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除草剂敌草胺的环境毒理研究进展

现代农药 2021年第2期20卷 1-6页

作者：罗跃黄文源刘旭东韩磊姚小龙吴小毛贵州大学作物保护研究所贵阳550025 贵州山地农业病虫害重点实验室贵阳550025

敌草胺是酰胺类手性除草剂,因具有良好的灭草活性而被广泛应用。敌草胺由于在环境中半衰期较长而药效持久,且易随水流扩散,因此对生物体和环境构成危害的潜在威胁性较大。本文叙述了敌草胺的结构、理化性质、特性及应用概况,综述了其在... 详细信息

敌草胺是酰胺类手性除草剂,因具有良好的灭草活性而被广泛应用。敌草胺由于在环境中半衰期较长而药效持久,且易随水流扩散,因此对生物体和环境构成危害的潜在威胁性较大。本文叙述了敌草胺的结构、理化性质、特性及应用概况,综述了其在环境中的分布和残留检测方法、动态、环境毒理与生态效应、生物降解等方面的研究进展,以期为敌草胺的分解代谢研究、污染治理和科学施用提供可借鉴依据。

关键词：敌草胺分解代谢残留分析环境毒理生物降解

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四随动式线加速度计动态校准装置的研制

计算机测量与控制 2020年第4期28卷 261-265页

作者：张功赵子伦杨硕王昱峰胡勇翔姚小龙北京航天计量测试技术研究所北京100076

常规振动台因输出幅值有限无法满足线加速度计高g值下的动态校准,针对该问题研制出带四随动平台的离心机;在分析了其工作原理基础上,从结构及电控两方面介绍了装置研制过程;结构方面首先介绍了装置轴系设计,其次以模拟计算出的轴系惯量... 详细信息

常规振动台因输出幅值有限无法满足线加速度计高g值下的动态校准,针对该问题研制出带四随动平台的离心机;在分析了其工作原理基础上,从结构及电控两方面介绍了装置研制过程;结构方面首先介绍了装置轴系设计,其次以模拟计算出的轴系惯量值及要求转速值为设计输入进行了电机选型计算,并介绍了测角码盘的配置情况;电控方面,以稳速台为例,采用"空间矢量脉宽调制+i_d=0控制"方法建立系统模型,并给出调速模式仿真结果;以随动台为例,位置环设计采用复合控制方法,利用动态误差系数法由"双十指标"推算出前馈控制器参数可行域;最后通过实验对装置速率精度及平稳性指标、跟随正弦指令的幅值误差及相移指标进行了测试,结果表明校准装置满足项目指标要求,系统达到预期控制效果。

关键词：线加速度计随动台离心机校准复合控制

程序性细胞死亡分子10调控EphB4信号通路促进胶质母细胞瘤迁移和侵袭的作用及其机制

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中华实验外科杂志 2021年第1期38卷 89-91页

作者：尧小龙田卫东万学焱游超王俊文张所军胡峰赵恺牛洪泉舒凯华中科技大学同济医学院附属同济医院神经外科武汉430030 湖北省第三人民医院神经外科武汉430030

目的探讨程序性细胞死亡分子10(PDCD10)调控胶质母细胞瘤(GBM)迁移和侵袭的作用与机制。方法采用慢病毒转染GBM细胞系(U251和U373)构建稳定转染的PDCD10过表达(oxPDCD10)或沉默(shPDCD10)的GBM细胞系。分别采用划痕实验和Transwell实验... 详细信息

目的探讨程序性细胞死亡分子10(PDCD10)调控胶质母细胞瘤(GBM)迁移和侵袭的作用与机制。方法采用慢病毒转染GBM细胞系(U251和U373)构建稳定转染的PDCD10过表达(oxPDCD10)或沉默(shPDCD10)的GBM细胞系。分别采用划痕实验和Transwell实验检测细胞迁移和侵袭。蛋白质印迹法(Western blot)检测PDCD10、酪氨酸蛋白激酶受体B4(EphB4)、细胞外调节蛋白激酶(Erk)1/2和pErk1/2的表达。在过表达PDCD10的GBM细胞进一步下调EphB4(siEphB4)。两组间比较采用t检验,多组间均数比较采用方差分析。结果PDCD10和EphB4在GBM患者中高表达且具有相关性(203.4±17.9比100.0±12.4,t=8.225,P<0.05),差异有统计学意义。shPDCD10的GBM细胞系迁移和侵袭低于对照组,而oxPDCD10的GBM细胞系迁移(152.8±27.3比97.6±16.4,P<0.05)和侵袭(152.9±11.8比89.4±16.6,P<0.05)高于对照组(t=5.405,P<0.05),差异均有统计学意义。shPDCD10引起EphB4和p-Erk1/2的表达低于对照组,而oxPDCD10调控EphB4表达高于对照组。在oxPDCD10的GBM细胞上转染siEphB4后,逆转了oxPDCD10引起的GBM细胞迁移和侵袭高于对照组(t=3.009,P<0.05),差异有统计学意义。结论GBM中PDCD10通过调控EphB4的表达,激活ErK1/2信号通路,促进胶质瘤的迁移与侵袭。

关键词：胶质母细胞瘤程序性细胞死亡分子10 迁移侵袭

啶酰菌胺中间体4'-氯-2-氨基联苯的合成

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山东化工 2016年第11期45卷 12-14,16页

作者：张慧丽姚晓龙康永利张文王轩栗晓东天津市均凯化工科技有限公司天津300384

以对氯苯硼酸为起始原料,与氟化氢钾反应得到对氯三氟苯硼酸钾,再与邻氯硝基苯经Suzuki偶联反应得到4'-氯-2-硝基联苯,最后经锌粉还原得到4'-氯-2-氨基联苯。总收率74.78%。该路线具有成本低、收率高、原材料易得、溶剂可回收套用、环... 详细信息

以对氯苯硼酸为起始原料,与氟化氢钾反应得到对氯三氟苯硼酸钾,再与邻氯硝基苯经Suzuki偶联反应得到4'-氯-2-硝基联苯,最后经锌粉还原得到4'-氯-2-氨基联苯。总收率74.78%。该路线具有成本低、收率高、原材料易得、溶剂可回收套用、环境友好等优点。

关键词：啶酰菌胺 2-氯烟酰氯 4'-氯-2-氨基联苯对氯苯硼酸

2-氨基-3-氯-5-三氟甲基吡啶的制备方法

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山东化工 2017年第7期46卷 20-21,24页

作者：姚晓龙康永利张文王轩张慧丽栗晓东天津市均凯化工科技有限公司天津300384

以2,3-二氯-5-三氟甲基吡啶或2-氟-3-氯-5-三氟甲基吡啶作为原料,与乙酰胺在20℃进行反应而制得3-氯-2-乙酰胺基-5-三氟甲基吡啶;之后经氢氧化钠50℃下水解而制得2-氨基-3-氯-5-三氟甲基吡啶。

关键词： 2-氨基-3-氯-5-三氟甲基吡啶 3-氯-2-乙酰胺基-5-三氟甲基吡啶 2,3-二氯-5-三氟甲基吡啶 2-氟-3-氯-5-三氟甲基吡啶

Bionic surface diode for droplet steering

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液滴(英文) 2023年第2期2卷 94-104页

作者： xiaolong Yang Biao Qi yao Lu Wang Zhang Xiaolei Wang College of Mechanical and Electrical Engineering Nanjing University of Aeronautics and AstronauticsNanjingChina Jiangsu Key Laboratory of Precision and Micro-Manufacturing Technology Nanjing University of Aeronautics and AstronauticsNanjingChina Department of Chemistry School of Physical and Chemical SciencesQueen Mary University of LondonLondonUK Engineering Product Development Singapore University of Technology and DesignSingaporeSingapore

Control of droplet sliding and its interfacial behavior such as sliding resistance and friction have important applications in microfluidic and energy-related *** provides many examples of interface-driven droplet sliding control;yet,to date,the continuous governing of the multiphase process and precise steering of droplet sliding remain ***,directional-dependent ultraslippery patterned surfaces with significant droplet sliding anisotropy were created by coordinating the heterogeneous wettability of the back of the dessert beetle,directional-dependent architecture of the butterfly wing,and ultraslippery configuration of the Nepenthes *** of the sliding resistance on typical ultraslippery patterned surfaces reveals that the directional-dependent triple phase line(TPL)immigration on the ultraslippery patterns dominates the strong sliding anisotropy,which can be modeled using the classic Furmidge *** particular,the sliding anisotropy for the semicircular ultraslippery patterned surface shows threefold higher than that of natural butterfly wings due to the most significant difference in TPL immigration in two opposite directions,which enables the simultaneous handling of multiple droplets without mass loss and steering of droplet sliding/*** work may transform the design space for the control of multiphase interface motion and the development of new lab-on-a-chip and droplet-based microsystems.

关键词： equation anisotropy multiphase

Interaction of Genotype,Environment,and Management on Organ-Specific Critical Nitrogen Dilution Curve in Wheat

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Plant Phenomics 2023年第3期5卷 612-625页

作者： Bo yao xiaolong Wang Yancheng Wang Tianyang Ye Enli Wang Qiang Cao Xia yao Yan Zhu Weixing Cao Xiaojun Liu Liang Tang National Engineering and Technology Center for Information Agriculture Engineering Research Center for Smart AgricultureMinistry of EducationKey Laboratory for Crop System Analysis and Decision MakingMinistry of Agriculture and Rural AffairsJiangsu Key Laboratory for Information AgricultureJiangsu Collaborative Innovation Center for Modern Crop ProductionNanjing Agricultural UniversityNanjing 210095JiangsuPR China CSIRO Agriculture and Food Cluniess Ross StreetBlack MountainACTAustralia

The organ-specific critical nitrogen(N_(c))dilution curves are widely thought to represent a new approach for crop nitrogen(N)nutrition diagnosis,N management,and crop *** N_(c) dilution curve can be described by a power function(N_(c)=A_(1)·W^(−A2)),while parameters A_(1) and A_(2) control the starting point and *** study aimed to investigate the uncertainty and drivers of organ-specific curves under different *** using hierarchical Bayesian theory,parameters A_(1) and A_(2) of the organ-specific N_(c) dilution curves for wheat were derived and evaluated under 14 different genotype×environment×management(G×E×M)N fertilizer *** results show that parameters A_(1) and A_(2) are highly *** the variation of parameter A_(1) was less than that of A_(2),the values of both parameters can change significantly in response to G×E×*** nutrition index(NNI)calculated using organ-specific N_(c) is in general consistent with NNI estimated with overall shoot N_(c),indicating that a simple organ-specific N_(c) dilution curve may be used for wheat N diagnosis to assist N ***,the significant differences in organ-specific N_(c) dilution curves across G×E×M conditions imply potential errors in N_(c) and crop N demand estimated using a general N_(c) dilution curve in crop models,highlighting a clear need for improvement in N_(c) calculations in such *** results provide new insights into how to improve modeling of crop nitrogen–biomass relations and N management practices under G×E×M.

关键词： Wheat diagnosis starting

The transcriptional regulators of virulence for Pseudomonas aeruginosa:Therapeutic opportunity and preventive potential of its clinical infections

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Genes & Diseases 2023年第5期10卷 2049-2063页

作者： xiaolong Shao Chunyan yao Yiqing Ding Haiyan Hu Guoliang Qian Mingliang He Xin Deng College of Plant Protection Laboratory of Plant ImmunityKey Laboratory of Integrated Management of Crop Diseases and PestsNanjing Agricultural UniversityNanjingJiangsu 210095China Department of Biomedical Sciences City University of Hong KongKowloon TongHong Kong SARChina School of Pharmaceutical Sciences Sun Yat-Sen UniversityUniversity TownGuangzhouGuangdong 510006China Tung Biomedical Sciences Centre City University of Hong KongKowloon TongHong Kong SARChina Shenzhen Research Institute City University of Hong KongShenzhenGuangdong 518057China

In Pseudomonas aeruginosa(***),transcription factors(TFs)are important mediators in the genetic regulation of adaptability and pathogenicity to respond to multiple environmental stresses and host *** *** genome harbours 371 putative TFs;of these,about 70 have been shown to regulate virulence-associated phenotypes by binding to the promoters of their target *** the past three decades,several techniques have been applied to identify TF binding sites on the *** genome,and an atlas of TF binding patterns has been *** virulence-associated regulons of TFs show complex crosstalk in ***'s regulatory *** this review,we summarise the recent literature on TF regulatory networks involved in the quorum-sensing system,biofilm formation,pyocyanin synthesis,motility,the type III secretion system,the type VI secretion system,and oxidative stress *** discuss future perspectives that could provide insights and targets for preventing clinical infections caused by *** based on the global regulatory network of transcriptional regulators.

关键词： Crosstalk Pseudomonas aeruginosa Regulatory network Transcriptional regulators Virulence

印刷行业典型挥发性有机物的排放特征与管控措施综述

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环境工程 2023年第S1期41卷 306-313,319页

作者：汪世宁崔江水罗弘宇阿里亚·阿布力海提姚小龙党培华雷雅茹高凤雨北京科技大学能源与环境工程学院北京100083 中国轻工业清洁生产和资源综合利用重点实验室(北京工商大学) 北京100048 工业典型污染物资源化处理北京市重点实验室(北京科技大学) 北京100083

挥发性有机物(VOCs)严重危害人体健康并促使空气中PM_(2.5)和O_(3)的生成。印刷行业作为VOCs的主要来源之一,正受到越来越多的关注。梳理了印刷工艺生产过程中的排污节点,通过文献调研总结了VOCs的排放特征。印刷行业VOCs主要产生于润... 详细信息

挥发性有机物(VOCs)严重危害人体健康并促使空气中PM_(2.5)和O_(3)的生成。印刷行业作为VOCs的主要来源之一,正受到越来越多的关注。梳理了印刷工艺生产过程中的排污节点,通过文献调研总结了VOCs的排放特征。印刷行业VOCs主要产生于润版、印刷、清洗和烘干等环节。排放形式、印刷产品、印刷形式和有机原辅材料的不同,使得排放的VOCs含量、种类和比例各不相同。最后总结了印刷行业VOCs的治理难点、管控政策和减排措施,以期为印刷行业VOCs的综合治理提供借鉴。

关键词：印刷行业挥发性有机物产污环节排放特征管控政策减排措施