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Detection of a temporal salient object benefits from visual stimulus-specific adaptation in avian midbrain inhibitory nucleus

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Integrative Zoology 2024年第2期19卷 288-306页

作者： Jiangtao WANG xiaoping RAO Shuman HUANG Zhizhong WANG Xiaoke NIU Minjie ZHU Songwei WANG Li SHI Department of Automation Zhengzhou University School of Electrical EngineeringZhengzhouChina State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics National Center for Magnetic Resonance in WuhanKey Laboratory of Magnetic Resonance in Biological SystemsInnovation Academy for Precision Measurement Science and TechnologyChinese Academy of SciencesWuhanChina Department of Automation Tsinghua UniversityBeijingChina

Food and predators are the most noteworthy objects for the basic survival of wild animals,and both are often deviant in both spatial and temporal domains and quickly attract an animal’s *** stimulus-specific adaptation(SSA)is considered a potential neural basis of salient sound detection in the temporal domain,related research on visual SSA is limited and its relationship with temporal saliency is *** avian nucleus isthmi pars magnocellularis(Imc),which is central to midbrain selective attention network,is an ideal site to investigate the neural correlate of visual SSA and detection of a salient object in the time ***,the constant order paradigm was applied to explore the visual SSA in the Imc of *** results showed that the firing rates of Imc neurons gradually decrease with repetitions of motion in the same direction,but recover when a motion in a deviant direction is presented,implying visual SSA to the direction of a moving ***,enhanced response for an object moving in other directions that were not presented ever in the paradigm is also *** verify the neural mechanism underlying these phenomena,we introduced a neural computation model involving a recoverable synaptic change with a“center-surround”pattern to reproduce the visual SSA and temporal saliency for the moving *** results suggest that the Imc produces visual SSA to motion direction,allowing temporal salient object detection,which may facilitate the detection of the sudden appearance of a predator.

关键词： adaptation attention model pigeon saliency

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NAT1.-mediated ac 4 C-modified ANKZF1.promotes tumor progression and lymphangiogenesis in clear-cell renal cell carcinoma by attenuating YWHAE-driven cytoplasmic retention of YAP1

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Cancer Communications 2024年第3期44卷 361-383页

作者： Daojia Miao Jian Shi Qingyang Lv Diaoyi Tan Chuanyi Zhao Zhiyong Xiong xiaoping Zhang Department of Urology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubeiP.R.China Institute of Urology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubeiP.R.China

Background:Lymphatic metastasis is one of the most common metastatic routes and indicates a poor prognosis in clear-cell renal cell carcinoma(ccRCC).N-acetyltransferase 1.(NAT1.)is known to catalyze N4-acetylcytidine(ac4C)modification of mRNA and participate in many cellular ***,its role in the lymphangiogenic process of ccRCC has not been *** study aimed to elucidate the role of NAT1. in ccRCC lymphangiogenesis,providing valuable insights into potential therapeutic targets for ***:ac4C modification and NAT1. expression levels in ccRCC were assessed using public databases and clinical *** investigations involved manipulating NAT1. expression in cellular and mouse models to study its role in *** insights were gained through a combination of RNA sequencing,mass spectrometry,co-immunoprecipitation,RNA immuno-precipitation,immunofluorescence,and site-specific mutation ***:We found that ac4C modification and NAT1. expression levels increased in ***1. promoted tumor progression and lymphangiogene-sis of ccRCC by enhancing the nuclear import of Yes1.associated transcriptional regulator(YAP1..Subsequently,we identified ankyrin repeat and zinc fin-ger peptidyl tRNA hydrolase 1.ANKZF1.as the functional target of NAT1.,and its upregulation in ccRCC was caused by NAT1.-mediated ac4C *** analyses demonstrated that ANKZF1.interacted with tyro-sine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon(YWHAE)to competitively inhibit cytoplasmic retention of YAP1.leading to transcriptional activation of pro-lymphangiogenic ***:These results suggested a pro-cancer role of NAT1.-mediated acetylation in ccRCC and identified the NAT1./ANKZF1.YAP1.axis as an under-reported pathway involving tumor progression and lymphangiogenesis in ccRCC.

关键词： clear-cell renal cell carcinoma N4-acetylcytidine N-acetyltransferase 1. YAP1.nuclear import

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A portable,auxiliary photovoltaic power system for electric vehicles based on a foldable scissors mechanism

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Energy and Built Environment 2024年第1期5卷 81-96页

作者： Zhou Jin Dongyang Li Daning Hao Zutao Zhang Liang Guo xiaoping Wu Yanping Yuan China Railway Wuhan Electrification Bureau Group Shanghai Electric Co. LtdShanghai 201799PR China School of Mechanical Engineering Southwest Jiaotong UniversityChengdu 610031PR China

In recent years,countries worldwide have actively advocated electric vehicles for environmental ***-ever,restrictions on the driving range and charging have hampered the promotion of electric *** study proposes a portable,auxiliary photovoltaic power system based on a foldable scissors mechanism for electric *** system includes a photovoltaic power generation module and an electricity transfer *** photovoltaic power generation module built based on a foldable scissors mechanism is five times smaller than in its unfolded state,improving its portability in its folded *** electricity transfer module transfers electricity into the cabin via wireless power transfer units and stores electricity in *** simulation exper-iments were conducted to evaluate the system’s performance:maximum output power of 1.736 W is measured when the load is 5Ω,while maximum wireless power transfer efficiency is up to 57.7% with 1.Ω *** elec-tric vehicle in Chengdu city was simulated for a case *** results show that the annual output of a single photovoltaic power system can drive the MINIEV for 423.625 km,indicating that the proposed system would be able to supply power for electric vehicles as an auxiliary power supply system.

关键词： Auxiliary photovoltaic power system Energy harvesting Scissors mechanism Solar collector Electric vehicle

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3D printedβ-sheet-reinforced natural polymer hydrogel bilayer tissue engineering scaffold

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Science China(Technological Sciences) 2024年第4期67卷 1170-1184页

作者： ZHAO XinRui NIE XiongFeng ZHANG xiaoping SUN YaGe YANG Rong BIAN XinYu ZHANG Qian WANG HongYing XU ZiYang LIU WenGuang School of Materials Science and Engineering Tianjin Key Laboratory of Composite and Functional MaterialsTianjin UniversityTianjin 300350China

It remains a significant challenge to fabricate natural polymer(NP)hydrogels with anti-swelling ability and high strengths in the physiological ***,theβ-sheet-reinforced NP hydrogel is developed by copolymerizing methacrylated gelatin(GelMA)and methacrylated silk fibroin(SFMA)in aqueous solution,followed by ethanol treatment(named GelMA-SFMAAL).Theβ-sheets formed by SFMA can act as a stable physical crosslink to enhance the mechanical properties and prolong the degradation of the GelMA ***,the chemical crosslinking in the GelMA-SFMA hydrogel prevents excessive aggregation of hydrophobicβ-sheets,thereby avoiding the formation of brittle *** obtained GelMA-SFMA-AL hydrogels exhibit considerably enhanced mechanical properties(Young's modulus:0.89–3.68 MPa;tensile strength:0.31.0.96 MPa;toughness:0.09–0.63 MJ/m^(3);compressive modulus:0.78–2.20 MPa;compressive strength:2.65–5.93 MPa)compared with GelMA-SFMA hydrogels(Young's modulus:0.04–0.1. MPa;tensile strength:0.04–0.07 MPa;toughness:0.01.0.02 MJ/m^(3);compressive modulus:0.03–0.09 MPa;compressive strength:0.30–0.64 MPa).A bilayer osteochondral scaffold is constructed via digital light processing(DLP)three-dimensiaonl(3D)printing technology,comprising GelMA-SFMA@diclofenac sodium(DS)-AL as the top layer and GelMA-SFMA@bioactive glass(BG)-AL as the bottom *** bilayer hydrogel scaffold is demonstrated to support cell attachment and spreading,and facilitate osteogenic differentiation of rat bone marrow stem cells in *** vivo implantation experiment suggests this bilayer scaffold is promising to be used for osteochondral tissue regeneration.

关键词： silk fibroin β-sheet high-strength hydrogel natural polymer osteochondral regeneration

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Efficacy and safety of extracorporeal shock wave therapy combined with sodium hyaluronate in treatment of knee osteoarthritis:a systematic review and Meta-analysis

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Journal of Traditional Chinese Medicine 2024年第2期44卷 243-250页

作者： ZHOU Mingwang DONG Zhuanli WEI Changhao FENG Lufang WANG xiaoping LIU Haiping JI Xing YANG Kehu LI Shenghua Department of Orthopaedics Gansu Provincial Hospital of Traditional Chinese MedicineLanzhou 730050China Department of Quality Management Lanzhou Petrochemical General HospitalLanzhou 730050China Department of Orthopaedics Lanzhou Petrochemical General HospitalLanzhou 730050China Evidence-Based Social Science Research Center School of Public HealthLanzhou UniversityLanzhou730000China Evidence-Based Medicine Center School of Basic Medical SciencesLanzhou UniversityLanzhou 730000China Key Laboratory of Evidence Based Medicine and Knowledge Translation of Gansu Province Lanzhou 730000China Center for Translational Medicine Gansu Provincial Hospital of Traditional Chinese MedicineLanzhou 730050China Department of Orthopaedics Gansu Provincial Hospital of Traditional Chinese MedicineLanzhou 730000China

OBJECTIVE:To assess the efficacy and safety of extracorporeal shockwave therapy(ESWT)combined with sodium hyaluronate(HA)for the treatment of knee osteoarthritis(KOA).METHODS:PubM ed,Embase,the Cochrane Library,Web of Science,China National Knowledge Infrastructure,Wanfang database,China Science and Technology Journal Database,and SinoMed were searched from inception to July *** quality of the randomized controlled trials was evaluated independently by two reviewers according to the criteria in the Cochrane Collaboration for Systematic *** identified articles were then screened individually using EndnoteX9 for eligibility in this *** heterogeneity among the articles was evaluated using ***:A total of 1. studies,comprising 2000 individuals,were included in this *** results showed that a significant improvement was observed in knee pain and function based on the clinical efficacy of ESWT combined with *** analysis of clinical efficacy showed that[relative risk(RR)=1.21.95%confidence interval(CI)(1.1.,1.30),P1..Statistical analysis of visual analog scale showed that[standardized mean difference(SMD)=-2.84,95%CI(-4.01.-1.66),P1..Western Ontario and McMaster University osteoarthritis index statistical analysis showed that[SMD=-1.57,95%CI(-2.52,-0.61.,P1..Lysholm score statistical analysis showed that[SMD=1.71.95%CI(0.98,2.44),P1..In addition,only minor side effects,such as redness and swelling of the skin,were ***:Medium to low quality evidence showed that ESWT combined with HA offers an inexpensive,welltolerated,safe,and effective method to improve pain and functionality in patients with ***,tightly controlled,randomized,large multicenter trials are warranted to validate the current findings.

关键词： osteoarthritis knee randomized controlled trial extracorporeal shockwave therapy hyaluronic acid Meta-analysis

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In situ high-quality LiF/Li_(3)N inorganic and phenyl-based organic solid electrolyte interphases for advanced lithium–oxygen batteries

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Carbon Energy 2024年第9期6卷 29-38页

作者： Qianyan Wang Minsheng Wu Yunkai Xu Chuyue Li Yuanjia Rong Yaling Liao Menglin Gao xiaoping Zhang Weirong Chen Jun Lu School of Electrical Engineering Southwest Jiaotong UniversityChengduChina College of Chemical and Biological Engineering Zhejiang UniversityHangzhouChina

Lithium metal shows a great advantage as the most promising anode for its unparalleled theoretical specific capacity and extremely low electrochemical ***,uncontrolled lithium dendrite growth and severe side reactions of the reactive intermediates and organic electrolytes still limit the broad application of lithium metal ***,we propose 4-nitrobenzenesulfonyl fluoride(NBSF)as an electrolyte additive for forming a stable organic-inorganic hybrid solid electrolyte interphase(SEI)layer on the lithium *** abundance of lithium fluoride and lithium nitride can guarantee the SEI layer's toughness and high ionic conductivity,achieving dendrite-free lithium ***,the phenyl group of NBSF significantly contributes to both the chemical stability of the SEI layer and the good adaptation to volume changes of the lithium *** lithium-oxygen batteries with NBSF exhibit prolonged cycle lives and excellent cycling *** simple approach is hoped to improve the development of the organic-inorganic SEI layer to stabilize the lithium anodes for lithium-oxygen batteries.

关键词： lithium anode lithium-oxygen batteries reactive oxygen species solid electrolyte interphase

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Progress of Transmural Healing in CrohnR1.;s Disease

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Journal of Biosciences and Medicines 2024年第5期12卷 276-292页

作者： Yinan Han xiaoping Tan Department of Gastroenterology First Hospital of Yangtze University Jingzhou China

Recently transmural healing (TH) has become a subject of increasing interest as a potential therapeutic purpose for inflammatory bowel disease (IBD). Crohn’s disease (CD) is characterized by chronic inflammation of the gastrointestinal tract, which can involve any part of the digestive tract, and the lesions are usually discontinuous, with progressive and destructive transmural lesions that can lead to irreversible damage such as fibrotic strictures, complications such as fistulas and abscesses. Disease remission remains the primary goal of therapeutic management;however transmural healing is a very promising endpoint for monitoring treatment response. Along with small bowel imaging tests such as computed tomography scans Intestinal imaging (CTE), magnetic resonance intestinal imaging (MRE), intestinal ultrasound (IUS) and other related imaging technologies are popularized in CD diagnosis and treatment benefit. Transmural healing has been initially used in clinical practice and the correlation between its rules and long-term clinical remission has been explored.

关键词： Transmural Healing Inflammatory Bowel Disease Crohn’s Disease

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Research Progress of Bowel Preparation for Colonoscopy

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Journal of Biosciences and Medicines 2024年第5期12卷 10-18页

作者： Yongquan Huang xiaoping Tan Medical College of Yangtze University Jingzhou China Department of Gastroenterology Zhuhai Fifth People&#8217s Hospital Zhuhai China

Colorectal cancer ranks third in the global cancer data in 2020. Colorectal scope is the most effective method to diagnose colorectal diseases such as benign and malignant colorectal tumors. The poor quality of intestinal preparation causes an increased rate of missed diagnosis of colorectal tumors, reduces the rate of cecal intubation for colorectal examination, increases the discomfort, and reduces the compliance of re-examination. Therefore, we should try our best to improve the quality of intestinal preparation. This study reviewed the latest advances related to the preoperative preparation for colonoscopy. Recent research shows that smartphone apps can provide more detailed education and guidance on bowel preparation;Pre-packaged foods are more suitable as a way to eat before colonoscopy. The use of smaller doses, better taste of cathartic agents, and some auxiliary measures, combined with the patient’s situation to provide personalized intestinal preparation measures to improve the quality of intestinal preparation. Starting from the quality of colonoscopy bowel preparation, continuous improvement of patients’ tolerance to bowel preparation, continuous improvement of bowel preparation plan based on individual factors’ needs, and better communication with examined subjects by using existing scientific information technology, may be the hot spot of colonoscopy bowel preparation research in the next few years.

关键词： Colonoscopy Bowel Preparation Preoperative Education Quality of Bowel Preparation Polyethylene Glycol

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Progress in the Study of Laboratory Indicators Related to Acute Pancreatitis

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Journal of Biosciences and Medicines 2024年第1期12卷 7-18页

作者： Jiacheng Song xiaoping Tan Department of Gastroenterology First Hospital of Yangtze University Jingzhou China Digestive Disease Research Institution Yangtze University Jingzhou China Clinical Medical College Yangtze University Jingzhou China

Acute pancreatitis (AP) is one of the more common gastrointestinal diseases in clinics and is characterized by rapid progression, many complications, and high mortality. When it develops into severe pancreatitis, its prognosis is poor. Therefore, early assessment of the degree of inflammatory response plays a crucial role in the treatment plan and prognosis of patients. More and more studies have shown that the levels of D-dimer (D-D), angiotensin-2 (Ang-2), phosphate, heparin-binding protein (HBP), retinol-binding protein-4 (RBP4), and osteoblastic protein (OPN) are closely related to the severity of acute pan-creatitis and can be used as effective indicators for early assessment of AP. In this paper, the research progress of the above indicators in assessing the severity of AP is summarized.

关键词： Acute Pancreatitis Laboratory Indicators Progression Assessment

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Progress in the Study of Inflammatory Bowel Disease Patients with Primary Non-Responsiveness

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Journal of Biosciences and Medicines 2024年第1期12卷 72-85页

作者： Yixue Liu xiaoping Tan Department of Gastroenterology First Hospital of Yangtze University Jingzhou China Digestive Disease Research Institution of Yangtze University Jingzhou China Clinical Medical College Yangtze University Jingzhou China

Inflammatory bowel disease (IBD) is a group of chronic, nonspecific intestinal inflammatory disorders characterized by localized and systemic inflammation. The use of biologic agents in the treatment of IBD patients is widespread, and the occurrence of primary non-responsiveness during treatment is also significant. This review briefly summarizes the possible reasons for primary non-responsiveness in IBD patients, as well as predictive markers and current strategies to address it, providing a theoretical reference for early identification and management of IBD patients who do not respond to treatment.

关键词： Inflammatory Bowel Disease Primary Non-Responsiveness Anti-Tumor Necrosis Factor

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