检索结果-南通市图书馆

Food Science and Human Wellness 2024年第2期13卷 1040-1054页

作者： Xiaomin Li Qing Liu Songyu Xie xiaoping wu Junsheng Fu College of Life Sciences Mycological Research CenterFujian Agriculture and Forestry UniversityFuzhou 350002China

Hepatocellular carcinoma(HCC)is one of the common most malignant tumors.This study aimed to determine the in vitro and in vivo anticancer activity of cordycepin and elucidate its mechanism of action.The results of in vitro and in vivo studies revealed that cordycepin inhibited proliferation and migration in HepG-2 cells and inhibited the growth of HepG-2 xenograft-bearing nude mice by inducing apoptosis.Transcriptome sequencing analysis revealed a total of 403 differential genes,which revealed that cordycepin may play an anti-HCC role by regulating Hippo signaling pathway.The regulatory effects of cordycepin on the Hippo signaling pathway was further investigated using a YAP1 inhibitor.The results demonstrated that cordycepin upregulated the expression of MST1 and LAST1,and subsequently inhibited YAP1,which activated the Hippo signaling pathway.This in turn downregulated the expression of GBP3 and ETV5,and subsequently inhibited cell proliferation and migration.Additionally,YAP1 regulated the expression of Bax and Bcl-2,regulated the mitochondrial apoptotic pathway,and induced apoptosis by upregulating the expression of the caspase-3 protein.In summary,this study reveals that cordycepin exerts its anti-hepatocarcinoma effect through regulating Hippo signaling pathway,and GBP3 and ETV5 may be potential therapeutic targets for hepatocarcinoma.

关键词： Cordycepin Hepatocellular carcinoma Hippo signaling pathway GBP3 ETV5

Fermented Lentinus edodes extract containingα-glucan ameliorates concanavalin A-induced autoimmune hepatitis in mice

在线全文

学校读者我要写书评

暂无评论

Food Science and Human Wellness 2024年第4期13卷 2102-2115页

作者： Xin Hu Dan Cheng Yingxia Zhang Po Li xiaoping wu Junsheng Fu College of Life Sciences Fujian Agriculture and Forestry UniversityFuzhou 350002China Mycological Research Center Fujian Agriculture and Forestry UniversityFuzhou 350002China Shanghai Lithy One-Health Group Technology Co. Ltd.Shanghai 200235China

Autoimmune hepatitis(AIH)is a chronic inflammatory liver disease that threatens human health worldwide.The aim of this study was to detect the protective effect of a fermented Lentinus edodes extract containingα-glucan(FLA),in a concanavalin A(Con A)-induced AIH mouse model and to determine the underlying liver-protective mechanism.The results showed that compared with the model group,the level of proinflammatory cytokines in serum of FLA pretreated mice was significantly decreased,and the degree of inflammatory cell infiltration in liver,thymus and spleen was significantly reduced.Quantitative polymerase chain reaction,immunohistochemistry,and Western blotting showed that FLA pre-treatment inhibited the Con A-induced apoptosis of hepatocytes by down-regulating the expression of BAX and up-regulating the expression of BCL-2.Further research found that FLA may improve liver injury in mice by activating NRF2 signaling pathway and inhibiting TRAF6/NF-κB signaling pathway.Thus,FLA may improve liver injury in mice by shifting gut microbial composition to reduce the release of inflammatory cytokines in the serum and prevent the necrosis of hepatocytes.Up-regulation of NRF2 signaling pathway,down-regulation of TRAF6/NF-κB signaling pathway,and an increase in the relative abundance of Lactobacillus_johnsonii and Ligilactobacillus_murinus play a protective role in liver.

关键词： Autoimmune hepatitis Concanavalin A Lentinus edodes TRAF6/NF-κB NRF2

Explainable-AI-based two-stage solution for WSN object localization using zero-touch mobile transceivers

在线全文

学校读者我要写书评

暂无评论

Science China(Information Sciences) 2024年第7期67卷 27-45页

作者： Kai FANG Junxin CHEN Han ZHU Thippa Reddy GADEKALLU xiaoping wu Wei WANG School of Mathematics and Computer Science Zhejiang A&F University School of Software Dalian University of Technology Faculty of Applied Sciences Macao Polytechnic University Department of Electrical and Computer Engineering Lebanese American University School of Information Engineering Huzhou University Guangdong-Hong Kong-Macao Joint Laboratory for Emotional Intelligence and Pervasive Computing Artificial Intelligence Research Institute Shenzhen MSU-BIT University

Artificial intelligence technology is widely used in the field of wireless sensor networks(WSN).Due to its inexplicability, the interference factors in the process of WSN object localization cannot be effectively eliminated. In this paper, an explainable-AI-based two-stage solution is proposed for WSN object localization. In this solution, mobile transceivers are used to enlarge the positioning range and eliminate the blind area for object localization. The motion parameters of transceivers are considered to be unavailable,and the localization problem is highly nonlinear with respect to the unknown parameters. To address this,an explainable AI model is proposed to solve the localization problem. Since the relationship among the variables is difficult to fully include in the first-stage traditional model, we develop a two-stage explainable AI solution for this localization problem. The two-stage solution is actually a comprehensive consideration of the relationship between variables. The solution can continue to use the constraints unused in the firststage during the second-stage, thereby improving the performance of the solution. Therefore, the two-stage solution has stronger robustness compared to the closed-form solution. Experimental results show that the performance of both the two-stage solution and the traditional solution will be affected by numerical changes in unknown parameters. However, the two-stage solution performs better than the traditional solution, especially with a small number of mobile transceivers and sensors or in the presence of high noise. Furthermore,we have also verified the feasibility of the proposed explainable-AI-based two-stage solution.

关键词： explainable AI object localization semidefinite relaxation mobile transceiver two-stage solution closed-form solution

A portable,auxiliary photovoltaic power system for electric vehicles based on a foldable scissors mechanism

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Energy and Built Environment

Energy and Built Environment 2024年第1期5卷 81-96页

作者： Zhou Jin Dongyang Li Daning Hao Zutao Zhang Liang Guo xiaoping wu Yanping Yuan China Railway wuhan Electrification Bureau Group Shanghai Electric Co. LtdShanghai 201799PR China School of Mechanical Engineering Southwest Jiaotong UniversityChengdu 610031PR China

In recent years,countries worldwide have actively advocated electric vehicles for environmental protection.How-ever,restrictions on the driving range and charging have hampered the promotion of electric vehicles.This study proposes a portable,auxiliary photovoltaic power system based on a foldable scissors mechanism for electric vehicles.The system includes a photovoltaic power generation module and an electricity transfer module.The photovoltaic power generation module built based on a foldable scissors mechanism is five times smaller than in its unfolded state,improving its portability in its folded state.The electricity transfer module transfers electricity into the cabin via wireless power transfer units and stores electricity in supercapacitors.Solar simulation exper-iments were conducted to evaluate the system’s performance:maximum output power of 1.736 W is measured when the load is 5Ω,while maximum wireless power transfer efficiency is up to 57.7% with 10Ω load.An elec-tric vehicle in Chengdu city was simulated for a case study.The results show that the annual output of a single photovoltaic power system can drive the MINIEV for 423.625 km,indicating that the proposed system would be able to supply power for electric vehicles as an auxiliary power supply system.

关键词： Auxiliary photovoltaic power system Energy harvesting Scissors mechanism Solar collector Electric vehicle

Highly ordered crystallization ofα-FAPbl_(3) films via homogeneous seeds for efficient perovskite solar cells

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2024年第7期94卷 625-634页

作者： Guohui Luo Linfeng Zhang Liyun Guo Xiuhong Geng Penghui Ren Yi Zhang Haihua Hu xiaoping wu Lingbo Xu Ping Lin Haiyan He Xuegong Yu Peng Wang Can Cui Key Laboratory of Optical Field Manipulation of Zhejiang Province Department of PhysicsZhejiang Sci-Tech UniversityHangzhou 310018ZhejiangChina Zhejiang Provincial Key Laboratory of Fiber Materials and Manufacturing Technology Zhejiang Sci-Tech UniversityHangzhou 310018ZhejiangChina Hangzhou City University Hangzhou 310015ZhejiangChina Key Laboratory of Solar Energy Utilization and Energy Saving Technology of Zhejiang Province Zhejiang Baima Lake Laboratory Co.Ltd.Hangzhou 310012ZhejiangChina State Key Laboratory of Silicon Materials and School of Materials Science and Engineering Zhejiang UniversityHangzhou 310027ZhejiangChina

Formamidine lead triodide(FAPbI_(3))perovskites have become the most promising photovoltaic materials for perovskite solar cells with record power conversion efficiency(PcE).However,random nucleation,phase transition,and lattice defects are still the key challenges limiting the quality of FAPbI_(3)films.Previous studies show that the introduction or adding of seeds in the precursor is effective to promote the nucleation and crystallization of perovskite films.Nevertheless,the seed-assisted approach focuses on heterogeneous seeds or hetero-composites,which inevitably induce a lattice-mismatch,the genera-tion of strain or defects,and the phase segregation in the perovskite films.Herein,we first demonstrate that high-quality perovskite films are controllably prepared usingα-and δ-phases mixed FAPbI_(3) micro-crystal as the homogeneous seeds with the one-step antisolvent method.The partially dissolved seeds with suitable sizes improve the crystallinity of the perovskite flm with preferable orientation,improved carrier lifetime,and increased carrier mobility.More importantly,theα-phase-containing seeds promote the formation of α-phase FAPbI_(3) films,leading to the reduction of residual lattice strain and the suppres-sion of I-ion migration.Besides,the adding of dimethyl 2,6-pyridine dicarboxylate(DPD)into the pre-cursor further suppresses the generation of defects,contributing to the PCE of devices prepared in air ambient being significantly improved to 23.75%,among the highest PCEs for fully air-processed FAPbl_(3) solar cells.The unpackaged target devices possess a high stability,maintaining 80%of the initial PCE under simulated solar illumination exceeding 8o0 h.

关键词： Perovskite solar cells FAPbI_(3) Homogeneous seeds Strain Phase stability

Develop potential multi-target drugs by self-assembly of quercetin with amino acids and metal ion to achieve significant efficacy in anti-Alzheimer’s disease

在线全文

学校读者我要写书评

暂无评论

Nano Research 2022年第6期15卷 5173-5182页

作者： Chunling Zhu Yuheng Yang Xiaowen Li Xingyu Chen Xucong Lin xiaoping wu Institute of Food Safety and Environment Monitoring College of ChemistryFuzhou UniversityFuzhou 350116China

Exploring multi-target drugs(MTDs)is a prevalent method against Alzheimer’s disease(AD).However,the current developed MTDs based on the“framework combination”technique or using flavonoids have not realized better healing effects owing to a complex metabolic process and low bioavailability.Here,we propose an alternative strategy to develop self-assembled nanoparticles(NPs)as MTDs using 9-fluorenylmethyloxycarbonyl-tryptophan(Fmoc-Trp),quercetin(Que),and Fe^(2+)as building blocks through coordination and electrostatic interaction to generate Fmoc-Trp-Fe^(2+)-Que(FTFQ)NPs.Whether in cell or in vivo,FTFQ NPs exhibited considerable biocompatibility attributing to the inherent biological affinity of assembly units.By combining the advantages of assemble approach and nanostructures,the obtained FTFQ NPs greatly enhanced the bioavailability of Que and displayed synergistic therapeutic effects through reducing Aβaggregation in direct/indirect means and eliminating the toxicity induced by ROS and Aβoligomer/fibrils.Furthermore,FTFQ NPs could obviously restore the AD zebrafish’s mobility and stimulus response ability.More importantly,developing self-assembly NPs as MTDs could be an efficient and general method to promote other novel MTDs by extending the assemble units to other drugs,peptides,and metal ions.Based on above benefits,these self-assembled NPs could be as potential MTDs and show great promising application in AD treatment.

关键词： Alzheimer’s disease multi-target drugs(MTDs) self-assembled nanoparticles(NPs) quercetin(Que)

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

工尺谱移调记谱与多调记谱之探析

音乐研究 2024年第1期 64-78,I0001-I0008页

作者：吴晓萍中央音乐学院

移调记谱和多调记谱较为普遍地存在于各种形式的工尺谱中,甚至发现有的工尺谱本中存在七调记谱的情形。通过对昆曲工尺谱、传统琵琶工尺谱、西安鼓乐俗字谱、智化寺京音乐工尺谱、河北音乐会工尺谱中存在的移调记谱与多调记谱现象予以分... 详细信息

移调记谱和多调记谱较为普遍地存在于各种形式的工尺谱中,甚至发现有的工尺谱本中存在七调记谱的情形。通过对昆曲工尺谱、传统琵琶工尺谱、西安鼓乐俗字谱、智化寺京音乐工尺谱、河北音乐会工尺谱中存在的移调记谱与多调记谱现象予以分析,探讨移调记谱的形成原因,以及多调记谱与古代“随月用律”传统之间的传承关系,以期为工尺谱研究提供案例,并对传统音乐形态学研究起到积极的推动作用。

关键词：工尺谱移调记谱多调记谱随月用律

Dynamic response of the cell traction force to osmotic shock

在线全文

学校读者我要写书评

暂无评论

Microsystems & Nanoengineering 2023年第5期9卷 321-331页

作者： Yongman Liu Wenjie wu Shuo Feng Ye Chen xiaoping wu Qingchuan Zhang Shangquan wu School of Biomedical Engineering Anhui Medical University230032 HefeiChina CAS Key Laboratory of Mechanical Behavior and Design of Material Department of Modern MechanicsCAS Center for Excellence in Complex System MechanicsUniversity of Science and Technology of China230026 HefeiChina

Osmotic pressure is vital to many physiological activities,such as cell proliferation,wound healing and disease treatment.However,how cells interact with the extracellular matrix(ECM)when subjected to osmotic shock remains unclear.Here,we visualize the mechanical interactions between cells and the ECM during osmotic shock by quantifying the dynamic evolution of the cell traction force.We show that both hypertonic and hypotonic shocks induce continuous and large changes in cell traction force.Moreover,the traction force varies with cell volume:the traction force increases as cells shrink and decreases as cells swell.However,the direction of the traction force is independent of cell volume changes and is always toward the center of the cell-substrate interface.Furthermore,we reveal a mechanical mechanism in which the change in cortical tension caused by osmotic shock leads to the variation in traction force,which suggests a simple method for measuring changes in cell cortical tension.These findings provide new insights into the mechanical force response of cells to the external environment and may provide a deeper understanding of how the ECM regulates cell structure and function.

关键词： traction healing wound

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

网约车实时订单在线选择策略设计与竞争分析

运筹与管理 2024年第4期33卷 153-158页

作者：武小平兰梦月西安邮电大学现代邮政学院陕西西安710061

针对现实中网约车司机追求自身利益最大化而产生的频繁“拒单”现象,为优化乘客满意度、网约车平台调度效率和司机个人收益,提出派单模式下网约车司机实时订单决策问题,并采用在线策略设计与竞争分析展开研究。本文讨论了订单行驶距离... 详细信息

针对现实中网约车司机追求自身利益最大化而产生的频繁“拒单”现象,为优化乘客满意度、网约车平台调度效率和司机个人收益,提出派单模式下网约车司机实时订单决策问题,并采用在线策略设计与竞争分析展开研究。本文讨论了订单行驶距离小于返空距离的情形,即订单不收取车辆返空费。研究了一般网络上网约车实时在线调度的竞争比下界,并设计了最优调度策略——阈值策略(PT策略),分析了策略的竞争性能。最后,通过算例分析证明,PT策略能有效帮助网约车司机提高工作期间实时订单的总收益,从而降低司机“拒单”行为,在实际生活中具有很强的实用性,对网约车司机、网约车平台和政府具有一定管理启示。

关键词：网约车调度实时订单选择在线问题竞争比

维普期刊数据库博看期刊

数字人文视角下图书档案文献资源的协同开发研究

在线全文

学校读者我要写书评

暂无评论

山西档案 2024年第3期 94-96页

作者：巫晓萍福建省图书馆福州350001

数字人文研究范式的兴起为图书馆学、档案学等学科带来新的发展契机。然而,当前图书档案在数字资源建设与知识服务中尚存在“条块分割”“数据孤岛”等问题,制约了文献信息资源内在价值的充分彰显。在系统梳理国内外相关研究与实践的基... 详细信息

数字人文研究范式的兴起为图书馆学、档案学等学科带来新的发展契机。然而,当前图书档案在数字资源建设与知识服务中尚存在“条块分割”“数据孤岛”等问题,制约了文献信息资源内在价值的充分彰显。在系统梳理国内外相关研究与实践的基础上,分析制约图书档案文献资源融合的关键障碍,进而探析数字人文环境下图书档案文献资源融合的关键要素,从异构资源整合、知识组织与关联、情境化知识服务三个层面探寻其协同发展模式,以期为我国数字人文环境下的文献资源重构与优化提供借鉴和指南。

关键词：数字人文图书馆档案馆文献资源协同开发