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Antiglycative and anti-inflammatory effects of lipophilized tyrosol derivatives

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食物生产加工与营养(英文)

食物生产加工与营养(英文) 2020年第1期2卷 280-286页

作者： xiaoqian hu Mingfu Wang Fereidoon Shahidi School of Public Health Xiamen UniversityXiamen 361102FujianChina College of Food Science and Technology Shanghai Ocean UniversityShanghai 201306China Department of Biochemistry Memorial University of NewfoundlandSt.John’sNL A1B 3X9Canada

To expand the application of tyrosol,a series of lipophilized tyrosol derivatives were synthesized via esterification of tyrosol with fatty acids of different chain lengths.The antiglycative activity of tyrosol esters so prepared was subsequently examined in the bovine serumalbumin/glucose system.A quasi-parabolic shape was observed when the activity was plotted against alkyl chain length.Additionally,the anti-inflammatory effects of these derivatives were evaluated against methylglyoxalinduced inflammation in RAW264.7 cells.The same trend on anti-inflammatory activity was found as in the antiglycation study.The results showed that tyrosol esters with C12:0 and C14:0 were two most efficient ones among all the tested derivatives.Thus,some lipophilized tyrosol derivatives were stronger antiglycative and anti-inflammatory agents compared to the parent compound,tyrosol.

关键词： Tyrosyl esters Lipophilization Glycation Methylglyoxal Inflammation Phenolipids

晶化时间对铝合金超疏水复合膜减粘脱附性能的影响

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兵器材料科学与工程 2024年第2期47卷 122-128页

作者：胡小骞曾舜柯翟彦博西南大学工程技术学院重庆400715

用水热法对铝合金微弧氧化膜(MAO)进行12、24、36 h晶化处理,使其表面负载水滑石(LDHs)微粒,再用水浴法对MAO-LDHs复合膜进行十六烷基三甲氧基硅烷(HDTM)疏水改性,获得MAO-LDHs-HDTM超疏水复合膜,探究不同晶化时间对超疏水复合膜的减粘... 详细信息

用水热法对铝合金微弧氧化膜(MAO)进行12、24、36 h晶化处理,使其表面负载水滑石(LDHs)微粒,再用水浴法对MAO-LDHs复合膜进行十六烷基三甲氧基硅烷(HDTM)疏水改性,获得MAO-LDHs-HDTM超疏水复合膜,探究不同晶化时间对超疏水复合膜的减粘脱附效果。结果表明:随晶化时间的增长,“片状”和“针状”物LDHs晶体在MAO膜的表面孔隙原位生长,特征峰的峰值与晶化时间成正比,MAO-LDHs-HDTM复合膜的静态接触角均大于150°,达到超疏水效果;相较于铝合金基体,MAO-LDHs-HDTM超疏水复合膜硬度显著增强;土壤粘附测试中,3种不同晶化时间复合膜受到的阻力均值随土壤含水率的增加而下降,在15%含水率土壤中,晶化时间为12 h的复合膜和25%含水率土壤中,晶化时间为24 h的复合膜土壤粘附情况更优。

关键词：铝合金微弧氧化超疏水减粘脱附

体教融合背景下我国地方青少年竞技体育后备人才培养协作治理体系研究——基于江苏省A市的案例分析

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体育科学 2024年第2期44卷 24-37页

作者：吴楚楚胡孝乾吴南宁清华大学体育部北京100084 清华大学社会科学学院北京100084 徐州市体育局江苏徐州221006

在青少年竞技体育后备人才培养方面,传统的三级训练网需要机制创新与完善,如何创新以实现跨领域、跨部门协作治理是难以解决的现实问题。采用批判实在主义立场下的主题分析法,以江苏省A市为代表性个案对我国地方如何实现竞技体育后备人... 详细信息

在青少年竞技体育后备人才培养方面,传统的三级训练网需要机制创新与完善,如何创新以实现跨领域、跨部门协作治理是难以解决的现实问题。采用批判实在主义立场下的主题分析法,以江苏省A市为代表性个案对我国地方如何实现竞技体育后备人才培养协作治理这一问题进行分析。结果表明,资源依赖、共同目标与信任关系是地方竞技体育后备人才培养协作治理的触发机制,事业单位是构建地方多部门协作与竞争结构的桥梁,正式制度保证协作治理良性运转,非正式治理奠定多方治理主体共识。据此建议地方搭建体教融合治理网络,平衡各方权力与利益分配;加强业余体校专业化建设,竞争与激励并举;增强地方治理统合能力,发挥地方自主性;重视政策企业家作用,系统性培育信念、知识与能力。

关键词：体教融合青少年竞技体育后备人才培养协作治理

Impact and inhibitory mechanism of phenolic compounds on the formation of toxic Maillard reaction products in food

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Frontiers of Agricultural Science and Engineering 2018年第3期5卷 321-329页

作者： Jing TENG xiaoqian hu Ningping TAO Mingfu WANG College of Food Science and Technology Shanghai Ocean University

As one of the dominant reactions occurring during thermal treatment of food, the Maillard reaction not only leads to the formation of aroma, browning color and taste compounds, but also contributes to the formation of some unpleasant toxic substances including acrylamide,heterocyclic amines and advanced glycation end products.Polyphenols, one of the most abundant antioxidants in the human diet, are contained in different kinds of foods. In this review, some recent studies on the impact of dietary polyphenols on the formation of acrylamide, heterocyclic amines and advanced glycation end products formed during the Maillard reaction are summarized, including the research work conducted with both chemical model systems and real food model systems; the possible inhibitory mechanisms of different polyphenols are also summarized and discussed in this review. Basically we found that some dietary polyphenols not only scavenge free radicals, but also react with reactive carbonyl species,thus lowering the formation of toxic Maillard reaction products. This review provides a useful theoretical foundation for the application of polyphenols in food safety, and suggests some directions for further study of natural products as inhibitors against the formation of toxic substances in thermally processed food.

关键词： acrylamide food safety heterocyclic amine Maillard reaction polyphenols

Carbon sequestration benefits of the grain for Green Program in the hilly red soil region of southern China

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International Soil and Water Conservation Research 2021年第2期9卷 271-278页

作者： xiaoqian hu Zhongwu Li Jia Chen Xiaodong Nie Junyu Liu Lingxia Wang Ke Ning College of Resources and Environmental Sciences Hunan Normal UniversityChangsha410081China College of Environmental Science and Engineering Hunan UniversityChangsha410082China Agricultural College of Guizhou University Guiyang550025China State Key Laboratory of Soil Erosion and Dryland Farming on the Loess Plateau Institute of Soil and Water ConservationChinese Academy of Science and Ministry of Water ResourcesYangling712100China

Soil erosion disturbs not only the global carbon cycle,but it is a complex environmental problem.Revegetation could reduce carbon emission by controlling soil erosion and increase carbon sequestration and accumulation by fixing carbon in vegetation and soil.The Grain for Green Program(GFGP)of China is the largest ecological restoration program in the world closely related to land-use/land-cover change(LUCC).Systematically assessing the carbon sequestration benefit of GFGP is crucial for a better understanding of the effects of implementing GFGP and providing reasonable vegetation management.Therefore,we selected the hilly red soil region(HRSR)of southern China as a study area,which is one of the main ecologically vulnerable areas in China.We assessed the carbon sequestration in the GFGP area of the HRSR using the InVEST(Integrated Valuation of Environmental Services and Tradeoffs)model based on land-use/land-cover datasets during 2000e2015.Our results show that implementing GFGP is conducive to the enhancement of carbon sequestration services.Total carbon sequestration showed an increasing trend at a rate of 15.43%from 2000 to 2015.The most significant change mainly happened in hunan Province with the shortest implementation time.The carbon sequestration of each carbon pool(namely aboveground biomass,belowground biomass,soil,and dead organic matter)also increased slightly.Additionally,for carbon sequestration,unused land converted to forest land is the most effective LUCC.This study can provide scientific support for the management and implementation of GFGP in the HRSR of China.

关键词： Carbon sequestration InVEST model GFGP area Climate change Unused land afforestation

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血培养阳性结果中血培养污染的鉴别分析

中华传染病杂志 2024年第3期42卷 154-159页

作者：胡潇倩张炜王暄哲刘红邵凌云复旦大学附属华山医院感染科上海市传染病与生物安全应急响应重点实验室国家传染病医学中心上海200040 复旦大学附属华山医院检验科上海200040

目的评估可用于识别血培养阳性结果中血培养污染与血流感染的临床指标,为临床识别血培养污染提供参考。方法回顾性分析2021年1月至12月复旦大学附属华山医院收治的303例血培养阳性患者的临床资料和血培养检出菌分布情况,比较血流感染组... 详细信息

目的评估可用于识别血培养阳性结果中血培养污染与血流感染的临床指标,为临床识别血培养污染提供参考。方法回顾性分析2021年1月至12月复旦大学附属华山医院收治的303例血培养阳性患者的临床资料和血培养检出菌分布情况,比较血流感染组和血培养污染组的年龄、科室分布、血培养报阳时间、中性粒细胞比例、降钙素原和C反应蛋白(CRP)等数据。统计学比较采用曼-惠特尼U检验和χ^(2)检验,采用多因素logistic回归分析对识别血培养污染有价值的临床指标。结果303例血培养阳性患者中血流感染组237例,血培养污染组66例,污染率为21.78%。两组患者的科室分布差异有统计学意义(χ^(2)=11.28,P=0.024)。血流感染组年龄≥60岁比例[52.7%(125/237)比36.4%(24/66)]、中性粒细胞比例[0.86(0.79,0.91)比0.82(0.75,0.88)]、降钙素原[1.05(0.23,6.64)μg/L比0.17(0.11,0.72)μg/L]和CRP[60.55(24.83,132.83)mg/L比40.64(8.98,95.83)mg/L]均高于血培养污染组,差异均有统计学意义(χ^(2)=5.54,U=9523.00、10906.00、9278.50,均P<0.05)。303例血培养阳性患者中,单次、2次和3次血培养阳性患者分别为253例、41例和9例。单次血培养阳性患者检出菌为凝固酶阴性葡萄球菌的污染率最高,为54.72%(29/53)。血流感染组的血培养报阳时间为3(3,4)d,短于血培养污染组的4(3,4)d,差异有统计学意义(U=6521.00,P=0.026)。多因素logistic回归分析显示,血培养报阳时间≤3 d、降钙素原≥2.00μg/L时,血培养阳性结果为血流感染的可能性更大[比值比(OR)=2.16、1.96,均P<0.05]。结论血培养相关微生物、血培养报阳时间和临床指标对识别血培养污染有一定的价值,当血培养报阳时间≤3 d、降钙素原≥2.00μg/L时血培养阳性结果为血流感染的可能性更大。

关键词：血培养降钙素原血流感染血培养相关微生物报阳时间

血清PTX3、CK-MB水平对慢性失代偿心力衰竭患者容量负荷的评估价值

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中国医师杂志 2024年第1期26卷 87-92页

作者：曹明善王春娣胡小倩孟令慧武瑜丰刘欢杨华邢台市中心医院检验科邢台054000 临西县人民医院心内科临西054900 邢台市人民医院检验科邢台054031

目的探讨血清正五聚蛋白3(PTX3)、肌酸激酶同工酶MB(CK-MB)水平对慢性失代偿心力衰竭(CDHF)患者容量负荷的评估价值。方法选取2019年7月至2022年7月于邢台市中心医院就诊的300例CDHF患者,根据患者容量平衡水平将其分为容量负荷过载组(n=... 详细信息

目的探讨血清正五聚蛋白3(PTX3)、肌酸激酶同工酶MB(CK-MB)水平对慢性失代偿心力衰竭(CDHF)患者容量负荷的评估价值。方法选取2019年7月至2022年7月于邢台市中心医院就诊的300例CDHF患者,根据患者容量平衡水平将其分为容量负荷过载组(n=182)和非容量负荷过载组(n=118)。对比分析两组临床资料,利用受试者工作特征(ROC)曲线分析血清PTX3、CK-MB水平对CDHF患者容量负荷的评估价值,利用单因素分析两组患者的临床疾病特征,采用logistic回归分析CDHF患者容量负荷的影响因素,构建列线图模型并验证。结果容量负荷过载组患者BMI、腰围、收缩压、舒张压、空腹血糖(FBG)、糖化血红蛋白(HbA1c)、C反应蛋白(CRP)、尿酸(UA)、胰岛素抵抗指数(HOMA-IR)均高于非容量负荷过载组,差异均有统计学意义(均P<0.05)。容量负荷过载组患者的PTX3、CK-MB、肺毛细血管楔压(PCWP)、CVP水平高于非容量负荷过载组,清蛋白、血红蛋白、红细胞比容低于非容量负荷过载组,差异均有统计学意义(均P<0.05)。ROC曲线显示,PTX3、CK-MB预测CDHF患者容量负荷过载的曲线下面积(AUC)为0.795、0.718,灵敏度分别为86.2%、83.7%,特异度分别为65.4%、68.6%,预测准确性较高;两项联合预测的AUC为0.817、灵敏度为92.5%、特异度为70.6%,预测准确性高于PTX3(Z=3.812,P<0.05)和CK-MB(Z=3.365,P<0.05)。PTX3、CK-MB、清蛋白、血红蛋白、红细胞比容、PCWP、中心静脉压(CVP)均为CDHF患者的容量负荷状态的影响因素(均P<0.05),据此建立的列线图风险预测模型在临床治疗上有着高准确性和强适用性。结论血清PTX3、CK-MB水平为CDHF患者发生容量过载的影响因素,联合清蛋白、血红蛋白、红细胞比容、PCWP、CVP等指标构建的列线图模型对CDHF的容量负荷状态具有较高的预测价值。

关键词：心力衰竭正五聚蛋白3 肌酸激酶,MB型容量负荷

BOPPPS教学模式结合PAD课堂在“生物化学”课程教学中的探索研究

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济宁学院学报 2024年第3期45卷 82-90页

作者：胡晓倩吴丽萍秦宏伟李伟于海东黄山学院生命与环境科学学院安徽黄山245041 济宁学院生命科学与生物工程学院山东曲阜273155

以黄山学院生物技术专业“生物化学”课程教学为例,介绍了BOPPPS教学模式结合PAD课堂开展“生物化学”课程教学的实施过程。BOPPPS和PAD课堂实践相结合,提升了学生在课堂上的参与度、积极性和主动性;通过PAD课堂隔堂讨论的“亮考帮”环... 详细信息

以黄山学院生物技术专业“生物化学”课程教学为例,介绍了BOPPPS教学模式结合PAD课堂开展“生物化学”课程教学的实施过程。BOPPPS和PAD课堂实践相结合,提升了学生在课堂上的参与度、积极性和主动性;通过PAD课堂隔堂讨论的“亮考帮”环节,一定程度上提升了学生的思维创新能力;通过案例以问题的方式作为BOPPPS教学模式的导入环节,PAD课堂思考题布置作为BOPPPS的前测环节,驱动学生必须进行有效思考来剖析案例和解决问题,一定程度上提升了课程的高阶性、创新性和挑战度;把提升学生学习自主性、积极性作为课程教学目的,科学实施和评价教学过程关键环节,形成重在培养创新能力的教学模式。BOPPPS教学模式与PAD课堂进行有机结合,可以塑造以学为中心,以能力达成为目标的课程教学模式,提升“生物化学”课程的教学效果。

关键词： BOPPPS教学模式 PAD课堂生物化学教学效果

Pancreatic β-cell failure, clinical implications, and therapeutic strategies in type 2 diabetes

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中华医学杂志(英文版) 2024年第7期137卷 791-805页

作者： Cui Daxin Feng Xingrong Lei Siman Zhang Hongmei hu Wanxin Yang Shanshan Yu xiaoqian Su Zhiguang Molecular Medicine Research Center and Department of Endocrinology and Metabolism West China Hospital Sichuan University Chengdu Sichuan 610041 China State Key Laboratory of Biotherapy Clinical Translational Innovation Center

Pancreatic β-cell failure due to a reduction in function and mass has been defined as a primary contributor to the progression of type 2 diabetes (T2D). Reserving insulin-producing β-cells and hence restoring insulin production are gaining attention in translational diabetes research, and β-cell replenishment has been the main focus for diabetes treatment. Significant findings in β-cell proliferation, transdifferentiation, pluripotent stem cell differentiation, and associated small molecules have served as promising strategies to regenerate β-cells. In this review, we summarize current knowledge on the mechanisms implicated in β-cell dynamic processes under physiological and diabetic conditions, in which genetic factors, age-related alterations, metabolic stresses, and compromised identity are critical factors contributing to β-cell failure in T2D. The article also focuses on recent advances in therapeutic strategies for diabetes treatment by promoting β-cell proliferation, inducing non-β-cell transdifferentiation, and reprograming stem cell differentiation. Although a significant challenge remains for each of these strategies, the recognition of the mechanisms responsible for β-cell development and mature endocrine cell plasticity and remarkable advances in the generation of exogenous β-cells from stem cells and single-cell studies pave the way for developing potential approaches to cure diabetes.

关键词： Pancreatic β-cell regeneration Diabetes Insulin Dedifferentiation Transdifferentiation Stem cell