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Fabrication of Crack-Free Flattened Bamboo and Its Macro-/MicroMorphological and Mechanical Properties

Journal of Renewable Materials 2021年第5期9卷 959-977页

作者： Zhichao Lou Tiancheng Yuan Qiuyi Wang Xinwu Wu Shouheng Hu xiaomeng hao Xianmiao Liu Yanjun Li College of Materials Science and Engineering Nanjing Forestry UniversityNanjing210037China Key Laboratory of National Forestry and Grassland Administration/Beijing for Bamboo&Rattan Science and Technology Beijing100102China International Center for Bamboo and Rattan Beijing100102China

This work aimed to help the bamboo industry develop methodology for producing imperfection-free bamboo boards that can serve either decorative or structural benefit to consumers seeking to engage with the ***,softened and slotted bamboo tubes were handled by a roller device with nails to render crack-free flattened bamboo *** temperature and time were optimized herein according to findings regarding chemical composition and board mechanical *** optimal softening parameters for saturated steam heat treatment is proved to be 160°C for 8 *** flattened bamboo board possesses an increased bending strength of 101.5 MPa and a decreased bending modulus of 7.7 GPa,being compared with only-softened *** corresponding changing mechanism is determined in-depth by the micro-morphological and mechanical results based on in-situ SEM and AFM *** the action of nails and rolling processes,the bamboo texture becomes compact with crushed and fragmented conduit *** resulting cell cavity then becomes stretched and compressed,taking on a morphology which allows for the mechanical penalties associated with flattening to be *** to the micro-mechanical results obtained by AFM,compared with unflatten bamboo,the Young’s modulus of the cell membrane in transverse direction(YT)decreases to 1.00 GPa while the corresponding Young’s modulus in radial direction(YR)increases to 7.29 GPa.

关键词： Flattened bamboo board saturated steam heat treatment macro-mechanics in-situ atomic force microscopy young’s modulus micromorphology

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Production of very-high-amylose cassava by post-transcriptional silencing of branching enzyme genes

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Journal of Integrative Plant Biology 2020年第6期62卷 832-846页

作者： Wenzhi Zhou Shanshan Zhao Shutao He Qiuxiang Ma Xinlu Lu xiaomeng hao Hongxia Wang Jun Yang Peng Zhang National Key Laboratory of Plant Molecular Genetics CAS Center for Excellence in Molecular Plant SciencesInstitute of Plant Physiology and EcologyShanghai Institutes for Biological Sciencesthe Chinese Academy of SciencesShanghai 200032China Shanghai Key Laboratory of Plant Functional Genomics and Resources Shanghai Chenshan Plant Science Research CenterShanghai Chenshan Botanical Gardenthe Chinese Academy of SciencesShanghai 201602China University of Chinese Academy of Sciences Beijing 100049China

High amylose starch can be produced by plants deficient in the function of branching enzymes(BEs).Here we report the production of transgenic cassava(Manihot esculenta Crantz)with starches containing up to 50%amylose due to the constitutive expression of hair-pin ds RNAs targeting the BE1 or BE2 *** BE1-RNAi plant lines(BE1i)and BE2-RNAi plant lines(BE2i)were grown up in the field,but with reduced total biomass *** high amylose content in the storage roots of BE2i plant lines was *** starch granules of BE1i and BE2i plants had similar morphology as wild type(WT),however,the size of BE1i starch granules were bigger than that of *** of amylograms and thermograms of all three sources of storage starches revealed dramatic changes to the pasting properties and a higher melting temperature for BE2i *** chain length distribution analysis showed a slight increase in chains of DP>36 in BE1i lines and a dramatic increase in glucan chains between DP 10-20 and DP>40 in BE2i ***,BE2i starches displayed a B-type X-ray diffraction pattern instead of the A-type pattern found in BE1i and WT ***,cassava BE1 and BE2 function differently in storage root starch biosynthesis.

关键词： chains branching pattern

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Artificial nanomotors: Fabrication, locomotion characterization, motion manipulation, and biomedical applications

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Interdisciplinary Materials 2022年第2期1卷 256-280页

作者： Liangmeng Wang xiaomeng hao Zhixue Gao Zili Yang Yi Long Ming Luo Jianguo Guan State Key Laboratory of Advanced Technology for Materials Synthesis and Processing International School of Materials Science and EngineeringWuhan University of TechnologyWuhanPeople's Republic of China School of Materials Science&Engineering Nanyang Technological UniversitySingaporeSingapore

Artificial nanomotors are nanoscale machines capable of converting surrounding other energy into mechanical motion and thus entering the tissues and cells of *** hold great potential to revolutionize the diagnosis and treatment of diseases by actively targeting the lesion location,though there are many new challenges that arise with decreasing the size to *** review sum-marizes and comments on the state-of-the-art artificial nanomotors with ad-vantages and *** starts with the fabrication methods,including common physical vapor deposition and colloidal chemistry methods,followed by the locomotion characterization and motion ***,the in vitro and in vivo biomedical applications are introduced in *** challenges and future prospects are discussed at the end.

关键词： biomedical application fabrication locomotion characterization motion manipulation nanomotor

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Design and testing research of LiDAR for detecting atmospheric turbulence

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Optoelectronics Letters 2025年第3期21卷 172-176页

作者： QIU Duoyang LI Xianyang YANG hao ZHU xiaomeng FANG Zhiyuan XU Xiang School of Advanced Manufacturing Engineering Hefei University Anhui Provincial Engineering Technology Research Center of Intelligent Vehicle Control and Integrated Design Technology Hefei University Science Island Branch of Graduate School University of Science and Technology of China School of Mechanical and Energy Engineering Ningbo Tech University Key Laboratory of Atmospheric Optics Anhui Institute of Optics and Fine Mechanics Chinese Academy of Sciences

Atmospheric turbulence is an important parameter affecting laser atmospheric transmission. This paper reports on a self-developed atmospheric turbulence detection Li DAR system (scanning differential image motion Li DAR(DIM-Li DAR) system). By designing and simulating the optical system of atmospheric turbulence detection Li DAR,the basic optical imaging accuracy has been determined.

关键词： A

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Analysis of miR-205 and miR-155 expression in the blood of breast cancer patients

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Chinese Journal of Cancer Research 2013年第1期25卷 46-54页

作者： Jingjing Liu Qixin Mao Yan Liu xiaomeng hao Sheng Zhang Jin Zhang 3rd Department of Breast Cancer China Tianjin Breast Cancer Prevention Treatment and Research center Tianjin Medical University Institute and Hospital Key laboratory of breast cancer prevention and therapy of ministry of education Key laboratory of cancer prevention and therapy in Tianjin

The purpose of this study was to identify and validate circulating microRNAs （miRNAs） in human plasma for use as breast cancer （BC） biomarkers and to analyze their relationship to clinicopathologic features and its preliminary biological function. Genome-wide expression profiling of miRNAs in BC was investigated by microarray analysis, miR-155 was up-regulated greater than two-fold in BC compared with Normal Adjacent Tissue （NAT）, whereas let-7b, miR-381, miR-10b, miR-125a-Sp, miR-335, miR-205 and miR-145 were down- regulated greater than two-fold. Our hypothesis was that circulating miRNAs are also present and differentially expressed in the serum of BC patients compared to controls. Using real-time PCR （RT-PCR）, we analyzed miR-205 and miR-155 in archived serum from 30 participants, 20 with breast cancer and I0 healthy people, miR-205 was down-regulated in BC patient serum while miR-155 was up-regulated. Furthermore, we analyzed the relationship between the expression levels of these two miRNAs and the clinicopathologic parameters of BC patients. High expression of miR155 was associated with clinical stage, molecular type, Ki-67 and p53 in BC patients （P〈0.05）. By contrast, we found no significant correlation between miR-205 and BC patient clinicopathologic parameters. Functional analysis showed that ectopic expression of miR-205 significantly inhibits cell proliferation and promotes apoptosis, miR-205 was down- regulated and miR-155 was up-regulated in BC patient serum, miR-155 was positive correlated with clinical stage and 16-67 and negatively correlated with p53 status.

关键词： Breast cancer microRNAs miR-205 miR-155

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Phosphoglucan, water dikinase(PWD/GWD3) regulates starch metabolism through protein interactions in cassava(Manihot esculenta Crantz)

Phosphoglucan, water dikinase(PWD/GWD3) regulates starch met...

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2019年全国热带作物学术年会

作者： xiaomeng hao Shutao He Peng Zhang National Key Laboratory of Plant Molecular Genetics CAS Center for Excellence in Molecular Plant Sciences Institute of Plant Physiology and Ecology Chinese Academy of Science University of Chinese Academy of Sciences

Starch phosphorylation is an important part of starch metabolism because of its role in starch *** phosphorylation is mediated by dikinases, the glucan,water dikinase(GWD) and the phosphoglucan, water dikinase(PWD/GWD3). At present, it is still unclear whether genes related to starch phosphorylation are also involved in starch synthesis process. Here, compared with wide type, GWD3-RNAi transgenic cassava showed starch accumulated phenotype as well as growth retardation, which indicates that GWD3 plays an important role in starch degradation. In addition, the properties of starch extracted from GWD3-RNAi transgenic cassava storage roots changed significantly, including the chain length distribution of amylopectin. Furthermore, the enzyme activities of soluble starch synthase(SSS), starch branching enzyme(SBE) and isoamylase(ISA) changed significantly in GWD3-RNAi transgenic cassava, compared with wide-type. Yeast two-hybridization and Co-IP results showed that GWD3 can interact with starch biosynthetic enzymes including SS2, ISA1 and ISA2, directly. Our findings suggest that GWD3 may not only participate in the starch degradation process, but also take part in the starch synthesis process through protein interactions and enzymatic activity regulation. This study shed new light on GWD3 function in the balance between starch synthesis and starch degradation.

关键词： Starch phosphorylation starch synthesis starch degradation

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Zelcovamycins from the endophyte Streptomyces sp.I15A-493 isolated from Huperzia serrata

Zelcovamycins from the endophyte Streptomyces sp.I15A-493 is...

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中国化学会第十二届全国天然有机化学学术会议

作者： Jiaqing Yu xiaomeng hao Jiao Li Yuanyuan Hu Yufeng Liu Maoluo Gan Institute of Medicinal Biotechnology Chinese Academy of Medical Sciences and Peking Union Medical College Jining Medical College

During the course of our ongoing program on screening antibiotics against drug-resistant Gram-negative bacteria,the extracts of Streptomyces sp.I15 A-493,the plant endophyte isolated from Huperzia serrata（*** Murray） Trev,were found to show significant antibacterial activity against drug-risistant Gram-negative *** compounds were isolated by using various chromatographic methods including Silica gel,Sephadex LH-20,and HPLC guided by the antibacterial *** structures of two compounds were determined by spectroscopic analysis and chemical *** 1 was identified as zelkovamycin while the structure of2 was determined to be cyclo（2-glycyl-alanyl-（2-amino-2-butenoyl）-（N-methylglycyl）-alanyl-1,3-thizaoyl-4-methoxytrptophanyl）-（2-mthyldehydrothreonyl0）] and named zelkovamycin *** structure of zelkovamycin（1） was revised as cyclo（2-glycyl-（2-amino-butanoyl）-（2-amino-2-butenoyl）-（N-methylglycyl）-alanyl-1,3-thizaoyl-4-methoxytrptophanyl）-（2-mthyldehydrothreonyl）].The absolute configuration of the amino acid except for 4-methoxytrptophanyl moiety in 1 was determined using advanced Marfey’s *** 1 and 2 showed significant antibacterial activities against Pseudomonas aeruginosa,Escherichia coli,and Staphylococcus aureus with MIC values of 4-256 μg/mL.

关键词： Endophyte actinomycete Streptomyces Zecovamycin Antibacterial Structure revision

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不同所有制煤炭企业资本结构差异影响因素研究

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改革与战略 2015年第10期31卷 159-162页

作者：雷平王学评郝晓蒙中国地质大学〈北京〉人文经管学院北京100083 中国地质图书馆北京100083

1998年以来我国不同所有制煤炭企业的资本结构走势截然对立,当国有煤炭企业资产负债率一路上扬时,非国有煤炭企业的资产负债率却进入了稳定的下降通道。根据权衡理论和顺序融资理论,文章采用1998—2009年规模以上煤炭企业微观的数据样本... 详细信息

1998年以来我国不同所有制煤炭企业的资本结构走势截然对立,当国有煤炭企业资产负债率一路上扬时,非国有煤炭企业的资产负债率却进入了稳定的下降通道。根据权衡理论和顺序融资理论,文章采用1998—2009年规模以上煤炭企业微观的数据样本,对影响煤炭企业资本结构的因素展开了动态面板实证研究回归,并基于回归结果对企业资本结构演变进行了模拟。结果表明:企业资本结构受多种因素影响,广受关注的所有制差异确实对煤炭企业资本结构的差异性变动有影响,但是程度很有限。对不同所有制煤炭企业资本结构差异造成最大影响的因素是企业的盈利能力因子,非国有企业相对较高的盈利能力解释近一半的资本结构差异。

关键词：煤炭企业资本结构所有制动态面板

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铜绿假单胞菌注射液联合新辅助化疗治疗乳腺癌的临床研究

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中国肿瘤临床 2010年第2期37卷 117-120页

作者：毛启新张敏郝晓甍张晟张瑾乳腺癌防治教育部重点实验室天津市肿瘤防治重点实验室天津医科大学附属肿瘤医院乳腺三科天津市300060

目的:拟评价铜绿假单胞菌注射液(PA-MSHA菌苗)联合新辅助化疗治疗乳腺癌的有效性和安全性。方法:本研究为开放、随机、对照试验。试验组乳腺癌患者20例,对照组20例,两组采用相同的化疗方案,试验组加用铜绿假单胞菌注射液。治疗结束后评... 详细信息

目的:拟评价铜绿假单胞菌注射液(PA-MSHA菌苗)联合新辅助化疗治疗乳腺癌的有效性和安全性。方法:本研究为开放、随机、对照试验。试验组乳腺癌患者20例,对照组20例,两组采用相同的化疗方案,试验组加用铜绿假单胞菌注射液。治疗结束后评价疗效,记录患者治疗前、后的Karnofsky评分,并在治疗前、后抽取患者静脉血,采用双抗体夹心ELISA法检测患者的免疫功能指标(IFN-γ、IL-2、IL-4、IL-10)和其他指标(Caspase-3、VEGF、MMP-2、MMP-9)的变化情况,观察并记录不良反应。结果:治疗后试验组的总缓解率(RR)高于对照组(P0.05);试验组治疗前和治疗后Karnofsky评分比较,差异有统计学意义(P<0.01),试验组治疗后Karnofsky评分显著高于对照组治疗后(P<0.01);试验组治疗后血清IFN-γ和IL-2水平高于对照组(P<0.01),IL-4和IL-10水平低于对照组(P<0.05);试验组治疗后血清Caspase-3浓度升高,VEGF、MMP-2和MMP-9血清浓度降低,治疗前、后比较差异有统计学意义(P<0.05);对照组MMP-9与治疗前相比显著降低(P<0.01)。结论:铜绿假单胞菌注射液与化疗药物联合应用治疗乳腺癌可以提高总缓解率,能明显改善乳腺癌患者的细胞免疫功能,同时诱导乳腺癌细胞凋亡,降低乳腺癌细胞的侵袭能力,是乳腺癌患者理想的辅助治疗药物。

关键词：乳腺肿瘤新辅助化疗铜绿假单胞菌注射液免疫功能

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紫杉醇脂质体和多西紫杉醇在乳腺癌新辅助化疗中的应用效果及安全性

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中华肿瘤杂志 2015年第5期37卷 379-382页

作者：苏薇张晟李春艳郝晓甍张瑾天津医科大学肿瘤医院乳腺肿瘤三科国家肿瘤临床医学研究中心天津乳腺癌防治研究中心天津市肿瘤防治重点实验室乳腺癌防治教育部重点实验室300060

目的分析比较紫杉醇脂质体和多西紫杉醇在乳腺癌新辅助化疗中的应用效果及安全性。方法回顾性分析188例接受新辅助化疗的可手术乳腺癌患者，根据不同用药情况分为紫杉醇脂质体组（86例）和多西紫杉醇组（102例），两组患者均联合表阿霉... 详细信息

目的分析比较紫杉醇脂质体和多西紫杉醇在乳腺癌新辅助化疗中的应用效果及安全性。方法回顾性分析188例接受新辅助化疗的可手术乳腺癌患者，根据不同用药情况分为紫杉醇脂质体组（86例）和多西紫杉醇组（102例），两组患者均联合表阿霉素和环磷酰胺，即三药联合方案新辅助化疗，每21d为1个周期，共6个周期，化疗结束后3周行手术治疗，对其化疗效果及不良反应进行分析。结果紫杉醇脂质体组和多西紫杉醇组患者的病理完全缓解率分别为10．5％（9／86）和9．8％（10／102），客观缓解率分别为80．2％（69／86）和79．4％（81／102），疾病控制率分别为95．3％（82／86）和93．1％（95／102），但差异无统计学意义（P〉0．05）。安全性分析显示，紫杉醇脂质体组的皮肤指甲毒性反应、体液潴留、口腔黏膜炎、过敏反应（包括颜面潮红、胸闷、心悸、呼吸困难等）、Ⅲ～Ⅳ级白细胞减少及中性粒细胞减少的发生率均低于多西紫杉醇组，差异均有统计学意义（均P〈0．05）。结论紫杉醇脂质体的抗肿瘤疗效与多西紫杉醇相近，但不良反应较少，且程度较轻，安全性更高。

关键词：乳腺肿瘤药物疗法联合紫杉醇脂质体多西紫杉醇治疗结果

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