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Acta Pharmaceutica Sinica B 2024年第7期14卷 2901-2926页

作者： xiaoman mao Shuang Wu Dandan Huang Chong Li College of Pharmaceutical Sciences Southwest UniversityChongqing 400715China Medical Research Institute Southwest UniversityChongqing 400715China School of Pharmaceutical Sciences Southern Medical UniversityGuangzhou 510515China

Despite the considerable advancements in chemotherapy as a cornerstone modality in cancer treatment,the prevalence of complications and pre-existing diseases is on the rise among cancer patients along with prolonged survival and aging *** relationships between these disorders and cancer are intricate,bearing significant influence on the survival and quality of life of individuals with cancer and presenting challenges for the prognosis and outcomes of ***,we review the prevailing complications and comorbidities that often accompany chemotherapy and summarize the lessons to learn from inadequate research and management of this scenario,with an emphasis on possible strategies for reducing potential complications and alleviating comorbidities,as well as an overview of current preclinical cancer models and practical advice for establishing bio-faithful preclinical models in such complex context.

关键词： Complications Comorbidities Chemotherapy Preclinical cancer models Drug design Drug delivery

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主题出版的动力机制与评价机制分析

出版与印刷 2022年第6期 29-37页

作者：韩建民周蔚华毛小曼杭州电子科技大学融媒体与主题出版研究院中国人民大学新闻学院上海市委宣传部出版处

文章就主题出版的动力机制与评价机制展开深度对谈。三位对谈人结合各自的工作实践和学术背景,就近年来主题出版取得的成就、主题出版的动力机制和评价机制展开了深入的讨论,并达成如下共识:主题出版从宏观到微观、从选题到市场、从国... 详细信息

文章就主题出版的动力机制与评价机制展开深度对谈。三位对谈人结合各自的工作实践和学术背景,就近年来主题出版取得的成就、主题出版的动力机制和评价机制展开了深入的讨论,并达成如下共识:主题出版从宏观到微观、从选题到市场、从国内到国际,以及从内容到形式四个方面均取得了显著的成绩;主题出版的理论研究推出了一批有价值的学术成果;目前主题出版工作需在解决公益性和市场性、时效性和长久性等方面努力;主题出版的动力机制来自出版主管部门的顶层设计和政策推动、出版单位的主动作为、编辑个人的成长需要、读者和市场的驱动四个方面,其根本动力是以人民为中心;制约主题出版动力机制的关键因素包括政策、出版单位、作者和市场,出版单位是最重要的因素,要最大化发挥出版单位的作用;主题出版动力机制优化要强调目标导向,在策划方面转变观念,形成政府推动、出版单位主导、市场化运作的格局;目前主题出版缺乏较为权威的评价体系;主题出版动力机制和评价机制既相互促进又相互制约;为实现主题出版的高质量发展,需要建立政府评价、社会评价、专家评价和市场评价有机统一的评价机制。

关键词：主题出版动力机制评价机制出版高质量发展

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Variation and Dynamics of Soil Nematode Communities in Greenhouses with Different Continuous Cropping Periods

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Horticultural Plant Journal 2020年第5期6卷 301-312页

作者： Xueliang Tian xiaoman Zhao Zhenchuan mao Bingyan Xie College of Resources and Environment Henan Institute of Science and TechnologyXinxiangHenan 453003China Institute of Vegetable and Flowers Chinese Academy of Agricultural SciencesBeijing 100081China

Continuous cropping in greenhouses can result in root-knot nematode outbreaks resulting from imbalances in the soil nematode ***,the changes in soil nematode communities in greenhouses with continuous crop production are *** compared soil nematode communities in greenhouses after 2 years(2-yr)and 10 years(10-yr)of continuous crop production by 18S rDNA high-throughput *** with the 2-yr greenhouse,soil in the 10-yr greenhouse showed acidification,nutrient accumulation and ***-feeding nematodes(BF)were dominant in the 2-yr greenhouse over the whole growing season,but plant-parasitic nematodes(PP)were the dominant group in the 10-yr greenhouse during the late growing *** gradually became the dominant group and had a relative abundance of 70.9%(maximum)in the 10-yr ***,with relative abundance ranging from 99.8%to 26.8%,was the predominant group in the 2-year ***β-diversity,hierarchical clustering analysis,unweighted UniFrac principal component analysis(PCA)and principal co-ordinates analysis(PCoA)all revealed that soil nematode communities in the two types of greenhouses were significantly *** analysis(RDA)showed that soil nematode communities in the 10-yr greenhouse were related to high soil organic material,total nitrogen,electrical conductivity and disease index of root-knot ***’s exact test and Pearson’s correlation coefficients revealed that Meloidogyne contributed to themain differences in soil nematode communities between the two types of *** dynamics of Meloidogyne were divided into dormant phase,low-level increasing phase and exponential phase during the whole *** soil nematode communities within the 2-yr and 10-yr greenhouses had significant variation and different *** work contributes to a deeper understanding of changes in the soil nematode community in greenhouses with different continuous cro

关键词： meloidogyne greenhouse soil nematode community continuous cropping high-throughput sequencing

脑膜中动脉栓塞治疗合并血液恶性肿瘤的慢性硬膜下血肿2例

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国际神经病学神经外科学杂志 2023年第2期50卷 53-55页

作者：孙军吴良发莫创骑毛小满刘悦陈骅南京市浦口人民医院江苏南京211800 南京医科大学附属第一医院江苏南京210029

报道2例合并血液恶性肿瘤的慢性硬膜下血肿患者,经脑膜中动脉栓塞治疗,取得较良好的临床疗效,回顾其诊治过程并复习相关文献资料,分析病例特点及处理方式,以期为该类型患者诊治提供参考。

关键词：脑膜中动脉栓塞慢性硬膜下血肿血液恶性肿瘤

三维塑型钛网颅骨成形术在颅骨缺损修复中的应用

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实用临床医药杂志 2021年第1期25卷 35-37页

作者：邵先矛吴良发王经发毛小满谢英彬卢明江苏省南京市浦口区中心医院神经外科江苏南京211800 江苏省连云港市灌南县人民医院神经外科江苏连云港222500

目的研究三维塑型钛网颅骨成形术在颅骨缺损修复中的效果。方法将45例额颞部颅骨缺损患者随机分为观察组(n=29)和对照组(n=16),观察组采用三维塑形钛网行颅骨成形术,对照组采用二维钛网人工塑形进行颅骨修补。比较2组美容满意度相关指... 详细信息

目的研究三维塑型钛网颅骨成形术在颅骨缺损修复中的效果。方法将45例额颞部颅骨缺损患者随机分为观察组(n=29)和对照组(n=16),观察组采用三维塑形钛网行颅骨成形术,对照组采用二维钛网人工塑形进行颅骨修补。比较2组美容满意度相关指标。结果术后随访3个月,观察组颅骨修补侧和健侧头型对称29例,颞肌塌陷1例;对照组颅骨修补侧和健侧头型对称12例,颞肌塌陷4例,头皮感染6例,线结外露5例,钛网翘起或外露3例,皮下积液3例。2组美容满意度相关指标和发生常见并发症患者例数比较,差异均有统计学意义(P<0.05)。结论三维塑型钛网颅骨成形术常见并发症发生率较低,患者美容满意度较高。

关键词：钛网颅骨缺损外观满意度颅骨成形术

自制简易脑立体定向仪辅助神经内镜治疗基底节区脑出血的疗效分析

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神经疾病与精神卫生 2022年第6期22卷 438-443页

作者：吴良发谢英彬唐宽宇邵先矛孙军毛小满颜伟南京市浦口区中心医院神经外科 211800 南京医科大学第一附属医院神经外科 210029

目的探讨自制简易脑立体定向仪辅助神经内镜治疗基底节区脑出血的疗效。方法回顾性收集2019年1月至2020年12月南京市浦口区中心医院收治的40例高血压基底节区脑出血患者的手术资料,按手术方式分为观察组(22例)和对照组(18例),观察组采... 详细信息

目的探讨自制简易脑立体定向仪辅助神经内镜治疗基底节区脑出血的疗效。方法回顾性收集2019年1月至2020年12月南京市浦口区中心医院收治的40例高血压基底节区脑出血患者的手术资料,按手术方式分为观察组(22例)和对照组(18例),观察组采用简易脑立体定向仪辅助内镜下血肿清除术,对照组采用常规骨瓣开颅血肿清除术。比较两组患者术前一般资料、手术时间、术中出血量、血肿清除率、术后并发症发生率,采用扩展格拉斯哥预后评分(GOS-E)比较两组患者术后3个月GOS-E良好率。结果观察组手术时间短于对照组[(65.8±10.5)min比(125.3±20.4)min]、术中出血量少于对照组[(50.2±10.6)ml比(295.3±18.5)ml]、血肿清除率高于对照组[(88.2±3.8)%比(70.3±5.6)%],差异均有统计学意义(均P0.05)。结论相较于常规开颅血肿清除术,自制简易脑立体定向仪辅助神经内镜治疗高血压基底节区脑出血的手术,能缩短手术时间,术中出血量少,血肿清除率高,能够改善患者近期预后。

关键词：高血压脑出血基底节区神经内镜立体定向仪疗效

Comparison of the precision of glacier flow rates derived from offset-tracking using Sentinel-2 and Landsat-8/9 imagery

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Advances in Polar Science 2024年第2期35卷 238-251页

作者： YANG Zhibin CHEN Zhuoqi LI Gang mao Yanting FENG xiaoman CHENG Xiao School of Geospatial Engineering and Science Sun Yat-sen Universityand Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai)Zhuhai 519082China Key Laboratory of Comprehensive Observation of Polar Environment(Sun Yat-sen University) Ministry of EducationZhuhai 519082China

Offset-tracking is an essential method for deriving glacier flow rates using optical ***-2(S2)and Landsat-8/9(L8/9)are popular optical satellites or constellations for polar studies,offering high spatial resolution with relatively short revisit time,wide swath width,and free *** evaluate and compare the precision of offset-tracking results yielded with these two kinds of data,in this study S2 and L8/9 imagery observed in Petermann Glacier in Greenland,Karakoram in High-Mountains Asia,and Amery Ice Shelf in the Antarctic are *** and various systematic error sources in the offset-tracking results including orbital and strip errors were analyzed and eliminated at the pre-process *** at the off-glacier(bare rock)region was evaluated by presuming that no deformation occurred;then for both glacierized and the off-glacier regions,precision of velocity time series was evaluated based on error propagation *** least squares method based on connected components was used to solve flow rates time series based on multi-pair images *** results indicated that S2 achieved slightly higher precision than L8/9 in terms of both single-pair derived displacements and least square solved daily flow rates time ***,the RMSE of daily velocity is 26%lower for S2 than L8/***,S2 provided higher temporal resolution for monitoring glacier flow rates.

关键词： Sentinel-2 Landsat glacier flow rates offset-tracking precision

The Functional Characterization of Bat and Human P[3] Rotavirus VP8*s

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Virologica Sinica 2021年第5期36卷 1187-1196页

作者： Dandi Li Mengxuan Wang Tongyao mao Mingwen Wang Qing Zhang Hong Wang Lili Pang xiaoman Sun Zhaojun Duan National Health Commission Key Laboratory for Medical Virology and Viral Diseases Beijing 102206China National Institute for Viral Disease Control and Prevention China CDCBeijing 102206China

P[3]rotavirus(RV)has been identified in many species,including human,simian,dog,and *** glycans,including sialic acid,histo-blood group antigens(HBGAs)are reported as RV attachment *** glycan binding specificity of different P[3]RV VP8*s were investigated in this *** HCR3 A and dog P[3]RV VP8*s recognized glycans with terminal sialic acid and hemagglutinated the red blood cells,while bat P[3]VP8*showed neither binding to glycans nor ***,the bat P[3]VP8*mutant of C189 Y obtained the ability to hemagglutinate the red blood cells,while human P[3]HCR3 A/M2-102 mutants of Y189 C lost the *** alignment and structural analysis indicated that residue 189 played an important role in the ligand recognition and may contribute to the cross-species *** superimposition exhibited that bat P[3]VP8*model was quite different from the simian P[3]Rhesus rotavirus(RRV)P[3]VP8*,indicating that bat P[3]RV was relatively distinct and partially contributed to the no binding to tested *** results promote our understanding of P[3]VP8*/glycans interactions and the potential transmission of bat/human P[3]RVs,offering more insight into the RV infection and prevalence.

关键词： Bat rotavirus PVP8* Glycan binding specificity Hemagglutination Sialic acid

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渣油加氢转化过程结焦物分析与表征

洁净煤技术 2019年第4期25卷 46-51页

作者：钟金龙毛学锋朱肖曼煤炭科学技术研究院有限公司煤化工分院北京100013 煤炭资源高效开采与洁净利用国家重点实验室北京100013 煤基节能环保炭材料北京市重点实验室北京100013

渣油加氢过程中易发生结焦现象,生成的结焦物可能会导致装置堵塞、催化剂失活、产物收率降低等。为了防止结焦现象的发生,需揭示结焦物的基本特性,以便为渣油加氢工艺设计、煤油共炼工艺设计、催化剂设计和工业生产提供参考。采用间歇... 详细信息

渣油加氢过程中易发生结焦现象,生成的结焦物可能会导致装置堵塞、催化剂失活、产物收率降低等。为了防止结焦现象的发生,需揭示结焦物的基本特性,以便为渣油加氢工艺设计、煤油共炼工艺设计、催化剂设计和工业生产提供参考。采用间歇式高压釜装置,模拟工业装置渣油加氢裂化条件,获取渣油加氢裂化的结焦物。采用红外光谱分析(IR)、核磁共振分析(NMR)、热重分析(TG)、X射线衍射分析(XRD)、扫描电镜-能谱仪分析(SEM-EDS)、元素分析等对渣油加氢过程中的结焦物进行分析和表征。结果表明,常压渣油在450℃加氢裂解时,出现结焦现象,氢耗率为2. 19%,气产率为8. 90%,结焦物产率达6. 95%;结焦物的H/C原子比为0. 66,结焦过程发生剧烈的脱氢反应。渣油的芳香环缩合度为0. 699 4,芳碳率为0. 395 6;结焦物的芳香环缩合度为0. 400 5,芳碳率为0. 7695。结焦物中含有大量的芳香环结构,在187℃和584℃失重最为剧烈;结焦物的主要成分是C,还含有少量O、Na、Cl、Ca、V等元素;结焦物呈球状和不规则块状,尺寸为30~50 nm,部分结焦物堆积后呈多孔状,孔径为500~1 000 nm。

关键词：渣油加氢转化结焦脱氢反应表征

不同偏移量追踪算法提取冰川流速的亚像素级精度比较

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冰川冻土 2024年第3期46卷 806-818页

作者：杨治斌李刚毛燕婷冯小蔓陈卓奇中山大学测绘科学与技术学院南方海洋科学与工程广东省实验室(珠海) 广东珠海519082 极地环境立体观测与应用教育部重点实验室(中山大学) 广东珠海519082

偏移量追踪技术不易失相关,是利用光学与SAR卫星影像监测冰川流速的主要手段。该技术通过互相关方法获得像素级偏移量,并通过插值算法达到亚像素级别。实地测量冰川流速不易获取,难以用于验证亚像素级算法精度,因此本文采用图像处理方... 详细信息

偏移量追踪技术不易失相关,是利用光学与SAR卫星影像监测冰川流速的主要手段。该技术通过互相关方法获得像素级偏移量,并通过插值算法达到亚像素级别。实地测量冰川流速不易获取,难以用于验证亚像素级算法精度,因此本文采用图像处理方法对其精度进行分析。本研究以格陵兰Petermann和Kangerlussuaq冰川为例,通过模拟实验设定偏移量场并生成模拟的偏移影像,将COSI-Corr、autoRIFT和ImGRAFT等偏移量追踪软件得到的结果与设定偏移量场对比,而后使用三次函数拟合判断是否存在系统误差,并通过拟合函数的反函数对其进行校正。结果表明COSI-Corr软件的偏移结果的亚像素级系统误差较小,而autoRIFT和ImGRAFT存在一定的亚像素级系统误差且与实验区无关。autoRIFT的亚像素级系统偏差最大,校正后其单方向RMSE平均提升了0.0054 pixels(px),提升率约为11%;而ImGRAFT(CCF-O)和ImGRAFT(NCC)的单方向RMSE平均分别提升了0.0014 px和0.0012 px,提升率较小。经校正后,autoRIFT精度最优,Petermann和Kangerlussuaq冰川区域的单方向综合精度分别为0.04 px和0.12 px;ImGRAFT(CCF-O)表现次之,不同实验条件下的单方向精度约为0.08 px;Im GRAFT (NCC)较差,Petermann和Kangerlussuaq冰川区域的单方向综合精度分别约为0.09 px和0.12 px。

关键词：偏移量追踪法 COSI-Corr autoRIFT ImGRAFT 插值精度冰川流速