检索结果-南通市图书馆

Repetitive traumatic brain injury–induced complement C1–related inflammation impairs long-term hippocampal neurogenesis

引用

Neural Regeneration Research 2025年第3期20卷 821-835页

作者： Jing Wang Bing Zhang Lanfang Li xiaomei tang Jinyu Zeng Yige Song Chao Xu Kai Zhao Guoqiang Liu Youming Lu Xinyan Li Kai Shu Department of Neurosurgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina Department of Neurosurgery Shanxi Bethune HospitalShanxi Academy of Medical SciencesTongji Shanxi HospitalThird Hospital of Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Department of Pathophysiology School of Basic Medicine and Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina Institute for Brain Research Wuhan Center of Brain ScienceHuazhong University of Science and TechnologyWuhanHubei ProvinceChina Department of Graduate Student Chongqing Medical UniversityChongqingChina Department of Basic Medicine School of Medical ScienceHubei University for NationalitiesEnshiHubei ProvinceChina Department of Anatomy School of Basic Medicine and Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

Repetitive traumatic brain injury impacts adult neurogenesis in the hippocampal dentate gyrus,leading to long-term cognitive ***,the mechanism underlying this neurogenesis impairment remains *** this study,we established a male mouse model of repetitive traumatic brain injury and performed long-term evaluation of neurogenesis of the hippocampal dentate gyrus after repetitive traumatic brain *** results showed that repetitive traumatic brain injury inhibited neural stem cell proliferation and development,delayed neuronal maturation,and reduced the complexity of neuronal dendrites and *** with repetitive traumatic brain injuryalso showed deficits in spatial memory ***,following repetitive traumatic brain injury,neuroinflammation was enhanced in the neurogenesis microenvironment where C1q levels were increased,C1q binding protein levels were decreased,and canonical Wnt/β-catenin signaling was *** inhibitor of C1 reversed the long-term impairment of neurogenesis induced by repetitive traumatic brain injury and improved neurological *** findings suggest that repetitive traumatic brain injury–induced C1-related inflammation impairs long-term neurogenesis in the dentate gyrus and contributes to spatial memory retrieval dysfunction.

关键词： complement C1 dendrite dentate gyrus hippocampus neural stem cell neurogenesis neuroinflammation neurological function neuron traumatic brain injury

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Authenticating GNSS civilian signals:a survey

引用

Satellite Navigation 2023年第1期4卷 196-213,I0006页

作者： Muzi Yuan xiaomei tang Gang Ou School of Electronic Science National University of Defense TechnologyChangshaChina

Civilian services of Global Navigation Satellite System are threatened by spoofng attacks since it is hard to determine the authenticity of a navigation signal with a detailed structure open to the *** authentication efectively protects the security of the signal by attaching unforgeable information to one or several elements of the *** can verify the authenticity of the signal by extracting and validating this *** good signal authentication schemes requires understanding possible spoofng modes,signal element specialty,and performance evaluation *** paper is an overview of navigation signal authentication,where the theories and reported approaches are described in detail.A design/performance matrix that demonstrates the advantages and defects of the signal element and its authentication design is *** are proposed to improve the robustness,security,efciency,and implementation hardness for future designs of navigation signal authentication.

关键词： GNSS spoofng Signal authentication Signal structure design Authentication scheme

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Denaturing high-performance liquid chromatography to diagnose cerebral autosomal dominant arteriopathy in Chinese patients with subcortical infarcts and leukoencephalopathy

引用

Neural Regeneration Research 2008年第6期3卷 674-678页

作者： xiaomei tang Biao Chen Research Institute of Gerontology Xuanwu Hospital of Capital Medical University Beijing 100053 China Department of Neurology Haidian Hospital Beijing 100080 China

BACKGROUND： Notch3 mutations are the molecular genetic foundation for cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy （CADASIL）. Of all currently available detection methods, direct sequencing or restriction enzymes are frequently used, but the cost is relatively high, because the Notch3 gene is composed of many exons and mutational sites are widely distributed. Denaturing high-performance liquid chromatography （DHPLC） exhibits high efficiency and specificity and has been applied to gene detection. To date, there has no report regarding DHPLC in gene detection of large-scale CADASIL families in China. OBJECTIVE： To explore the application and value of DHPLC in the diagnosis of CADASIL by a mutation screening for Notch3 gene in CADASIL probands and their family members. DESIGN, TIME AND SETTING： A comparative observation was performed at the Genetic Diagnosis Laboratory of Institute of Geriatrics, Xuanwu Hospital of Capital Medical University and the Key Laboratory for Neurodegenerative Disease of the Ministry of Education between August 2003 and May 2004. PARTICIPANTS： Fourteen CADASIL patients and their family members, comprising eight males and six females, aged 38-62 years, were included. Their key features included recurrent sub-cortical ischemic events and vascular dementia. In addition, 100 healthy physical examinees were selected as controls, including 52 males and 48 females, aged 56-72 years, who had no neurodegenerative disease or psychosis, and no history or high risk for cerebrovascular disease. METHODS： DNA was extracted from white blood cells. Ten hotspots of the Notch3 gene for sequence variation were first amplified by PCR, and the products were detected using DHPLC, Exons exhibiting a variant in the DHPLC profile underwent another PCR amplification, followed by DNA sequencing to identify the mutation type, In addition, patients with normal DHPLC peak profiles underwent PCR amplification for the remaining 13

关键词： CADASIL DHPLC Notch3 mutation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Analysis of GPS P(Y) signal power enhancement based on the observations with a semi-codeless receiver

引用

Satellite Navigation 2022年第3期3卷 71-79,I0003页

作者： xiaomei tang Muzi Yuan Feixue Wang College of Electronic Science National University of Defense TechnologyChangshaHunan ProvinceChina

The Global Position System(GPS)satellites of Block IIR-M and later versions can turn on the signal power enhancement if *** recent years,this power enhancement has been triggered several times when the U.S force was involved in local conflicts,which was observed by the monitoring receivers at International GNSS Service(IGS)/international GNSS Monitoring and Assessment System(iGMAS)stations or the high-gain antennas at monitoring ground *** specific power enhancement magnitudes with these two observation methods are *** observations of L1/L2 P(Y)power with a high-gain antenna are accurate,while the observations at IGS/iGMAS stations contain *** paper analyses the reasons for the observation biases with monitoring receivers at IGS/iGMAS stations and proposes a method verifying the accurate relation between the observed carrier-to-noise ratio(C/N_(0))data and the real power enhancement *** the power enhancement event happens,the observed L1/L2 P(Y)C/N_(0) data at IGS/iGMAS stations can be corrected using the model proposed in this *** the analysis,this paper concludes that the power of L1P(Y)increases by about 4.3–5.3 dB and the power of L2P(Y)by about 4.6–5.2 dB in power enhancement events,which matches the designed capability of GPS satellites as *** results are also verified by the data of high-gain antennas.

关键词： GPS P(Y)signal Power enhancement assessment Semi-codeless tracking

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

High-Precision Doppler Frequency Estimation Based Positioning Using OTFS Modulations by Red and Blue Frequency Shift Discriminator

引用

China Communications 2024年第2期21卷 17-31页

作者： Shaojing Wang xiaomei tang Jing Lei Chunjiang Ma Chao Wen Guangfu Sun School of Electronic Science National University of Defense TechnologyChangsha 410073China

Orthogonal Time Frequency and Space(OTFS) modulation is expected to provide high-speed and ultra-reliable communications for emerging mobile applications, including low-orbit satellite communications. Using the Doppler frequency for positioning is a promising research direction on communication and navigation integration. To tackle the high Doppler frequency and low signal-to-noise ratio(SNR) in satellite communication, this paper proposes a Red and Blue Frequency Shift Discriminator(RBFSD) based on the pseudo-noise(PN) *** paper derives that the cross-correlation function on the Doppler domain exhibits the characteristic of a Sinc function. Therefore, it applies modulation onto the Delay-Doppler domain using PN sequence and adjusts Doppler frequency estimation by red-shifting or blue-shifting. Simulation results show that the performance of Doppler frequency estimation is close to the Cramér-Rao Lower Bound when the SNR is greater than -15dB. The proposed algorithm is about 1/D times less complex than the existing PN pilot sequence algorithm, where D is the resolution of the fractional Doppler.

关键词： channel estimation communication and navigation integration Orthogonal Time Frequency and Space pseudo-noise sequence red-blue frequency shift discriminator

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

MDM2 inhibitors in cancer immunotherapy:Current status and perspective

引用

Genes & Diseases 2024年第6期11卷 331-350页

作者： Qinru Zeng Shaocheng Zeng Xiaofeng Dai Yun Ding Chunye Huang Ruiwen Ruan Jianping xiong xiaomei tang Jun Deng Department of Oncology The First Affiliated HospitalJiangxi Medical CollegeNanchang UniversityNanchangJiangxi 330006China Jiangxi Key Laboratory for Individual Cancer Therapy NanchangJiangxi 330006China Department of Oncology Jiangxi Chest HospitalNanchangJiangxi 330006China Postdoctoral innovation Practice Base The First Affiliated Hospital of Nanchang UniversityNanchangJiangxi 330006China

Murine double minute 2(MDM2)plays an essential role in the cell cycle,apoptosis,DNA repair,and oncogene activation through p53-dependent and p53-independent signaling *** preclinical studies have shown that MDM2 is involved in tumor immune ***,MDM2-based regulation of tumor cell-intrinsic immunoregulation and the immune microenvironment has attracted increasing research *** recent years,im-mune checkpoint inhibitors targeting PD-1/PD-L1 have been widely used in the ***-er,the effectiveness of a single agent is only approximately 20%-40%,which may be related to primary and secondary drug resistance caused by the dysregulation of ***,we reviewed the role of MDM2 in regulating the immune microenvironment,tumor immune evasion,and hyperprogression during *** addition,we summarized preclinical and clinical findings on the use of MDM2 inhibitors in combination with immunotherapy in tu-mors with MDM2 overexpression or *** results reveal that the inhibition of MDM2 could be a promising strategy for enhancing immunotherapy.

关键词： Immune hyperprogression Immune microenvironment Immunotherapy MDM2 MDM2 inhibitors p53

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Overexpression of PbrGA2ox1 enhances pear drought tolerance through the regulation of GA_(3)-inhibited reactive oxygen species detoxification and abscisic acid signaling

引用

Journal of Integrative Agriculture 2024年第9期23卷 2989-3011页

作者： Guoling Guo Haiyan Zhang Weiyu Dong Bo Xu Youyu Wang Qingchen Zhao Lun Liu xiaomei tang Li Liu Zhenfeng Ye Wei Heng Liwu Zhu Bing Jia School of Horticulture Anhui Agricultural UniversityHefei 230036China Anhui Wanbang Pharmaceutical Technology Co. Ltd.Hefei 230036China Science and Technology Department Anhui Agricultural UniversityHefei 230036China Hunan Suncas Agriculture Science Co. Ltd.Changsha 410016China

Drought stress is a devastating natural disaster driven by the continuing intensification of global warming,which seriously threatens the productivity and quality of several horticultural crops,including ***(GAs)play crucial roles in plant growth,development,and responses to drought *** studies have shown significant reductions of GA levels in plants under drought stress;however,our understanding of the intrinsic regulation mechanisms of GA-mediated drought stress in pear remains very ***,we show that drought stress can impair the accumulation of bioactive GAs(BGAs),and subsequently identified PbrGA2ox1 as a chloroplast-localized GA deactivation *** gene was significantly induced by drought stress and abscisic acid(ABA)treatment,but was suppressed by GA_(3)***2ox1-overexpressing transgenic tobacco plants(Nicotiana benthamiana)exhibited enhanced tolerance to dehydration and drought stresses,whereas knock-down of PbrGA2ox1 in pear(Pyrus betulaefolia)by virus-induced gene silencing led to elevated drought *** plants were hypersensitive to ABA,and had a lower BGAs content,enhanced reactive oxygen species(ROS)scavenging ability,and augmented ABA accumulation and signaling under drought stress compared to wild-type ***,the opposite effects were observed with PbrGA2ox1 silencing in ***,exogenous GA_(3)treatment aggravated the ROS toxic effect and restrained ABA synthesis and signaling,resulting in the compromised drought tolerance of *** summary,our results shed light on the mechanism by which BGAs are eliminated in pear leaves under drought stress,providing further insights into the mechanism regulating the effects of GA on the drought tolerance of plants.

关键词： pear gibberellin drought stress PbrGA2ox1 reactive oxygen species abscisic acid

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Analysis of Combined Therapy and Treatment Effect of Localized Ultraviolet Irradiation and Shengji Yuhong Cream on Diabetic Foot

引用

Journal of Clinical and Nursing Research 2019年第2期3卷 14-16页

作者： Yiping Zhang xiaomei tang Min Zhu Jumei Wang Department of Rehabilitation The Third People’s Hospital of TaizhouTaizhou225321China

Objective:To investigate the treatment effect of combined application of localized ultraviolet irradiation and Shengji Yuhong Cream on diabetic foot ***:Diabetic foot patients in the control group were treated with localized ultraviolet irradiation on the basis of conventional *** study group was added with Shengji Yuhong Cream on top of the localized ultraviolet irradiation on the basis of conventional ***:The results of ankle brachial index and dorsal foot skin temperature of that two groups before treatment were compared,P>*** treatment,the ankle brachial index and dorsal foot skin temperature of the study group were better than those of the control *** comparison between the groups and within the group was P<*** total effective rate of the study group(95.65%)was higher than that of the control group(71.11%),P<***:The application of localized ultraviolet irradiation and Shengji Yuhong Cream in the treatment of diabetic foot is effective.

关键词： diabetic foot localized ultraviolet irradiation Shengji Yuhong Cream combined treatment effect

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

高阶BOC信号多区域鉴别器的无模糊多径抑制算法

引用

国防科技大学学报 2016年第3期38卷 39-44页

作者：田丰唐小妹欧钢国防科技大学电子科学与工程学院湖南长沙410073 中国西安卫星测控中心佳木斯站黑龙江佳木斯154002

传统的高阶BOC信号多径抑制算法的有效收敛区间较小,不利于信号的稳定跟踪,因此提出一种多区域鉴别器的高阶BOC多径抑制算法。在伪码误差为零的附近区域,采用优化的QStrobe多径抑制鉴别器,而在其他区域采用收敛区间较大的正交BOC鉴别器... 详细信息

传统的高阶BOC信号多径抑制算法的有效收敛区间较小,不利于信号的稳定跟踪,因此提出一种多区域鉴别器的高阶BOC多径抑制算法。在伪码误差为零的附近区域,采用优化的QStrobe多径抑制鉴别器,而在其他区域采用收敛区间较大的正交BOC鉴别器。利用卡尔曼滤波器对跟踪误差进行开环估计,判断误差所处区域并进行鉴别器的实时切换。对BOC(15,2.5)和BOC(14,2)信号的仿真结果表明,该算法能够实现无模糊跟踪,且6 d B衰减多径误差包络面积比传统QStrobe算法分别改善了57%和51%。

关键词：二进制偏移载波多径全球导航卫星系统多区域鉴别器无模糊跟踪

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

GNSS多径信道模拟的聚类稀疏拟合方案

引用

国防科技大学学报 2023年第5期45卷 87-94页

作者：周顺欧钢唐小妹国防科技大学电子科学学院湖南长沙410073 国防科技大学第六十三研究所江苏南京210007

针对全球导航卫星系统(global navigation satellite system,GNSS)信道模拟计算量大、硬件资源开销大,不利于实时性能评估和实际工程应用的挑战,提出一种GNSS多径信道模拟的聚类稀疏拟合方案。利用基于K中心聚类信道冲击响应(channel im... 详细信息

针对全球导航卫星系统(global navigation satellite system,GNSS)信道模拟计算量大、硬件资源开销大,不利于实时性能评估和实际工程应用的挑战,提出一种GNSS多径信道模拟的聚类稀疏拟合方案。利用基于K中心聚类信道冲击响应(channel impulse response,CIR)参数萃取的稀疏拟合方法,得到等效精简CIR参数,再以稀疏抽头延迟线结构来实现信道模拟。所提方法在保持多径误差条件下,通过较少抽头数量的抽头延迟线结构滤波器拟合原始GNSS多径信道模型,可以大为简化GNSS信道模型仿真复杂度,而无须庞大的硬件资源。仿真结果表明,通过对参考信道模型生成的信道CIR参数进行稀疏拟合,所提出的方案和方法具有良好的效果。

关键词：卫星导航多径信道模拟 K中心聚类抽头延迟线

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：