检索结果-南通市图书馆

加味逍遥散通过外泌体miRNA途径发挥抗肝癌作用

在线全文

学校读者我要写书评

暂无评论

中国组织工程研究 2025年第19期29卷 4052-4062页

作者：刘晓明程金来黎如霜李妞妞秦秋云夏猛姚春广西中医药大学广西壮族自治区南宁市530200 广西中医药大学第一附属医院广西壮族自治区南宁市530200

背景:在课题组先前研究中发现加味逍遥散具有明显的抗肝癌作用,但具体作用机制不明。目的:基于高通量测序结合生物信息学,探讨加味逍遥散对二乙基亚硝胺慢性诱导的原发性肝癌模型大鼠血浆外泌体miRNA水平的调节作用。方法:将SD大鼠随机... 详细信息

背景:在课题组先前研究中发现加味逍遥散具有明显的抗肝癌作用,但具体作用机制不明。目的:基于高通量测序结合生物信息学,探讨加味逍遥散对二乙基亚硝胺慢性诱导的原发性肝癌模型大鼠血浆外泌体miRNA水平的调节作用。方法:将SD大鼠随机分为空白对照组、肝癌模型组、加味逍遥散组。以二乙基亚硝胺持续给药12周诱导肝癌模型,从第17周开始,加味逍遥散组大鼠给予加味逍遥散灌服,每日1次,直至第20周末停药,空白对照组和肝癌模型组大鼠给予等量生理盐水灌胃,通过检测大鼠肝组织的形态结构、肝癌标志物Glypican-3蛋白和血清甲胎蛋白表达验证抗肝癌效应。使用超速离心法分离提取各组大鼠血浆外泌体,利用高通量测序技术筛选出大鼠血浆外泌体中差异表达的miRNA,生物信息学预测加味逍遥散通过肝癌血浆来源外泌体miRNA发挥抗肝癌作用的潜在生物标志物,并进行功能分析。结果与结论:①加味逍遥散对肝癌模型大鼠肝组织的形态结构有显著改善作用,与肝癌模型组相比,加味逍遥散组肝癌标志物Glypican-3蛋白和血清甲胎蛋白的表达均显著降低;②生物信息学分析显示,加味逍遥散组对肝癌模型组上调的miR-223-3p与基因E2F1、NCOA1存在靶向结合位点,并且与肝癌生存率及预后密切相关。由此可见,加味逍遥散对肝癌有治疗作用,可能是通过肝癌血浆来源外泌体miR-223-3p靶向负调控NCOA1/E2F1进而发挥抗肝癌效应。

关键词：肝癌加味逍遥散外泌体 miRNA 生物信息学 miR-223-3p

LA-ICP-MS zircon U-Pb dating from granitoids in southern basement of Songliao basin:Constraints on ages of the basin basement

在线全文

学校读者我要写书评

暂无评论

Science China Earth Sciences 2007年第7期50卷 995-1004页

作者： GAO FuHong XU WenLiang YANG DeBin PEI FuPing liu xiaoming HU ZhaoChu College of Earth Sciences Jilin UniversityChangchun 130061China The Key Laboratory of Continental Dynamics Northwest UniversityXi’an 710069China

Seven LA-ICP-MS zircon U-Pb datings from granitoids in the southern basement of the Songliao basin were done in order to constrain the ages of the basin basement. The cathodoluminescence (CL) images of the zircons from seven granitoids indicate that they are euhedral-subhedral ones with striped ab-sorption and obvious oscillatory zoning rims. The dating results show that a weighted mean 206Pb/238U age is 236±3 Ma for quartz diorite (sample No.T6-1) located in the western slope of the basin,that weighted mean 206Pb/238U ages are 319±1 Ma (2126 m) and 361±2 Ma (1994 m) for diorite (sample ***1-1) and granite (sample ***1-2) located in northern part of southeastern uplift of the basin,respectively,and that weighted mean 206Pb/238U ages are 161±5 Ma,165±2 Ma,165±1 Ma and 161±4 Ma for samples Q2-1,SN121,SN122,and SN72 granitoids located in southern part of southeastern uplift of the basin,respectively. The statistical results of ages suggest that the middle Jurassic granitoids con-stitute the main part of basement granitoids,and that the Hercynian and Indo-Sino magmatisms also occur in the basin basement. It is implied that the Songliao basin should be a rift one formed in the intracontinent or active continental margin settings in the late Mesozoic after the Middle Jurassic orogeny took place.

关键词： Songliao basin basement granitoid zircon LA-ICP-MS U-Pb dating

Simultaneous in-situ determination of U-Pb age and trace elements in zircon by LA-ICP-MS in 20 μm spot size

在线全文

学校读者我要写书评

暂无评论

Chinese Science Bulletin 2007年第9期52卷 1257-1264页

作者： liu xiaoming GAO Shan DIWU ChunRong YUAN HongLin HU ZhaoChu National Key Laboratory of Geological Processes and Mineral Resources Faculty of Earth Sciences China University of Geosciences Wuhan 430074 China National Key Laboratory of Continental Dynamics Department of Geology Northwest University Xi'an 710069 China

Simultaneous in-situ determination of U-Pb ages and 20 trace elements of three international zircon standards(91500,GJ1 and TEMORA 1) and one laboratory zircon standard(SK10-2) separated from Cenozoic fine-grained gabbro was carried out on quadrupole ICP-MS equipped with 193 nm excimer laser in 20 μm spot size. The weighted mean 206Pb/238U ages of 91500,GJ1 and TEMORA 1 are 1064.4±4.8 Ma(2σ ),603.2±2.4 Ma(2σ ) and 418.2±2.4 Ma(2σ ),respectively. The relative standard de-viations(RSDs) of 206Pb/238U ages(2σ ) are less than 2.2% for single measurements and 0.6% for weighted means. The obtained weighted mean 206Pb/238U ages of three standard zircons agree with the recommended values within 2σ error. The weighted mean 206Pb/238U age of SK10-2 is 31.42±0.25 Ma(2σ ) and the RSDs of 206Pb/238U ages(2σ ) are between 2.4% and 5.7% for single measurements and less than 0.8% for weighted mean. The obtained weighted mean 206Pb/238U age is in good agreement with the age obtained by Yuan(2004). Trace element concentrations of NIST612 and NIST614 obtained under the same LA-ICP-MS operating conditions agree with the recommended values within analytical error. The results indicate that it is possible to measure U-Pb age and trace elements simultaneously by LA-ICP-MS in a small spot size of 20 μm.

关键词：锆石测年痕量元素 LA-ICP-MS 源尺寸焦斑同步现场测定

Magnetically Driven Soft Continuum Microrobot for Intravascular Operations in Microscale

在线全文

学校读者我要写书评

暂无评论

Cyborg and Bionic Systems 2022年第1期2022卷 265-272页

作者： Dan liu xiaoming liu Zhuo Chen Zhaofeng Zuo Xiaoqing Tang Qiang Huang Tatsuo Arai Key Laboratory of Biomimetic Robots and Sytems Ministry of EducationState Key Laboratory of Ielligent Control and Decision.of Complex SystemBeijing Advanced Innovation Center for Itelligent Robots and Systemsand School of Mechatronical EngineeringBeijing Institute of TechnologyBejing 100081China Center for Neuroscience and Biomedical Engineering The University of Electro-CommunicationsTokyo 1828585Japan

Remotely controlled soft continuum robots with active steering capability have broad prospects in medical ***,conventional continuum robots have the miniaturization *** paper presents a microscale soft continuum microrobot with steering and locomotion capabilties based on magnetic field *** magnetically driven soft continuum microrobot is made of NdFeB particles and polyd imethylsiloxane(PDMS),and it can be as small as 200 pum in ***,a hydrogel layer is covered on the surface of the microrobot,which not only overcomes the adhesion force between the microobjects and the soft tip but also reduces the friction between the microrobot and *** performance test indicates the soft continuum microrobot featured excellent control and steering *** experimental results demonstrate that the soft continuum microrobot can travel through the microfluidic channel by its own vibration and flexibly steer in a bifurcation ***,the micromanipulation of microbeads in the microfluidic channels proves that the proposed microscale soft continuum microrobot has a great potential for intravascu lar manipu lation.

关键词： friction robot overcome

Tunable metamaterial absorber based on resonant strontium titanate artificial atoms

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Materials Science & Technology 2021年第3期62卷 249-253页

作者： xiaoming liu Zhiyu Ren Tian Yang Luping Chen Qiang Wang Ji Zhou Key Laboratory of Electromagnetic Processing of Materials(Ministry of Education) Northeastern UniversityShenyang110819China Department of New Energy Science&Engineering School of MetallurgyNortheastern UniversityShenyang110819China State Key Laboratory of New Ceramics and Fine Processing School of Materials Science and EngineeringTsinghua UniversityBeijing100084China State Key Laboratory of Rolling and Automation Northeastern UniversityShenyang110819China

Dynamic control of the absorption frequency and intensity of metamaterial absorbers has attracted considerable attention,and many kinds of tunable metamaterial absorbers have been ***,due to the integration of separate resonant unit and tunable unit,these designed metamaterial absorbers suffer from complex structure and low *** numerically and experimentally demonstrate a tunable metamaterial absorber composed of artificial dielectric atoms as both resonant and tunable unit arrayed periodically in the background matrix on the metallic *** insensitive and wide incident angle absorption band with simulated and experimental absorptivity of 99%and 96%at 9.65 GHz are achieved at room *** absorption frequency can be gradually modulated by temperature,however,the absorption intensity at working frequency remains near *** dielectric atoms based tunable metamaterial absorbers with simple structure have potential applications as tempe rature sensors and frequency selective thermal emitters.

关键词： unity Tunable metamaterial absorber based on resonant strontium titanate artificial atoms

Paleoenvironmental implications of high-density records in Co-rich seamount crusts from the Pacific Ocean

在线全文

学校读者我要写书评

暂无评论

Science China Earth Sciences 2008年第10期51卷 1460-1469页

作者： WANG XiaoHong ZHOU LiPing WANG YiMin ZHANG XueHua liu xiaoming FAN XingTao liu KeXin ZHOU JianXiong Ministry of Education Key Laboratory for Earth Surface Processes Department of GeographyPeking UniversityBeijing 100871China National Research Center for Geoanalysis Beijing 100037China Guangzhou Marine Geological Survey Guangzhou 510760China The Key Laboratory of Continental Dynamics Northwest UniversityXi’an 710069China The Key Laboratory of Heavy Ion Physics Ministry of EducationPeking UniversityBeijing 100871China Institute of Mineral Resources Chinese Academy of Geological SciencesBeijing 100037China

Co-rich seamount crusts have been shown to possess great potential for providing information on paleoceanographic and paleoclimatic changes. High resolution data are essential to decipher and correctly understand such high-density records. With the development of modern microprobe techniques, detailed sampling of crusts can be performed and it is possible to retrieve detailed information about envi- ronmental changes recorded in the seamount crusts. We report here geochemical results of more than 40 elements (including all rare earth elements) of four Co-rich seamount crust samples, which were collected from seamounts in the central and western Pacific Ocean. These data were obtained with two micro-probe techniques: Electron Probe Micro Analyzer and Laser Ablation Inductively Coupled Plasma Mass Spectrometry. The chronological framework of the seamount crust samples was determined using the cos- mogenic 10Be and the Co-chronometer. Records of elemental composition, P, and Al/(Fe + Mn) and Y/Ho ratios across the sections of the four samples are used to identify paleoceanographic and paleoclimatic events over the past ~30 Ma. These data show that: (1) Al/(Fe + Mn) in the western Pacific seamount crust is a useful proxy for the assessment of changes of source materials related to the variability of the Asian monsoon; (2) P and Y/Ho can be used as proxies to infer biogenic episodes. Finally we discuss the methodology related to dating and micro-probe analysis used in crust study.

关键词： Co-rich seamount crust micro-probe chronology geochemical record paleo-oceanic environment

Magnetic Microrobots Fabricated by Photopolymerization and Assembly

在线全文

学校读者我要写书评

暂无评论

Cyborg and Bionic Systems 2023年第1期4卷 41-46页

作者： Xiyue Liang Yue Zhao Dan liu Yan Deng Tatsuo Arai Masaru Kojima xiaoming liu Key Laboratory of Biomimetic Robots and Systems Ministry of EducationState Key Laboratory of Intelligent Control and Decision of Complex SystemBeijing Advanced Innovation Center for Intelligent Robots and Systemsand School of Mechatronical EngineeringBeijing Institute of TechnologyBeijing 100081China Center for Neuroscience and Biomedical Engineering The University of Electro-CommunicationsTokyo 182-8585Japan Department of Materials Engineering Science Osaka UniversityOsaka 560-8531Japan

Magnetic soft microrobots have great potential to access narrow spaces and conduct multiple tasks in the biomedical *** now,drug delivery,microsurgery,disease diagnosis,and dredging the blocked blood vessel have been realized by magnetic soft microrobots in vivo or in ***,as the tasks become more and more complex,more functional units have been embedded in the body of the developed magnetic *** magnetic soft microrobots with complex designed geometries,mechanisms,and magnetic orientation are now greatly challenging the fabrication of the magnetic *** this paper,we propose a new method combining photopolymerization and assembly for the fabrication of magnetic soft *** the micro-hand assembly system,magnetic modules with different shapes and materials are firstly arrayed with precise position and orientation ***,the developed photopolymerization system is employed to fix and link these modules with soft *** on the proposed fabrication method,3 kinds of soft magnetic microrobots were fabricated,and the fundamental locomotion was *** believe that the presented fabrication strategy could help accelerate the clinical application of magnetic microrobots.

关键词： Magnetic system precise

Field-Controlled Microrobots Fabricated by Photopolymerization

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cyborg and Bionic Systems 2023年第1期4卷 260-273页

作者： Xiyue Liang Zhuo Chen Yan Deng Dan liu xiaoming liu Qiang Huang Tatsuo Arai School of Mechatronical Engineering Beijing Institute of TechnologyBeijing 100081China Center for Neuroscience and Biomedical Engineering The University of Electro-CommunicationsTokyo 182-8585Japan

Field-controlled microrobots have attracted extensive research in the biological and medical fields due to the prominent characteristics including high flexibility,small size,strong controllability,remote manipulation,and minimal damage to living ***,the fabrication of these field-controlled microrobots with complex and high-precision 2-or 3-dimensional structures remains *** photopolymerization technology is often chosen to fabricate field-controlled microrobots due to its fastprinting velocity,high accuracy,and high surface *** review categorizes the photopolymerization technologies utilized in the fabrication of field-controlled microrobots into stereolithography,digital light processing,and 2-photon ***,the photopolymerized microrobots actuated by different field forces and their functions are ***,we conclude the future development and potential applications of photopolymerization for the fabrication of field-controlled microrobots.

关键词： field printing utilized

Geochronology and geochemistry of mafic dykes in the Helanshan complex: Implications for Mesozoic tectonics in the North China Craton

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Geoscience Frontiers 2018年第6期9卷 1711-1724页

作者： Zhenghui Li xiaoming liu Yunpeng Dong M.Santosh Feifei Zhang Jie Xu State Key Laboratory of Continental Dynamics Department of Geology Northwest University Department of Earth Sciences Western University(Canada) School of Earth Sciences and Resources China University of Geosciences (Beijing) Department of Earth Sciences University of Adelaide

The Helanshan tectonic belt(HTB) is a major tectonic divide between the Alxa and Ordos blocks in the North China Craton. The geochronology and petrogenesis of the mafic dykes in the northern HTB are keys to understanding the tectonic evolution of this belt. The mafic dykes, intruded into the Neoarchean-Paleoproterozoic metamorphic basement, are mainly composed of diabase with a mineral assemblage of plagioclase(45%-60%), pyroxene(25%-35%), minor quartz and Fe-Ti oxides. The LA-ICPMS U-Pb analysis of zircon grains from representative dykes yield a weighted mean age of 206 ± 1.9 Ma, which represents the crystallization age of the dyke. The diabases show high contents of Fe_2 O_3~T(11.88-17.55 wt.%), low contents of SiO_2(45.65-50.95 wt.%) and MgO(3.31-5.50 wt.%) with low Mg#(=100×MgO/(MgO + FeO) atomic ration) of 33-44. They are characterized by enrichment of light rare earth elements(LREEs) and large ion lithophile elements(LILEs)(e.g., Rb, Ba and Pb), and slight depletion of high field strength elements(HFSEs). These features suggest that the magma has undergone extensive fractionation of olivine and pyroxene but only minor crustal contamination during its evolution. Their high Sm contents and La/Sm ratios, and low Sm/Yb ratios indicate that magma from which the dykes formed was derived from low degree(about 5%) partial melting of an enriched garnet + spinel lherzolite mantle source. Together with regional geology, these geochemical and geochronological data suggest that the mafic dykes in the HTB were formed in an intracontinental extensional setting during the late Triassic.

关键词： Mafic dykes Geochemistry Zircon UePb geochronology Hf isotope Helanshan Tectonic Belt North China Craton