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早产儿肠道内营养支持技术

中华实用儿科临床杂志 2015年第2期30卷 89-91页

作者：肖玲莉贲晓明同济大学附属第一妇婴保健院新生儿科上海200040

早产儿出生后，由于宫内营养储备不足，肠道不成熟以及医疗因素，如窒息、酸中毒、手术等，有更高的营养需求。早产儿为了达到理想的生长速度，需要持续的评估和足够的热量和营养供给。建议早产儿出生后早期进行肠道启动，待临床情况稳... 详细信息

早产儿出生后，由于宫内营养储备不足，肠道不成熟以及医疗因素，如窒息、酸中毒、手术等，有更高的营养需求。早产儿为了达到理想的生长速度，需要持续的评估和足够的热量和营养供给。建议早产儿出生后早期进行肠道启动，待临床情况稳定后逐步达到完全肠内喂养。多种征象可能提示早产儿喂养不耐受，临床医师需综合判断。某些药物如红霉素治疗早产儿喂养不耐受还有待研究证实。

关键词：婴儿,早产肠内营养喂养不耐受

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早产儿生长监测与随访

中华实用儿科临床杂志 2015年第2期30卷 92-96页

作者：刘颖钏贲晓明同济大学附属第一妇婴保健院新生儿科上海200040

早产儿出院时常存在明显的体质量低下，早产儿出院后营养缺乏风险增加，需密切随访，监测生长并早期干预。强化母乳或早产儿配方奶可帮助早产儿更好的生长，对于出院时体质量小于同胎龄第10百分位及出生体质量低于1500g的婴儿，建议使... 详细信息

早产儿出院时常存在明显的体质量低下，早产儿出院后营养缺乏风险增加，需密切随访，监测生长并早期干预。强化母乳或早产儿配方奶可帮助早产儿更好的生长，对于出院时体质量小于同胎龄第10百分位及出生体质量低于1500g的婴儿，建议使用强化母乳或早产儿配方奶。早产儿出院后，未强化母乳喂养的早产儿生长不良的风险高于早产儿配方奶喂养。临床实践中建议早产儿出院后采用强化母乳喂养。支气管肺发育不良患儿出院后生长障碍风险增加，蛋白质和矿物质强化配方奶在短期内可以为生长提供有利条件。

关键词：婴儿,早产生长母乳母乳强化剂早产儿方奶

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早产儿临床营养支持策略

中华实用儿科临床杂志 2015年第2期30卷 81-84页

作者：邬方彦贲晓明同济大学附属第一妇婴保健院新生儿科上海200040

随着近年来早产儿成活率的提高，营养支持成为新生儿重症监护的一个重要内容。积极的营养支持策略可减少宫外生长发育迟缓，加快体格生长，促进智能发育。但体质量过度增长，也可能会增加远期肥胖和心血管疾病的风险。现主要介绍并解读... 详细信息

随着近年来早产儿成活率的提高，营养支持成为新生儿重症监护的一个重要内容。积极的营养支持策略可减少宫外生长发育迟缓，加快体格生长，促进智能发育。但体质量过度增长，也可能会增加远期肥胖和心血管疾病的风险。现主要介绍并解读“2010欧州儿科胃肠肝病学与营养学会（ESPGHAN）对于早产儿肠内营养需求的建议”，为早产儿医护人员提供一个循证医学的营养摄入指南。

关键词：婴儿,早产营养支持策略肠内营养肠外营养指南

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早产儿肠道外营养支持技术

中华实用儿科临床杂志 2015年第2期30卷 85-89页

作者：印学蕾贲晓明同济大学附属第一妇婴保健院新生儿科上海200040

早产儿出生后常需要选择合适的肠道外营养输入途径。而早产儿静脉营养液的组成和配置也有特殊要求，以满足早产儿独特的生理特点和发育规律。早产儿出生后最初几天不显性失水较多，需要维持内环境稳定，而1周后则需要逐渐实现稳定的增... 详细信息

早产儿出生后常需要选择合适的肠道外营养输入途径。而早产儿静脉营养液的组成和配置也有特殊要求，以满足早产儿独特的生理特点和发育规律。早产儿出生后最初几天不显性失水较多，需要维持内环境稳定，而1周后则需要逐渐实现稳定的增长速率。静脉营养可能发生各种并发症，如感染、代谢性并发症等。注意监测指标，及时调整剂量，以及尽早过渡到全肠内营养，可以有效预防并发症的发生。

关键词：婴儿,早产肠道外营养并发症

All-trans retinoic acid in pulmonary vascular structural remodeling in rats with pulmonary hypertension induced by monocrotaline

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Chinese Medical Journal 2001年第5期114卷 14-17,102-103页

作者：秦玉明周爱卿贲晓明沈捷梁瑛李奋上海第二医科大学附属新华医院儿科研究所上海200092

Objective To determine whether all-trans retinoic acid (atR A) exerts an inhibitory effect on rats with pulmonary hypertension induced by *** All rats were given a single subcutaneous injection of either monocrotaline (60 mg/kg) or ***-injected rats received either atRA (30 mg· kg-1· day-1) or saline through oral-gastro intubation. On Days 7, 14, 21, and 28 respectively after monocrotaline injection, cardiovascular catheters were inserted to examine the mean pulmonary artery pressure of rats in each group. Meanwhile, the matrix metalloproteinase-1 (MMP-1) mRNA expression and hydroxyproline content in the main pulmonary artery were determined by RT-PCR and chromornetry, *** The mean pulmonary artery pressure of rats in the model group increased significantly on day 21 and reached a peak on Day 28 compared with the control group (25.7+4.3 mm Hg vs 15.1 ± 1.5 mm Hg and 38.5 ± 6.4 mm Hg vs 16.4 ± 2.0 mm Hg, P ＜ 0.01 ). MMP-1 mRNA overexpression was present on Day 14 (0.72 ± 0.15 vs 0.39 ± 0.08, P ＜ 0.01 ) and was rapidly down-regulated on Day 21 and 28 compared with Day 14, but was still higher than that in the control. The hydroxyoroline content of the main pulmonary artery dropped significantly on Day 14 (4.01 ± 1.13 μg/mg vs 5.10 ± 0.91 μg/mg, P ＜ 0.05)and increased significantly on Days 21 and 28 compared with the control, atRA inhibited the MMP-1 mRNA overexpression from Day 14 to Day 28 and reduced the hydroxyproline content (5.59 ± 0.70 μg/mg vs 7.96 ± 1.13 μg/mg and 7.77 ± 0.96 μg/mg vs 9.93 ± 1.27μg/mg, P ＜ 0.01 ) and the mean pulmonary artery pressure compared with the model group ( 19.6 ± 3.2 mm Hg vs 25.7 ± 4.3 mm Hg and 26.3 ± 4.6 mm Hg vs 38.5±6.4 mm Hg, P＜0.01).Conclusion atRA inhibits MMP-1 overexpression and the accumulation of collagen, which might elicit favorable geometric remodeling in rat pulmonary hypertension induced by monocrotaline.

关键词： atRA · pulmonary hypertension · matrix metalloproteinase 1 · hydroxyproline

Placental leptin correlates with intrauterine fetal growth and development

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Chinese Medical Journal 2001年第6期114卷 76-79,109页

作者：贲晓明秦玉明吴圣楣张伟利蔡威上海第二医科大学附属新华医院儿科研究所上海200092

Objective　To study the role of placental leptin in intrauterine cord leptin production and its relationship with neonatal anthropometry. Methods　Forty women and their babies (40) were enrolled in this study. Placental tissues were assayed for leptin mRNA by reverse transcription/polymerase chain reaction (RT/PCR), and assayed for the obese gene protein leptin by Western-blot and immunohistochemistry. Blood was taken from the umbilical cord of the babies at delivery. Serum leptin was measured by radio-immunoassay. Neonatal anthropometric measurements were recorded within 48 hours after delivery. Linear regression analysis was used to explore the relationship between placental leptin, cord leptin and neonatal anthropometric measures. Results　The obese gene was expressed in placental tissue at comparable or greater levels than that in adipose tissue. The placentas of the small for gestational age (SGA) neonates expressed leptin mRNA and protein at significantly lower levels than those of the appropriate for gestational age (AGA) neonates (P=0.0034 and 0.0076), while the placentas of the large for gestational age (LGA) neonates expressed leptin mRNA and protein at significantly higher levels than those of the AGA neonates (P=0.043 and 0.021). Linear regression analysis showed placental ob gene transcription and leptin translation correlated significantly with cord leptin (r=0.39 and 0.43), and neonatal Ponderal Index (r=0.66 and 0.69). Conclusion　The placenta provides a source of leptin for the growing fetus, and this placental leptin might be a growth factor in intrauterine fetal development.

关键词： leptin · placenta · intrauterine fetal growth

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胎儿和新生儿甲状腺功能亢进症的诊治进展

医学综述 2019年第1期25卷 103-107页

作者：柯芳芳贲晓明同济大学附属第一妇婴保健院新生儿科上海200040

胎儿和新生儿甲状腺功能亢进症(甲亢)是同一疾病的不同阶段。根据病因可分为自身免疫性甲亢和非自身免疫性甲亢,其表现缺乏特异性,常呈现多系统受累。合理的孕期管理包括促甲状腺激素受体抗体(TRAb)水平、胎儿彩色多普勒超声及胎心率的... 详细信息

胎儿和新生儿甲状腺功能亢进症(甲亢)是同一疾病的不同阶段。根据病因可分为自身免疫性甲亢和非自身免疫性甲亢,其表现缺乏特异性,常呈现多系统受累。合理的孕期管理包括促甲状腺激素受体抗体(TRAb)水平、胎儿彩色多普勒超声及胎心率的动态监测可帮助早期发现胎儿甲亢。而恰当的新生儿筛查如生后0~5 d TRAb水平、3~7 d促甲状腺激素和游离甲状腺素水平的检测则可对新生儿甲亢做出可靠预测。胎儿甲亢的治疗主要通过调整母亲的抗甲状腺药物。新生儿自身免疫性甲亢多数为暂时性的,以药物治疗为主;非自身免疫性甲亢停药后易复发,根本的治疗为甲状腺切除术和(或)放射性碘治疗。

关键词：新生儿甲状腺功能亢进 Graves病基因突变

Establishment of a new animal model to study pediatric VALI utilizing high tidal volume in piglets

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Establishment of a new animal model to study pediatric VALI ...

中华医学会第十七次全国儿科学术大会

作者： Xuhua Ge,Dongmei Chen,Juan Li,Zhuo Li,xiaoming ben,Wenliang Yu Emergency Department,Nanjing Children’s Hospital Affiliated to Nanjing Medical University,Nanjing 210008, China

AIM To set up piglets ventilation induced lung injury and long-term survival model. METHODS 21 healthy piglets were chosen to perform the experiment and divided into 3 groups: the pre-experimental group(group A,n=9),injury group(group B,n=6) and the control group (group C,n=6).All the animals are performed with tracheal intubation,carotid artery and carotid vein *** pre-experimental group received 60-80 ml / kg tidal volume ventilation,while the injury group received a tidal volume of 50 ml / *** piglets were then tested with arterial blood gas analysis per hour and ventilation was stopped till death or till the partial pressure of oxygen in blood / inspired oxygen concentration(Pa02/Fi02) < 300 *** control group breathed *** monitored the vital signs and respiratory mechanics,blood gas values and hemodynamic parameters at different time points (group A,B Oh-model been set up;group C 0 h-6 h).T-test or single-factor ANOVA was used to analyze the experimental *** the experiment,tissues of the left lung were taken for pathological study. RESULTS About six hours after large tidal volume ventilation,the Pa02/Fi02 values of group A and B declined significantly compared to the control group(P<0.05),and the lung morphology was in accordance with acute lung injury criteria;then the piglets were given 50 ml / kg tidal volume ventilation and could get long-term survival. CONCLUSION A new ventilator-induced lung injury model in piglets was successfully established using 50 ml / kg large tidal volume mechanical ventilation,then,the piglets could survive in long-term.

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沈阳市鸟岛斜拉桥主塔冬期施工

辽宁省交通高等专科学校学报 2006年第2期8卷 4-6页

作者：王少春贲晓明沈阳市市政建设工程公司辽宁沈阳110024

介绍沈阳市鸟岛斜拉桥主塔混凝土冬期施工方法。

关键词：斜拉桥主塔冬期施工保温措施热损失