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Effects of maltogenicα-amylase treatment on the proportion of slowly digestible starch and the structural properties of pea starch

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Food Bioscience 2022年第4期48卷 551-558页

作者： Yi Zheng Huanxin Zhang Ruomin Li xiaoling zhu Mengwei zhu School of Food Science and Technology Jiangsu Agri-animal Husbandry Vocational CollegeTaizhou225300PR China College of Food Science and Engineering Jiangsu Ocean UniversityLianyungang222005China

In this study,pea starch was modified with maltogenicα-amylase and then its physicochemical properties,chain length distribution,and in vitro digestibility were *** analysis of the starch products resulting from the maltogenicα-amylase treatment revealed a decrease in the molecular weight,an increase in the proportion of short chains[degree of polymerization(DP)13),and a decrease in viscosity,resulting in slower *** results indicated that maltogenicα-amylase can selectively hydrolyzeα-1,4-andα-1,6-glycosides to some *** theα-1,4 linkage of starch facilitated the transfer of the non-reducing D-glucosyl residues of maltose,thereby generating anα-1,6 branch *** reaction between maltogenicα-amylase and pea starch was affected by the reaction time and enzyme *** maximum slowly digestible starch content(38.5%)was obtained by digesting samples with 60.0 ppm maltogenicα-amylase for 4.0 *** findings demonstrate that modifying pea starch using maltogenicα-amylase can generate starch products with new branching structures conducive to slow digestion.

关键词： Pea starch Maltogenicα-amylase Slowly digestible starch(SDS) Glycemic index(GI) Enzymatic modification Hydrolysis

Microbial phenolic metabolites 3-(3',4'-dihydroxyphenyl)propanoic acid and 3',4'-dihydroxyphenylacetic acid prevent obesity in mice fed high-fat diet

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Food Science and Human Wellness 2024年第1期13卷 327-338页

作者： Wanbing Chen Ruonan Liu xiaoling zhu Qun Lu Hong Yang Rui Liu College of Food Science and Technology Huazhong Agricultural UniversityWuhan 430000China Key Laboratory of Environment Correlative Dietology(Huazhong Agricultural University) Ministry of educationWuhan 430000China Wuhan Engineering Research Center of Bee Products on Quality and Safety Control Wuhan 430000China Key Laboratory of Urban Agriculture in Central China Ministry of Agriculture and Rural AffairsWuhan 430000China Hubei Provincial Institute for Food Supervision and Test Wuhan 430070China

Obesity is associated with numerous metabolic disorders,and dietary polyphenols have been confirmed to have beneficial effects on the metabolism in ***,the effect of 3-(3’,4’-dihydroxyphenyl)propanoic acid(DHPA)and 3’,4’-dihydroxyphenylacetic acid(DHAA),two main metabolites of dietary polyphenols,on obesity remains poorly *** this study,DHPA and DHAA were found to alleviate obesity,as well as regulate insulin resistance,lipid metabolism,and oxidative stress response in high-fat diet(HFD)***,the 16S rRNA sequencing and UHPLC-Q-TOF/MS demonstrated that DHPA and DHAA only slightly disturbed the intestinal microbiome,but significantly altered the urine metabolome of HFD mice mainly by regulating pentose and glucuronate interconversion,tyrosine metabolism,pentose phosphate and tricarboxylic acid(TCA)cycle as indicated by metabolic pathway analysis based on Kyoto Encyclopedia of Genes and Genomes(KEGG)*** analysis revealed that the differential metabolites are strongly associated with body weight,blood glucose,insulin level,and superoxide dismutase(SOD)enzyme *** results revealed that DHPA and DHAA exert their anti-obesity effect by regulating important metabolites in the glucose,lipid and tyrosine metabolism pathways.

关键词： Obesity Dietary polyphenol metabolites Gut microbiota Metabonomics

A prodrug nanoplatform via esterification of STING agonist and IDO inhibitor for synergistic cancer immunotherapy

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Nano Research 2022年第10期15卷 9215-9222页

作者： Madiha Zahra Syeda Tu Hong Min Zhang Yanfei Han xiaoling zhu Songmin Ying Longguang Tang International Institutes of Medicine the Fourth Affiliated Hospital of Zhejiang University School of MedicineYiwu 322000China Department of Pharmacology and Department of Respiratory and Critical Care Medicine of the Second Affiliated Hospital Zhejiang University School of MedicineKey Laboratory of Respiratory Disease of Zhejiang ProvinceHangzhou 310009China

Cancer immunotherapy has made significant progress in the last few decades,revolutionizing ***,low patient response rates and potential immune-related adverse events continue to be major clinical *** nanomedicine,by virtue of its regulated delivery and modular flexibility,has shown the potential to strengthen antitumor immune responses and sensitize tumors to *** this study,we developed tumor microenvironment(TME)responsive nanomedicine to achieve specific and localized amplification of the immune response in tumor tissue in a safe and effective manner,while simultaneously reducing immune-related side *** synthesized the TME responsive prodrug by coupling MSA-2,a stimulator of interferon genes(STING)agonist,and NLG-919,an indoleamine 2,3 dioxygenase(IDO)*** prodrug was assembled into nanoparticles to enhance the solubility and *** synthesizing a TME responsive prodrug,we aim to explore the therapeutic efficacy of combined regimen(STING agonist and IDO inhibitor)for cancer,and reduce the unwanted side effects of STING agonism on normal *** prodrug and nanoparticles were characterized by mass spectrometry,dynamic light scattering(DLS),and transmission electron microscopy(TEM).Following that,we investigated the tumor accumulation,anti-tumor activity,and toxicity in vitro and in *** nanoparticles demonstrated the ability to inhibit the tumor growth and activate antitumor immune response by modulating immune cells populations in tumor *** TME responsive nanomedicine provided an effective tool for precise targeting,promoting antitumor immunity,and efficient tumor growth inhibition with *** of this study may have implications for future clinical trials.

关键词： prodrug esterase-responsive immunotherapy stimulator of interferon genes(STING) indoleamine 2 3 dioxygenase(IDO)

A Location Privacy Preserving Solution to Resist Passive and Active Attacks in VANET

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China Communications 2014年第9期11卷 60-67页

作者： zhu xiaoling HU Donghui HOU Zhengfeng DING Liang School of Computer & Information Hefei University of Technology Hefei 230009 Anhui Province E R. China

Existing location privacy- preserving methods, without a trusted third party, cannot resist conspiracy attacks and active attacks. This paper proposes a novel solution for location based service （LBS） in vehicular ad hoc network （VANET）. Firstly, the relationship among anonymity degree, expected company area and vehicle density is discussed. Then, a companion set F is set up by k neighbor vehicles. Based on secure multi-party computation, each vehicle in V can compute the centroid, not revealing its location to each other. The centroid as a cloaking location is sent to LBS provider （P） and P returns a point of interest （POI）. Due to a distributed secret sharing structure, P cannot obtain the positions of non-complicity vehicles by colluding with multiple internal vehicles. To detect fake data from dishonest vehicles, zero knowledge proof is adopted. Comparing with other related methods, our solution can resist passive and active attacks from internal and external nodes. It provides strong privacy protection for LBS in VANET.

关键词： vehicular ad hoc network locationbased services location k-anonymity securemulti-party computation

Redetermination of the Crystal Structure of Vesignieite

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Acta Geologica Sinica(English Edition) 1991年第2期65卷 145-151页

作者： Ma Zhesheng He Ruilin zhu xiaoling China University of Geosciences Institute of Geology and Mineral Resources, Shaanxi Institute of Mineral Depostis, Chinese Academy of Geological Sciences China University of Geosciences China

Vesignieite, Cu_3Ba(VO_4)_2(OH)_2, crystallizes in space group C_2 / m with a°=1.0270(2), b°=0.5911(1),c°=0.7711(2)nm and β=116.42(3)°. The intensity data were collected with the RIGAKU RASA-IISsingle-crystal four-circle diffractometer. The structure was determined by Patterson and Fourier methods andrefined by the least-square technique to a final R index of 0.051 for 614 independent diffraction points with|F? |>3σ|F?|. The crystal structure analysis shows that vesignieite has a layer structure parallel to (001). The powder diffraction lines were reindexed.

关键词： Redetermination of the Crystal Structure of Vesignieite

The First Principle Study of <i>β</i>-CuAgSe Subcells

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Journal of Applied Mathematics and Physics 2021年第7期9卷 1549-1559页

作者： xiaoling zhu Chenglong Shi Zhipeng Shao College of Science University of Shanghai for Science and Technology Shanghai China

CuAgSe has been considered as a promising thermoelectric material because of its high mobility and low thermal conductivity. The superior performance of CuAgSe is closely related to its crystal structure and electric properties. In this work, the stabilities and electronic structures of different three CuAgSe subcells have been theoretically investigated using Vienna Ab initio Simulation Package (VASP) with DFT calculations. We found that the different occupations of copper atoms would affect the stability and electronic structures of CuAgSe subcells. The various directions of Cu-Se chain in neighbor layers will result in different stabilities and electronic properties.

关键词： CuAgSe Subcells Stability Electronic Property

Factors influencing prehospital delay for patients with acute myocardial infarction

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Journal of Geriatric Cardiology 2007年第1期4卷 11-13页

作者： Shujuan CHENG Lufen GUO Juyuan LIU xiaoling zhu Hongbing YAN Emergency Department Beijing Anzhen Hospital Beijing 100029 China Emergency Department Beijing Anzhen Hospital Beijing 100029 China Public Health and Family Medicine Department Capital Medical University Beijing 100069 China Emergency Department Beijing Anzhen Hospital Beijing 100029 China Emergency Department Beijing Anzhen Hospital Beijing 100029 China

Objective To investigate the influencing factors for prehospital delay in patients with acute myocardial infarction (AMI). Methods A total of 807 consecutive patients with AMI who presented to the emergency department of Beijing Anzhen Hospital were analyzed. The influence of several potential risk factors on the prehospital delay time (PDT) was evaluated by comparing patients admitted more than 2 hours after onset of chese pain with those admitted within 2 hours after onset. Results Among 807 patients, 402 came to the hospital within 2 hours while the others arrived at the hospital after 2 hours. The median PDT was 130 min. Among the potential variables, advanced age, history of diabetes mellitus, occurrence of symptom at night and use of emergency medical service significantly affected PDT by multivariate analysis. Conclusion Interventions aimed at reducing the prehospital delay in AMI should primarily focus on the awareness of the risk and help-seeking behavior of patients.

关键词： acute myocardial infarction emergency medical service risk factor prehospital delay time

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校园文化品牌活动构建和阅读推广

大学图书馆学报 2011年第2期29卷 31-37页

作者：朱小玲浙江工商大学图书馆杭州310018

以高校校园文化活动问卷调查为线索,分析了当前校园文化活动的现状,探讨了图书馆与校园文化的关系,并以读书节开展的阅读推广活动为样板,详细阐述了图书馆如何通过开展图书漂流、书库寻宝、读书会、文化长廊、专家学者书目推荐、讲座、... 详细信息

以高校校园文化活动问卷调查为线索,分析了当前校园文化活动的现状,探讨了图书馆与校园文化的关系,并以读书节开展的阅读推广活动为样板,详细阐述了图书馆如何通过开展图书漂流、书库寻宝、读书会、文化长廊、专家学者书目推荐、讲座、征文大赛、名著改编等生动活泼的阅读推广活动,与读者互动,创建校园阅读文化品牌活动。

关键词：校园文化品牌读书节阅读推广

Development of biofertilizers for sustainable agriculture over four decades(1980-2022)

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Geography and Sustainability 2024年第1期5卷 19-28页

作者： Guangxu Zhao xiaoling zhu Gang Zheng Guangfan Meng Ziliang Dong Ju Hye Baek Che Ok Jeon Yanlai Yao Yuan Hu Xuan Jie Zhang Baolei Jia Xianghu Laboratory Hangzhou 311231China School of Bioengineering State Key Laboratory of Biobased Material and Green PapermakingQilu University of Technology(Shandong Academy of Sciences)Jinan 250000China Shandong Academy of Agricultural Sciences Jinan 250000China Taiji Group Chongqing 400000China Department of Life Science Chung-Ang UniversitySeoul 06974Republic of Korea Institute of Environment ResourceSoil and FertilizersZhejiang Academy of Agricultural SciencesHangzhou 310021China State Key Laboratory of Elemento-Organic Chemistry Department of Chemical BiologyNational Pesticide Engineering Research Center(Tianjin)Nankai UniversityTianjin 300071China

The application of biofertilizers is becoming an inevitable trend to substitute chemical fertilizers for sustainable *** better understand the development of biofertilizers from 1980 to 2022,we used bibliometric mining to analyze 12,880 journal articles related to *** network cooccurrence analysis suggested that the biofertilizers research can be separated into three *** first stage(1980-2005)focused on nitrogen *** second stage(2006-2015)concentrated on the mechanisms for increasing plant *** third stage(2016-2022)was the application of biofertilizers to improve the soil *** keyword analysis revealed the mechanisms of biofertilizers to improve plant-growth:biofertilizers can impact the nutritional status of plants,regulate plant hormones,and improve soil environments and the *** bacteria use as biofertilizers,included Pseudomonas,Azospirillum,and Bacillus,were also identified through bibliometric *** findings provide critical discernment to aid further study of biofertilizers for sustainable agriculture.

关键词： Biofertilizer Plant-growth-promoting bacteria Plant-growth promoting rhizobacteria Bibliometric Research hotspots