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TNFR2 expression on non-bone marrow-derived cells is crucial for lipopolysaccharide-induced septic shock and downregulation of soluble TNFR2 level in serum

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Cellular & Molecular Immunology 2011年第2期8卷 164-171页

作者： Lijie Rong Jingjing Deng xiaopu zhao Xiaoman Liu Xia Xu Zhihai Qin National Laboratory of Biomacromolecules China-Japan Joint Laboratory of Structural Virology and ImmunologyInstitute of BiophysicsChinese Academy of SciencesBeijingChina Graduate University of Chinese Academy of Sciences Institute of BiophysicsBeijingChina

Persistently high serum levels of soluble tumor-necrosis factor(TNF)receptor 2(sTNFR2)have been observed in septic shock and many inflammatory ***,its origin and regulation during these pathological processes are still largely *** this study,murine bone marrow(BM)chimeras selectively expressing TNFR2 on either BM-derived or non-BM-derived cells were generated and challenged with lipopolysaccharide(LPS).The results show that TNFR2 expression on non-BM-derived cells is crucial for both the sensitivity of mice to LPS and the downregulation of sTNFR2 in *** importantly,sTNFR2 was released from both BM-and non-BM-derived ***-BM TNFR1 expression influenced the sensitivity of mice to LPS challenge but not the level of serum *** results provide the first in vivo evidence for the origin and regulation of sTNFR2 in serum and could aid in the development of novel anti-TNF strategies against septic shock.

关键词： LPS non-BM-derived cells sTNFR2

TNFR-2 dependent caspase-8 repression is necessary for peripheral MDSC accumulation

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TNFR-2 dependent caspase-8 repression is necessary for perip...

Research on mechanical alloying and sintering of TiC/Ti powders

第八届全国免疫学学术大会

作者： Lijie Rong Xueqiang zhao xiaopu zhao Zhihai Qin Institute of Biophysics CAS

Myeloid-derived suppressor cells(MDSCs)often expand extensively during inflammation and tumor progression in mice and ***,molecular mechanisms governing the accumulationof this group of cells are still not well *** we report that peripheral accumulation of MDSCs is drastically impaired in mice deficient of both TNF receptors(TNFR-/-),which correlates to spontaneous rejection of transplanted tumors independent of their TNFR *** transfer of TNFR-competent,but not TNFR-deficient MDSCs,does rescuetumor growth in TNFR-/-mice in dose-dependent *** of TNFR-2,but not

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金刚石与磨料磨具工程 2008年第S1期28卷 168-171页

作者： Sun Jinfeng,Li xiaopu,Wang Mingzhi,zhao Yucheng (State Key Laboratory of Metastable Materials Science & Technology,Yanshan University, Qinhuangdao 066004,Hebei,China)

In order to improve the sintering activity of TiC which was usually added into the binder of polycrystalline diamond(PCD) and polycrystalline cubic boron nitride(PCBN),the powders of TiC and Ti mixed as molar ratio of TiC:Ti = 1:0.3 were treated by mechanical *** structure and the morphology of the milled powders were analyzed by X-ray diffraction(XRD) and scan electron microscope(SEM), *** milled powders were sintered by cubic hinge *** structure of the sintered sample was analyzed by X-ray diffraction and the hardness was *** results showed that the grain size of the TiC and the Ti powders were decreased,as the milling time increased,and the nonstoichiometric compound of TiC_x was *** sintering activity of the TiC/Ti powders treated by mechanical alloying increased *** hardness of the sintered sample improved from 829.2 HV for the raw powders to 2587.37 HV for the powders mechanical alloyed 20 hours.

关键词： binder TiC sintering nonstoichiometric compound hardness

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上海城市轨道交通网络级视频监控系统的研制

城市轨道交通研究 2020年第S02期23卷 132-137页

作者：赵晓朴上海地铁维护保障有限公司通号分公司上海200235

随着城市轨道交通网络规模的不断发展,网络化的运营管理模式对作为运营安全、公共安全保障重要辅助工具的视频监控系统提出了新的要求,将各线路视频监控系统整合集成为网络级视频监控系统势在必行。如何将各条在建、既有的城市轨道交通... 详细信息

随着城市轨道交通网络规模的不断发展,网络化的运营管理模式对作为运营安全、公共安全保障重要辅助工具的视频监控系统提出了新的要求,将各线路视频监控系统整合集成为网络级视频监控系统势在必行。如何将各条在建、既有的城市轨道交通线路的视频监控系统进行接入及改造,在保障系统的兼容性、稳定性以及系统平稳过渡的基础上实现多制式视频监控系统下的统一视频调用和管理,上海城市轨道交通申通网络级视频监控系统给出了针对此类问题的有效解决方案,以解决多制式、多系统、多平台兼容和对接的问题。

关键词：城市轨道交通网络级视频监控系统改造

基于软件通信体系架构的OFDM波形的设计与实现

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自动化应用 2023年第10期64卷 239-241,244页

作者：赵小璞中国电子科技集团公司第七研究所单位广东广州510000

基于软件通信体系架构设计实现了通用硬件、软件平台和组件化OFDM波形。通用硬件平台采用Xilinx公司的ZYNQ SOC芯片和ADI公司的AD9361为核心处理芯片,并设计了覆盖30 MHz~2 GHz的宽频段信道模块;通用软件平台按照SCA 4.1标准研制了核心... 详细信息

基于软件通信体系架构设计实现了通用硬件、软件平台和组件化OFDM波形。通用硬件平台采用Xilinx公司的ZYNQ SOC芯片和ADI公司的AD9361为核心处理芯片,并设计了覆盖30 MHz~2 GHz的宽频段信道模块;通用软件平台按照SCA 4.1标准研制了核心框架软件;OFDM波形按照波形标准API接口进行了组件化封装,并通过平台设备和服务组件接口与底层平台适配。最后测试了波形的功率谱、误码率、接收灵敏度等指标,结果证明,波形性能可以满足设计指标要求。

关键词：软件通信体系架构软件无线电 OFDM 波形组件

一种基于软件通信体系结构的波形组件动态部署方法

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计算机测量与控制 2014年第9期22卷 3058-3060页

作者：石贱弟赵小璞陈俊可中国电子科技集团公司第七研究所广州510310

简述了软件无线电波形及波形组件,分析了SCA波形软件装配描述文件SAD,提出了一种基于软件通信体系结构和波形组件管理器的组件动态部署方法,并设计实现了组件管理器;使用组件管理器为组件的创建和部署提供统一接口,为波形组件的动态部... 详细信息

简述了软件无线电波形及波形组件,分析了SCA波形软件装配描述文件SAD,提出了一种基于软件通信体系结构和波形组件管理器的组件动态部署方法,并设计实现了组件管理器;使用组件管理器为组件的创建和部署提供统一接口,为波形组件的动态部署操作提供灵活方便的通用接口实现;以宽带网络波形为例,在vxWorks下进行了波形组件的部署试验;结果表明,该方法可以满足SCA波形组件的动态创建和部署要求,解决了波形组件的创建和部署操作与其它操作夹杂在一起,耦合度高的问题,从而提高了组件的可重用性、可移植性和可维护性。

关键词：软件通信体系结构波形组件动态部署软件无线电

Significant changes in the physicochemical properties of BC-containing particles during the cold season in Beijing

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Journal of Environmental Sciences 2025年第5期151卷 667-676页

作者： Shuya Hu Linghan Zeng Gang zhao Shiyi Chen Chunsheng zhao Weilun zhao Min Hu State Key Joint Laboratory of Environmental Simulation and Pollution Control International Joint Research Center for Atmospheric Research(IJRC)College of Environmental Sciences and EngineeringPeking UniversityBeijing 100871China Department of Atmospheric and Oceanic Sciences School of PhysicsPeking UniversityBeijing 100871China Collaborative Innovation Center of Atmospheric Environment and Equipment Technology Nanjing University of Information Science and TechnologyNanjing 210044China

The ambient air quality has improved significantly under strict emission controls in Beijing,China over the last *** carbon(BC),as a short-lived climate forcer in ambient aerosols,profoundly impacts the air quality and *** studies have demonstrated a decline in the mass concentration of *** this study,we characterized the chemical compositions and size distributions of BC-containing particles during the cold season of 2022 in Beijing using state-of-the-art instruments capable of exclusively measuring BCcontaining *** optical properties of BC-containing particles were further calculated based on the Mie ***,we compared the properties of BC-containing particles in 2022 with the results of previous *** results showed that the diameters of BC cores became larger while the coating thickness of BC-containing particles became thinner in *** the coating materials,the mass fraction of nitrate increased obviously,and even replaced organic matter as the dominant component during the peak of the pollution *** in chemical compositions and size distributions resulted in lower mass absorption cross-sections(MAC)of BC-containing particles from 10.5±1.1 m^(2)/g in 2016 to 7.3±0.8 m^(2)/g in 2022,reduced by 30.5%.Our results demonstrate the synergistic benefits of air pollution control in improving air quality and mitigating climate ***,the MAC of BC adopted in climate models should vary with the changing air pollution *** study emphasizes that it is imperative to conduct long-term observations of BC-containing particles to better estimate BC’s climate effects.

关键词： Black carbon Chemical composition Size distribution Light absorption ability

Impact of Startup Strategy and Buffer Tank Volume on the Compressor Inlet State for a 3-MW sCO_(2)Brayton Cycle

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Journal of Thermal Science 2025年第1期34卷 159-175页

作者： zhao Decai WANG Bo Key Laboratory of Advanced Energy and Power Institute of Engineering Thermophysics(IET)Chinese Academy of Sciences(CAS)Beijing 100190China University of Chinese Academy of Sciences Beijing 100049China

The supercritical carbon dioxide(sCO_(2))Brayton cycle system has become an emerging and highly promising method of thermal power conversion due to its efficiency advantage,system compactness,and excellent adaptability of the heat *** the low carbon sCO_(2)Brayton cycle testbed with cycle output power approaching 3 MW,a relatively detailed dynamic simulation model of the entire system is constructed to explore the dynamic response characteristics of the system with different startup strategies and different buffer tank volumes during the startup *** simulation results indicate that the smaller the volume of the buffer tank,the more rapid and obvious the parameter fluctuation in the buffer tank during the *** the allowable relative deviation limit of density is 5%,then the ratio of the buffer tank volume to the volume of the entire closed loop should not be lower than 36.80%.The strategy of simultaneous temperature and speed increase during turbine bypass start can effectively reduce the fluctuation of compressor inlet parameters and reach the steady-state more *** paper provides the recommended matching table for the opening of the turbine bypass valve(TBV)and the main regulating valve(MGV)to reduce the parameter fluctuation during the bypass *** effectiveness of the proposed turbine bypass and bypass switching startup strategy is verified by simulation,which may be used as a reference for test bench's future debugging and operation.

关键词： sCO_(2)Brayton cycle dynamic model buffer tank startup strategy dynamic characteristic

Utilizing BP neural networks to accurately reconstruct the tritium depth profile in materials for BIXS

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Nuclear Science and Techniques 2025年第1期36卷 103-114页

作者： Chen zhao Wei Jin Yan Shi Chang-An Chen Yi-Ying zhao Institute of Materials China Academy of Engineering PhysicsJiangyou 621908China

β-ray-induced X-ray spectroscopy(BIXS)is a promising method for tritium detection in solid materials because of its unique advantages,such as large detection depth,nondestructive testing capabilities,and low requirements for sample ***,high-accuracy reconstruction of the tritium depth profile remains a significant challenge for this *** this study,a novel reconstruction method based on a backpropagation(BP)neural network algorithm that demonstrates high accuracy,broad applicability,and robust noise resistance is *** average reconstruction error calculated using the BP network(8.0%)was much lower than that obtained using traditional numerical methods(26.5%).In addition,the BP method can accurately reconstruct BIX spectra of samples with an unknown range of tritium and exhibits wide applicability to spectra with various tritium ***,the BP network demonstrates superior accuracy and stability compared to numerical methods when reconstructing the spectra,with a relative uncertainty ranging from 0 to 10%.This study highlights the advantages of BP networks in accurately reconstructing the tritium depth profile from BIXS and promotes their further application in tritium detection.

关键词： β-ray-induced X-ray spectroscopy Tritium detection BP network Ridge regression Reconstruction problem