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Structural effects of sulfonamides on the proliferation dynamics of sulfonamide resistance genes in the sequencing batch reactors and the mechanism

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Journal of Environmental Sciences 2024年第1期135卷 161-173页

作者： Ligui Wu Mingyu Wang Lingling Rong Wenbiao Wang Linwei Chen Qiaofeng Wu Haoyu Sun Xiangfeng Huang xiaoming zou College of Environmental Science and Engineering Tongji UniversityShanghai 200092China School of Life Science Jinggangshan UniversityJi’an 343009China Key Laboratory of Organic Compound Pollution Control Engineering(MOE) School of Environmental and Chemical EngineeringShanghai UniversityShanghai 200444China Fuzhou Urban and Rural Construction Group Co.Ltd. Fuzhou 350007China

Antibiotic resistance genes(ARGs)can be easily promoted by antibiotics,however,the structural effects of antibiotics on the proliferation of ARGs dynamic and the associated mechanisms remain obscure in,especially,activated sludge sequencing batch *** the present study,the effects of 9 sulfonamides(SAs)with different structures on the proliferation dynamic of sulfonamide resistance genes(Suls)in the activated sludge sequencing batch reactors and the corresponding mechanisms were determined(30 days),and the results showed that the largest proliferation value(ΔA^(R))of Suls dynamic for SAs(sulfachloropyridazine)was approximately 2.9 times than that of the smallest one(sulfadiazine).The proliferation of Suls was significantly related to the structural features(minHBint6,SssNH,SHBd and SpMax2_Bhm)that represent the biological activity of *** interpret the phenomenon,a mechanistic model was developed and the results indicated that the biodegradation of SAs(T_(1/2))rather than conjugative transfer frequency or mutation frequency tends to be the key process for affecting Suls proliferation.T_(1/2)was proved to be dependent on the interactions between SAs and receptors(E_(binding)),the cleavage mode(bond dissociation energy),and the site of nucleophilic ***,the metagenomic analysis showed that SAs posed significant effect on antibiotic resistome and Tnp31 played a vital role in the proliferation of ***,our findings provide important insight into a theoretical basis for understanding the structural effects of SAs on the proliferation of ARGs in SBR systems.

关键词： Activated sludge Sulfonamides Suls Proliferation Mechanism

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Heme oxygenase 1-mediated ferroptosis in Kupffer cells initiates liver injury during heat stroke

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Acta Pharmaceutica Sinica B 2024年第9期14卷 3983-4000页

作者： Ru Li Riqing Wei Chenxin Liu Keying Zhang Sixiao He Zhifeng Liu Junhao Huang Youyong Tang Qiyuan An Ligen Lin Lishe Gan Liying Zhao xiaoming zou Fudi Wang Yuan Ping Qiang Ma The Seventh Affiliated Hospital Southern Medical UniversityFoshan 528244China Department of Biopharmaceutics School of Laboratory Medicine and BiotechnologySouthern Medical UniversityGuangzhou 510000China Medical Critical Care Medicine General Hospital of Southern Theatre Command of PLAGuangzhou 510000China Guangdong Branch Center National Clinical Research Center for Geriatric Diseases(Chinese PLA General Hospital)Guangzhou 510000China State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoAvenida da UniversidadeTaip1Macao 999078China School of Pharmaceutical Sciences Zhejiang Chinese Medical UniversityHangzhou 311402China Department of General Surgery Nanfang Hospitalthe First School of Clinical MedicineSouthern Medical UniversityGuangzhou 510000China The Fourth Affiliated Hospital the First Affiliated HospitalSchool of Public HealthInstitute of Translational MedicineCancer CenterState Key Laboratory of Experimental HematologyZhejiang University School of MedicineHangzhou 310000China The First Affiliated Hospital the Second Affiliated HospitalBasic Medical SciencesSchool of Public HealthHengyang Medical SchoolUniversity of South ChinaHengyang 421200China College of Pharmaceutical Sciences Zhejiang UniversityHangzhou 310000China Liangzhu Laboratory Zhejiang University Medical CenterHangzhou 310000China Guangdong Provincial Key Laboratory of Immune Regulation and Immunotherapy School of Laboratory Medicine and BiotechnologySouthern Medical UniversityGuangzhou 510000China

With the escalating prevalence of global heat waves,heat stroke has become a prominent health concern,leading to substantial liver *** other forms of liver injury,heat strokeinduced damage is characterized by heat cytotoxicity and heightened inflammation,directly contributing to elevated mortality *** clinical assessments have identified elevated bilirubin levels as indicative of Kupffer cell dysfunction,their specific correlation with heat stroke liver injury remains *** hypothesis proposes the involvement of Kupffer cell ferroptosis during heat stroke,initiating IL-1bmediated *** single-cell RNA sequencing of murine macrophages,a distinct and highly susceptible Kupffer cell subtype,Clec4Ft/CD206t,emerged,with heme oxygenase 1(HMOX-1)playing a pivotal ***,heat-induced HMOX-1,regulated by early growth response factor 1,mediated ferroptosis in Kupffer cells,specifically in the Clec4F t/CD206 t subtype(KC2),activating phosphatidylinositol 4-kinase beta and promoting PI4P *** cascade triggered NLRP3 inflammasome activation and maturation of *** findings underscore the critical role of targeted therapy against HMOX-1 in ferroptosis within Kupffer cells,particularly in Clec4F t/CD206 t *** an approach has the potential to mitigate inflammation and alleviate acute liver injury in the context of heat stroke,offering a promising avenue for future therapeutic interventions.

关键词： Heat stroke Liver injury Kupffer cells Ferroptosis Heme oxygenase 1 Phosphatidylinositol 4-kinase beta NLRP3 Early growth response factor 1

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风场经柔直送出系统次同步振荡传播特性研究

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华中科技大学学报（自然科学版） 2024年第7期52卷 29-36页

作者：曹跃龙邹小明仇子铭杜雄重庆大学电气工程学院重庆400044 江苏省电力试验研究院有限公司江苏南京211103 国网江苏省电力有限公司电力科学研究院江苏南京211103

针对风电场经柔直送出系统中的次同步振荡会在换流器交直流侧之间传播的问题,提出了次同步振荡传播系数来定量描述次同步振荡在柔直系统中的传播.基于次同步振荡传播系数,研究了次同步振荡在柔直系统中的传播特性,并以此为依据确定了风... 详细信息

针对风电场经柔直送出系统中的次同步振荡会在换流器交直流侧之间传播的问题,提出了次同步振荡传播系数来定量描述次同步振荡在柔直系统中的传播.基于次同步振荡传播系数,研究了次同步振荡在柔直系统中的传播特性,并以此为依据确定了风场经柔直送出系统中次同步振荡监测设备的布置位置,同时提出了确定振荡主导换流器的判据.结果表明:次同步振荡在从送端换流器的交流侧传播到直流侧的过程中可能放大振荡,并进一步传播到受端换流器的交流侧,因此在柔直直流侧与受端换流器交流侧都应该布置振荡监测设备;次同步振荡几乎不能从送端换流器直流侧传播到其交流侧,因此当风场观测到明显振荡现象时,可以判断送端换流站为振荡主导换流器.

关键词：风场基于模块化多电平的柔直系统次同步振荡振荡传播振荡监测

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考虑构网型风电频率响应的电力系统低频减载策略研究

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可再生能源 2024年第8期42卷 1089-1095页

作者：邹小明李强汪成根贾勇勇汤奕江苏省电力试验研究院有限公司江苏南京210000 东南大学电气工程学院江苏南京210096

大规模构网型风电机组并网会改变电力系统频率响应特性,而传统低频减载策略尚未计及构网型风电机组的影响,可能导致大功率缺额后的系统减载量不合理。文章提出一种考虑构网型风电频率响应的电力系统低频减载策略。首先,基于构网型风电... 详细信息

大规模构网型风电机组并网会改变电力系统频率响应特性,而传统低频减载策略尚未计及构网型风电机组的影响,可能导致大功率缺额后的系统减载量不合理。文章提出一种考虑构网型风电频率响应的电力系统低频减载策略。首先,基于构网型风电虚拟惯量和一次调频控制模型,建立计及构网型风电频率响应的系统频率响应简化模型;其次,分析构网型风电的有功响应特性对系统不平衡功率量的影响,进而精细化估算用于指导电网多轮次减载的不平衡功率量,从而提出自适应低频减载实施策略;最后,通过算例分析,验证了文章所提低频减载策略的可行性和有效性。

关键词：构网型风电机组虚拟惯量一次调频功率缺额低频减载

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口服降糖药物联合基础胰岛素控制不佳转换为德谷门冬双胰岛素治疗2型糖尿病患者1例

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中华糖尿病杂志 2024年第Z1期16卷 43-45页

作者：季晓洁邹骁鸣胡丽芳田晓航程欣无锡市惠山区中医医院内分泌科无锡

报道1例在无锡市惠山区中医医院内分泌科就诊, 院外使用口服降糖药物联合基础胰岛素血糖控制不佳, 后转化为德谷门冬双胰岛素联合二甲双胍、达格列净的2型糖尿病患者的治疗过程。患者糖尿病病程18年, 合并多个并发症(糖尿病性周围神经... 详细信息

报道1例在无锡市惠山区中医医院内分泌科就诊, 院外使用口服降糖药物联合基础胰岛素血糖控制不佳, 后转化为德谷门冬双胰岛素联合二甲双胍、达格列净的2型糖尿病患者的治疗过程。患者糖尿病病程18年, 合并多个并发症(糖尿病性周围神经病变、糖尿病视网膜病变)。入院时空腹血糖(FPG)12.63 mmol/L, 餐后2 h血糖(2hPG)22.07 mmol/L, 糖化血红蛋白(HbA1c)12.10%。入院后给予胰岛素每日4次强化治疗, 为进一步简化院外治疗方案, 同时结合患者饮食特点, 后转换为德谷门冬双胰岛素(12 U, 早餐前皮下注射)联合口服药达格列净(10 mg, 1次/d)、二甲双胍(0.5 g, 3次/d)治疗。1年后患者复诊, HbA1c 7.25%, 血糖控制良好。

关键词：糖尿病, 2型胰岛素治疗德谷门冬双胰岛素

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Variations in net litter nutrient input associated with tree species influence on soil nutrient contents in a subtropical evergreen broad-leaved forest

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Chinese Science Bulletin 2014年第1期59卷 46-53页

作者： Lu Qiao Doug Allen Schaefer xiaoming zou Key Laboratory of Tropical Forest Ecology Xishuangbanna Tropical Botanical Garden Chinese Academy of Sciences University of Chinese Academy of Sciences Department of Environmental Studies University of Puerto Rico

The influence of tree species on soils has received much attention,but we know little about either the pattern and underlying mechanisms of net nutrient and carbon inputs under canopy for various tree species or the effects of net nutrient input on soil nutrient *** address these issues,we selected three tree species with distinct leaf sizes and arranged litter traps around the target individuals to test what affected net nutrient and carbon inputs under canopy of target individuals,and how net nutrient inputs influenced soil nutrient *** results showed that net litter manganese(Mn)and lignin inputs were significantly different among these tree species,as well as soil exchangeable potassium(K),available iron(Fe)and available *** results also revealed that the species with the smallest sized leaves may stimulate more net Mn and lignin inputs than the species with the largest sized *** the same time,net nutrient inputs correlated with soil available Fe,while the ratio of lignin to nitrogen of net litter correlated with total phosphorus *** results demonstrated that litter production may be the main factor deciding net nutrient and carbon inputs under different tree species’canopy,which significantly differentiated soil iron’s availability.

关键词：土壤养分含量亚热带常绿阔叶林树种枯落物输入营养养分投入木质素

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Impedance Modeling and Stability Analysis of a Three-phase Three-level NPC Inverter Connected to the Grid

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CSEE Journal of Power and Energy Systems 2020年第2期6卷 270-278页

作者： Bo Zhang Xiong Du Jingbo Zhao Jiapei Zhou xiaoming zou State Key Laboratory of Power Transmission Equipment&System Security and New Technology(Chongqing University) Shapingba DistrictChongqing 400044China Power System Technology Center Electric Power Research Institute of State GridJiangsu Electric Power Co.Ltd.Jiangsu 320115China HVDC Simulation Center Department of HVDC technologyGlobal Energy Interconnection Research InstituteBeijing 102209China

The interaction between grid-connected inverters and the grid may cause stability issues,and compromise the reliable operation of the *** study investigates the stability of a three-level neutral point clamped(NPC)inverter connected to the grid using impedance-based *** the impedance model of a three-phase three-level NPC inverter has not yet been reported,this study fills the literature gap by analyzing the influence of three-level DC-side neutral point control on the impedance *** fully considering the DC bus dynamics and DC voltage control loop,and the current loop and phase-locked loop(PLL),the admittance model of a three-phase three-level NPC inverter is established and verified by ***,in the stability analysis of a threelevel NPC inverter grid-connected system,the frequency coupling introduced by the PLL and DC bus dynamics is included with the help of an established admittance *** stability of the grid-connected system under different grid short circuit ratios(SCR)and operating power levels is analyzed according to the Nyquist stability *** experimental results revealed that the established impedance model of the three-phase three-level NPC inverter can properly represent the stability of this system.

关键词： Grid-connected inverter neutral point control stability three-level

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Method to characterize color of biochar and its prediction with biochar yield as model property

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Biochar 2021年第4期3卷 687-699页

作者： Yuxing Fan Yingying Xiong Yingying Zhang Zhangsong Jiang Haihui Tang Ligui Wu Mi Li Xiaoyu Xiao Cui Hu xiaoming zou School of Life Science Jinggangshan UniversityJi’an 343009China College of Environmental Science and Engineering Guilin University of TechnologyGuilin 541004China Zhongke-Ji’an Institute for Eco-Environmental Sciences Ji’an 343016China

Biochar has trigged increasing attention in the last decade due to its multiple functionalities,in which,color is not only the visual appearance,but also a useful indicator of relevant properties as well as an important tool to predict biochar’s ***,biochar color characterization remains challenged *** this work,three different feedstock-derived biochars were produced and basic color information(from color spaces RGB,HSB and CIE L^(*)a^(*)b^(*))of their scanned images was *** principal component analysis(PCA)and nonmetric multidimensional scaling analysis(NMDS)were employed on the combinations of different color indexes to cluster *** the assumption that clusters from both PCA and NMDS were as consistent as possible with that of visual intuition of biochar color,we identified feedstock-independent color indexes[(R+G-B)/(R+G+B),(R+B-G)/(R+G+B),(G+B-R)/(R+G+B),L,a,b]to characterize color of bio-char,which can in microscopic perspective elucidate color differences with respect to pyrolysis temperature and feedstock ***,prediction ability of color indexes with biochar yield as model property was explored and good performance was observed for both partial least squares regression(R2=0.8653)and neural network regression(R^(2)=0.9720)with the latter being more *** proposed color indexes will find more applications in prediction of biochar properties and functions in future.

关键词： Biochar Color Prediction Yield

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手术治疗肠系膜上动脉综合征的术式探讨

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中国实用外科杂志 2006年第6期26卷 471-472页

作者：邹小明哈尔滨医科大学附属第二医院外科黑龙江哈尔滨150086

肠系膜上动脉综合征（superior mesenteric artery syndrome，SMAS）临床上并不罕见。经不完全统计，自1994年7月至2005年12月排除1位作者多次报道共有60篇，共791例。发病年龄位于15～50岁之间，以20—30岁多见，儿童偶见报道。791例... 详细信息

肠系膜上动脉综合征（superior mesenteric artery syndrome，SMAS）临床上并不罕见。经不完全统计，自1994年7月至2005年12月排除1位作者多次报道共有60篇，共791例。发病年龄位于15～50岁之间，以20—30岁多见，儿童偶见报道。791例中非手术治疗220例。手术治疗571例，其中Treitz韧带松解术69例，胃空肠吻合术18例，胃大部切除BillrothⅡ式吻合术45例，十二指肠空肠吻合术325例，血管前移位术49例，环形引流术65例。本文仅就其手术治疗方式作一探讨。

关键词：肠系膜上动脉综合征非手术治疗术式探讨 BillrothⅡ式十二指肠空肠吻合术 syndrome 胃空肠吻合术 artery 手术治疗方式韧带松解术

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Clavien-Dindo classification and risk factors of complications after pancreaticoduodenectomy

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Discussion of Clinical Cases 2018年第3期5卷 13-17页

作者： xiaoming zou Zhelin Yun Shengbin Zhang Jin Zhao Bing Li Department of General Surgery The Third Affiliated Hospital of Inner Mongolia Medical UniversityBaotouChina

Objective: To analyze Clavien-Dindo classification and risk factors of complications after pancreaticoduodenectomy and inves-tigate the relationship between the major risk factors and Clavien-Dindo classification of complications. Methods: The retrospective case-control study was adopted. The clinical data of 200 patients who underwent pancreatico-duodenectomy at the Third Affiliated Hospital of Inner Mongolia Medical University from January 2010 to June 2015 were collected. The patients underwent Whipple procedure or pylorus-preserving pancreaticoduodenectomy according to the tumor site. Observation indicators included: (1) postoperative complications using Clavien-Dindo classification;(2) univariate and multivariate analyses: patients' basic information, surgery-related factors, pancreas-related factors;(3) relationship between independent risk factors and Clavien-Dindo classification of complications after pancreaticoduodenectomy. The chi-square test was applied to univariate analysis and categorical data. The comparison between groups was done by using independent samples nonparametric test (Kolmogorov-Smirnov Z), and multivariate analysis was done by using Logistic regression model. Results: (1) Postoperative complications: Of 200 patients, 122 underwent Whipple procedure and 78 underwent pylorus-preserving pancreaticoduodenectomy, including 6 cases combined with vascular reconstructions and 1 case with RFA of liver tumors. Ninety-eight patients had postoperative complications, including 41 patients with no less than 2 types of complications. After surgery, pancreatic fistula was detected in 80 patients, including 42 cases with grade A, 28 cases with grade B and 10 cases with grade C;incisional infection in 29 patients;gastric retention in 24 patients;intra-abdominal infection in 16 patients;intra-abdominal hemorrhage in 10 patients, including 8 patients receiving interventional treatment;biliary leakage in 7 patients and unplanned reoperation in 2 patients. Th

关键词： Pancreatic diseases Pancreaticoduodenectomy Surgical procedures Post-operative complications Risk factors Clavien-Dindo classification

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