Notably,in vitro and in vivo mechanistic studies revealed that Zbtb18 transcriptional activation of Farnesoid X receptor(FXR)mediated FAO and Clathrin Heavy Chain(CLTC)protein hinders NLRP3 inflammasome activity.This key mechanism by which hepatocyte’s Zbtb18 expression alleviates NAFLD and consequent liver fibrosis was further verified by FXR’s deletion and forced expression in mice and cultured mouse primary hepatocytes(MPHs).Moreover,CLTC deletion significantly abrogated the hepatic Zbtb18 overexpression-driven inhibition of NLRP3 inflammasome activity in macrophages.Altogether,Zbtb18 transcriptionally activates the FXR-mediated FAO and CLTC expression,which inhibits NLRP3 inflammasome’s activity alleviating inflammatory stress and insulin resistance,representing an attractive remedy for hepatic steatosis and fibrosis.

关键词： hepatic Hepatic impaired

The chemokine CCL17 is a novel therapeutic target for cardiovascular aging

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Signal Transduction and Targeted Therapy 2023年第5期8卷 2068-2071页

作者： Yang Zhang Xiaoqiang Tang Zeyuan Wang Lun Wang Zhangwei Chen Ju-Ying Qian Zhuang Tian Shu-Yang Zhang Department of Cardiology Peking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijingChina Department of Cardiology Zhongshan HospitalFudan UniversityShanghai Institute of Cardiovascular DiseasesShanghai200032China Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE State Key Laboratory of BiotherapyWest China Second University HospitalSichuan UniversityChengdu610041China

Dear Editor,Aging results in higher susceptibility to age-related disease,especially cardiovascular disease,which has become a public health priority.1,2 Recent studies have progressively unraveled the critical role of vasculature as a gatekeeper of life-span and health-span.3 In this light,vascular rejuvenation is geroprotective.The circulating proteomic signature is tightly related to aging and aging-induced vascular diseases,4 but drugs targeting circulating proteins are not available.

关键词： aging protective signature