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P波入射下固固界面的二阶谐波场特性

声学学报 2020年第4期45卷 594-600页

作者：吴宁韩庆邦仲晓敏河海大学物联网工程学院常州213022

应用二阶势理论研究了P波入射到固-固界面情况下的二阶谐波场。运用变动参数法求解二阶非齐次势函数方程的边值问题,数值计算了二阶谐波位移与入射角的关系,结果表明当入射角到达某个角度时,二阶谐波场的位移会急剧增大。同时,当入射角... 详细信息

应用二阶势理论研究了P波入射到固-固界面情况下的二阶谐波场。运用变动参数法求解二阶非齐次势函数方程的边值问题,数值计算了二阶谐波位移与入射角的关系,结果表明当入射角到达某个角度时,二阶谐波场的位移会急剧增大。同时,当入射角度为θ_w时,特解位移趋近无限大的有关现象依然出现,关于边界面的影响也做了讨论。

关键词：二阶谐波函数方程边值问题数值计算非齐次入射角特解边界面

覆膜和灌水处理下土壤水分动态与玉米生长模拟研究

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农业机械学报 2018年第9期49卷 195-204页

作者：赵引毛晓敏薄丽媛中国农业大学水利与土木工程学院北京100083

采用作物模型模拟作物生长过程和产量,是应对气候变化和人类活动的影响、实现农业节水增产的重要途径。覆膜和节水灌溉技术在我国西北旱区农田应用广泛,本研究基于覆膜增温对气积温的补偿效应以及覆膜和冠层截留对降雨入渗的影响对Aqua ... 详细信息

采用作物模型模拟作物生长过程和产量,是应对气候变化和人类活动的影响、实现农业节水增产的重要途径。覆膜和节水灌溉技术在我国西北旱区农田应用广泛,本研究基于覆膜增温对气积温的补偿效应以及覆膜和冠层截留对降雨入渗的影响对Aqua Crop模型进行了改进,使其适用于我国西北旱区覆膜制种玉米的模拟。利用2017年石羊河流域制种玉米的实测数据对改进模型进行了率定与验证,并模拟预测了未来气温升高和覆膜比变化情景下作物产量及水分利用效率(wUE)的变化规律。结果表明:改进的Aqua Crop模型能很好地模拟制种玉米生长发育阶段和冠层覆盖率,各处理冠层覆盖率的模拟值与实测值之间的R^2均不小于0.95,RMSE为3.9%~10.1%,NRMSE为4.9%~15.3%。而在1m土层贮水量的模拟上,各处理R^2在0.60~0.92之间,RMSE在9.5~17.1 mm之间,NRMSE处于4.4%~8.9%之间。改进的Aqua Crop模型在模拟不覆膜高水M0w1和M0w3处理的制种玉米干物质累积量、产量上模拟效果较差,其他处理的干物质累积量的R^2不小于0.98,RMSE为0.64~1.66 t/hm^2,NRMSE为9.9%~16.7%,产量的相对误差(RE)为-13.3%~4.5%,wUE则表现为除M0w1处理外,其他处理模拟效果较优,RE为-23.9%~18.1%。未来气温升高对作物产量及提高水分利用效率产生不利的影响。覆膜条件下,增温1.6℃和3.3℃分别比在实际温度下减产12.8%和20.7%,wUE降低3.0%和2.1%。不覆膜条件下减产率分别为13.9%和25.1%,wUE分别降低3.8%和7.6%。覆膜比例为50%时,可在保证产量的同时,提高水分利用效率,达到增产节水的效果。

关键词：土壤水分制种玉米覆膜灌水量 AquaCrop模型情景预测

胚宝胶囊联合来曲唑治疗排卵障碍性不孕症的效果观察及对患者血清性激素水平的影响

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中国基层医药 2021年第3期28卷 353-356页

作者：黄小敏台州市肿瘤医院妇产科浙江省317502

目的探讨胚宝胶囊联合来曲唑治疗排卵障碍性不孕症的效果及对患者血清性激素水平的影响。方法选择台州市肿瘤医院2017年1月至2019年12月收治的排卵障碍性不孕症患者60例,按照随机数字表法分为观察组(30例)与对照组(30例),对照组患者给... 详细信息

目的探讨胚宝胶囊联合来曲唑治疗排卵障碍性不孕症的效果及对患者血清性激素水平的影响。方法选择台州市肿瘤医院2017年1月至2019年12月收治的排卵障碍性不孕症患者60例,按照随机数字表法分为观察组(30例)与对照组(30例),对照组患者给予来曲唑治疗,观察组患者给予胚宝胶囊联合来曲唑治疗。两组患者均于月经周期第5天开始服药,连服5 d,共3个周期。比较两组治疗前后优势卵泡直径、子宫内膜厚度、卵巢动脉阻力指数和搏动指数、血清性激素水平变化,及排卵率和妊娠率。结果观察组治疗后优势卵泡直径(18.41±0.54)mm和子宫内膜厚度(8.79±0.56)mm,均高于对照组的(17.79±0.47)mm和(7.82±0.62)mm(t=4.744、6.359,均Png/L和黄体生成素(9.47±0.61)IU/L,均高于对照组的(0.78±0.12)μg/L、(58.23±5.46)ng/L和(8.18±0.65)IU/L(t=4.456、11.297、7.926,均P<0.05);观察组排卵率[60.00%(18/30)]和妊娠率[46.67%(14/30)]均高于对照组[33.33%(10/30)]和[23.33%(7/30)](χ^(2)=4.286、3.897,均P<0.05)。结论胚宝胶囊联合来曲唑治疗排卵障碍性不孕症效果明显,可改善患者血清性激素水平,促进排卵和提高妊娠率。

关键词：不育,女(雌)性无排卵子宫内膜卵泡孕酮雌二醇胚宝胶囊来曲唑

Short-and medium-chain chlorinated paraffins in imported commercial dry cat and dog food in China:Concentrations,distributions and risk assessment

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Emerging Contaminants 2020年第1期6卷 268-273页

作者： Shujun Dong Su Zhang Ruiguo w.ng Xiaolong Xia Mengdie Fan Yaxin w.ng Jie Cheng xiaomin Li Tong Li wei Zhang Shulin wei Yun Zou Peilong w.ng Institute of Quality Standard and Testing Technology for Agro-Products Chinese Academy of Agricultural SciencesBeijing100081China Inspection and Testing Center of Agricultural and Livestock Products of Tibet Lhasa850000China China MS Center Shimadzu(China)Co.LtdBeijing100020China

Chlorinated paraffins(CPs)are produced in large amounts and used *** intake is the primary pathway for the exposure of pets to CPs,but limited information is available concerning the potential contamination of pet food by *** the present study,the concentrations and congener group profiles of short-chain CPs(SCCPs)and medium-chain CPs(MCCPs)were assessed in 35 imported commercial dry cat and dog foods collected in China,and the estimated daily intakes of SCCPs and MCCPs for cats and dogs through the consumption of such foods was *** concentrations of SCCPs and MCCPs in the cat and dog foods were determined to be in the ranges of 108e45,300 ng/g(median:1340 ng/g)and 3.8e52,700 ng/g(median:11 ng/g),*** predominant congener groups were C10Cl6 for SCCPs and C14Cl7-8 for *** high levels of CPs found in certain pet foods suggest the potential for adverse health effects.

关键词： Short-chain chlorinated paraffin Medium-chain chlorinated paraffin Cat food Dog food Dietary exposure

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黄土斜坡土体强度特性的三轴试验研究

干旱区资源与环境 2014年第8期28卷 151-155页

作者：何小亮刘潇敏西北大学地质学系/大陆动力学国家重点试验室西安710069 中国水电顾问集团西北勘测设计研究院西安710065

以陕西泾阳南塬某黄土斜坡第九层（L9）黄土为研究对象,采用常规三轴试验探讨土体在三轴剪切过程中的应力~应变关系、含水率和围压对抗剪强度的影响、粘聚力和内摩擦角随含水率的变化规律等问题。试验成果表明：1）w=5.3%时,L9黄土应力... 详细信息

以陕西泾阳南塬某黄土斜坡第九层（L9）黄土为研究对象,采用常规三轴试验探讨土体在三轴剪切过程中的应力~应变关系、含水率和围压对抗剪强度的影响、粘聚力和内摩擦角随含水率的变化规律等问题。试验成果表明：1）w=5.3%时,L9黄土应力~应变曲线呈应变软化,试样在50KPa、100KPa围压下发生脆性破坏;w=12.3%、19.3%、25%时,应力~应变曲线均表现为应变硬化,试样呈塑性破坏。2）在相同围压下,L9黄土抗剪强度随含水率的增加而减小;含水率从19.3%增加到25%（饱和）时,抗剪强度下降最快,降幅达75%。3）随着含水率的增加,L9黄土的粘聚力和内摩擦角降低;粘聚力在w=5.3%~12.3%阶段内下降最快,降幅达73%;内摩擦角在w=19.3%~25%阶段内下降最快,降幅为60%。研究成果对于今后黄土塬滑坡（边坡）工程治理、监测,尤其是黄土塬边坡安全的早期预测有重要的参考价值。

关键词：黄土三轴剪切试验强度特性

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颅骨嗜酸性肉芽肿的CT和MRI诊断

临床放射学杂志 2007年第3期26卷 248-250页

作者：傅筱敏韩本谊上海市杨浦区市东医院放射科 200438

目的探讨颅骨嗜酸性肉芽肿的CT和MRI表现,提高对其诊断和鉴别诊断水平。资料与方法回顾性分析21例经手术病理证实的颅骨嗜酸性肉芽肿的CT和MRI表现,17例行CT平扫,12例行MR检查,10例行MR增强扫描。结果21例共发现24个病灶,其中单发19例(... 详细信息

目的探讨颅骨嗜酸性肉芽肿的CT和MRI表现,提高对其诊断和鉴别诊断水平。资料与方法回顾性分析21例经手术病理证实的颅骨嗜酸性肉芽肿的CT和MRI表现,17例行CT平扫,12例行MR检查,10例行MR增强扫描。结果21例共发现24个病灶,其中单发19例(眼眶2例,斜坡2例,额骨9例,颞骨1例,顶骨4例,枕骨1例),多发2例。CT像上主要表现为颅骨板障的破坏,边界清楚,部分病灶内可见残留的小骨片以及大小不等的软组织肿块,密度不均匀。MR表现为T1低信号,T2高信号,CT和MRI增强扫描明显强化。结论颅骨嗜酸性肉芽肿的CT和MRI表现有一定的特征,CT和MRI有助于明确颅骨嗜酸性肉芽肿的诊断。

关键词：颅骨嗜酸性肉芽肿体层摄影术,X线计算机磁共振成像

香蕉低聚糖的微波、超高压法提取与柱层析分离纯化

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中国食品学报 2016年第9期16卷 107-112页

作者：易晓敏唐雪娟王娟华南理工大学轻工与食品学院广州510641

以香蕉为原料,研究微波法与超高压法提取香蕉低聚糖的工艺,并通过正交试验优化2种提取方法。比较Sephadex G-25葡聚糖凝胶柱层析和DEAE Sepharose Fast Flow琼脂糖凝胶柱层析对香蕉低聚糖提取液的分离纯化效果。结果显示:微波法提取低... 详细信息

以香蕉为原料,研究微波法与超高压法提取香蕉低聚糖的工艺,并通过正交试验优化2种提取方法。比较Sephadex G-25葡聚糖凝胶柱层析和DEAE Sepharose Fast Flow琼脂糖凝胶柱层析对香蕉低聚糖提取液的分离纯化效果。结果显示:微波法提取低聚糖的优化工艺为:微波功率462 w,微波时间2.5 min,料液比1∶15 g/m L;超高压法提取香蕉低聚糖的优化工艺为:压力300 MPa,保压时间15 min,料液比1∶2 g/m L。微波法提取香蕉低聚糖的得率【17.72±0.49%】高于超高压法提取香蕉低聚糖的得率【8.05±0.03%】。Sephadex G-25葡聚糖凝胶分离香蕉低聚糖提取液的效果优于DEAE Sepharose Fast Flow琼脂糖凝胶,分离得到4个洗脱峰,表明香蕉中至少含有4种低聚糖。

关键词：香蕉低聚糖提取微波超高压分离纯化

Enzyme-linked immunosorbent assays for quantification of MMAE-conjugated ADCs and total antibodies in cynomolgus monkey sera

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Journal of Pharmaceutical Analysis 2022年第4期12卷 645-652页

作者： Min Pei Tingting Liu Lu Ouyang Jianhua Sun Xiaojie Deng xiaomin Sun wei wu Peng Huang Yi-Li Chen Xiaorong Tan Xiaoyue Liu Peng Zhu Yongzhen Liu Deheng w.ng Junliang wu Qi w.ng Guifeng w.ng Likun Gong Qiuping Qin Chunhe w.ng Biotherapeutics Discovery Research Center Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai201203China School of Pharmacy University of Chinese Academy of SciencesBeijing100049China Center for Drug Safety Evaluation and Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai201203China Research and Development Center Dartsbio Pharmaceuticals Ltd.ZhongshanGuangdong528400China Zhongshan Institute for Drug Discovery Shanghai Institute of Materia MedicaChinese Academy of SciencesZhongshanGuangdong528400China School of Pharmacy Shanghai Engineering Research Center of ImmunotherapeuticsFudan UniversityShanghai201203China

Antibody-drug conjugates(ADCs)are commonly heterogeneous and require extensive assessment of exposure-efficacy and exposure-safety relationships in preclinical and clinical *** this study,we report the generation of a monoclonal antibody against monomethyl auristatin E(MMAE)and the development,validation,and application of sensitive and high-throughput enzyme-linked immunosorbent assays(ELISA)to measure the concentrations of MMAE-conjugated ADCs and total antibodies(tAb,antibodies in ADC plus unconjugated antibodies)in cynomolgus monkey *** assays were successfully applied to in vitro plasma stability and pharmacokinetic(PK)studies of SMADC001,an MMAE-conjugated ADC against trophoblast cell surface antigen 2(TROP-2).The plasma stability of SMADC001 was better than that of similar ADCs coupled with PEG4-Val-Cit,Lys(m-dPEG24)-Cit,and Val-Cit *** developed ELISA methods for the calibration standards of ADC and tAb revealed a correlation between serum concentrations and the OD450 values,with R2 at 1.000,and the dynamic range was 0.3-35.0 ng/mL and 0.2-22.0 ng/mL,respectively;the intra-and inter-assay accuracy bias%ranged from -12.2% to -5.2%,precision ranged from -12.4% to -1.4%,and the relative standard deviation(RSD)was less than 6.6% and 8.7%,*** total error was less than 20.4%.The development and validation steps of these two assays met the acceptance criteria for all addressed validation parameters,which suggested that these can be applied to quantify MMAE-conjugated ADCs,as well as in PK ***,these assays can be easily adopted for development of other similar immunoassays.

关键词： Monomethyl auristatin E Antibody-drug conjugates Pharmacokinetics Trophoblast cell surface antigen 2

A new type of Mo-bearing quartz vein by acid leaching:evidence from Dahu-Qinnan Mine,northern belt of the Xiaoqinling gold province,central China

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Global Geology 2020年第4期23卷 214-224页

作者： ZHAng Yuanhou MAO Jingwen PIRAJNO Franco LI Zongyan QIAO Cuijie ZHAng xiaomin HE Yue ZHAng Shuaimin College of Earth Sciences Jilin UniversityChangchun 130061China Institute of Mineral Resources Chinese Academy of Geological SciencesBeijing 130037China Geological Survey of western Australia Perth WA6004Australia Jinyuan Mining Industry Co. LtdLingbao472500 HenanChina

Dahu-Qinnan molybdenum deposit,located in the northern part of the Xiaoqinling gold province,belongs to the Xiaoqinling-waifangshan sub-zone of the eastern Qinling Mo-w metallogenic belt,central *** mineralization is associated with Au-bearing quartz *** paper is based on field observations and PIMA analytical data on the occurrences,and details textures and alteration patterns of Mo-bearing quartz veins in Dahu-Qinnan *** Mo-bearing quartz veins exhibit friable with cream colored,vuggy,infilling texture and brecciated *** breccia clasts within Mo-bearing quartz veins are dominated by gneissic rocks of the Taihua Supergroup,and Mesozoic porphyritic granite dyke with stockwork and disseminated molybdenite *** breccias are replaced by clay *** associated with molybdenite-bearing quartz veins is characterized by K-feldspar(only in the breccias),sericite,sillicification(residual silica),kaolinite,smectite and *** with other sulfide minerals infills fissures and pore spaces in the quartz *** the results of above,and according to the observed geological events in the area and taking into account the geological setting,molybdenite-bearing quartz veins are likely to have been affected by late acid *** precursor porphyry Mo ore,associated with porphyry granite dyke formed probably at ca.245--211 Ma during the continent-continenl collision of Qinling orogeny.

关键词： Mo-bearing quartz vein porphyry molybdenum body acid leaching Mesozoic Dahu-Qinnan